Instructions:
Clinical and pharmacological group
13.001 (Histamine H1 receptor blocker. Antiallergic drug)
Release form, composition and packaging
| ◊ Film-coated tablets | 1 tab. |
| fexofenadine (as hydrochloride) | 120 mg |
10 pieces. — contour cell packaging (1) — cardboard packs. 10 pcs. — contour cell packaging (2) — cardboard packs. 10 pcs. — cellular contour packages (3) — cardboard packs.
| ◊ Film-coated tablets | 1 tab. |
| fexofenadine (as hydrochloride) | 180 mg |
10 pieces. — contour cell packaging (1) — cardboard packs. 10 pcs. — contour cell packaging (2) — cardboard packs. 10 pcs. — cellular contour packages (3) — cardboard packs.
pharmachologic effect
Fexofenadine hydrochloride is a non-sedating H1 blocker of histamine receptors and is a pharmacologically active metabolite of terfenadine. The antihistamine effect appears 1 hour after administration, reaches a maximum after 6 hours and continues for 24 hours. With repeated use, no development of tolerance was observed. Does not have anticholinergic, adrenolytic or sedative effects. Does not cause changes in the function of calcium and potassium channels, the QT interval at therapeutic doses.
Pharmacokinetics
After oral administration, it is quickly absorbed from the gastrointestinal tract, ТCmax - 1-3 hours. Average Cmax after taking 180 mg is approximately 494 ng/ml, after taking 120 mg - 427 ng/ml, Plasma protein binding - 60-70 % (mainly with albumin and alpha 1-glycoprotein). Does not penetrate the blood-brain barrier.
T1/2 after repeated doses is 14.4 hours. In patients with moderate (creatinine clearance 41-80 ml/min) and severe (11-40 ml/min) renal failure, T1/2 increases by 59 and 72%, respectively; in patients on hemodialysis, T1/2 increases by 31%.
Subjects (5% of the dose) to partial extra-chechen metabolism. It is excreted predominantly (80%) with bile, 11% by the kidneys unchanged.
Dosage
Inside.
For seasonal allergic rhinitis, adults and children over 12 years of age, 120 mg 1 time per day. For chronic urticaria - 180 mg 1 time per day.
Overdose
Symptoms: dizziness, drowsiness and dry mouth. In case of overdose, standard measures are recommended to remove unabsorbed drug from the gastrointestinal tract. Symptomatic and supportive therapy is recommended. Hemodialysis is ineffective.
Drug interactions
When used together with erythromycin or ketoconazole, the plasma concentration of fexofenadine increases by 2-3 times. Taking aluminum or magnesium-containing antacids 15 minutes before taking fexofenadine leads to a decrease in the bioavailability of the latter (the time interval between their administration should be at least 2 hours). Does not interact with omeprazole or drugs metabolized in the liver.
Use during pregnancy and lactation
Contraindicated during pregnancy and lactation.
Side effects
Headache, drowsiness, nausea, dizziness.
Rarely (less than 1 case in 1000 prescriptions): feeling tired, insomnia, nervousness, sleep disturbance.
In some cases: skin rash, urticaria, itching, other hypersensitivity reactions (angioedema, shortness of breath).
Storage conditions and periods
List B. In a dry place, protected from light and out of reach of children, at a temperature not exceeding 25°C. Shelf life - 2 years.
Indications
— seasonal allergic rhinitis;
- chronic urticaria.
Contraindications
- pregnancy;
- lactation period;
- children under 12 years of age;
- hypersensitivity.
With caution: chronic renal failure. (The recommended daily dose in such patients is 60 mg once).
special instructions
When taking the drug Gifast, it is possible to perform work that requires a high concentration of attention and speed of psychomotor reactions (with the exception of people who have a non-standard reaction to drugs). Thus, before starting to perform these works (driving vehicles, operating machinery), you must first check your individual reaction to the drug.
Use for renal impairment
With caution: chronic renal failure. (The recommended daily dose in such patients is 60 mg once).
