Vitamins Complivit Calcium D3: instructions for use for children, reviews, price, composition

Composition of Complivit Calcium D3

Chewable tablet with orange (or mint) flavor contains calcium carbonate 1.25 g and vitamin D3 (colecalciferol granulate) 5 mcg.
Complivit Calcium D3 Forte contains an increased dose of colecalciferol - 10 mcg.

Additional components: powder flavor (orange, mint), citric acid, povidone, magnesium stearate, aspartame , starch, lactose.

Composition of the granulate: sodium aluminum silicate, butylated hydroxytoluene, colecalciferol, water, modified starch, sucrose, medium chain triglycerides, gelatin.

The powder for the preparation of children's suspension contains 1000 IU of vitamin D3 and 10 g of calcium in the form of carbonate.

Complivit Calcium D3, 30 chewable tablets, orange flavor

Registration Certificate Holder

PHARMSTANDARD-UfaVITA (Russia)

Dosage form

Medicine - Complivit® Calcium D3 (Complivit Calcium D3)

Description

Chewable mint tablets

with a rough porous surface, round, biconvex, white to off-white with a creamy tint interspersed with gray color, with a faint fruity odor.

1 tab.

calcium carbonate 1.25 g, which corresponds to a calcium content of 500 mg colecalciferol (Vit. D3) in the form of granules* 5 μg (200 IU)

Excipients

: lactose, povidone (low molecular weight polyvinylpyrrolidone), potato starch, croscarmellose sodium (Vivasol), citric acid, aspartame, magnesium stearate, flavoring.

* Granulate composition:

butylated hydroxytoluene, sucrose, gelatin, sodium aluminum silicate, medium chain triglycerides, modified starch, water.

30 pcs. - polyethylene cans (1) - cardboard packs. 60 pcs. - polyethylene cans (1) - cardboard packs. 90 pcs. - polyethylene cans (1) - cardboard packs. 100 pieces. - polyethylene cans (1) - cardboard packs. 120 pcs. - polyethylene cans (1) - cardboard packs.

Indications

prevention and complex therapy of osteoporosis (menopausal, senile, steroid, idiopathic);
prevention and treatment of calcium and/or vitamin D3 deficiency.

Contraindications for use

hypercalcemia;
hypercalciuria;
calcium nephrourolithiasis;
hypervitaminosis D;
decalcifying tumors (myeloma, bone metastases, sarcoidosis);
osteoporosis caused by immobilization;
phenylketonuria (contains aspartame);
pulmonary tuberculosis (active form);
chronic renal failure;
children under 3 years of age;
hypersensitivity to the components of the drug.

pharmachologic effect

A combined drug whose effect is determined by its constituent components. Regulates the exchange of calcium and phosphates, reduces resorption and increases bone density, compensates for the lack of calcium and colecalciferol (vitamin D3) in the body, enhances the absorption of calcium in the intestines and the reabsorption of phosphates in the kidneys, promotes bone mineralization.

Calcium is involved in the formation of bone tissue, blood clotting, maintaining stable cardiac activity, and in the processes of transmitting nerve impulses.

Colecalciferol promotes the absorption of calcium in the intestine, the formation and mineralization of bone and dental tissue.

The use of calcium and colecalciferol prevents an increase in the production of parathyroid hormone, which is a stimulator of increased bone resorption.

Drug interactions

The activity of colecalciferol may be decreased when used concomitantly with phenytoin or barbiturates.

With simultaneous treatment with cardiac glycosides, monitoring of the ECG and clinical condition is necessary, because Calcium preparations can potentiate the therapeutic and toxic effects of cardiac glycosides.

Calcium and colecalciferol preparations can increase the absorption of tetracyclines from the gastrointestinal tract. Therefore, the time interval between doses of drugs should be at least 3 hours.

To prevent decreased absorption of bisphosphonate drugs or sodium fluoride, it is recommended to take Complivit® Calcium D3 no earlier than two hours after taking them.

GCS reduce absorption, therefore, when treating GCS, an increase in the dose of Complivit® Calcium D3 may be required.

Simultaneous treatment with cholestyramine preparations or laxatives based on mineral or vegetable oil may reduce the absorption of colecalciferol.

With simultaneous use of thiazide diuretics, the risk of developing hypercalcemia increases, because they increase tubular reabsorption of calcium. Furosemide and other “loop” diuretics, on the contrary, increase calcium excretion by the kidneys.

Dosage regimen

The drug should be taken orally, preferably with meals.

For adults

for
the treatment of osteoporosis,
1 tablet is prescribed.
2-3 times a day, for the prevention of osteoporosis
- 1 tablet.
2 times/day. For calcium and vitamin D3 deficiency, adults and children over 12 years of age
are prescribed 1 tablet.
1-2 times/day; children from 5 to 12 years old
– 1-2 tablets/day;
For children from 3 to 5 years old,
the dose is determined by the doctor individually.

The tablets are chewed or swallowed whole.

Overdose

Symptoms

: thirst, polyuria, loss of appetite, nausea, vomiting, constipation, dizziness, weakness, headache, fainting, coma;
with long-term use - calcification of blood vessels and tissues; laboratory indicators - hypercalciuria, hypercalcemia (calcium in plasma about 2.6 mmol). Treatment:
rehydration, loop diuretics, corticosteroids, calcitonin, bisphosphonates, calcium-restricted diet, hemodialysis.

If symptoms of overdose are detected, the patient should consult a doctor.

Side effect

From the digestive system:

dyspeptic reactions (constipation, flatulence, nausea, stomach pain, diarrhea).
Metabolism:
hypercalcemia, hypercalciuria.

Other:

allergic reactions.

special instructions

Complivit® Calcium D3 contains aspartame, which is transformed into phenylalanine in the body, so the drug should not be prescribed to patients suffering from phenylketonuria.

During the treatment period, it is necessary to constantly monitor the excretion of calcium in the urine and the concentration of calcium and creatinine in the blood plasma. If calciuria exceeds 7.5 mmol/day (300 mg/day), it is necessary to reduce the dose or stop taking the drug.

In elderly people, the need for calcium is 1500 mg/day, for colecalciferol – 500-1000 IU/day.

To avoid overdose, additional intake of colecalciferol from other sources must be taken into account.

Storage conditions

The drug should be stored out of the reach of children, in a dry place, protected from light, at a temperature not exceeding 25°C.

Best before date

Shelf life: 2 years.

Use during pregnancy and breastfeeding

Restrictions during pregnancy - With caution. Restrictions when breastfeeding - With caution.

The drug should be used with caution during pregnancy and lactation (breastfeeding).

During pregnancy, the daily dose should not exceed 1500 mg of calcium and 600 IU of vitamin D3.

Vitamin D and its metabolites can be excreted in breast milk.

