Complivit-asset
Combined multivitamin preparation with micro- and macroelements.
The compatibility of the components in one tablet is ensured by a special technology for the production of vitamin-mineral complexes.
The pharmacological effect of the drug is due to the properties of its constituent vitamins and minerals.
Retinol acetate ensures normal function of the skin, mucous membranes, as well as vision function.
α-tocopherol acetate has antioxidant properties, maintains the stability of red blood cells, prevents hemolysis, and has a positive effect on the functions of the gonads, nervous and muscle tissue.
Ergocalciferol is involved in maintaining the metabolism of calcium and phosphorus, improves their absorption in the small intestine, and prevents the development of rickets.
Thiamine hydrochloride as a coenzyme is involved in carbohydrate metabolism and the functioning of the nervous system.
Riboflavin is the most important catalyst for the processes of cellular respiration and visual perception.
Pyridoxine hydrochloride as a coenzyme takes part in protein metabolism and the synthesis of neurotransmitters.
Ascorbic acid ensures collagen synthesis, participates in the formation and maintenance of the structure and function of cartilage, bones, teeth, affects the formation of hemoglobin, and the maturation of red blood cells.
Nicotinamide is involved in the processes of tissue respiration, fat and carbohydrate metabolism.
Folic acid takes part in the synthesis of amino acids, nucleotides, nucleic acids; necessary for normal erythropoiesis.
Rutin is involved in redox processes, has antioxidant properties, and promotes the deposition of ascorbic acid in tissues.
Calcium pantothenate, as a component of coenzyme A, is involved in the processes of acetylation and oxidation; promotes the construction and regeneration of epithelium and endothelium.
Cyanocobalamin is involved in the synthesis of nucleotides and is an important factor in normal growth, hematopoiesis and development of epithelial cells; necessary for folic acid metabolism and myelin synthesis.
Iron is involved in erythropoiesis and, as part of hemoglobin, ensures the transport of oxygen to tissues.
Cobalt regulates metabolic processes and increases the body's defenses.
Calcium is necessary for the formation of bone matter, blood clotting, the process of transmission of nerve impulses, contraction of skeletal and smooth muscles, and normal myocardial activity.
Copper prevents anemia and oxygen starvation of organs and tissues, and helps prevent osteoporosis. Strengthens the walls of blood vessels.
Zinc is involved in the metabolism of nucleic acids, proteins, fats, carbohydrates, fatty acids and hormones.
Magnesium plays an important role in protein biosynthesis and energy metabolism, reduces the excitability of the nervous system, and prevents the formation of kidney stones.
Phosphorus strengthens bone tissue and teeth, enhances mineralization, and is part of the ATP source of cell energy.
Manganese is necessary for normal growth, metabolism, osteogenesis processes, carbohydrate and lipid metabolism.
Selenium is involved in the regulation of tissue elasticity, has an antioxidant effect, protects cells and tissues of the body from the effects of adverse environmental factors.
Iodine is part of the thyroid hormones, which control the intensity of energy metabolism and actively influence the mental and physical development of a person, and the state of the central nervous system.
Fluoride is an essential element for normal growth and development of the body and reduces the incidence of dental caries.
Pharmacokinetics
The effect of the drug Complivit-Active is the combined effect of its components, so kinetic observations are not possible; Collectively, the components cannot be traced using markers or bioassays.
Complivit Calcium D3 for babies 200mg+50IU/5ml 43g N1
Trade name of the drug : Complivit® Calcium D3 for babies International non-proprietary or generic name: Calcium carbonate + Colecalciferol &. Dosage form: powder for the preparation of suspension for oral administration.
Composition per 43.0 g of powder: Active substances: calcium carbonate (in terms of calcium) – 4.0 g; colecalciferol (in terms of 100% colecalciferol) - 0.027 mg (1000 IU), in the form of a granulate containing: cholecalciferol, d,l-alpha-tocopherol, triglycerides with medium-length fatty acid residues, sucrose, acacia gum, corn starch, calcium phosphate, water. Excipients: sorbitol (sorbitol), pregelatinized starch (pregel), colloidal silicon dioxide (aerosil), orange flavor.
Composition per 5 ml of suspension: Active substances : calcium carbonate (in terms of calcium) - 200 mg/5 ml; colecalciferol (in terms of 100% colecalciferol) - 0.00135 mg (50 IU)/5 ml, in the form of a granulate containing: cholecalciferol, d,l-alpha-tocopherol, triglycerides with medium-length fatty acid residues, sucrose, acacia gum , corn starch, calcium phosphate, water. Excipients: sorbitol (sorbitol), pregelatinized starch (pregel), colloidal silicon dioxide (aerosil), orange flavor.
Description white or almost white powder with a characteristic orange odor.
Description of the prepared suspension : a homogeneous suspension of white or almost white color with a characteristic odor of orange.
Pharmacotherapeutic group: calcium-phosphorus metabolism regulator ATC code : [A12AX]
Pharmacological properties A combined drug intended to replenish the deficiency of calcium and vitamin D3 in the body.
Pharmacodynamics . Calcium is involved in the formation of bone tissue, increases its density, participates in the mineralization of teeth, in the regulation of nerve conduction and muscle contractions, in maintaining the stability of cardiac activity, and in the process of blood clotting.
Vitamin D3 (colecalciferol) regulates the exchange of calcium and phosphorus in the body, increases the absorption of calcium in the intestines, promotes bone mineralization, the formation of the bone skeleton and teeth in children.