Conditions for dispensing from pharmacies
Over the counter.
Gifast tablet film 120 mg pack contact cell/pack of cards x10
Clinical and pharmacological group Histamine H1 receptor blocker. Antiallergic drug Release form, composition and packaging
◊ Film-coated tablets 1 tab. fexofenadine (in the form of hydrochloride) 120 mg
10 pieces. — cellular contour packages (1) — cardboard packs. 10 pieces. — contour cell packaging (2) — cardboard packs. 10 pieces. — cellular contour packages (3) — cardboard packs.
◊ Film-coated tablets 1 tab. fexofenadine (in the form of hydrochloride) 180 mg Pharmacological action Fexofenadine hydrochloride is a non-sedating H1 blocker - histamine receptors, and is a pharmacologically active metabolite of terfenadine. The antihistamine effect appears 1 hour after administration, reaches a maximum after 6 hours and continues for 24 hours. With repeated use, no development of tolerance was observed. Does not have anticholinergic, adrenolytic or sedative effects. Does not cause changes in the function of calcium and potassium channels, the QT interval at therapeutic doses.
Pharmacokinetics After oral administration, it is quickly absorbed from the gastrointestinal tract, TCmax - 1-3 hours. Average Cmax after administration of 180 mg is approximately 494 ng/ml, after administration of 120 mg - 427 ng/ml, Plasma protein binding - 60- 70% (mainly with albumin and alpha 1-glycoprotein). Does not penetrate the blood-brain barrier.
T1/2 after repeated doses is 14.4 hours. In patients with moderate (creatinine clearance 41-80 ml/min) and severe (11-40 ml/min) renal failure, T1/2 increases by 59 and 72%, respectively, in patients those on hemodialysis, T1/2 increases by 31%.
Subjects (5% of the dose) to partial extra-chechen metabolism. It is excreted predominantly (80%) with bile, 11% by the kidneys unchanged.
Dosage Inside.
For seasonal allergic rhinitis, adults and children over 12 years of age, 120 mg 1 time per day. For chronic urticaria - 180 mg 1 time per day.
Overdose Symptoms: dizziness, drowsiness and dry mouth. In case of overdose, standard measures are recommended to remove unabsorbed drug from the gastrointestinal tract. Symptomatic and supportive therapy is recommended. Hemodialysis is ineffective.
Drug interactions When used together with erythromycin or ketoconazole, the plasma concentration of fexofenadine increases by 2-3 times. Taking aluminum or magnesium-containing antacids 15 minutes before taking fexofenadine leads to a decrease in the bioavailability of the latter (the time interval between their administration should be at least 2 hours). Does not interact with omeprazole or drugs metabolized in the liver.
Pregnancy and lactation Contraindicated during pregnancy and lactation.
Side effects Headache, drowsiness, nausea, dizziness.
Rarely (less than 1 case in 1000 prescriptions): feeling tired, insomnia, nervousness, sleep disturbance.
In some cases: skin rash, urticaria, itching, other hypersensitivity reactions (angioedema, shortness of breath).
Storage conditions and periods List B. In a dry place, protected from light and out of reach of children, at a temperature not exceeding 25°C. Shelf life - 2 years.
Indications: seasonal allergic rhinitis,
- chronic urticaria.
Contraindications: pregnancy,
- lactation period,
- children under 12 years of age,
- hypersensitivity.
With caution: chronic renal failure. (The recommended daily dose in such patients is 60 mg once).
Special instructions When taking the drug Gifast, it is possible to perform work that requires a high concentration of attention and speed of psychomotor reactions (with the exception of people who have a non-standard reaction to drugs). Thus, before starting to perform these works (driving vehicles, operating machinery), you must first check your individual reaction to the drug.
AllergologyAnaphylactic shock Bronchial asthma Quincke's edema Hay fever In case of impaired renal function With caution: chronic renal failure. (The recommended daily dose in such patients is 60 mg once).
Use in childhood Contraindicated in children under 12 years of age.