Overdose during pregnancy can lead to disruption of the mental and physical development of the child.

Use for renal impairment

Restrictions for impaired renal function - Contraindicated.

The use of the drug is contraindicated in chronic renal failure.

Use in children

Restrictions for children - With caution.

Contraindication: children under 3 years of age.

Terms of sale

The drug is approved for use as a means of OTC.

Contacts for inquiries

PHARMSTANDARD JSC (Russia)

141701 Moscow region. Dolgoprudny, Likhachevsky pr-d, 5B Tel./fax E-mail

pharmachologic effect

A two-component medicine, the medicinal effect of which consists of the effects of the active components. The medication promotes bone mineralization , stimulates the reabsorption of phosphates in the renal system, and increases the absorption of calcium from the intestinal lumen.

The medication is able to replenish the deficiency of colecalciferol and calcium, increase bone density, reduce bone resorption, and regulate the exchange of phosphates and calcium in the body.

Calcium takes part in the process of blood clotting and the formation of the skeletal system, in the transmission of impulses along the neuromuscular pathway. Ensures stable operation and functioning of the cardiovascular system.

Colecalciferol promotes the mineralization of dental tissue and the skeletal system and participates in their formation. Ensures complete absorption of Ca from the intestinal lumen and digestive tract.

The combined use of colecalciferol and calcium enhances the production of parathyroid hormone , which acts as a stimulator in relation to bone resorption.

Complivit Aqua D3

Complivit® Aqua D3 is an aqueous solution of vitamin D3 at an affordable price.*

Suitable for children from 4 weeks of age!

Vitamin D deficiency among the population in Russia reaches 83%.1 Complivit Aqua D3 is a new modern water-soluble form of vitamin D.

A special technology for its production allows fat-soluble vitamin D3 to be converted into a micellar (water-soluble) form, where the hydrophobic ends of the molecule are oriented inward, and the hydrophilic ends are oriented outward.

This form is already ready for absorption in the small intestine, regardless of the function of the gastrointestinal tract3. Compared to the usual oil form, the aqueous form of Complivit® Aqua D3 has a number of advantages and features:

better absorbed from the gastrointestinal tract4,
absorption is not affected by insufficient bile production (for example, in premature infants)4,7
Available in a convenient dosage form: in the form of drops for oral administration

Composition: 1 ml contains colecalciferol (vitamin D3) – 0.375 mg (15000 IU)

Release form: drops for oral administration, dropper bottle 10 ml, 20 ml

Shelf life: 2 years.

Indications for use

Prevention of vitamin D deficiency and diseases associated with its deficiency (rickets, osteomalacia). Treatment of rickets. Complex therapy of osteoporosis of various origins. 2015 is the latest data.

Question answer

1. What is vitamin D for?

Vitamin D is an important vitamin that is involved in regulating many processes in the body. There are several forms of vitamin D; vitamin D35 is considered the “true” one.

The main role of vitamin D is to ensure the absorption of calcium and phosphorus. With severe vitamin D deficiency, bones become fragile, muscle weakness appears, children develop rickets, muscle hypotonia, and adults develop osteoporosis and osteomalacia.

Vitamin D also performs the following functions in the body1,4,5,7,11:

Participates in the regulation of muscle tone.
Participates in maintaining the body's antitumor defense.
Participates in maintaining the body's antitumor defense.
Regulates the metabolism of glucose and insulin.
Regulates blood pressure levels.
Participates in the regulation of the functioning of the thyroid gland.

Another important function of vitamin D is its participation in maintaining immunity, incl. congenital10. In recent years, the active participation of vitamin D in the regulation of immunogenesis and cell proliferation has been shown. Vitamin D is a potential immunomodulator and is involved in the regulation of the body’s immune response to various infectious diseases.8,9 Therefore, vitamin D deficiency can lead to a decrease in the body’s resistance to infections and an increase in the incidence of acute respiratory viral infections and influenza.

2. Vitamin D is produced in the body, why take it additionally?

The main source of vitamin D in the body is synthesis in the skin under the influence of ultraviolet rays from the sun. However, most of our country is located in the northern latitude above the 35th parallel, and due to the more acute angle of incidence of the sun's rays and their dispersion in the atmosphere, from November to March the skin practically does not produce vitamin D, regardless of the time spent in the sun.1 In addition, the application of special cosmetics that protect the skin from sunburn and photoaging blocks the production of vitamin D by almost 100%12.

The second source of vitamin D is high-fat foods. This is primarily cod, herring, butter, margarine, milk, egg yolk, etc. However, a high-fat diet often entails an increase in body weight, additional stress on the heart, blood vessels and liver.

Therefore, in order to obtain the required amount of vitamin D, it is currently customary in developed countries to use foods fortified with it or specially developed supplements/medicines.

3. Why is vitamin D so important for children?

In Russia, among young children, vitamin D deficiency is detected in 50-70%6. Vitamin D is especially important in the first year of life, when the child is actively growing and developing. The main function of vitamin D is to help the body absorb calcium so that teeth and bones form correctly and are healthy and strong. A lack of vitamin D can lead to the development of childhood rickets, which causes softening of bone tissue. As a result, deformations of the skeletal bones occur (flat occiput, curvature of the limbs, deformation of the ribs, etc.). In addition, muscle weakness, dysfunction of the autonomic nervous system and a tendency to colds are often observed. It is quite difficult to obtain the daily requirement of vitamin D from food, which is why children are often prescribed vitamin D supplements.

4. Why is vitamin D needed for adults?

Receptors for active forms of vitamin D are located in almost all tissues of the body1,2,5, so people of all ages need it! Vitamin D is especially necessary when1,2:

high levels of air pollution
lack of sunlight
lack of foods rich in vitamin D in the diet
impaired absorption of vitamin D, absorption in the intestines
metabolic disorders, obesity
taking glucocorticoids
over the age of 50 years, incl. due to decreased production of vit. D and little sun exposure.

5. Advantages of Complivit Aqua D3 for children and adults.

Compared to the usual oil form, the aqueous form of Complivit® Aqua D3 has a number of advantages and features:

better absorbed from the gastrointestinal tract4
absorption is not affected by insufficient bile production (for example, in premature infants)4,7
Available in a convenient dosage form: in the form of drops for oral administration

Take care of your health and the health of your children with Complivit® Aqua D3!

Contraindications

phenylketonuria (contains aspartame);
hypervitaminosis D;
hypercalciuria;
osteoporosis due to immobilization;
chronic pathology of the renal system;
pulmonary tuberculosis (active stage);
calcium nephrourolithiasis;
decalcifying neoplasms ( sarcoidosis , metastases to the skeletal system, myeloma);
hypercalcemia;
individual hypersensitivity.

Age limit - up to 3 years.

