Calcium Complivit D3 for babies
Instructions Composition Recommendations
Children under three years old
Children 3 - 11 years old Teenagers 12 - 18 years old
Where to buy
Complivit Calcium D3 for babies - The only* medicinal product of calcium and vitamin D3 for children from birth! Without dyes and preservatives!
Registration number: LRS-009129/10
Trade name of the drug : Complivit Calcium D3 for babies
International nonproprietary or group name: Calcium carbonate + Colecalciferol.
Dosage form: powder for the preparation of suspension for oral administration.
Composition per 43.0 g of powder:
Active ingredients: calcium carbonate (in terms of calcium) – 4.0 g; colecalciferol (in terms of 100% colecalciferol) - 0.027 mg (1000 IU), in the form of a granulate containing: cholecalciferol, d,l-alpha-tocopherol, triglycerides with medium-length fatty acid residues, sucrose, acacia gum, corn starch, calcium phosphate, water. Excipients: sorbitol (sorbitol), pregelatinized starch (pregel), colloidal silicon dioxide (aerosil), orange flavor.
Composition per 5 ml suspension:
Active ingredients : calcium carbonate (in terms of calcium) - 200 mg/5 ml; colecalciferol (in terms of 100% colecalciferol) - 0.00135 mg (50 IU)/5 ml, in the form of a granulate containing: cholecalciferol, d,l-alpha-tocopherol, triglycerides with medium-length fatty acid residues, sucrose, acacia gum , corn starch, calcium phosphate, water. Excipients: sorbitol (sorbitol), pregelatinized starch (pregel), colloidal silicon dioxide (aerosil), orange flavor.
Description
white or almost white powder with a characteristic odor of orange.
Description of the prepared suspension : a homogeneous suspension of white or almost white color with a characteristic odor of orange.
Pharmacotherapeutic group: calcium-phosphorus metabolism regulator
ATX code : [A12AX]
Pharmacological properties
A combined drug designed to compensate for the deficiency of calcium and vitamin D3 in the body.
Pharmacodynamics . Calcium is involved in the formation of bone tissue, increases its density, participates in the mineralization of teeth, in the regulation of nerve conduction and muscle contractions, in maintaining the stability of cardiac activity, and in the process of blood clotting.
Vitamin D3 (colecalciferol) regulates the exchange of calcium and phosphorus in the body, increases the absorption of calcium in the intestines, promotes bone mineralization, the formation of the bone skeleton and teeth in children.
The drug reduces the production of parathyroid hormone, which is a stimulator of increased bone resorption.
Indications for use
Prevention of calcium and vitamin D3 deficiency in young children.
Contraindications
Hypersensitivity, hypercalcemia, hypercalciuria, calcium nephrourolithiasis, hypervitaminosis D, decalcifying tumors (myeloma, bone metastases, sarcoidosis), osteoporosis due to immobilization, active form of pulmonary tuberculosis; sucrase/isomaltase deficiency, fructose intolerance, glucose-galactose malabsorption.
Carefully
Renal failure, benign granulomatosis, taking cardiac glycosides and thiazide diuretics.
Directions for use and doses
The drug is taken orally with meals. The dosage form is specially designed for young children under 3 years of age.
Preparation of a suspension from powder: Add boiled and cooled water to the bottle containing the powder.
2/3 of the bottle volume, mix thoroughly (for 1-2 minutes). Add boiled and cooled water to a volume of 100 ml (up to the neck of the bottle) and mix again. Shake the contents of the bottle before each dose.
5 ml of the resulting suspension contains calcium carbonate in terms of elemental calcium - 200 mg, colecalciferol - 50 IU.
Children over 1 year of age – 5-10 ml once a day; children under 1 year - 5 ml of suspension 1 time per day, as recommended by a doctor. The drug is prescribed to other age groups if necessary in appropriate doses on the recommendation of a doctor.
The duration of the prophylaxis course is 1 month, a longer course is prescribed by a doctor.
