Skin itching, redness, inflammation and other symptoms of dermatitis bring physiological and aesthetic discomfort. But these manifestations are also a favorable environment for the development of various bacterial infections. Primary and secondary infection complicates the process of treating the disease. Therefore, external use of a drug should not only reduce the severity of external symptoms, but also affect bacteria. This is especially true for acute and adolescent inflammation, since infection contributes to the transition of the disease to a chronic form. Akriderm GENTA cream combines the properties of a topical drug for external use and a broad-spectrum antibiotic, which allows for successful therapy. On our website you can read the instructions, from which you will learn what Akriderm GENTA (cream) is used for and how to use it depending on the diagnosis, severity of the disease and other individual characteristics of the patient.
Composition of the drug
A long-lasting therapeutic effect from the use of the cream was achieved due to the unique combined composition of Akriderm GENTA. The drug delivers a powerful blow to the source of inflammation with two active substances at once - betamethasone dipropionate (0.064 g) and gentamicin sulfate (0.1 g). The first component is a glucocorticosteroid, the second is an antibiotic of the aminoglycoside group. It is thanks to them that the product can significantly improve the condition of the skin.
Akriderm GENTA cream is most effective in the fight against acute inflammation, as it is quickly absorbed due to the increased concentration of purified water in the composition of the drug. It also contains excipients:
- methyl parahydroxybenzoate;
- propylene glycol;
- liquid paraffin;
- macrogol cetostearate;
- cetostearyl alcohol;
- disodium edetate;
- sodium hydrogen phosphate dodecahydrate;
- potassium dihydrogen phosphate.
Thanks to its thoughtful composition, Akriderm GENTA is easy to use and suitable for wet and thin areas of the skin.
Price
The cost of Macrogol depends on which pharmacy chain sells the medicine.
On average, the minimum and maximum prices for a package of 4 bags may differ by 90-100 rubles in Russia and 50-65 hryvnia in Ukraine.
Average price in Russia
The average price of Macrogol in Russia is about 280 rubles per pack of 10 sachets.
Average price in Ukraine
In Ukraine, the laxative Macrogol can be purchased for 178-190 hryvnia per package containing 12 packets of the drug.
pharmachologic effect
The presence of several active substances provides several therapeutic effects at once:
- anti-inflammatory;
- antiallergic;
- antipruritic;
- antibacterial.
In addition, when applied topically, betamethasone dipropionate constricts blood vessels. The cream also has a softening and cooling effect, which helps soothe affected skin and reduce inflammation.
Gentamicin is bactericidal. This aminoglycoside antibiotic is active against many gram-negative bacteria and gram-positive microorganisms, including those resistant to other antibiotics. It provides topical treatment for primary and secondary bacterial skin infections.
Indications for use
Akriderm GENTA is a drug with wide application possibilities. Prescribed primarily for the treatment of diseases that respond well to glucocorticosteroid therapy. Such pathologies include:
- dermatitis (simple and allergic), especially secondary infections;
- eczema (atopic, childhood, coin-shaped);
- atopic dermatitis (diffuse neurodermatitis);
- simple chronic lichen (limited neurodermatitis);
- solar dermatitis;
- exfoliative dermatitis;
- radiation dermatitis;
- diaper rash;
- psoriasis;
- itching
Analogs
Pharmacy chains sell many structural analogues of Macrogol, which contain the same active ingredient:
- Lavacol;
- Realaxan;
- Transipeg;
- Forlax;
- Fortrans;
- Osmogol.
Unlike Macrogol, they add flavorings and sweeteners, which make taking laxatives more pleasant.
However, such additives in most cases affect the cost of drugs, making them inaccessible to some segments of the population.
Video on the topic: Examination of the large intestine
Contraindications
Akriderm GENTA belongs to the class of potent drugs, so its use requires caution, and before starting therapy you must consult a specialist. During the consultation, the specialist will also be able to check the patient for contraindications to the use of this drug. They can be divided into strict and relative. The first include:
- hypersensitivity to any of the active or excipients;
- individual intolerance to any of the components of the drug;
- lupus;
- vaccination;
- viral skin infections;
- perioral dermatitis;
- rosacea;
- skin manifestations of syphilis;
- skin post-vaccination reactions;
- children's age (up to 2 years).
Relative contraindications are pregnancy (especially the first trimester), lactation period and children over 2 years of age. The use of the drug is possible during pregnancy if it has been established that the benefit to the mother outweighs the possible risk to the fetus. Breastfeeding women can use Akriderm GENTA if they stop breastfeeding for the period of treatment. Therapy with the drug for children is carried out only under the strict supervision of a doctor.
Principle of application depending on the expected effect
A one-time use of the drug leads to a basic cleansing of the body, without showing the full effect of its influence, which consists of consistent muscle stimulation of the intestinal walls when used regularly for a short time.
In addition, by deeply cleansing the body of old deposits on the inner surface and not allowing toxic elements to diffuse into the bloodstream, Macrogol has a powerful positive effect on the body as a whole. Which is manifested by the following signs:
- Activation of metabolic processes.
