Vormin - instructions for use and reviews from parasitologists

Chewable tablets "Vormil" are used for the indications listed below.

Intestinal forms of helminthiasis and skin syndrome Larva Migrans (short-term treatment with small doses): enterobiasis, hookworm and necatoriasis, hymenolepiasis, taeniasis, strongyloidiasis, ascariasis, trichuriasis, clonorchiasis, opisthorchiasis, giardiasis in children.

Systemic helminthic infections (long-term treatment with high doses):

cystic echinococcosis (caused by Echinococcus granulosus):

• if surgical intervention is not possible;
• before surgery;
• after surgery, if preoperative treatment was short, if the spread of helminths is observed or live forms were found during surgery;
• after percutaneous drainage of cysts for diagnostic or therapeutic purposes;

alveolar echinococcosis (caused by Echinococcus multiocularis):

• in case of inoperable disease, in particular in cases of local or distant metastases;
• after palliative surgery;
• after radical surgery or liver transplantation;

neurocysticercosis (caused by Taenia solium larvae):

• in the presence of single or multiple cysts or granulomatous brain lesions;
• with arachnoid or intraventricular cysts;
• with racemic cysts;

capillarosis (caused by Capillaria philippinensis), gnathostomiasis (caused by Gnathostoma spinigerum and related species), trichinosis (caused by Trichinella spiralis and T.pseudospiralis), toxocariasis (caused by Toxocara canis and related species).

Pharmacological action of Vormil

Wormil tablets are for oral use only. After their consumption, protein synthesis and glucose metabolism are disrupted in the parasite's body.

By suppressing internal metabolic processes, this drug prevents their further existence and reproduction, which leads to their death. This is the basis of the anthelmintic activity of this anthelmintic.

Absorption of Vormin occurs slowly, the main part (90%) does not leave the intestine, only a small part of this drug (10%) has a therapeutic effect. It is capable of accumulating in small doses in liver cells and in the subcutaneous fat layer.

This chemical is eliminated from the body through bowel movements.

Compound:

Active ingredient: albendazole;

1 chewable tablet contains 400 mg albendazole.

Excipients: corn starch, microcrystalline cellulose, sodium methylparaben (E 219), sodium gyropylparaben (E 217), sodium starch glycolate (type A), colloidal anhydrous silicon dioxide, talc, magnesium stearate, fruit flavoring, aspartame (E 951 ).

Dosage form. Chewable tablets.

Pharmacotherapeutic group. Means used for nematodes.

ATS code P02C A03.

Indications for use of Vormin

Vormin is able to provide positive dynamics in the treatment of many helminthiasis causing:

• Pinworms.
• Worms.
• Solitaire.
• Roundworms.
• Tapeworms (bovine and pork chain).

Particular effectiveness can be achieved by using it in combination with other dosage forms.

It suppresses parasitic forms and is used for:

• Enterobiasis.
• Ascariasis.
• Trichinosis.
• Echinococcosis.
• Diseases caused by different types of helminths.
• Taeniasis.
• Hookworm.
• Strongyloidiasis.

In addition, this drug can be used to prevent the occurrence of parasitic pathology during frequent contact with sick patients.

Features of application

Pregnant

The drug is contraindicated for use during pregnancy and lactation or for the treatment of women planning pregnancy.

Children

The drug is contraindicated for the treatment of children under 2 years of age in this dosage form.

Drivers

Considering the presence of such an adverse reaction as dizziness, it is recommended to refrain from driving vehicles or operating other mechanisms during the period of use of albendazole.

Scheme for using Vormin

To correctly calculate the dose of the drug, a thorough diagnosis is carried out to help determine the type of parasitic infestation. Only after this the doctor prescribes the drug.

This is the usual use of the drug to suppress the vital activity of helminths, the treatment regimen is applied taking into account the type of worms. Therefore, in the treatment of the following pathologies, various treatment regimens and tactics are used.