Side effect
Allergic reactions. When using the drug in recommended doses, no other side effects were identified. If recommended doses are exceeded or other drugs containing calcium are taken simultaneously, hypercalcemia and hypercalciuria (increased calcium levels in the blood and urine) may develop.
Possible side effects of vitamin D3 also include: decreased appetite, polyuria, constipation, headache, myalgia, arthralgia, increased blood pressure, arrhythmias, impaired renal function, exacerbation of the tuberculosis process in the lungs.
Possible side effects of calcium carbonate also include: gastralgia, constipation or diarrhea, flatulence, nausea, secondary increased gastric secretion.
Overdose
Symptoms: thirst, polyuria, loss of appetite, nausea, vomiting, constipation, dizziness, weakness, headache, fainting, coma; with long-term use, calcification of blood vessels and tissues. Laboratory indicators in case of overdose: hypercalciuria, hypercalcemia. Treatment: stop taking the drug, consult a doctor, restricted diet
calcium, rehydration, diuretics, glucocorticosteroids, in severe cases - hemodialysis.
Interaction with other drugs
Calcium and vitamin D3 preparations reduce the absorption of bisphosphonates, digoxin, iron supplements and tetracycline antibiotics (an interval between doses of at least 2-3 hours is required).
It is possible to enhance the effect of cardiac glycosides (with simultaneous use, monitoring of the ECG and the patient’s condition is necessary).
Phenytoin, barbiturates, and primidone reduce the effect of vitamin D3 by enhancing its metabolism.
Vitamin A, tocopherol, ascorbic acid, pantothenic acid, thiamine, riboflavin weaken the toxic effect of vitamin D3.
Glucocorticosteroids reduce the absorption of calcium ions in the intestine.
Cholestyramine, colestipol and mineral oils reduce the absorption of vitamin D3 and require an increase in its dosage.
Thiazide diuretics increase the risk of hypercalcemia.
Vitamin D increases the absorption of phosphorus-containing drugs and the risk of hyperphosphatemia. When used simultaneously with sodium fluoride, the interval between doses should be at least 2 hours; with oral forms of tetracyclines - at least 3 hours.
Long-term therapy with vitamin D3 against the background of simultaneous use of Al3+ and Mg2+-containing antacids increases their concentration in the blood and the risk of intoxication (especially in the presence of chronic renal failure).
Concomitant use with other vitamin D analogues and calcium preparations increases the risk of developing hypervitaminosis D.
special instructions
To avoid overdose, do not use simultaneously with vitamin complexes containing calcium and vitamin D3.
When using vitamin D3 prophylactically, it is necessary to keep in mind the possibility of overdose, especially in children (you should not prescribe more than 10-15 mg per year). Long-term use in high doses leads to chronic hypervitaminosis D3. With long-term treatment, it is necessary to monitor the concentration of Ca2+ in the blood and urine (especially when combined with thiazide diuretics).
It should be borne in mind that sensitivity to vitamin D varies from patient to patient, and in some patients taking even therapeutic doses can cause symptoms of hypervitaminosis.
The sensitivity of newborns to vitamin D varies, some may be sensitive even to very low doses, so prophylaxis should be carried out under the supervision of a physician.
Breastfed newborns, especially those born to mothers with dark skin and/or insufficient sun exposure, are at high risk of developing vitamin D deficiency.
Release form
Powder for the preparation of suspension for oral administration 200 mg + 50 IU/5 ml.
43.0 g in 100 ml bottles of dark (amber) glass. One bottle, along with instructions for use and a measuring spoon, is placed in a cardboard pack.
Storage conditions
Store in a place protected from light, at a temperature not exceeding 25 °C.
Store the prepared suspension in a place protected from light, at a temperature not exceeding 15 ºС (in the refrigerator). Do not freeze.
Keep out of the reach of children.
Best before date
Powder for preparation of suspension for oral administration should be stored for 2 years. Store the prepared suspension for no more than 20 days. Do not use after the expiration date stated on the package.