Complivit Calcium D3 Forte chewable tablets No. 30 mint

Compound

Active substances:

calcium carbonate	1.25 g,
which corresponds to the calcium content	500 mg
colecalciferol (vit. D3)*	0.01 mg (400 IU)

* in the form of granulate containing colecalciferol - 0.27%, DL-α-tocopherol - 0.0275%, medium chain triglycerides - 10.7%, sucrose - 36%, acacia gum - 22%, corn starch - 27%, calcium phosphate (E341) - 0.5 %, water - up to 100%).
Excipients: lactose monohydrate (milk sugar) - 333.118 mg, povidone (medium molecular weight polyvinylpyrrolidone, povidone K17) - 68.24 mg, polysorbate 80 - 1.731 mg, potato starch - 18.969 mg, croscarmellose sodium - 50.282 mg, citric acid - 3.325 mg, aspartame (E951) - 5.95 mg, magnesium stearate - 15.75 mg, peppermint leaf oil - 2.625 mg.

Pharmacokinetics

Colecalciferol

Vitamin D3 is easily absorbed from the small intestine (about 80% of the dose taken). Colecalciferol and its metabolites circulate in the blood bound to a specific globulin. Colecalciferol is converted in the liver by hydroxylation to 25-hydroxycalciferol. It is then converted in the kidneys to the active form 1,25-hydroxycalciferol. 1,25-hydroxycalciferol is a metabolite responsible for increasing calcium absorption. Unmetabolized vitamin D3 is stored in adipose and muscle tissue. Excreted through the intestines and kidneys.

Calcium

Calcium is absorbed in ionized form from the proximal small intestine through an active, D-vitamin dependent transport mechanism. Typically, the amount of calcium absorbed from the gastrointestinal tract is approximately 30% of the dose taken. 99% of calcium in the body is concentrated in the hard tissues of teeth and bones. The remaining 1% is found in intra- and extracellular fluids. About 50% of the total calcium content in the blood is in physiological active ionized form, of which approximately 10% is complexed with citrate, phosphate or other anions, the remaining 40% is associated with proteins, primarily albumin. Calcium is excreted by the intestines, kidneys and sweat glands. Renal excretion depends on glomerular filtration and tubular reabsorption of calcium.

Indications for use

Prevention and complex therapy of osteoporosis (menopausal, senile, “steroidal”, idiopathic) and its complications (bone fractures).
Replenishment of calcium and/or vitamin D3 deficiency.

Contraindications

Hypersensitivity to the components of the drug (including lactose intolerance, lactase deficiency, sucrase/isomaltase deficiency, fructose intolerance, glucose-galactose malabsorption), hypercalcemia, hypercalciuria, calcium nephrourolithiasis, hypervitaminosis D, decalcifying tumors (myeloma, bone metastases, sarcoidosis ), osteoporosis due to immobilization, phenylketonuria (contains aspartame), pulmonary tuberculosis (active form), chronic renal failure, children under 3 years of age.

With caution: pregnancy, lactation period.

Directions for use and doses

Inside, chew or swallow whole, preferably during meals, with water.

Adults: for the treatment of osteoporosis - 1 tablet 2-3 times a day, for the prevention of osteoporosis - 1 tablet 2 times a day.

To compensate for calcium and/or vitamin D3 deficiency:

Adults and children over 12 years old - 1 tablet 1-2 times a day.
Children from 3 to 12 years old - 1 tablet per day or as prescribed by a doctor.

Storage conditions

At a temperature not higher than 25 °C. Keep out of the reach of children.

Best before date

3 years. Do not use after the expiration date stated on the package.

special instructions

To avoid overdose, additional vitamin D3 intake from other sources must be taken into account.
Complivit® Calcium Dz Forte contains aspartame, which is transformed into phenylalanine in the body, so the drug should not be taken by patients suffering from phenylketonuria.

During the treatment period, it is necessary to constantly monitor the excretion of calcium in the urine and the concentration of calcium and creatinine in the blood plasma (in case of calciuria exceeding 7.5 mmol/day (300 mg/day), it is necessary to reduce the dose or stop taking it).

In older people, the need for calcium is 1500 mg/day, for vitamin D3 - 0.5-1 thousand IU/day.

Description

Calcium-phosphorus metabolism regulator.

Pharmacodynamics

A combined drug whose effect is determined by its constituent components.
Regulates the exchange of calcium and phosphates, reduces resorption and increases bone density, replenishes the lack of calcium and vitamin D3 in the body, enhances the absorption of calcium in the intestines and the reabsorption of phosphates in the kidneys, promotes bone mineralization. Calcium is involved in the formation of bone tissue, blood clotting, maintaining stable cardiac activity, and in carrying out the processes of transmission of nerve impulses.

Vitamin D3 (colecalciferol) - promotes the absorption of calcium in the intestines, the formation and mineralization of bone and dental tissue. The use of calcium and vitamin D3 prevents the increase in the production of parathyroid hormone, which is a stimulator of increased bone resorption.

Side effects

Allergic reactions. Dyspeptic disorders of the gastrointestinal tract (constipation, flatulence, nausea, stomach pain, diarrhea). Hypercalcemia and hypercalciuria (increased calcium levels in the blood and urine).

Use during pregnancy and breastfeeding

The daily dose should not exceed 1500 mg of calcium and 600 IU of vitamin D3. Hypercalcemia, which develops against the background of an overdose, during pregnancy can cause defects in the mental and physical development of the child. Vitamin D and its metabolites can pass into breast milk, so it is necessary to consider the intake of calcium and vitamin D from other sources in the mother and child.

Interaction

The activity of vitamin D3 may decrease when used concomitantly with phenytoin or barbiturates.

During simultaneous treatment with cardiac glycosides, monitoring of the ECG and clinical condition is necessary, since calcium preparations can potentiate the therapeutic and toxic effects of cardiac glycosides.

Calcium and vitamin D3 supplements may increase the absorption of tetracyclines: from the gastrointestinal tract. Therefore, the time interval between doses of drugs should be at least three hours.

To prevent decreased absorption of bisphosphonate drugs or sodium fluoride, it is recommended to take Complivit Calcium Dz Forte no earlier than two hours after taking them.

Glucocorticosteroids reduce the absorption of calcium, so treatment with glucocorticosteroids may require an increase in the dose of Complivit Calcium Dz Forte.

Simultaneous treatment with cholestyramine or laxatives based on mineral or vegetable oil may reduce the absorption of vitamin D3.

With simultaneous use of thiazide diuretics, the risk of hypercalcemia increases, as they increase tubular reabsorption of calcium. Furosemide and other “loop” diuretics, on the contrary, increase calcium excretion by the kidneys.

Overdose

If you notice signs of overdose, consult a doctor.

Symptoms: thirst, polyuria, loss of appetite, nausea, vomiting, constipation, dizziness, weakness, headache, fainting, coma; with long-term use: calcification of blood vessels and tissues.