Instructions for use depending on the disease:

1. Enterobiasis. Vormin is used in an amount of 100 mg once, after meals. To avoid reinfection and reinfection, it is recommended that all family members use it. After a two-week break, the drug is reused.
2. If the disease is ascariasis, hookworm, shadow, strongyliasis or several parasites, it is recommended to take Vormin 100 mg in the morning after meals and in the evening after dinner. The duration of treatment is no more than 3 days.
3. Trichinosis. Vormin is taken for 3 days at a dose of no more than 400 mg (2 times a day), starting from the 4th day and ending with the 10th day, the dose of the drugs is increased to 500 mg and divided into three parts. They are taken in the morning, at lunch and in the evening.
4. Echinococcosis. During the first 3 days, the amount of the drug used is 500 mg, taken twice a day, after this period, for 3 days, this dose is divided into three parts. Subsequent doses of Vormin are calculated based on the patient’s body weight (1 kg of body weight, which is equivalent to taking 30 mg of the drug). This amount can be taken throughout the day, divided into equal doses and given three times.
5. A small dose of the drug (25 to 100 milligrams) can be used for prevention.

This will help determine how effective and appropriate the treatment was. If the results are positive, treatment with this drug will need to be repeated. Or any other medicine prescribed by your doctor.

Vormin tablets 100 mg No. 24

Compound

Active substance: mebendazole 100 mg.
Excipients: calcium hydrogen phosphate 132 mg, corn starch 50 mg, gelatin 5 mg, purified talc 6 mg, magnesium stearate 3 mg, sodium lauryl sulfate 1.5 mg, vanillin 0.582 mg, sunset yellow dye (FCF) 0.08 mg, orange flavor (DC116 ) 0.582 mg.

Pharmacokinetics

Practically not absorbed in the intestines. After taking the drug at a dose of 100 mg twice a day for three consecutive days, the plasma concentration of mebendazole and its metabolite (2-amino derivative) does not exceed 0.03 mcg/ml and 0.09 mcg/ml, respectively. Communication with plasma proteins - 90%. It is unevenly distributed throughout the organs, accumulates in adipose tissue, liver, and helminth larvae. In the liver it is metabolized to a 2-amino derivative, which does not have anthelmintic activity. The half-life is from 3 to 6 hours. More than 90% of the dose is excreted unchanged by the intestines. About 10% is excreted by the kidneys.

Indications for use

Enterobiasis, ascariasis, hookworm disease, strongyloidiasis, trichuriasis, taeniasis, both with monoinfestation and mixed helminthiasis, echinococcosis (if surgical treatment is not possible), trichinosis.

Contraindications

• Hypersensitivity to mebendazole or other components of the drug;
• ulcerative colitis;
• Crohn's disease;
• liver failure;
• children's age (up to 3 years);
• simultaneous use with metronidazole, phenytoin, carbamazepine, ritonavir.

Directions for use and doses

Inside, with a small amount of water. If necessary, the tablet can be chewed, crushed and mixed with food.

Adults and children over 3 years of age: for enterobiasis - once, 100 mg. In case of a high probability of re-infestation, take again after 2-4 weeks at the same dose. It is recommended to treat all family members simultaneously. For ascariasis, trichuriasis, hookworm, taeniasis, strongyloidiasis and mixed helminthiasis - 100 mg in the morning and evening for 3 days. If the symptoms of the disease persist, it is recommended to repeat the course of treatment after 3 weeks.

Adults and children over 14 years of age: for echinococcosis in the first 3 days - 500 mg 2 times a day, in the next 3 days the dose is increased to 500 mg 3 times a day; subsequently the dose is increased to 1000-1500 mg 3 times a day. The average duration of treatment for echinococcosis caused by Echinococcus granulosus is 4-6 weeks, caused by Echinococcus multilocularis - up to two years.

For trichinosis, on day 1, 3 times a day, 200-300 mg, on day 2, 4 times a day, 200-300 mg, and from days 3 to 14, 3 times a day, 500 mg.

Storage conditions

At a temperature not exceeding 25°C, out of the reach of children.

Best before date

4 years. Do not use after the expiration date stated on the packaging.

special instructions

With long-term use, it is necessary to monitor the peripheral blood picture, liver and kidney function.