- Cleansing the surface of the skin.
- Stabilization of the digestive process.
- Improving general well-being.
- Increasing the activity of the whole body.
Directions for use and dosage
The treatment regimen and dose are selected by a specialist individually for each patient, taking into account the severity of the disease, clinical picture and physiological characteristics. The instructions provide the standard procedure and application mode. Adults should apply a small amount of the product to the affected areas of the skin in a circular motion, rubbing lightly. The recommended frequency of application is 2 times a day - morning and evening. In mild cases, single use is possible. The duration of treatment depends on the effectiveness and tolerability of therapy and is usually no more than 2-4 weeks.
Macrogol
Macrogol
(lat.
Macrogol
) - a laxative drug.
Another common name is macrogol
. From a chemistry perspective, the names “macrogol” and “polyethylene glycol” are synonyms. Polyethylene glycol, a polymer of ethylene glycol, is a high molecular weight substance that is a long linear polymer with the empirical formula C2nH4n+2On+1. Polyhydric alcohol. A number is sometimes added to the name of this polymer indicating its molecular weight. Thus, macrogol-4000, widespread in medicine, has a molecular weight of 4000.
Macrogol is the international nonproprietary name (INN) of the drug. According to the pharmacological index, macrogol belongs to the group “Laxatives”. According to ATC, it belongs to the group “Osmotic laxatives” and has code A06AD15. Macrogol forms hydrogen bonds with water molecules in the intestinal lumen, increases the fluid content in the chyme, stimulates mechanoreceptors, and improves intestinal motility. Macrogol increases the volume of chyme and prevents the loss of electrolytes in feces. As a result, the evacuation reflex is restored and defecation is normalized. Macrogol is not absorbed, not metabolized, and does not change the acidity of chyme.
Indications for use of macrolog
- symptomatic treatment of constipation in adults
- for bowel cleansing before colonoscopy, x-ray examinations or surgery
Method of administration of macrogol and dose
Macrogol is taken orally in a dose of 10-20 g once a day, in the morning, before or during meals.
Before use, dissolve the powder at the rate of 10 g per glass of water. The effect of macrogol begins a day or two after taking the drug. Unlike most laxative drugs, when taking laxatives with an osmotic effect: macrogol and lactulose, there is no irritation of the chemoreceptors of the mucous membrane and no damage to it, even with prolonged use of the drugs. The high effectiveness of macrogol and lactulose and the absence of serious adverse reactions make these drugs the most preferred laxatives,
used in the treatment of chronic constipation. Several randomized placebo-controlled studies have shown that macrogol is practically free of toxic and side effects and is highly effective in the treatment of constipation (Roitberg G.E., Strutynsky A.V. Internal diseases. Digestive system. M.: MEDpress- inform, 2007).
Osmotic laxatives based on macrogol and lactulose are considered second-line drugs for the treatment of constipation of any type. Macrogol and lactulose are recommended when non-medicinal methods and dietary fiber are ineffective (Shulpekova Yu.O.).
In the treatment of chronic constipation in elderly and senile patients, lactitol has higher clinical efficacy, fewer side effects and a faster response to therapy compared to macrogol. This is due to the more pronounced effect of the latter on the motor activity of the colon, which is confirmed by electrogastroenterography data, as well as the normalization of the disturbed intestinal ecosystem, which was expressed by more significant changes in the concentration and qualitative composition of short-chain fatty acids, which are metabolites of the obligate microflora of the colon (Minushkin O.N. . and etc.).
The use of macrogol before colonoscopy, X-ray examinations and surgical interventions on the intestine
Macrogol 4000, due to its high molecular weight, is not absorbed from the gastrointestinal tract and is not metabolized, prevents the absorption of water from the stomach and intestines and promotes accelerated evacuation of intestinal contents.
The use of a solution with macrogol 4000 is much more effective than using the standard method: the descending colon, sigmoid and rectum are cleansed significantly better. Examination of the mucous membrane of the entire colon using macrogol 4000 was possible in 75% of patients, and with preparation using the standard method only in 20%. The average time required for a physician to examine the bowel was 24 minutes when using macrogol 4000 solution, and 35 minutes when preparing using the standard method. Although patients generally tolerated Macrogol 4000 well, the salty taste of the solution caused some to limit their fluid intake. To eliminate this drawback, the drug Fortrans was developed, the active ingredient of which is also macrogol. One sachet of Fortrans (containing 64 g of macrogol) is dissolved in 1 liter of water. The dose of the drug is set at the rate of 1 liter of solution per 15–20 kg of the patient’s body weight. The solution is taken 200 ml every 20 minutes in the evening before the procedure. Or 2 liters in the afternoon the day before and 1 liter in the morning on the day of the study. To prepare patients with severe heart failure and erosive and ulcerative lesions of the intestines, for whom the intake of such volumes of liquid is unacceptable, Forlax is used, containing in one sachet 10 g of macrogol 4000, which is dissolved in 250 ml of water and taken either 2 sachets per day in the morning at meal times during the three days preceding the procedure, or 2 sachets in the morning and evening. During this time, the proximal parts of the intestine are gradually released. To cleanse the distal sections, one small cleansing enema is given in the morning on the day of the study (Golysheva S.V., Grigorieva G.A. Macrogol preparations in preparing patients for colonoscopy and surgical interventions. Diseases of the digestive organs No. 2, 2004). See also the article: “Preparation of the colon for instrumental studies.”