Treatment: introduction of large amounts of fluid into the body, use of loop diuretics (for example, furossmide), glucocorticosteroids, calcitonin, bisphosphoiates. If clinical symptoms of overdose develop, the concentration of calcium and creatinine in the blood should be determined. In case of increased concentration of calcium or creatinine in the blood serum, the dose of the drug should be reduced or treatment should be temporarily stopped.

Complivit Calcium D3, instructions for use (Method and dosage)

therapy : 2-3 times a day, 1 tablet. For preventive purposes, 1 tablet is prescribed twice a day.

If there is a lack of vitamin D3 and calcium, 1 tablet is prescribed 1-2 times a day (adults and children over 12 years old). In pediatric practice, for children 3-5 years old, the dose is selected taking into account individual characteristics and concomitant pathology; children 5-12 years old - 1-2 tablets per day. How to take the tablets: You can either chew them or swallow them whole during meals.

Instructions for Complivit Calcium D3 Forte

Morning and evening (twice a day) 1 tablet with meals. The scheme may vary depending on the clinical picture and individual characteristics.

Instructions for kids

The dosage form in powder form is designed specifically for use in pediatric practice (age category - up to 3 years). A suspension is prepared from the powder and taken orally during meals.

How to prepare the suspension?

Shake the bottle thoroughly to completely separate the powder particles from the walls and bottom, add warm boiled water, filling 2/3 of the bottle. Shake for 2 minutes, achieving structural homogeneity of the solution, then add water to the neck of the bottle, shake thoroughly. The bottle of powder and suspension must be shaken before each use.

Calcium Complivit D3: instructions for use

Registration number:
Trade name of the drug: Complivit® Calcium D3
International nonproprietary name or group name: Calcium carbonate + Colecalciferol.

Dosage form: chewable tablets [orange].

Composition per tablet

Active components:

Calcium - 500 mg

(in the form of calcium carbonate - 1.250 g) Colecalciferol (vitamin D3) - 0.005 mg (200 IU) (in terms of 100% colecalciferol) (in the form of granules containing colecalciferol - 0.27%, D, L-alpha-tocopherol - 0.0275%, medium chain triglycerides - 10.7%, sucrose - 36%, acacia gum - 22%, corn starch - 27%, calcium phosphate (E 341) - 0.5%, water up to 100%).

Excipients: lactose monohydrate (milk sugar) - 327.406 mg, povidone (medium molecular weight polyvinylpyrrolidone, povidone K 30) - 68.223 mg, potato starch - 20.541 mg, croscarmellose sodium - 49.875 mg, citric acid - 3.325 mg, aspartame (E 951) - 5.95 mg, magnesium stearate - 15.75 mg, orange flavor (powder) - 8.925 mg.

Description: chewable tablets: round, biconvex with a rough, porous surface from white to white with a creamy tint, with a faint fruity odor. May have small inclusions of a grayish color.

Pharmacotherapeutic group: calcium-phosphorus metabolism regulator.

ATX code: [A12AX].

Pharmacological properties Pharmacodynamics

A combined drug that regulates the exchange of calcium and phosphorus in the body (bones, teeth, nails, hair, muscles). Reduces resorption (resorption) and increases

bone tissue density, replenishing the lack of calcium and vitamin D3 in the body, enhances the absorption of calcium in the intestines and the reabsorption of phosphates in the kidneys, promotes the mineralization of bone tissue and dental tissue.

Calcium is involved in the formation of bone tissue, in maintaining stable cardiac activity, in the regulation of nerve conduction, muscle contractions, hormone production, and is a component of the blood coagulation system.

Adequate calcium intake is especially important during growth, pregnancy and breastfeeding.

Vitamin D3 (colecalciferol) – increases the absorption of calcium in the intestine, promotes the formation and mineralization of bone and dental tissue.

The use of calcium and vitamin D3 prevents an increase in the production of parathyroid hormone (PTH), which is a stimulator of increased bone resorption (leaching of calcium from the bones).

Pharmacokinetics

Calcium

Absorption: Calcium is absorbed in ionized form in the proximal small intestine through an active, D-vitamin dependent transport mechanism. Typically, the amount of calcium absorbed in the gastrointestinal tract is approximately 30% of the dose taken.

Distribution and Metabolism: 99% of calcium in the body is concentrated in the rigid structure of bones and teeth. The remaining 1% is found in intracellular and extracellular fluids. About 50% of the total calcium content in the blood is in physiological active ionized form, of which approximately 10% is complexed with citrate, phosphate or other anions, the remaining 40% is associated with proteins, primarily albumin.

Excretion: Calcium is excreted by the intestines, kidneys and sweat glands. Renal excretion depends on glomerular filtration and tubular reabsorption of calcium.

Vitamin D3

Absorption: Vitamin D3 is easily absorbed in the small intestine (about 80% of the dose taken).

Distribution and metabolism: colecalciferol and its metabolites circulate in the blood bound to a specific globulin. Colecalciferol is converted in the liver by hydroxylation to 25-hydroxycalciferol. It is then converted in the kidneys to the active form 1,25-hydroxycalciferol. 1,25-hydroxycalciferol is a metabolite responsible for increasing calcium absorption.

Unmetabolized vitamin D3 is stored in adipose and muscle tissue.

Excretion: Vitamin D3 is excreted by the intestines and kidneys.

Indications for use

Prevention and treatment of calcium and/or vitamin D3 deficiency.

Prevention and complex therapy of osteoporosis and its complications (bone fractures).

Contraindications

Hypersensitivity to the components of the drug.
Hypercalcemia (increased concentration of calcium in the blood).
Hypercalciuria (increased calcium in the urine).
Nephrolithiasis.
Hypervitaminosis D.
Decalcifying tumors (myeloma, bone metastases, sarcoidosis).
Pulmonary tuberculosis (active form).
Severe renal failure.

The drug in tablet dosage form is not used in children under 3 years of age. Complivit® Calcium D3 contains aspartame, which is transformed into phenylalanine in the body. Therefore, the drug should not be taken by patients with phenylketonuria.

The drug contains lactose and sucrose, so its use is not recommended for patients with hereditary intolerance to lactose, fructose, glucose-galactose malabsorption, lactase or sucrase/isomaltase deficiency.

With caution: pregnancy, breastfeeding, renal failure.

Use during pregnancy and breastfeeding

Complivit® Calcium D3 is used during pregnancy to compensate for the deficiency of calcium and vitamin D3 in the body. During pregnancy, the daily dose should not exceed 1500 mg of calcium and 600 IU of vitamin D3. Hypercalcemia due to overdose during pregnancy can have an adverse effect on the developing fetus.

