Comparing Akriderm and Akriderm GK | Determining the best

Expert: Abramova Tsilya

Akriderm is an ointment for topical use based on betamethasone. Akriderm GK is a drug with an additional composition and a wider range of applications. We analyzed both ointments to understand in which cases it is better to give preference to one or the other.

Description of Akriderm and Akriderm GK

Akriderm hormonal ointment is based on betamethasone. This is a potent remedy that must be used according to indications. It is usually prescribed when non-hormonal ointments do not provide the desired result. Manufacturer: Akrikhin, Russian Federation.

Betamethasone is a glucocorticosteroid substance that can inhibit the release of inflammatory mediators. The pronounced effect of the drug allows it to be used to quickly eliminate dermatological manifestations such as swelling, itching, redness in severe diseases.

Akriderm GK contains not only betamethasone, but the following substances:

1. gentamicin – antibacterial agent;
2. Clotrimazole is an antifungal agent.

pharmachologic effect

"Akriderm" is a glucocorticosteroid for external use. In addition to the above-mentioned actions of betamethasone dipropionate, the drug has a vasoconstrictor and antiproliferative effect. The use of this drug prevents the accumulation of leukocytes, and also inhibits the release of lysosomal enzymes and pro-inflammatory mediators at the site of inflammation. In addition, the drug:

• inhibits phagocytosis;
• reduces vascular tissue permeability;
• prevents the formation of inflammatory edema.

Thus, when using Akriderm, the severity of various manifestations of skin diseases, including swelling, erythema, pain, irritation and itching, decreases.

Research and effectiveness

Before determining the causative agent of the disease, combination drugs with a wide spectrum of antibacterial action are prescribed. These include Akriderm GK. It may be the drug of choice, as it is active against common bacterial and fungal pathogens.

Research results show a good therapeutic effect of the ointment in the treatment of dermatoses, chronic inflammatory diseases, and fungal-bacterial infections. Using the product gives a quick anti-inflammatory effect. Due to its effectiveness and relative safety, it is recommended for dermatoses of various origins. The use of the drug provides a high level of bacterial cure.

Source

to: Kasikhina E.I., Glazko I.I. “Problems of mixed infection: solutions and features of pathogenesis,” 2014.

ACRIDERM® PREPARATIONS FOR THE TREATMENT OF VARIOUS TYPES OF DERMATOSES

1. Instructions for medical use of Akriderm® GK.

2. According to the independent retail audit company of pharmacies IQVIA, among topical steroids containing a combination of “hormone + antibiotic + antifungal agent”, calculated per 1 g for the period January-March 2022

3. Efficacy and tolerability of the Akriderm® “line” in the practice of a dermatovenerologist, Matushevskaya E.V., Shakurov I.G., Khismatullina Z.R., Klin. derm. and Venerol., 2008, No. 2, pp. 12-17

— Efficacy and safety of using Akriderm® GK cream in children with allergic dermatitis, Liang N.A., Kornacheva L.A., Cheburkin A.A.,

— Experience in the use of Akriderm® drugs in complex therapy of patients with chronic dermatoses, Chigodaykin G.P., Kovaleva Zh.V., Neminushchiy Yu.G., Beketov A.M., Current issues of dermatovenerology: materials of the XVI regional scientific and practical conference dedicated to 110th anniversary of Professor Gitelzon I.I., Krasnoyarsk, 2006, pp. 134-135

— Clinical and immunological parameters in patients with atopic dermatitis during treatment with Akriderm® line drugs, Ertneeva I.Ya., Matushevskaya E.V., Svirshchevskaya E.V., Clinical dermatology and venereology, 2008, No. 5, pp. 35-39

4. Glucocorticosteroids for local use in a modern strategy for the treatment of inflammatory dermatoses in pediatric practice. Batyrshina S.V. 09 (14) Practical Medicine. 2014: 30-35

5. Patent No. 2223097, Patent No. 2325912

6. Topical hormonal drugs are the first choice drugs for the treatment of dermatitis. Federal clinical guidelines for the management of patients with atopic dermatitis and eczema. 2015

7. Redness, itching, inflammation, infection in the following diseases: simple and allergic dermatitis (especially complicated by secondary infection), diffuse neurodermatitis (including atopic dermatitis), limited neurodermatitis (including simple chronic lichen), eczema , ringworm (dermatophytosis, candidiasis, lichen versicolor). According to the instructions of Akriderm GK

8. Instructions for medical use Akriderm®

9. Khardikova S.A. Rational choice of a combined topical glucocorticosteroid in an outpatient appointment with a dermatovenerologist // Clinical dermatology and venereology, 2018. No. 2. pp. 67-72.