Professional medical publications addressing the effects of macrogol (polyethylene glycol) on the gastrointestinal tract and its use in clinical practice
- Matsukatova B.O., Erdes S.I. Experience with the use of osmotic laxatives in the treatment of constipation in children // Questions of Dietetics. 2015. T. 5. No. 2. pp. 5–20.
- Erdes S.I., Matsukatova B.O., Revyakina S.A., Kasanave E.V. The effectiveness of osmotic laxative polyethylene glycol 4000 in the treatment of constipation in children // RZHGGK. - 2011. - T.21. — No. 6. — P.23-32.
- Samedov B.Kh. Recommendations for the use of espumizan during endoscopic examinations of the gastrointestinal tract and transendoscopic manipulations // North-West Bulletin of Endoscopy. – 2003.
- Pasechnikov V.D. Functional constipation caused by slow transit of intestinal contents // Farmateka. – 2003. – No. 10. – p. 16–23.
- Minushkin O.N., Ardatskaya M.D., Voskoboynikova I.V., Kolkhir V.K. Analysis of the clinical effectiveness of the drugs Exportal and Forlax // RZHGGK. - 2010. - T.20. - No. 5. - Adj. No. 36. — P.118.
- Shulpekova Yu.O. Constipation and methods of its treatment // Breast cancer. Diseases of the digestive system. – 2006. – Volume 8. – No. 2. – pp. 90–96.
- Description of the drug for patients (UK, pdf): “Macrogol Grapefruit Flavor, 10 g powder for oral solution. Macrogol Lemon Flavor, 10 g powder for oral solution. Package Leafleat. Information for the User"
On the website gastroscan.ru in the literature catalog there is a section “Laxatives”, containing medical articles relating to laxatives and their use.
Contraindications to the use of macrogol
- inflammatory diseases and ulcerative lesions of the colon mucosa, ulcerative colitis, Crohn's disease
- partial or complete intestinal obstruction
- abdominal pain of unknown origin
- hypersensitivity to polyethylene glycol
Long-term use of macrogol is not recommended without consulting a doctor.
Macrogol during pregnancy and breastfeeding.
Macrogol can be prescribed during pregnancy and breastfeeding.
Macrogol overdose
Due to the lack of systemic absorption, overdose is unlikely.
Interaction of macrolog with other drugs
The absorption of drugs taken simultaneously with macrogol may slow down, so macrogol is taken no earlier than 2 hours after taking other drugs.
Brand names of drugs containing macrogol
Medicines with the only active substance macrogol:
Lavacol, Osmogol, Realaxan, Tranzipeg, Forlax, Forteza Rompharm, Fortrans.
Macrogol in combination with other active ingredients:
- macrogol + potassium iodide + sodium chloride, brand Polyoxidin (belongs to the ATC group B05AA “Plasma replacement drugs and plasma protein fractions”)
- macrogol + sodium chloride + sodium bicarbonate, potassium chloride, trademark Endofalk (ATC code A06AD65 “Macrogol in combination with other drugs”)
Macrogol
is also used
in the pharmaceutical industry
in the production of various drugs as an excipient (the most commonly used is Macrogol 6000). For example, it is found in the enteric and film-coated preparations Ganaton, Bifiform, Festal, Omez, Sanpraz, Lanzoptol, Itomed, Emanera, Livodex, Festal N, Razo, in Gaviscon, De-Nol tablets, as well as in the vitamin and mineral complexes Complivit and others.
By order of the Government of the Russian Federation of December 30, 2009 No. 2135-r, macrogol (powder for the preparation of solution for oral administration) is included in the List of vital and essential medicines.
Macrogol has contraindications, application features and side effects. Before using macrogol, you should consult your doctor.
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Side effects
The risk of side effects is directly related to the area of application and duration of therapy. The method of treatment also affects the appearance of certain uncomfortable sensations. If Akriderm GENTA is used together with occlusive dressings, this can lead to maceration, infection, skin atrophy, stretch marks and miliaria. With prolonged treatment on large surfaces, the following may occur:
- itching;
- burning;
- irritation;
- dry skin;
- folliculitis;
- hypertrichosis;
- steroid acne;
- hypopigmentation;
- weight gain;
- osteoporosis;
- increased blood pressure;
- swelling;
- ulceration of the mucous membrane of the gastrointestinal tract;
- exacerbation of hidden foci of infection;
- hyperglycemia;
- nervous excitement;
- insomnia;
- dysmenorrhea.