Complivit® Calcium D3 is used during breastfeeding. Calcium and vitamin D3 can pass into breast milk, so mother and baby's intake of calcium and vitamin D from other sources must be considered.

Directions for use and doses

Complivit® Calcium D3, chewable tablets, taken orally with meals. The tablet should be chewed or dissolved. After this, if necessary, you can drink water.

Adults: for the treatment of osteoporosis - 1 tablet 2-3 times a day, for the prevention of osteoporosis - 1 tablet 2 times a day.

For calcium and/or vitamin D3 deficiency:

Adults and children over 12 years old – 1 tablet 2 times a day. Children from 5 years to 12 years – 1-2 tablets per day.

Children from 3 to 5 years old - dosage in accordance with the doctor’s recommendations.

Special patient groups

Patients with impaired liver function:

No dose adjustment is required.

Patients with impaired renal function:

The drug should not be used in severe renal failure.

Elderly patients:

The dose is the same as for adults. A possible decrease in creatinine clearance should be taken into account.

Duration of treatment

When used for prevention and in complex therapy of osteoporosis, the duration of treatment is determined by the doctor individually.

When used to replenish calcium and/or vitamin D3 deficiency, the average duration of treatment is at least 4-6 weeks. The number of repeat courses during the year is determined individually.

Side effect

The frequency of side effects of the drug is assessed as follows: very often: > 1/10, often: > 1/100, <1/10, infrequently: > 1/1,000, < 1/100, rarely: > 1/10,000, < 1/1,000, very rare: <1/10,000.

Metabolic and nutritional disorders: uncommon - hypercalcemia, hypercalciuria.

Gastrointestinal disorders: rarely - constipation, flatulence, nausea, abdominal pain, diarrhea, dyspepsia.

Skin and subcutaneous tissue disorders: very rarely - allergic reactions (itching, rash, urticaria).

Overdose

Symptoms of overdose (hypercalcemia): thirst, polyuria, anorexia, nausea, vomiting, constipation, abdominal pain, bone pain, muscle weakness, fatigue, mental disorders, dizziness, headache, fainting, coma, nephrocalcinosis, urolithiasis, in severe cases - cardiac arrhythmias. With long-term use of excessive doses (over 2500 mg of calcium) - kidney damage, soft tissue calcification.

Laboratory indicators in case of overdose: hypercalciuria, hypercalcemia (plasma calcium about 2.6 mmol).

If signs of overdose are detected, you should stop taking calcium and vitamin D, as well as thiazide diuretics and cardiac glycosides, and consult a doctor.

Treatment: gastric lavage, replenishment of fluid loss, use of loop diuretics (for example, furosemide), glucocorticosteroid drugs, calcitonin, bisphosphonates, calcium-restricted diet, hemodialysis.

It is necessary to monitor the content of electrolytes in the blood plasma, renal function and diuresis.

In severe cases, it is necessary to measure central venous pressure (CVP) and monitor the electrocardiogram (ECG).

Interactions with other drugs and foods The activity of vitamin D3 may be reduced when used concomitantly with phenytoin or barbiturates.

Hypercalcemia can potentiate the toxic effects of cardiac glycosides when used simultaneously with calcium and vitamin D preparations. Monitoring of ECG and serum calcium levels is necessary.

Calcium supplements may reduce the absorption of tetracyclines from the gastrointestinal tract. Therefore, tetracycline drugs should be taken at least 2 hours before or 4-6 hours after taking Complivit® Calcium D3.

To prevent decreased absorption of bisphosphonate drugs, it is recommended to take them at least an hour before taking Complivit® Calcium D3.

Glucocorticosteroids reduce calcium absorption, so treatment with glucocorticosteroids may require an increase in the dose of Complivit® Calcium D3.

Simultaneous treatment with cholestyramine preparations or laxatives based on mineral or vegetable oil may reduce the absorption of vitamin D3.

With simultaneous use of thiazide diuretics, the risk of hypercalcemia increases, as they increase tubular reabsorption of calcium. When using thiazide diuretics simultaneously, serum calcium levels should be regularly monitored. Furosemide and other “loop” diuretics, on the contrary, increase calcium excretion by the kidneys.

Calcium reduces the effectiveness of levothyroxine by reducing its absorption. The period of time between doses of levothyroxine and Complivit® Calcium D3 should be at least 4 hours.

The absorption of quinolone antibiotics is reduced when used simultaneously with calcium supplements. Therefore, quinolone antibiotics should be taken 2 hours before or 6 hours after taking Complivit® Calcium D3.

Eating foods containing oxalates (sorrel, rhubarb, spinach) and phytin (cereals) reduces calcium absorption, so you should not take Complivit® Calcium D3 within 2 hours after eating sorrel, rhubarb, spinach and cereals.

special instructions

During long-term therapy, serum calcium and creatinine levels should be monitored. Monitoring is especially important in elderly patients during concomitant treatment with cardiac glycosides and diuretics (see section “Interactions with other drugs and foods”) and in patients with an increased tendency to form kidney stones. In cases of hypercalcemia or signs of renal impairment, reduce the dose or discontinue treatment.

Vitamin D3 should be taken with caution in patients with renal failure. In this case, it is necessary to monitor the calcium and phosphate levels in the blood serum. The risk of soft tissue calcification must also be considered. To avoid overdose, additional vitamin D intake from other sources must be taken into account.

In older people, the need for calcium is 1500 mg/day, for vitamin D3 – 0.5-1 thousand IU/day.

Calcium and vitamin D3 should be used with caution in immobilized patients with osteoporosis due to the risk of hypercalcemia.

Concomitant use with tetracycline or quinolone antibiotics is usually not recommended or should be done with caution (see section “Interaction with other drugs and foods”).

Effect on the ability to drive vehicles and machinery The drug Complivit® Calcium D3 does not affect the ability to drive vehicles or work with technically complex mechanisms.

Release form

Chewable tablets [orange].

30, 60, 90, 100 or 120 tablets in polymer jars. The jars are sealed with a screw-on lid. Each jar, covered with a protective heat-shrink cap, along with instructions for use, is placed in a cardboard pack.

Or jars of 60, 90, 100 or 120 tablets with a multi-page label containing the full text of the instructions for use, covered with a protective heat-shrink cap, are placed in a transport container.

Storage conditions

At a temperature not higher than 25 ºС. Keep out of the reach of children.

Best before date

3 years.

Do not use after the expiration date stated on the packaging.

Vacation conditions

Over the counter.

Marketing authorization holder/organization receiving consumer complaints:

PJSC OTCPharm, Russia, 123317, Moscow, st. Testovskaya, 10 Tel.: +7 (800) 775-98-19 Fax www.otcpharm.ru

, 450077, Russia, Republic of Bashkortostan, Ufa, st. Khudayberdina, 28, tel./fax, www.pharmstd.ru

Overdose

fainting conditions;
decreased appetite;
coma;
headache;
constipation;
dyspeptic manifestations;
polyuria;
thirst.