When prescribed simultaneously with cimetidine, it is necessary to monitor the concentration of mebendazole in the blood plasma and adjust the dose of Vormin (especially with long-term use).

In patients with diabetes mellitus, it is necessary to monitor plasma glucose levels.

Within 24 hours after administration, the consumption of ethanol and fatty foods is prohibited, and a laxative is not prescribed.

If a dose is missed, the missed dose should be taken as soon as possible, and subsequent doses should be taken at the recommended interval.

Periodic examination of smears of the anal area and feces after completion of treatment is mandatory: therapy is considered effective if there are no helminths or their eggs within the next 7 days.

Description

Anthelmintic.

Use in children

Contraindicated in children under 3 years of age.

Pharmacodynamics

Broad-spectrum anthelmintic drug; most effective against Enterobius vermicularis, Trichuris trichiura, Ascaris lumbricoides, Ancylostoma duodenale, Necator americanus, Strongyloides stercoralis, Taenia solium, Echinococcus granulosus, Echinococcus multilocularis, Trichinella spiralis, Trichinella nativa, Trichinella nelsoni. Causing an irreversible disruption of glucose utilization, it depletes glycogen reserves in the tissues of helminths, prevents the synthesis of cellular tubulin, and also inhibits the synthesis of ATP.

Side effects

Allergic reactions: skin rash, urticaria, angioedema, Stevens-Johnson syndrome, toxic epidermal necrolysis, exanthema, anaphylactic and anaphylactoid reactions.

From the hematopoietic organs: leukopenia, neutropenia, eosinophilia, anemia.

From the digestive system: vomiting, diarrhea, nausea, abdominal pain; increased activity of “liver” transaminases, alkaline phosphatase, hepatitis (when used in high doses for a long time).

From the central nervous system: dizziness, headache, drowsiness, convulsions.

From the urinary system: hypercreatininemia, hematuria, cylindruria, glomerulonephritis (when used in high doses for a long time).

Other: hair loss.

May have a negative effect on fetal development.

Use during pregnancy and breastfeeding

The use of the drug during pregnancy and lactation is contraindicated.

Interaction

Reduces the need for insulin in patients with diabetes.

Co-administration with lipophilic substances should be avoided.

Cimetidine can increase the concentration of mebendazole in the blood plasma, while carbamazepine and other metabolic inducers decrease it.

Overdose

Symptoms: abdominal pain, nausea, vomiting, diarrhea. When used in high doses for a long time: reversible liver dysfunction, hepatitis, neutropenia.

Treatment: gastric lavage, taking activated carbon, symptomatic therapy. There is no specific antidote.

Impact on the ability to drive vehicles and operate machinery

Patients taking Vormin should refrain from driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Side effects when using Vormin

Based on the results of statistical studies, as well as recent research by scientists in the field of use of Vormin, it is believed that the drug is very well tolerated. And only in rare cases can side effects occur.

They may look like:

Acute, sudden attacks of headache may be a side effect of taking the drug.

The appearance of dyspeptic disorders:

• Violation of the act of defecation.
• The appearance of bouncing.
• Nausea progressing to vomiting.
• Spasmodic sharp pain spreading throughout the abdomen.

• Adverse reactions from the nervous system may occur: Acute, sudden attacks of headache.
• Loss of strength, accompanied by dizziness.

Overdose.

Symptoms: nausea, vomiting, diarrhea, tachycardia, drowsiness, blurred vision, visual hallucinations, speech impairment, dizziness, loss of consciousness, liver enlargement, increased transaminase levels, jaundice; respiratory distress, brownish-red or orange discoloration of the skin, urine, sweat, saliva, tears and feces in proportion to the dose of the drug.

Treatment: gastric lavage is performed and symptomatic and supportive therapy is used.

Overdose when using Vormin

The occurrence of undesirable effects in the form of an overdose is very rare. Most often, the patient himself is to blame, who chooses and prescribes the dose himself.

In this case, the following may appear:

1. Severe, sharp, cramping pain in the abdomen, localized in the epigastrium.
2. In case of acute overdose, nausea and uncontrollable vomiting appear.
3. Liver function is impaired and jaundice may occur.
4. Clinical and biochemical blood parameters change.