10. Simple and allergic dermatitis (especially complicated by secondary infection), diffuse neurodermatitis (including atopic dermatitis), limited neurodermatitis (including simple chronic lichen), eczema, dermatomycosis (dermatophytosis, candidiasis, lichen versicolor), especially when localized in the groin area and large folds of skin.

Contraindications

Each glucocorticosteroid drug has strict restrictions on its use. Akriderm is not prescribed until one year of age or during pregnancy. When it is necessary to treat a child, the ointment can only be used under the supervision of a doctor.

Betamethasone can disrupt hormonal levels, so the ointment is used with caution in childhood and during lactation.

Other contraindications for use:

1. viral skin diseases;
2. benign and malignant neoplasms;
3. open wounds;
4. perioral dermatitis;
5. lupus;
6. post-vaccination reactions;
7. intolerance to components and allergies to them.

Side effects

Corticosteroid ointment can provoke systemic reactions, since when applied topically, a certain amount enters the bloodstream. If any unpleasant symptoms appear, you should immediately visit a doctor for symptomatic treatment and choose another medicine.

Possible side effects from using the ointment:

1. allergies – itching, dry skin, irritation;
2. rash, urticaria;
3. prickly heat;
4. folliculitis;
5. atrophic processes of the skin;
6. maceration;
7. hyperglycemia;
8. hypertrichosis;
9. swelling;
10. osteoporosis;
11. increased blood pressure.

Side effects

When using the drug, side effects are possible, which, as a rule, are mild. Also, the severity of side effects depends on the duration of treatment and the extent of the surfaces on which the cream is applied.

When using Akriderm externally, the following may be observed:

• skin itching;
• burning;
• irritation;
• dry skin;
• folliculitis;
• hypertrichosis;
• striae;
• acne;
• hypopigmentation;
• perioral dermatitis;
• allergic contact dermatitis.

When using Akriderm together with occlusive dressings, skin maceration, secondary infection, skin atrophy, local hirsutism, telangiectasia, miliaria, and purpura are possible. If these adverse reactions occur, as well as those that are not included in the instructions, you must stop therapy and consult a doctor for additional advice.

Dosage

The ointment is applied to the skin in a thin layer 2 times a day. The frequency of use may be changed by the doctor depending on the course of the disease. Do not allow the product to come into contact with the eyes. The course of treatment usually lasts up to 4 weeks. Treatment for more than a month may lead to an overdose. If there is no effect of use, you should consult a dermatologist.

For acne

For acne, HA may be prescribed. Its use allows you to quickly get rid of skin problems. For dry skin types, ointment is used, for oily skin types, cream is used. The drug is effective for purulent rashes. It can be used for the face for no longer than 5 days, for the body - up to 2 weeks. The ointment is applied pointwise to the rash with a sterile cotton swab.

From deprivation

GK ointment can be used for lichen. It is effective because it copes well with itching, inflammation and swelling of the skin. It also fights fungus and bacteria. In this case, regular Akriderm ointment will help prevent skin thickening. The course of use of the product is about 2 weeks, after which you need to undergo a re-examination by a doctor.

For allergies

For allergic diseases, corticosteroid ointment may be prescribed when other local remedies are ineffective. If allergies are complicated by bacterial skin lesions, Akriderm GK or SK should be used.

Akriderm medications themselves can also cause allergies. Treatment is permissible only as prescribed by a doctor. If after the first application, the symptoms intensify, you need to abandon this medicine and choose an analogue together with your doctor.

From fungus

Due to the content of the antifungal agent clotrimazole, Akriderm GK can be used for fungal skin infections. It is used for 14-30 days, 2 times a day.

For eczema

For eczema, all types of ointments can be used. The most effective treatment option is medicated bandages. The drug is applied 2 times for 40-50 minutes. The course is standard – up to 3 weeks.

Treatment can lead to dry skin, so it is recommended to use a natural moisturizing cream in parallel.

Characteristics of Akriderm

Release form of the drug: cream and ointment. The composition of 1 g of the drug includes betamethasone dipropionate (active ingredient), in the amount of 0.64 mg.

The drug has anti-inflammatory, anti-allergic, anti-exudative, anti-edematous and antipruritic effects.

Akriderm is prescribed for eczema.

The active component of the drug, being a corticosteroid, helps to inhibit the increase in the number of leukocytes, the release of lysosome enzymes and inflammatory mediators in the inflamed area. In addition, the drug suppresses phagocytosis, reduces the permeability of blood vessels and tissues, and prevents the appearance of swelling in areas of the body with inflammation.