Long-term use of large doses causes calcification of organs, tissues, and blood vessels. According to the results of biochemical analysis, hypercalcemia and hypercalciuria are determined.

Therapy includes measures for rehydration , taking “loop” diuretics, glucocorticosteroids, bisphosphonates, and calcitonin.

Prescribing a diet with limited Ca intake is effective. Hemodialysis has a good effect .

Interaction

Thiazide diuretics increase the risk of hypercalcemia due to their ability to enhance tubular Ca reabsorption. The opposite effect (increased excretion of calcium from the body by the renal system) is recorded during therapy with “loop” diuretics ( Furosemide ).

The absorption of colecalciferol is reduced when treated with laxative medications based on vegetable oil (or mineral oil). A similar effect is observed when taking Cholestyramine .

Therapy with glucocorticosteroids may require dose adjustment of Complivit Calcium D3 (more often an increase in dosage is required).

The time interval between doses of Complivit and sodium fluoride, bisphosphonates should be at least 2 hours.

The medication may increase the rate of absorption of Tetracycline (and similar antibiotics ) from the digestive tract, so it is recommended to maintain a 3-hour break between doses.

Cardiac glycosides require a more thorough examination of the patient with cardiovascular pathology, since Ca preparations can enhance both the toxic effect and the therapeutic effect of most glycosides.

The effectiveness of colecalciferol is reduced when treated with barbiturates and phenytoin.

Complivit Calcium D3 chewable tablets No. 30 orange

Compound

Active ingredients: calcium carbonate 1.25 g, which corresponds to a calcium content of 500 mg;
colecalciferol (Vit. D3) in the form of granules* 5 mcg (200 IU). Excipients: lactose, povidone (low molecular weight polyvinylpyrrolidone), potato starch, croscarmellose sodium (Vivasol), citric acid, aspartame, magnesium stearate, orange flavor (powder).

* Composition of the granulate: colecalciferol, butylated hydroxytoluene, sucrose, gelatin, sodium aluminosilicate, medium chain triglycerides, modified starch, water.

Pharmacokinetics

Colecalciferol is absorbed from the small intestine.

Calcium is absorbed in ionized form in the proximal small intestine through an active, vitamin D-dependent transport mechanism.

Indications for use

Prevention and complex therapy of osteoporosis (menopausal, senile, steroid, idiopathic);
prevention and treatment of calcium and/or vitamin D3 deficiency.

Contraindications

Hypercalcemia;
hypercalciuria;
calcium nephrourolithiasis;
hypervitaminosis D;
decalcifying tumors (myeloma, bone metastases, sarcoidosis);
osteoporosis caused by immobilization;
phenylketonuria (contains aspartame);
pulmonary tuberculosis (active form);
chronic renal failure;
children under 3 years of age;
hypersensitivity to the components of the drug.

Directions for use and doses

The drug should be taken orally, preferably with meals.

For the treatment of osteoporosis, adults are prescribed 1 tablet. 2-3 times a day, for the prevention of osteoporosis - 1 tablet. 2 times/day.

For calcium and vitamin D3 deficiency, adults and children over 12 years of age are prescribed 1 tablet. 1-2 times/day; children from 5 to 12 years old – 1-2 tablets/day; For children from 3 to 5 years old, the dose is determined by the doctor individually.

The tablets are chewed or swallowed whole.

Storage conditions

The drug should be stored out of the reach of children, in a dry place, protected from light, at a temperature not exceeding 25°C.

Best before date

2 years. Do not use after the expiration date stated on the package.

special instructions

Complivit® Calcium D3 contains aspartame, which is transformed into phenylalanine in the body, so the drug should not be prescribed to patients suffering from phenylketonuria.

In elderly people, the need for calcium is 1500 mg/day, for colecalciferol – 500-1000 IU/day.

To avoid overdose, additional intake of colecalciferol from other sources must be taken into account.

Description

Calcium-phosphorus metabolism regulator.

Use in children

Contraindication: children under 3 years of age.

Pharmacodynamics

Calcium is involved in the formation of bone tissue, blood clotting, maintaining stable cardiac activity, and in the processes of transmitting nerve impulses.

Colecalciferol promotes the absorption of calcium in the intestine, the formation and mineralization of bone and dental tissue.

The use of calcium and colecalciferol prevents an increase in the production of parathyroid hormone, which is a stimulator of increased bone resorption.

Side effects

From the digestive system: dyspeptic reactions (constipation, flatulence, nausea, stomach pain, diarrhea).

Metabolism: hypercalcemia, hypercalciuria.

Other: allergic reactions.

Use during pregnancy and breastfeeding

The drug should be used with caution during pregnancy and lactation (breastfeeding).

During pregnancy, the daily dose should not exceed 1500 mg of calcium and 600 IU of vitamin D3.

Vitamin D and its metabolites can be excreted in breast milk.

Overdose during pregnancy can lead to disruption of the mental and physical development of the child.

Interaction

The activity of colecalciferol may be decreased when used concomitantly with phenytoin or barbiturates.

Calcium and colecalciferol preparations can increase the absorption of tetracyclines from the gastrointestinal tract. Therefore, the time interval between doses of drugs should be at least 3 hours.

To prevent decreased absorption of bisphosphonate drugs or sodium fluoride, it is recommended to take Complivit® Calcium D3 no earlier than two hours after taking them.

GCS reduce absorption, therefore, when treating GCS, an increase in the dose of Complivit® Calcium D3 may be required.

Simultaneous treatment with cholestyramine preparations or laxatives based on mineral or vegetable oil may reduce the absorption of colecalciferol.

Overdose

Symptoms: thirst, polyuria, loss of appetite, nausea, vomiting, constipation, dizziness, weakness, headache, fainting, coma; with long-term use - calcification of blood vessels and tissues; laboratory indicators - hypercalciuria, hypercalcemia (calcium in plasma about 2.6 mmol).

Treatment: rehydration, loop diuretics, corticosteroids, calcitonin, bisphosphonates, calcium-restricted diet, hemodialysis.

If symptoms of overdose are detected, the patient should consult a doctor.

special instructions

The medication contains aspartame, which can be transformed to phenylalanine, which limits the use of the drug in patients with phenylketonuria . Monitoring of calcium excretion in urine, creatinine and calcium levels based on the results of biochemical analysis is mandatory.

When calciuria (more than 7.5 mmol per day), treatment is stopped (dose reduction is allowed). In elderly patients, the daily requirement for colecalciferol is 500-1000 IU, for calcium - 1500 mg. The attending physician should calculate the dose of the medication taking into account the intake of colecalciferol and calcium from other possible sources.