The drug reduces the production of parathyroid hormone, which is a stimulator of increased bone resorption.
Indications for use Prevention of calcium and vitamin D3 deficiency in young children.
Contraindications Hypersensitivity, hypercalcemia, hypercalciuria, calcium nephrourolithiasis, hypervitaminosis D, decalcifying tumors (myeloma, bone metastases, sarcoidosis), osteoporosis due to immobilization, active form of pulmonary tuberculosis; sucrase/isomaltase deficiency, fructose intolerance, glucose-galactose malabsorption.
With caution Renal failure, benign granulomatosis, taking cardiac glycosides and thiazide diuretics.
Method of administration and dosage The drug is taken orally with meals. The dosage form is specially designed for young children under 3 years of age.
Preparation of a suspension from powder: Add boiled and cooled water to the bottle containing the powder.
2/3 of the bottle volume, mix thoroughly (for 1-2 minutes). Add boiled and cooled water to a volume of 100 ml (up to the neck of the bottle) and mix again. Shake the contents of the bottle before each dose.
5 ml of the resulting suspension contains calcium carbonate in terms of elemental calcium - 200 mg, colecalciferol - 50 IU.
Children over 1 year of age – 5-10 ml once a day; children under 1 year - 5 ml of suspension 1 time per day, as recommended by a doctor. The drug is prescribed to other age groups if necessary in appropriate doses on the recommendation of a doctor.
The duration of the prophylaxis course is 1 month, a longer course is prescribed by a doctor.
Side effects Allergic reactions. When using the drug in recommended doses, no other side effects were identified. If recommended doses are exceeded or other drugs containing calcium are taken simultaneously, hypercalcemia and hypercalciuria (increased calcium levels in the blood and urine) may develop.
Possible side effects of vitamin D3 also include: decreased appetite, polyuria, constipation, headache, myalgia, arthralgia, increased blood pressure, arrhythmias, impaired renal function, exacerbation of the tuberculosis process in the lungs.
Possible side effects of calcium carbonate also include: gastralgia, constipation or diarrhea, flatulence, nausea, secondary increased gastric secretion.
Overdose Symptoms: thirst, polyuria, loss of appetite, nausea, vomiting, constipation, dizziness, weakness, headache, fainting, coma; with long-term use, calcification of blood vessels and tissues. Laboratory indicators in case of overdose: hypercalciuria, hypercalcemia. Treatment: stopping the drug, seeing a doctor, calcium-restricted diet, rehydration, diuretics, glucocorticosteroids, and in severe cases, hemodialysis.
Interaction with other drugs Calcium and vitamin D3 preparations reduce the absorption of bisphosphonates, digoxin, iron supplements and tetracycline antibiotics (an interval between doses of at least 2-3 hours is required).
It is possible to enhance the effect of cardiac glycosides (with simultaneous use, monitoring of the ECG and the patient’s condition is necessary).
Phenytoin, barbiturates, and primidone reduce the effect of vitamin D3 by enhancing its metabolism.
Vitamin A, tocopherol, ascorbic acid, pantothenic acid, thiamine, riboflavin weaken the toxic effect of vitamin D3.
Glucocorticosteroids reduce the absorption of calcium ions in the intestine.
Cholestyramine, colestipol and mineral oils reduce the absorption of vitamin D3 and require an increase in its dosage.
Thiazide diuretics increase the risk of hypercalcemia.
Vitamin D increases the absorption of phosphorus-containing drugs and the risk of hyperphosphatemia. When used simultaneously with sodium fluoride, the interval between doses should be at least 2 hours; with oral forms of tetracyclines - at least 3 hours.
Long-term therapy with vitamin D3 against the background of simultaneous use of Al3+ and Mg2+-containing antacids increases their concentration in the blood and the risk of intoxication (especially in the presence of chronic renal failure).
Concomitant use with other vitamin D analogues and calcium preparations increases the risk of developing hypervitaminosis D.
Special instructions To avoid overdose, do not use simultaneously with vitamin complexes containing calcium and vitamin D3.
When using vitamin D3 prophylactically, it is necessary to keep in mind the possibility of overdose, especially in children (you should not prescribe more than 10-15 mg per year). Long-term use in high doses leads to chronic hypervitaminosis D3. With long-term treatment, it is necessary to monitor the concentration of Ca2+ in the blood and urine (especially when combined with thiazide diuretics).
It should be borne in mind that sensitivity to vitamin D varies from patient to patient, and in some patients taking even therapeutic doses can cause symptoms of hypervitaminosis.
The sensitivity of newborns to vitamin D varies, some may be sensitive even to very low doses, so prophylaxis should be carried out under the supervision of a physician.
Breastfed newborns, especially those born to mothers with dark skin and/or insufficient sun exposure, are at high risk of developing vitamin D deficiency.
Release form Powder for the preparation of suspension for oral administration 200 mg + 50 IU/5 ml.
43.0 g in 100 ml bottles of dark (amber) glass. One bottle, along with instructions for use and a measuring spoon, is placed in a cardboard pack.
Storage conditions Store in a place protected from light, at a temperature not exceeding 25 °C.
Store the prepared suspension in a place protected from light, at a temperature not exceeding 15 °C (in the refrigerator). Do not freeze.
Keep out of the reach of children.
Shelf life Powder for preparation of suspension for oral administration should be stored for 2 years. Store the prepared suspension for no more than 20 days. Do not use after the expiration date stated on the package.
Conditions for dispensing from pharmacies Without a prescription