The medicine is intended for the treatment of dermatological diseases such as:

• dermatitis (contact, seborrheic, dyshidrotic);
• neurodermatitis;
• photodermatosis;
• eczema;
• psoriasis.

The drug can only be used externally. It is necessary to distribute the product in an even layer over the damaged areas of the skin. It is advisable to perform the procedure in the morning and evening. Therapy with this drug lasts from 14 to 28 days.

While using the medicine, the following side effects may occur:

• itching;
• rash;
• redness;
• irritation;
• dryness;
• increased body hair growth;
• purulent inflammation of the hair follicle.

If side symptoms occur, you must stop using the external remedy.

It is prohibited to use the medication if you have:

• hypersensitivity to drug substances;
• tuberculosis skin disease;
• skin manifestations of syphilis;
• chicken pox;
• herpetic rashes;
• allergic reaction to the vaccine;
• open skin lesions (wounds);
• trophic ulcerative lesions of the leg;
• rosacea;
• acne.

The drug is also contraindicated for use during the lactation period and for children under 12 months.

Who is it suitable for?

Akriderm has anti-inflammatory, decongestant, antiexudative, antihistamine effects. This allows it to be used for various skin lesions when more gentle drugs do not have an effect.

Main indications for the use of different types of ointment:

Akriderm GK is a combined local remedy containing an antibiotic and an antifungal agent. This leads to wider application.

Reviews from doctors

Petr Petrovich, 49 years old, dermatologist, Moscow

Akriderm GK cream is an inexpensive analogue of Triderm. The medication can be used to treat insect bites, dermatoses, and fungal diseases. The product helps eliminate itching, burning, swelling and hyperemia of the skin.

Victor Vitalievich, 55 years old, dermatologist, Murmansk

The drug Akriderm is an effective remedy for the treatment of eczema, psoriasis, and neurodermatitis. The drug contains a synthetic hormone, so it is recommended to use the ointment during the acute phase of inflammation for 3 weeks. With the correct treatment regimen, the medication does not have a negative effect on the body.

Cost and analogues

The following products are analogues of Akriderm:

1. Beloderm is a local remedy based on betamethasone, acts strongly and quickly directly at the site of the inflammatory process, reduces external manifestations and subjective sensations such as pain, irritation, itching, and constant discomfort;
2. Diprospan is a drug in a solution based on betamethasone, which is prescribed in severe cases to relieve symptoms during the acute period of the disease;
3. Celestoderm-B is a betamethasone-based cream used for skin diseases with a secondary infection.

As an alternative to these drugs, the doctor may prescribe analogues of action, but with other active ingredients. Popular products include Triderm, Betaderm, Celeston, Diprosalik, Candid-B, Kanzinon.

Patient reviews about Akriderm and Akriderm GK

Julia, 34 years old, Pskov. In the summer I suffer from severe allergies to insect bites. It appears in the form of rashes all over the body. I applied Akriderm to my face, arms and legs. I did not feel any side effects, but the doctor warned about the development of complications if the medicine gets on the mucous membranes.

Sergey, 33 years old, Kazan. The doctor recommended Akriderm GK for the treatment of foot fungus; it copes well with signs of inflammation. The cream was applied according to the scheme for 14 days, twice a day. After two weeks, not a trace of the fungus remained.

Which drug is better

Classic ointment is considered safer

and is prescribed for many chronic skin diseases. It is well suited for allergic dermatitis and urticaria. This drug is less likely to cause adverse reactions. However, it is not always effective. When there is a bacterial or fungal complication, the combined ointment Akriderm GK is used.

It is recommended to use the HA product

for acute symptoms of a dermatological disease with a short course. When the classic ointment turns out to be ineffective, its supplemented version is also shown. For bacterial and fungal infections - only Akriderm GK, since the classic remedy is useless in these cases.

You should not give preference to Akriderm GC just because it is “stronger”. Firstly, this does not make sense when the indications allow the use of ordinary ointment. Secondly, the cost of the HA product is almost 4 times higher.

Both medications can be purchased without a prescription, but self-medication is highly discouraged. Hormonal ointments have many side effects and contraindications. Before use, be sure to consult a doctor.

What is better Akriderm or Akriderm GK

The choice of product depends on the type of dermatological problem, its age, and the degree of skin damage. The patient should not choose the drug himself, only after consulting a doctor, taking into account the possible risks. However, each of them is intended for different stages of skin damage. If the patient suffers from severe allergic reactions, dermatitis, insect bites, then doctors recommend treatment with a classic drug. During fungal and bacterial infections, and in case of secondary infection against the background of a developing disease, preference is given to Akriderm GK, and in the form of a cream.