Complivit Calcium D3 tablet chew No. 120 orange

Compound

Active ingredients: calcium - 500 mg, colecalciferol (vit. D3) in the form of granules * - 5 mcg (200 IU).
Excipients: lactose, povidone (low molecular weight polyvinylpyrrolidone), potato starch, croscarmellose sodium (Vivasol), citric acid, aspartame, magnesium stearate, orange flavor (powder). *Granulate composition: colecalciferol, butylated hydroxytoluene, sucrose, gelatin, sodium aluminosilicate, medium chain triglycerides, modified starch, water.

Pharmacokinetics

Colecalciferol is absorbed from the small intestine.
Calcium is absorbed in ionized form in the proximal small intestine through an active, vitamin D-dependent transport mechanism.

Indications for use

prevention and complex therapy of osteoporosis (menopausal, senile, steroid, idiopathic);

prevention and treatment of calcium and/or vitamin D3 deficiency.

Contraindications

hypercalcemia;
hypercalciuria;
calcium nephrourolithiasis;
hypervitaminosis D;
decalcifying tumors (myeloma, bone metastases, sarcoidosis);
osteoporosis caused by immobilization;
phenylketonuria (contains aspartame);
pulmonary tuberculosis (active form);
chronic renal failure;
children under 3 years of age;
hypersensitivity to the components of the drug.

Directions for use and doses

Inside, chew or swallow whole, preferably during meals, with water.
Adults: for the treatment of osteoporosis - 1 tablet 2-3 times a day, for the prevention of osteoporosis - 1 tablet 2 times a day.

For calcium and vitamin D deficiency: Adults and children over 12 years old - 1 tablet 1-2 times a day.

Children from 5 years to 12 years - 1-2 tablets per day.

Children from 3 to 5 years old - dosage in accordance with the doctor’s recommendations.

Storage conditions

Store out of the reach of children at a temperature not exceeding 25°C.

Best before date

3 years. Do not use after the expiration date stated on the package.

special instructions

Complivit® Calcium DZ contains aspartame, which is transformed into phenylalanine in the body, so the drug should not be taken by patients suffering from phenylketonuria.
During the treatment period, it is necessary to constantly monitor the excretion of calcium in the urine and the concentration of calcium and creatinine in the blood plasma (in case of calciuria exceeding 7.5 mmol/day (300 mg/day), it is necessary to reduce the dose or stop taking it).

In older people, the need for calcium is 1500 mg/day, for vitamin D - 0.5-1 thousand IU/day.

To avoid overdose, additional intake of vitamin D from other sources must be taken into account.

Description

Calcium-phosphorus metabolism regulator.

Dosage form

Chewable tablets (orange) with a rough porous surface, round, biconvex, white to off-white with a creamy tint interspersed with gray color, with a faint fruity odor.

Use in children

Contraindication: children under 3 years of age.

Pharmacodynamics

A combined drug whose effect is determined by its constituent components.
Regulates the exchange of calcium and phosphates, reduces resorption and increases bone density, compensates for the lack of calcium and colecalciferol (vitamin D3) in the body, enhances the absorption of calcium in the intestines and the reabsorption of phosphates in the kidneys, promotes bone mineralization. Calcium is involved in the formation of bone tissue, blood clotting, maintaining stable cardiac activity, and in the processes of transmitting nerve impulses.

Colecalciferol promotes the absorption of calcium in the intestine, the formation and mineralization of bone and dental tissue.

The use of calcium and colecalciferol prevents an increase in the production of parathyroid hormone, which is a stimulator of increased bone resorption.

Side effects

From the digestive system: dyspeptic reactions (constipation, flatulence, nausea, stomach pain, diarrhea).
Metabolism: hypercalcemia, hypercalciuria.

Other: allergic reactions.

Use during pregnancy and breastfeeding

During pregnancy, the daily dose should not exceed 1500 mg of calcium and 600 IU of vitamin D3.
Vitamin D and its metabolites can pass into breast milk.

An overdose during pregnancy can lead to disruption of the mental and physical development of the child.

Interaction

The activity of vitamin D3 may be reduced when used simultaneously with phenytoin or barbiturates.
With simultaneous treatment with cardiac glycosides, monitoring of the ECG and clinical condition is necessary, because Calcium preparations can potentiate the therapeutic and toxic effects of cardiac glycosides.
Calcium and vitamin D supplements can increase the absorption of tetracyclines from the gastrointestinal tract. Therefore, the time interval between doses of drugs should be at least 3 hours.
To prevent decreased absorption of bisphosphonate drugs or sodium fluoride, it is recommended to take Complivit® Calcium DZ no earlier than two hours after taking them.
Glucocorticosteroids reduce the absorption of calcium, so treatment with glucocorticosteroids may require an increase in the dose of Complivit® Calcium DZ.
Simultaneous treatment with colesteramine preparations or laxatives based on mineral or vegetable oil can reduce the absorption of vitamin D3.
With simultaneous use of thiazide diuretics, the risk of hypercalcemia increases, as they increase tubular reabsorption of calcium. Furosemide and other loop diuretics, on the contrary, increase calcium excretion by the kidneys.

Overdose

Symptoms: thirst, polyuria, loss of appetite, nausea, vomiting, constipation, dizziness, weakness, headache, fainting, coma;
with long-term use: calcification of blood vessels and tissues. Laboratory indicators in case of overdose: hypercalciuria, hypercalcemia (plasma calcium about 2.6 mmol).

Treatment: rehydration, loop diuretics, glucocorticosteroid drugs, calcitonin, bisphosphonates, calcium-restricted diet, hemodialysis. If you notice symptoms of an overdose, consult a doctor.

Analogs

Level 4 ATX code matches:
Natekal D3

Calcium D3 Nycomed

Vitrum Calcium with vitamin D3

Natekal D3;
Calcium D3 Nycomed;
Revital Calcium D3.

Reviews of Complivit Calcium D3

The medication is well tolerated and is one of the main drugs that treating doctors actively prescribe to their patients for the corresponding pathology. Complivit Calcium D3 Forte contains an increased dose of colecalciferol and can be prescribed at the beginning of therapy with a subsequent transition to Complivit Calcium D3 .

Reviews about the drugs are positive; patients note an improvement in the condition of their teeth, nails, and hair during treatment. Young mothers share their experience of using the medicine for their babies, leaving positive reviews on medical thematic forums.

Complivit calcium D3 tablet gev orange core x30

Calcium Complivit D3: instructions for use

Registration number:

Trade name of the drug: Complivit® Calcium D3

International nonproprietary name or group name: Calcium carbonate + Colecalciferol.

Dosage form: chewable tablets [orange].