Conditions for dispensing from pharmacies
Over the counter
Name and address of the manufacturer/organization receiving claims:
OJSC "Pharmstandard - Leksredstva", 305022, Russia, Kursk, st. 2nd Aggregatnaya, 1a/18 Tel./fax, www.pharmstd.ru
Representative
OJSC Pharmstandard-Leksredstva
* Among the drugs are “calcium carbonate”, “calcium lactogluconate”, “calcium citrate” as of September 1, 2019.
https://grls.rosminzdrav.ru Where to buy
Immune organs
After we have examined the concept of immunity and its main types, it is necessary to pay attention to the organs that provide it.
There are central and peripheral organs of the immune system.
The central ones include:
- Red bone marrow. Found in bones. Serves as a source of formation of all blood cells, including cells of the immune system.
- Thymus. It further matures some of the immune system cells coming from the red bone marrow.
Peripheral organs:
- Lymph nodes.
- Spleen.
- Accumulations of lymphoid cells in the skin, respiratory organs, and intestines.
Symptoms of vitamin deficiency
A lack of certain vitamins can lead to decreased immunity.
Hypovitaminosis, as a rule, has nonspecific symptoms. These include: increased fatigue, decreased body defenses, weakness, lethargy. Vitamin deficiencies have more specific (certain) symptoms. We will not dwell on each vitamin deficiency in more detail, but will only consider vitamins, the lack of which can lead to a decrease in immunity.
These include:
- Vitamin A . Its deficiency is manifested by damage to the eyes, skin, and increased susceptibility to infections.
- Vitamins of group B6 (pyridoxine, pyridoxal). A lack of these substances can lead to dermatitis, lymphopenia (decreased levels of immune cells), anemia, and convulsions.
- Biotin . A deficiency of this substance can lead to seborrhea, hair loss, and deterioration of the immune system.
- Vitamin C . A lack of vitamin C leads to increased fragility of blood vessels, fatigue, pain in the limbs, tooth loss, poor wound healing, and increased susceptibility to infections.
- Vitamin D . A lack of vitamin D leads to the development of rickets in the baby, which is also accompanied by a decrease in immunity and an increase in the overall morbidity of the baby.
Features of the formation of immunity in children
The formation of immunity in children has its own characteristics depending on age.
A feature of the formation of the immune system in children is the presence of so-called “ critical ” periods:
- The first critical period after the birth of a baby is the neonatal period. At this time, the baby encounters a huge number of pathogens. The immune system during this period is subject to strong immunosuppressive effects. This period is characterized by low resistance to many infections. There is a tendency to develop common infections.
- The second period occurs at the age of 3-6 months. It is characterized by a weakening of immune reactions due to the destruction of antibodies that were transmitted from the mother.
- The third period develops in the second year of life. During this period, the baby's contact with the outside world increases significantly. At this age, many abnormalities of the immune system appear, as well as autoimmune (directed against one’s own body) diseases. Children are prone to repeated acute respiratory infections.
- The fourth period occurs in the 4th-6th years of life. This period is characterized by a high prevalence of allergic and parasitic diseases. During this period, many chronic diseases develop.
- The fifth period occurs during adolescence. For girls this corresponds to 12-13 years old, for boys - from 14-15 years old. A large growth spurt is accompanied by a decrease in the mass of lymphoid (immune) organs. An increase in the formation of male sex hormones leads to a decrease in the cellular component of immunity. In this regard, many allergic diseases are weakened. The influence of the external environment on the development of immunity is increasing. At this time, there is a new rise in the incidence of chronic inflammatory, autoimmune, and viral diseases.
The processes of formation of the immune system in children can slow down under the influence of various external factors:
- Xenobiotics (chemicals).
- Intrauterine infections
- Frequent ARVI and digestive tract infections.
- The influence of environmental environmental factors and many others.
Some external factors can slow down the development of the immune system in children.
These factors, which slow down the formation of the immune system in children, lead to functional immaturity of the immune system and, accordingly, predispose them to the development of immunodeficiency states (a state of reduced immunity).
