Compound
Ambroxol tablets contain 30 mg of ambroxol hydrochloride as an active component and excipients: lactose monohydrate , corn starch (Amylum maidis), microcrystalline cellulose (Cellulose microcristallic), stearate (Magnesium stearate), dioxide silicon (Silicii dioxydum).
5 ml of Ambroxol syrup contains 15 mg of ambroxol hydrochloride and a number of other ingredients: sodium benzoate (E211, Sodium benzoate), propylene glycol, glycerin (Glycerinum), sodium saccharin (Saccharin sodium), sorbitol (E420 ; Sorbitol), hydroxyethylcellulose (Hydroxyethylcellulose), citric acid monohydrate (Citric acid monohydrate), flavors (apricot, raspberry, orange), menthol (Mentholum), purified water (Aquae purificati).
pharmachologic effect
The drug belongs to the group of mucolytic drugs and is used as an expectorant for diseases affecting the respiratory tract .
It stimulates the motor function of the respiratory tract and has a pronounced secretolytic and expectorant effect .
Stimulates the formation of sputum ( tracheobronchial tree secretion ) of reduced viscosity due to changes in the structure of sputum mucopolysaccharides and increases the production of glycoproteins (thus exerting a mucokinetic effect ).
While taking Ambroxol, the motor activity of ciliated cilia of epithelial tissue and the transport of pathogenic agents of the mucociliary system .
An important property of the drug is its ability to increase the amount of pulmonary surfactant ( anti-atelectic factor ), which maintains surface tension, uniformity of configuration, volume and compliance indicators of the lungs.
In addition, thanks to Ambroxol, the breakdown of surfactant and its synthesis and secretion is enhanced in large alveolar cells ( type II alveolar pneumocytes ), which are involved in the transport of fluids through the alveolar-capillary system .
The peculiarity of the drug is that, while reducing the viscosity of sputum, it practically does not provoke an increase in its volume, and, thus, does not cause those negative effects that develop while taking expectorants. a liquefying effect on sputum by disrupting the integrity of the disulfide bonds of acidic mucopolysaccharides and the sputum gel.
In accordance with OKPD (all-Russian product classifier), Ambroxol code is 24.42.13.723.
Can children take Ambroxol?
Infants during the neonatal period (the first 28 days of life) and before reaching the age of two do not have the full ability to cough. Their reflex function of mucus rejection is reduced, and the shocks of exhaled air when coughing are not powerful enough to remove phlegm. Therefore, children under two years of age should not be given mucolytics.
Increased mucus production while taking Ambroxol will cause its accumulation in the lower parts of the lungs and bronchi, which will lead to the addition of a secondary bacterial infection, which will develop pneumonia.
In this connection, taking the drug in syrup form is indicated only for those patients who have already learned to cough - over 2 years of age.
Pharmacodynamics and pharmacokinetics
Ambroxol helps normalize the function of the serous and mucosal glands located in the bronchial mucosa , helps reduce the number of cystic cavities in the mucous membrane and stimulates the production of the serous component without causing bronchial obstruction .
Research results indicate that after treatment with the drug in patients with bronchial obstruction, the ventilation function of the lungs significantly improves, and the severity of symptoms of hypoxemia decreases.
There is also data that allows us to conclude that the drug has an immunomodulatory effect : it strengthens local immunity by activating tissue mononuclear phagocytes and increasing the production of secretory immunoglobulin of the IgA class .
Ambroxol suppresses the production of TNF and interleukin 1 by mononuclear phagocytes , which are mediators of inflammation, and also helps to enhance the natural defense of the lungs by increasing the activity of macrophages .
It has also been proven that Ambroxol is capable of having anti-edematous and anti-inflammatory effects , effectively relieves the symptoms of exacerbated chronic bronchitis and prevents the development of idiopathic pulmonary fibrosis .
Some authors report that in in vitro models, Ambroxol is able to inhibit neutrophil chemotaxis .
Ambroxol is absorbed quite quickly and completely through any route of administration, penetrating well into the lung tissue. The plasma concentration of the substance reaches its maximum within two hours after taking the drug per os.
The biotransformation process occurs in the liver . Metabolic products are glucuronides and dibromanthranilic acid .
About 90% is excreted from the body in the urine in the form of water-soluble metabolites ; About 5% is excreted unchanged.