Composition per tablet

Active components:

Calcium - 500 mg

(in the form of calcium carbonate - 1.250 g) Colecalciferol (vitamin D3) - 0.005 mg (200 IU) (in terms of 100% colecalciferol) (in the form of granulate containing colecalciferol - 0.27%, , D, L-alpha-tocopherol , - 0.0275%, medium chain triglycerides - 10.7%, sucrose - 36%, acacia gum - .22%, corn starch - 27%, calcium phosphate (E 341) - 0.5%, water up to 100% ).

Description: chewable tablets: round, biconvex with a rough, porous surface from white to white with a creamy tint, with a faint fruity odor. May have small inclusions of a grayish color.

Pharmacotherapeutic group: calcium-phosphorus metabolism regulator.

ATX code: [A12AX].

Pharmacological properties Pharmacodynamics

A combined drug that regulates the exchange of calcium and phosphorus in the body (bones, teeth, nails, hair, muscles). Reduces resorption (resorption) and increases

Adequate calcium intake is especially important during growth, pregnancy and breastfeeding.

Vitamin D3 (colecalciferol) – increases the absorption of calcium in the intestine, promotes the formation and mineralization of bone and dental tissue.

The use of calcium and vitamin D3 prevents an increase in the production of parathyroid hormone (PTH), which is a stimulator of increased bone resorption (leaching of calcium from the bones).

Pharmacokinetics

Calcium

Excretion: Calcium is excreted by the intestines, kidneys and sweat glands. Renal excretion depends on glomerular filtration and tubular reabsorption of calcium.

Vitamin D3

Absorption: Vitamin D3 is easily absorbed in the small intestine (about 80% of the dose taken).

Unmetabolized vitamin D3 is stored in adipose and muscle tissue.

Excretion: Vitamin D3 is excreted by the intestines and kidneys.

Indications for use

Prevention and treatment of calcium and/or vitamin D3 deficiency.

Prevention and complex therapy of osteoporosis and its complications (bone fractures).

Contraindications

Hypersensitivity to the components of the drug. Hypercalcemia (increased concentration of calcium in the blood). Hypercalciuria (increased calcium in the urine). Nephrolithiasis. Hypervitaminosis D. Decalcifying tumors (myeloma, bone metastases, sarcoidosis). Pulmonary tuberculosis (active form). Severe renal failure.

With caution: pregnancy, breastfeeding, renal failure.

Use during pregnancy and breastfeeding

Complivit® Calcium D3 is used during breastfeeding. Calcium and vitamin D3 can pass into breast milk, so mother and baby's intake of calcium and vitamin D from other sources must be considered.

Directions for use and doses

Complivit® Calcium D3, chewable tablets, taken orally with meals. The tablet should be chewed or dissolved. After this, if necessary, you can drink water.

Adults: for the treatment of osteoporosis - 1 tablet 2-3 times a day, for the prevention of osteoporosis - 1 tablet 2 times a day.

For calcium and/or vitamin D3 deficiency:

Adults and children over 12 years old – 1 tablet 2 times a day. Children from 5 years to 12 years – 1-2 tablets per day.

Children from 3 to 5 years old - dosage in accordance with the doctor’s recommendations.

Special patient groups

Patients with impaired liver function:

No dose adjustment is required.

Patients with impaired renal function:

The drug should not be used in severe renal failure.

Elderly patients:

The dose is the same as for adults. A possible decrease in creatinine clearance should be taken into account.

Duration of treatment

When used for prevention and in complex therapy of osteoporosis, the duration of treatment is determined by the doctor individually.

When used to replenish calcium and/or vitamin D3 deficiency, the average duration of treatment is at least 4-6 weeks. The number of repeat courses during the year is determined individually.

Side effect

The frequency of side effects of the drug is assessed as follows: very often: >, 1/10, often: >, 1/100, <, 1/10, infrequently: >, 1/1,000, <, 1/100, rarely: >, 1/10,000, <, 1/1,000, very rare: <, 1/10,000.

Metabolic and nutritional disorders: uncommon - hypercalcemia, hypercalciuria.

Gastrointestinal disorders: rarely - constipation, flatulence, nausea, abdominal pain, diarrhea, dyspepsia.

Skin and subcutaneous tissue disorders: very rarely - allergic reactions (itching, rash, urticaria).

Overdose

Laboratory indicators in case of overdose: hypercalciuria, hypercalcemia (plasma calcium about 2.6 mmol).

If signs of overdose are detected, you should stop taking calcium and vitamin D, as well as thiazide diuretics and cardiac glycosides, and consult a doctor.

Treatment: gastric lavage, replenishment of fluid loss, use of loop diuretics (for example, furosemide), glucocorticosteroid drugs, calcitonin, bisphosphonates, calcium-restricted diet, hemodialysis.

It is necessary to monitor the content of electrolytes in the blood plasma, renal function and diuresis.

In severe cases, it is necessary to measure central venous pressure (CVP) and monitor the electrocardiogram (ECG).

Interactions with other drugs and foods The activity of vitamin D3 may be reduced when used concomitantly with phenytoin or barbiturates.

Hypercalcemia can potentiate the toxic effects of cardiac glycosides when used simultaneously with calcium and vitamin D preparations. Monitoring of ECG and serum calcium levels is necessary.

To prevent decreased absorption of bisphosphonate drugs, it is recommended to take them at least an hour before taking Complivit® Calcium D3.

Glucocorticosteroids reduce calcium absorption, so treatment with glucocorticosteroids may require an increase in the dose of Complivit® Calcium D3.

Simultaneous treatment with cholestyramine preparations or laxatives based on mineral or vegetable oil may reduce the absorption of vitamin D3.

Calcium reduces the effectiveness of levothyroxine by reducing its absorption. The period of time between doses of levothyroxine and Complivit® Calcium D3 should be at least 4 hours.

special instructions

Complivita Calcium D3 price, where to buy

The cost of the medication depends on the pharmacy chain, sales region, and release form (on average, rubles).

The price of Complivit Calcium D3 Forte is 400 rubles per 100 tablets, and the drug for children is 150 rubles per bottle.

Online pharmacies in RussiaRussia

ZdravCity

Complivit Calcium D3 (orange), calcium + vitamin D3 tab.
60 pcs. JSC Pharmstandard-UfaVITA 284 rub. order
Complivit Calcium D3 Forte (mint), calcium + vitamin D3, tab. chewing 30 pcs. JSC Pharmstandard-UfaVITA
RUB 247 order
Complivit Calcium D3 for babies, calcium + vitamin D3 powder for children. 43gPharmstandard-Leksredstva OJSC
RUB 306 order
Complivit Calcium D3 tab. chewing with orange flavor 500 mg + 200 IU 100 pcs. Pharmstandard-Ufavita Ufa Vitamin Plant OJSC
415 rub. order
Complivit Calcium D3 Forte (mint), calcium + vitamin D3, tab. chewing 100 pcs. JSC Pharmstandard-UfaVITA
RUR 538 order