Pharmacodynamics and pharmacokinetics
Pharmacodynamics
Combined drug with local anesthetic and anti-inflammatory effects .
Phenazone is a non-steroidal anti-inflammatory drug, an analgesic with anti-inflammatory action. Blocks cyclooxygenase and inhibits prostaglandin synthesis.
Lidocaine is a local anesthetic. It disrupts the conduction of pain impulses due to antagonism with sodium and calcium in the nerve fiber membrane. A successful combination of two active substances promotes rapid analgesic action, increases its intensity and duration. The drug stimulates the liquefaction of mucus and its removal from the middle ear cavity through the Eustachian tube and eardrum.
Pharmacokinetics
If the integrity of the eardrum is preserved, it does not penetrate the body.
Indications for use
- otitis media in the catarrhal ;
- otitis barotraumatic;
- otitis media after the flu.
Which is better Otipax or Lorotox?
Since Otipax and Lorotox have identical active ingredients, they are produced in the form of drops for external use - they are considered complete analogues. If there is an inflammatory process in the outer ear, you can use one of these remedies, which are available at the pharmacy. Comparative characteristics are presented in the table.
Index | Lorotox | Otipax |
Active ingredients | Phenazone, Lidocaine | Phenazone, Lidocaine |
Indications for use | Otitis | Otitis |
Side effects | Allergy | Allergy |
Contraindications for use | Intolerance, eardrum perforation | Intolerance, eardrum perforation |
Use for children, pregnant women, lactation | Allowed | Allowed |
Price | 250 | 350 |
Country of issue | Russia | France |
Company manufacturer | Gratex | Biocode |
If the patient is not sure about the Russian company, you can choose Otipax. Although Lorotox fully matches it in quality, despite the fact that it is cheaper. Therefore, the pharmacy chooses one of the products that is available.
Otipax for children
In childhood, an infection from the nasopharynx often enters the middle ear and causes otitis media. The safest drug for catarrhal otitis is Otipax for children, which has anti-inflammatory and analgesic effects.
In addition to catarrhal otitis, it is used for ear congestion ( eustachitis ) in children, for external otitis, some forms of purulent otitis and after removal of foreign bodies. They are used in children to relieve pain in the preperforative stage of otitis media , starting in infancy.
Instructions for Otipax for children
The drops are preheated to 38-40 °C. It is better to instill drops onto a turunda made of cotton wool or gauze inserted into the ear. Children under one year old use 1-2 drops, from 1 to 2 years old - 3 drops, children of preschool age and schoolchildren - 4 drops 3 times a day.
After instillation, you need to seal the ear canal with cotton wool, lubricated with Vaseline - the drug will not evaporate and its effectiveness will be higher. A one-time use of the drug gives a short-term effect, so its course use is necessary. The anti-inflammatory effect is observed on days 2–3.
How to drip Otipax
The medicine should be dripped into the external auditory canal of the ear.
For an adult, it will be enough to drop 4 drops into each ear 3 times a day.
The maximum duration of treatment is 10 days. Before starting treatment with Otipax, you need to ensure the integrity of the eardrums. Therefore, you must first be examined by a doctor and study the instructions in detail.
Before dropping the medicine, you need to hold the bottle in your hands for a while so that it warms up. This will prevent the discomfort that usually occurs when cold liquid enters the ear.
First you need to remove the cap from the bottle, then turn it over and point it into the ear canal. After this, you need to press on the center of the dropper and squeeze out the required number of drops (depending on age). After the manipulations, you need to tightly close the bottle and put it back in the packaging.
Otipax's analogs
Level 4 ATC code matches:
Antipyrine
Otinum
Otirelax
The pharmacy chain widely offers drops for topical use for otitis media. Structural analogues are Folicap and Otirelax , similar in action to Sofradex , Otinum , Anauran , Uniflox , Tsipromed , Garazon , Polydexa .
The price of Otipax analogues differs significantly. Thus, Otirelax 15 ml can be purchased for 100-200 rubles, Sofradex 5 ml for 190-500 rubles. The cost of Otinum 10 ml is 170-300 rubles, Anaurana 25 ml is 270-470 rubles.
Which is better: Otipax or Otinum?
Otinum has anti-inflammatory and moderate local anesthetic effects. The difference between the two drugs is the active substance: Otinum contains choline salicylate , a derivative of salicylic acid, and there is no anesthetic, so the analgesic effect is not so pronounced. If it enters the middle ear, ototoxicity occurs. Used in children from 1 year of age. Manufacturer ICN Polfa Rzeszow (Poland)
Anauran or Otipax - which is better?
Anauran contains the local anesthetic lidocaine and the antibiotics polymyxin and neomycin . From the point of view of the anti-inflammatory effect, this drug is stronger, however, the presence of ototoxic antibiotics is a contraindication to their use in case of perforation of the eardrum. The drug is effective for external and otitis media before perforation occurs. Has no age restrictions. Manufacturer: Zambon SPA (Italy).
Sofradex or Otipax - which is better?
