Immunovenin® - normal human immunoglobulin
Dosage regimen and method of administration
The drug is administered intravenously, by drip.
Immunovenin ® immediately before administration is dissolved in the supplied solvent - water for injection. After dissolution, the drug is a colorless or slightly yellowish transparent liquid, slight opalescence is allowed. For children, a single dose of the drug is 0.15 - 0.2 g (3 - 4 ml) per kg of body weight, but not more than 1.25 g (25 ml). Immediately before administration, Immunovenin ® is dissolved in the supplied solvent and further diluted with 0.9% sodium chloride solution at the rate of 1 part of the drug and 4 parts of the diluting solution.
Diluted immunoglobulin is administered at a rate of 8-10 drops per minute (faster administration may cause the development of a collapsoid reaction). Infusions are carried out daily for 3-5 days.
For adults, a single dose of the drug is 1.25 - 2.5 g (25 - 50 ml). Dissolved Immunovenin ® (without additional dilution) is administered at a rate of 30-40 drops per minute (faster administration may cause the development of a collaptoid reaction). The course of treatment consists of 3-10 infusions, given every 24-72 hours (depending on the severity of the disease).
Replacement therapy for primary immunodeficiencies: a single dose is 0.4 - 0.8 g (8 - 16 ml) per kg of body weight once. Administration is repeated every 2 - 4 weeks at a dose of 0.2 - 0.8 g (4 - 16 ml) per kg of body weight to maintain the IgG titer in plasma at a level of 4 - 6 g/l.
Plasma IgG levels should be monitored to determine the optimal dose and interval between doses.
Replacement therapy for secondary immunodeficiencies in patients with myeloma and chronic lymphocytic leukemia with recurrent infections; replacement therapy in children with congenital HIV infection with recurrent infections: the dose is 0.2 - 0.4 g (4 - 8 ml) per kg of body weight. The administration is repeated after 3-4 weeks to maintain the IgG titer in plasma at a level of 4-6 g/l. Plasma IgG levels should be monitored to determine the optimal dose and interval between doses.
Immunovenin ® is used only in a hospital setting, subject to all aseptic rules. The drug and solvent are not suitable for use in bottles with damaged integrity, labeling, as well as if the color of the drug and solvent changes, if the transparency of the solvent changes, if the expiration date has expired, or if stored incorrectly. Before administration, the bottles are kept at a temperature of (20±2) ºС for at least 2 hours. The drug must dissolve completely within 10 minutes in the volume of the supplied solvent.
The dissolved drug cannot be stored.