T1/2 - from 10 to 12 hours. It increases in patients with severe forms of renal failure , but remains unchanged in patients with impaired liver function .
Azt Long and Ambroxol: which is better
ACC is based on the substance acetylcysteine, which, like Ambroxol, improves the rheological properties of sputum: it accelerates its production, reducing viscosity. The ciliated epithelium of the respiratory tract instantly reacts to the irritant, provoking a cough. A drug with the prefix “Long” indicates that the effect of a single dose is prolonged up to 12 hours. This means you need to take it in the morning, once a day. Taking Azz Long at night will cause the patient to have a cough that will suffocate him all night, preventing him from falling asleep.
When choosing between ACC and Ambroxol, you need to rely on the convenience of the release form for the patient and individual intolerance to the components.
Indications for use: what are Ambroxol tablets for and what is Ambroxol in syrup form for?
It is known that the viscosity, elasticity and adhesiveness of sputum determine how easily it is separated and expectorated.
Therefore, mucolytic drugs are especially useful for diseases of the respiratory system , conditions that are accompanied by the formation and accumulation in the bronchi and lungs of viscous, poorly separated mucous or purulent-mucous sputum .
Indications for use of Ambroxol are:
- obstructive bronchitis (in acute and chronic forms);
- pneumonia;
- tracheitis;
- constrictive bronchiolitis;
- laryngitis;
- rhinitis;
- cystic fibrosis;
- bronchial asthma;
- pharyngitis;
- atelectasis , developed as a result of mucoid blockage of the bronchi , in patients with a tracheostomy tube , etc.;
- respiratory distress syndrome (shock lung) in adults;
- respiratory distress syndrome (RDS) in newborn infants (including children born prematurely) and other diseases associated with impaired bronchial secretion and accompanied by increased formation of viscous mucus.
Contraindications
The drug is not used to treat patients with hypersensitivity to one or more of its components, as well as women in the first 13 weeks of pregnancy.
Ambroxol tablets are contraindicated in patients diagnosed with gastric and duodenal ulcers (the drug may affect the clinical picture of these diseases), as well as in the case of the development of epileptic syndrome of various natures.
An additional contraindication for syrup is hereditary fructose intolerance.
Ambroxol is contraindicated for dry cough , which usually accompanies influenza and other acute respiratory viral infections .
Side effects
Adverse reactions associated with taking Ambroxol are rare. The drug is non-toxic and well tolerated by patients.
In some cases, the body may respond to treatment with dyspeptic symptoms , skin rash , angioedema , allergic reactions , general weakness, and headache .
Isolated cases of the development of serious skin lesions ( Lyell's disease or Stevens-Johnson disease ) have also been recorded. Most likely, they are explained by the severe course of the disease or the reaction of a particular organism to the simultaneous use of several drugs.
How long to take Ambroxol
If an infection occurs in the respiratory tract, the source of infection must be removed from the body as soon as possible, which is actively facilitated by Ambroxol. However, often the cause of cough is bacterial infection of the lower respiratory tract, which the body cannot always cope with on its own. Therefore, over-the-counter use of the drug is possible for no longer than 5 days. If after this period the symptoms of malaise persist, the patient must consult a doctor to prescribe antibacterial therapy.
Instructions for use of Ambroxol
Ambroxol tablets: instructions for use
Ambroxol hydrochloride tablets are intended for oral administration. They should be taken with a small amount of liquid.
The recommended dose for adult patients and children over the age of twelve is 30 mg (one tablet). The frequency of doses is 2 (if necessary, the drug can be taken 3 times a day).
In case of exacerbation of chronic diseases, the dose of Ambroxol in tablets is doubled (up to 60 mg). The frequency of doses is 2 times a day.
Cough tablets are used to treat children over six years of age. The therapeutic dose for children from six to twelve years of age is from 1.2 to 1.6 mg/kg/day in 3 divided doses.
The duration of treatment is determined individually depending on the severity of the disease and the patient’s response to therapy. As a rule, it ranges from 10 to 14 days.
Ambroxol syrup: instructions for use
For all categories of patients over twelve years of age, during the first 2-3 days of the disease, the recommended dose is 10 ml (equivalent to the volume of two teaspoons). Then the treatment is continued, taking the syrup 3 times a day. 5 ml (equivalent to the volume of one teaspoon).