Conditions for dispensing from pharmacies Without a prescription.
Hyfast
Clinical and pharmacological group Histamine H1 receptor blocker. Antiallergic drug Release form, composition and packaging
◊ Film-coated tablets 1 tab. fexofenadine (in the form of hydrochloride) 120 mg
10 pieces. — cellular contour packages (1) — cardboard packs. 10 pieces. — contour cell packaging (2) — cardboard packs. 10 pieces. — cellular contour packages (3) — cardboard packs.
◊ Film-coated tablets 1 tab. fexofenadine (in the form of hydrochloride) 180 mg Pharmacological action Fexofenadine hydrochloride is a non-sedating H1 blocker - histamine receptors, and is a pharmacologically active metabolite of terfenadine. The antihistamine effect appears 1 hour after administration, reaches a maximum after 6 hours and continues for 24 hours. With repeated use, no development of tolerance was observed. Does not have anticholinergic, adrenolytic or sedative effects. Does not cause changes in the function of calcium and potassium channels, the QT interval at therapeutic doses.
Pharmacokinetics After oral administration, it is quickly absorbed from the gastrointestinal tract, TCmax - 1-3 hours. Average Cmax after administration of 180 mg is approximately 494 ng/ml, after administration of 120 mg - 427 ng/ml, Plasma protein binding - 60- 70% (mainly with albumin and alpha 1-glycoprotein). Does not penetrate the blood-brain barrier.
T1/2 after repeated doses is 14.4 hours. In patients with moderate (creatinine clearance 41-80 ml/min) and severe (11-40 ml/min) renal failure, T1/2 increases by 59 and 72%, respectively, in patients those on hemodialysis, T1/2 increases by 31%.
Subjects (5% of the dose) to partial extra-chechen metabolism. It is excreted predominantly (80%) with bile, 11% by the kidneys unchanged.
Dosage Inside.
For seasonal allergic rhinitis, adults and children over 12 years of age, 120 mg 1 time per day. For chronic urticaria - 180 mg 1 time per day.
Overdose Symptoms: dizziness, drowsiness and dry mouth. In case of overdose, standard measures are recommended to remove unabsorbed drug from the gastrointestinal tract. Symptomatic and supportive therapy is recommended. Hemodialysis is ineffective.
Drug interactions When used together with erythromycin or ketoconazole, the plasma concentration of fexofenadine increases by 2-3 times. Taking aluminum or magnesium-containing antacids 15 minutes before taking fexofenadine leads to a decrease in the bioavailability of the latter (the time interval between their administration should be at least 2 hours). Does not interact with omeprazole or drugs metabolized in the liver.
Pregnancy and lactation Contraindicated during pregnancy and lactation.
Side effects Headache, drowsiness, nausea, dizziness.
Rarely (less than 1 case in 1000 prescriptions): feeling tired, insomnia, nervousness, sleep disturbance.
In some cases: skin rash, urticaria, itching, other hypersensitivity reactions (angioedema, shortness of breath).
Storage conditions and periods List B. In a dry place, protected from light and out of reach of children, at a temperature not exceeding 25°C. Shelf life - 2 years.
Indications: seasonal allergic rhinitis,
- chronic urticaria.
Contraindications: pregnancy,
- lactation period,
- children under 12 years of age,
- hypersensitivity.
With caution: chronic renal failure. (The recommended daily dose in such patients is 60 mg once).
Special instructions When taking the drug Gifast, it is possible to perform work that requires a high concentration of attention and speed of psychomotor reactions (with the exception of people who have a non-standard reaction to drugs). Thus, before starting to perform these works (driving vehicles, operating machinery), you must first check your individual reaction to the drug.
AllergologyAnaphylactic shock Bronchial asthma Quincke's edema Hay fever In case of impaired renal function With caution: chronic renal failure. (The recommended daily dose in such patients is 60 mg once).
Use in childhood Contraindicated in children under 12 years of age.
Conditions for dispensing from pharmacies Without a prescription.