Sofradex contains two antibiotics ( framycetin and gramicidin ) and the glucocorticoid dexamethasone . In terms of the strength of its anti-inflammatory effect, it is superior to the drug described. Glucocorticoids are not ototoxic, but antibiotics are otoxic. Drops are intended for the treatment of otitis without compromising the integrity of the eardrum. Of course, only a doctor can determine this during examination, and accordingly, recommend this or that drug. Used in children from 7 years of age. Manufacturer: Aventis Pharma (India).
Otirelax or Otipax - which is better?
Otirelax is a structural analogue of Otipax (their composition is the same) and the same effect. The difference is that the latter is an original drug, and Otirelax is a generic produced by Rompharm Company SRL (Romania).
Otofa or Otipax - which is better?
Otofa combines a pronounced antibacterial effect and the absence of ototoxic action. The active substance is rifamycin , which is not an ototoxic antibiotic and these drops can be used in the perforated stage. In this regard, this drug has an advantage, since all the drugs described above (Sofradex, Otinum, Otipax, Anauran) have a main contraindication - perforation of the eardrum .
Contraindications
People who have perforated eardrums or have increased susceptibility to the constituent components should avoid taking the drug. If there are ear injuries, then taking medication can only worsen the situation.
It is also not recommended for athletes to take before the start of competitions, since the elements present in the composition may show a positive response when tested for doping.
Particular caution should be taken when taking the medicine during pregnancy and breastfeeding.
Reviews about Otipax
Otipax drops act on the inflamed eardrum, reducing its tension and swelling, which cause pain. For otitis media, it is important that ear drops have a pronounced analgesic effect, since the main symptom of otitis media is pain. Otipax ear drops have a rapid analgesic effect, which is very important for children. The local anesthetic lidocaine helps reduce pain after 5 minutes, and complete disappearance after 20–30 minutes. They are prescribed on the first day of the disease to relieve pain.
Reviews about Otipax drops are only positive. Everyone notes a quick and long-lasting (2-3 hours) analgesic effect. The important thing is that the drops can be used for 6 months after you open the bottle and can be used by the whole family, including infants.
These ear drops were used not only for otitis of a bacterial nature, but also for barotraumatic otitis that occurs in children during flights.
- “... We always take these drops with us on vacation. After the flight, my son’s ears often hurt, and otitis occurs when diving.”
Many parents report that the drug was prescribed to their children, in whom ARVI is often complicated by otitis media, for the purpose of its prevention. At the first signs of respiratory infections and runny nose, drops in the nose and drops in the ears were prescribed.
Adverse reactions and overdose
After using the medication, undesirable reactions may occur, namely the appearance of an allergy at the site of use of the drug, the symptoms of which are a burning sensation, peeling of the skin, and redness.
If such signs appear, you should stop treatment and inform your doctor.
The drug is characterized by low adsorption. That is why, if the specified dose is observed, cases of overdose are not permissible. If you neglect the instructions, side reactions may appear in a more pronounced form.
Otipax price, where to buy
You can buy it in many pharmacies, since Russia, Ukraine, and Belarus have registered this drug.
How much does 1 bottle of the drug cost at the pharmacy? The cost in pharmacies in Russian cities is approximately the same. In Moscow you can buy it for 190 - 270 rubles. The price of Otipax ear drops in Voronezh ranges from 200 to 280 rubles; in St. Petersburg you can buy drops for children for 200-270 rubles.
The Ukrainian pharmacy chain (Kyiv, Kharkov, Dnepropetrovsk) offers these ear drops for 90-120 hryvnia.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Otipax ear drops
15mlBiocodex Laboratoires RUR 420 order
Pharmacy Dialogue
- Otipax ear drops bottle 16g (15ml)Biocodex
427 RUR order
show more
Pharmacy24
- Otipax 16 g drops Biocodex, France
85 UAH. order
PaniPharmacy
- Otipax liquid Otipax u/k 16g France, Biocodex
91 UAH order
show more
The importance of timely use of drops
When an inflammatory reaction occurs in the outer and middle ear, its cause must be identified in a timely manner. It can be allergic, fungal, bacterial, viral. If this is not done, the inflammatory process will spread deeper. Possible extensive damage to the eardrum. If this happens, severe suppuration will occur. It will need to be opened. This is fraught with many complications, including hearing loss.
Many ear drops have side effects. Some of them negatively affect the trophism of the ear canal, for example, glucocorticosteroids. Therefore, doctors strongly recommend using them only for their intended purpose after diagnosis. Thanks to her, they determine which medicine to choose.
For example, for infection, drops containing an antibiotic and a glucocorticosteroid are prescribed. In case of intolerance, the latter substance can be replaced with lidocaine, which has an analgesic effect.
Despite the fact that ear drops have only a local effect, they are used for a short course. The eardrum is easily susceptible to negative influences, including side effects from long-term use of drops. All of them must be used strictly according to the instructions received from the doctor. Be sure to monitor the expiration date. Drops should not be used for more than 1 month after opening. When instilled, they are held carefully, correctly, without touching the tip.