To eliminate these negative symptoms, it is necessary to urgently stop taking the drug. Since there is no specific antidote, symptomatic treatment is required.

Overdose management:

1. The patient urgently needs to undergo gastric lavage (this can be done by inducing a chewing reflex). The stomach should be emptied.
2. Take medications from the pharmacological group of enterosorbents (Polysorb, Sorbek, Atoxil, Enterosgel, Activated carbon).
3. If the gag reflex persists for a long time, to avoid dehydration, put the patient to bed and give him a hot drink (unsweetened hot rosehip tea).

If the clinical picture of an overdose persists and becomes more severe, the patient is hospitalized in a hospital.

Adverse reactions.

From the digestive tract and liver: stomatitis, dry mouth, heartburn, nausea, vomiting, abdominal pain, flatulence, diarrhea, constipation.

Hepatobiliary disorders: transient increase in liver enzyme activity, jaundice, hepatitis, hepatocellular disorders.

From the cardiovascular system: increased blood pressure, tachycardia.

From the central nervous system and peripheral nervous system: insomnia or drowsiness, headache, dizziness, dizziness, confusion, disorientation, hallucinations, convulsions, decreased visual acuity.

From the blood and lymphatic system: leukopenia, neutropenia, thrombocytopenia, anemia including aplastic anemia, agranulocytosis, pancytopenia. Patients with liver disease, including hepatic echinococcosis, are more prone to bone marrow suppression.

From the skin and subcutaneous tissue: skin rash, hyperemia, polymorphic erythema, Stevens-Johnson syndrome, alopecia inverse, itching, urticaria, pemphigus, dermatitis, edema.

From the kidneys and urinary system: impaired renal function, acute renal failure, proteinuria.

General disorders: pain in bones, throat, fever, weakness.

Hypersensitivity reactions including anaphylactic/anaphylactoid reactions are possible.

Prophylactic use

Wormin is the best way to prevent pathological processes caused by helminthic parasites.

If someone in the family has worms, then the use of this drug is mandatory for everyone.

This should be done as the worm larvae spread throughout the house.

They have a high degree of adaptability and survival in the environment.

Under these conditions, it is impossible to comply with all the rules of cleanliness and hygiene. It should also be borne in mind that the disease can sometimes be asymptomatic.

This can lead to the development of pathological processes in various organs and systems of the body.

To prevent lesions caused by helminth infections, take 4 tablets at regular intervals during the first day. This therapy lasts no more than 3 days.

Indications.

Intestinal forms of helminthiases and skin syndrome Larva Migrans (short-term treatment with small doses): enterobiasis, hookworm and necatoriasis, hymenolepiasis, taeniasis, strongyloidiasis, ascariasis, trichocephalosis, clonorchiasis, opisthorchiasis, giardiasis in children.

Systemic helminthic infections (long-term treatment with high doses):

- cystic echinococcosis (caused by Echinococcus granulosus): if surgical intervention is not possible, before surgery

- after surgery, if preoperative treatment was short, if the spread of helminths is observed or live forms were found during the operation;

— after percutaneous drainage of cysts for diagnostic or therapeutic purposes;

alveolar echinococcosis (caused by Echinococcus multilocularis):

- for inoperable diseases, in particular in cases of local or distant metastases;

— after palliative surgery;

— after radical surgery or liver transplantation;

neurocysticercosis (caused by Taenia solium larvae):

- in the presence of single or multiple cysts or granulomatous brain lesions;

- with arachnoid or intraventricular cysts;

- with racemic cysts;

capillarosis (caused by Capillaria philippinensis), gnathostomiasis (caused by Gnathostoma spinigerum and related species), trichinosis (caused by Trichinella spiralis and T.pseudospiralis), toxocariasis (caused by Toxocara canis and related species).

Drug interactions with Vormin

While taking this medicine you should consider:

• Simultaneous use with anticonvulsants (carbamazepine, finlepsin, Lamictal) leads to a decrease in the therapeutic effect of the drug Vormin.
• Wormin and cimetidine. This combination can cause the Vormin chemicals to become overactive. This is fraught with symptoms of overdose.
• Propranolol (a lipophilic drug) reduces the absorption of vormin, so they are not prescribed together.
• The use of this drug for diabetes mellitus requires a reduction in the dose of insulin.

Special instructions for use

Additional recommendations for taking the drug:

• With long-term use of this drug, therapy should be carried out under the constant supervision of laboratory blood tests. Used to eliminate unwanted liver or kidney failure.
• It is unacceptable to consume alcoholic beverages, even after a full course, they should not be consumed for 2 days.
• There are no dietary restrictions when taking Vormin. The only exception is hot, spicy and smoked dishes.
• After treatment, the patient and all family members should check their stool for helminth eggs. Treatment will only be successful if the test result is negative.
• During treatment for parasitic worms, the patient should avoid swimming and use only the shower. Follow the rules of personal hygiene, change your underwear at least twice a day. Make sure you iron with a hot iron.
• Before treatment, and especially in the first 2 days, you should not use laxatives. This is due to the fact that to achieve the full therapeutic effect, it is necessary to maintain the correct concentration of the drug in the gastrointestinal tract.
• During therapy, be sure to rinse all rooms with chlorine solution. Use this solution to wipe objects that are in direct contact with human hands (handles, taps, switches).
• There is no data on the effect of Vormin on the speed of psychomotor reactions. However, if the patient experiences dizziness and headaches, it is better not to drive.

Note!

Description of the drug Vormil table. chewing 400 mg No. 3 on this page is a simplified author’s version of the apteka911 website, created on the basis of the instructions for use.
Before purchasing or using the drug, you should consult your doctor and read the manufacturer's original instructions (attached to each package of the drug). Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.

Storage conditions and dispensing rules in pharmacies

If stored correctly (ambient temperature does not exceed 25 degrees), this drug can be stored for 2 years from the date of release.

Ideally, it should not be exposed to direct sunlight. When choosing where to store it, make sure that it does not fall into the hands of children.

You can buy it at a pharmacy chain without presenting a prescription.

How much Vormin will cost depends on the region. The average price varies from 120 to 160 rubles. When ordering through the online store, Vormin will cost from 80 to 120 rubles.

Analogs

Like any other form of the drug, Vormin has many substitutes in terms of the chemical structure and action of the drug. If for some reason the use of this drug is not considered possible, the doctor selects another drug based on Mebendazole.

Recently, the following Vormin analogues have been widely used:

1. Mebendazole. Country of origin: Latvia. It is produced pharmaceutically in the form of tablets of 100 mg, 6 tablets in a conval. The average price does not exceed 160 rubles. Indications for use are exactly the same as in the case of Vormina. Not recommended in case of hypersensitivity to the components of the drug; it is not used by pregnant women or during breastfeeding. Contraindicated for children under two years of age.
2. Vermox. Produced by the Italian pharmaceutical company Janssen Sillag in tablets of 100 milligrams, 6 tablets, the average price, depending on the region, can be 70-95 rubles. It is effective against helminths caused by roundworms, pinworms, whipworms and tapeworms such as bovine and pork chainworms. The main criteria for which this medicine should not be prescribed are pregnancy, breastfeeding, and infants under 3 years of age. The biggest plus is the low likelihood of side effects and consequences of an overdose.
3. Pirantel. Produced in India and Ukraine by Polpharma. The Indian drug can be purchased at a price of 250 rubles for 30 tablets. Pyrantel may also be available as a suspension. Its price does not exceed 40 rubles. Used for enterobiasis, necatoriasis, hookworm. Thanks to its numerous pharmacological forms, it can be used in children in the form of a suspension from 6 months of age. The most basic contraindication is allergies and chronic pathological processes in the liver.
4. Decaris. Produced by the pharmaceutical company Gedeon Richter (Hungary). The tablet form (one tablet) has a price of 180 rubles. It is used for ascariasis, necatoriasis, hookworm disease. It is well tolerated and can be used during pregnancy (under medical supervision) and in children under 3 years of age. The main contraindication is individual intolerance to the components of the drug. Side effects are very rare.
5. Helminthox. French drug from, tablets No. 3, 250 mg, price 130 rubles. The main chemical compound is Pyrantel. Indications and contraindications are the same as for Pirantel. It can be used in the youngest patients, starting from 6 months of age, in the form of a suspension. Used during pregnancy under medical supervision. Side effects that are very likely to occur from the digestive system include nausea, vomiting, and loss of appetite.
6. Biltricide. Country of origin: Germany The drug is available in the form of tablets No. 6 (600 mg). Its price is high and amounts to 1000 rubles. For this reason, it is not very popular among the population. It is used for schistosomiasis, opisthorchiasis, taeniasis, paragonimiasis. This also gives positive dynamics in the treatment of diseases caused by single flukes, cattle flukes or chain pigs. It is approved for use in pregnant women only in the second or third trimester. The drug is not recommended for use when breastfeeding a baby. Can be used in children from 4 years of age. The drug is not used for serious pathologies of the liver, kidneys, or if the patient has symptoms of arrhythmias. It is generally very well tolerated and side effects are rare.
7. Piperazine adipate. Pharmaceutical produces this drug in Ukraine in an amount of 200 mg. 10 tablets can be purchased for 12 rubles. It is effective against worms caused by pinworms or roundworms. Contraindications to its use are serious neurological pathologies and kidney diseases. It is allowed to use during pregnancy, in all trimesters, and can also be used when the mother is breastfeeding.
8. Pamoata pyrantel. Mainly used to treat animals. Effective in the treatment of roundworms and tapeworms. They are sold in kilograms. 1 kilogram costs 4,500 rubles.
9. Medamin. The average price does not exceed 60 rubles. It is highly effective in the fight against roundworms. Not prescribed for chronic pathologies of the nervous system, acute gastritis with symptoms of nausea, vomiting and diarrhea, or during pregnancy. Children can take from 3 years of age. This drug is not sold in Russia because it has not passed state registration.

Pharmacological properties.

Pharmacodynamics. Albendazole is an antiprotozoal and anthelmintic drug from the benzimidazole carbamate group. The drug acts on both intestinal and tissue parasites in the form of eggs, larvae and adult helminths. The anthelmintic effect of albendazole is due to inhibition of tubulin polymerization, which leads to metabolic disturbances and death of helminths.

Albendazole is active against the following intestinal parasites: nematodes - Ascaris lumbricoides, Trichuris trichiura, Enterobius vermicularis, Ancylostoma duodenale, Necator americanus, Strongyloides stercoralis, Cutanéus Larva Migrans; cystodes - Hymenolepsis nana, Taenia solium, Taenia saginata; trematodes - Opisthorchis viverrini, Clonorchis sinensis; protozoans - Giardia lamblia (intestinalis or duodenalis).

Albendazole is active against tissue parasites, including cystic and alveolar echinococcosis, caused by invasion of Echinococcosus granulosus and Echinococcosus multilocularis, respectively. Albendazole is an effective treatment for neurocysticercosis caused by larval infestation of Taenia solium, capillariasis caused by Capillaria philippinensis, and gnathostomiasis caused by Gnathostoma spinigerum infestation.

Albendazole destroys cysts or significantly reduces their size (up to 80%) in patients with granular echinococcosis. After treatment with albendazole, the number of nonviable cysts increases to 90% compared to 10% in patients not treated. After using albendazole for the treatment of cysts caused by Echinococcus multilocularis, complete recovery was observed in a minority of patients; in the majority, improvement or stabilization of the condition was observed.

Pharmacokinetics. After oral administration, the drug is poorly absorbed (up to 5%) from the digestive tract. Simultaneous use of fatty foods increases the absorption of the drug by approximately 5 times.

Albendazole is rapidly metabolized in the liver during the first pass. The main metabolite, albendazole sulfate, retains half the pharmacological activity of the primary substance.

The half-life of albendazole sulfate from blood plasma is approximately 8.5 hours. Albendazole sulfate and other metabolites are excreted primarily in the bile, and only a small portion is excreted in the urine. After long-term use of the drug in high doses, its removal from the cysts continues for several weeks.