Syrup for children is dosed depending on the age of the child. Thus, children aged five to twelve years are recommended to take 5 ml of syrup (30 mg of active ingredient per day) 2 times a day. If necessary, the frequency of doses is increased to 3 (the daily dose of ambroxol in this case is 45 mg).
Children aged two to six years are prescribed to take 2.5 ml of syrup 3 times a day; children under two years old - 2.5 ml of syrup 2 times a day. This is equivalent to 22.5 and 15 mg of active ingredient per day, respectively.
If the patient is indicated for long-term treatment, the dose may be halved.
Instructions for Ambroxol: dosage regimen of Abroxol for inhalation, as well as solution for injection and infusion
Adult patients are prescribed one or two inhalations per day using 3 ml of inhalation solution; Children over 5 years of age are recommended to take one inhalation per day using 2 ml of solution (equivalent to 15 mg of the active substance).
If the drug is prescribed in the form of an injection solution, the optimal dose for an adult patient is from 30 to 60 mg/day. Divide it into three administrations. The maximum single dose is 30 mg.
Typically, the solution is injected into a vein or muscle, although subcutaneous administration is also acceptable. For shock lung syndrome, the dose of ambroxol is 10 mg/kg/day. The drug should be administered 3 or 4 times a day. In cases where it is appropriate, the daily dose is increased to 30 mg/kg. It is administered in 3-4 doses.
How often can you take Ambroxol?
I use the drug in three dosage forms:
- pills;
- nebulizer solution;
- syrup.
Tablets are indicated for children over 12 years of age and adults. The frequency of administration should not exceed 2 times. In rare cases, the doctor may increase the dosage, but it is important to note that taking the pill at night to increase the frequency of doses is contraindicated.
Children are more often prescribed syrup for oral administration or inhalation with ambroxol. The single dose depends on the age and weight of the patient. To prepare the solution, use 4 ml of saline solution and 2 ml of the drug. The duration of the procedure for children under 7 years of age should not exceed 4 minutes. For patients from 7 to 13 years old, increase the duration of inhalation to 6 minutes. Adults are recommended to breathe the solution for at least 10 minutes.
Syrup for oral administration is given to the child three times a day, a teaspoon. The last dose should not be later than two hours before bedtime.
Interaction
The use of Ambroxol in combination with antibiotics helps to increase the concentration of the active substance of the latter in the bronchial mucosa and pulmonary alveoli , which in turn improves the clinical situation with bacterial infections of the lungs .
The combination of a drug with antibiotics of an antibiotic alone , even in cases where the effectiveness of an antibacterial drug .
Ambroxol enhances the effect of Ampicillin , Amoxicillin , and Theophyllinum and promotes their better penetration into bronchial secretions .
No antagonistic interactions of the drug with diuretics and cardiac glycosides .
The use of Ambroxol with drugs that suppress the cough reflex significantly complicates the discharge of sputum while reducing the intensity of the cough .
The drug is compatible with drugs that are used to slow down labor.
Analogs
Level 4 ATX code matches:
Mukolik
Abrol
Ambrosan
Bronchorus
ACC 100
ACC 200
ACC Long
ACC
Mukolwan
Lazolvan
Bromhexine 8
Bromhexine 8 Berlin-Chemie
Bromhexine
Bronchobos
Carbocisteine
Erdomed
Pulmozyme
Pectolvan C
Halixol
Ambrobene
Analogues of Ambroxol are the drugs Ambrobene , Ambrohexal , Ambroxol-Vial , Ambroxol-Zdorovye , Ambroxol-Vishfa , Ambroxol-Darnitsa , Lazolvan , , Bronkhoxol , Neo-Bronchol , Halixol , Medox , etc.
Which is better: Ambroxol or Bromhexine? What are these pills for?
The active ingredient Ambroxol is an active metabolite of bromhexine hydrochloride (a substance that is a synthetic analogue of the alkaloid vasicine ). At the same time, the therapeutic effectiveness of Ambroxol is an order of magnitude higher than that of its predecessor.
In addition, Ambroxol is better tolerated by patients, has virtually no contraindications (even infants and pregnant women can take it), and side effects from its use develop extremely rarely.
What is ambroxol hydrochloride
Ambroxol hydrochloride is a substance that directly affects the secretory function of the respiratory tract, causing the glands to work more actively, which leads to increased production of sputum. In addition, Ambroxol directly affects the motor function of the trachea and bronchi, which explains the expectorant effect. The tissues of the upper and lower respiratory tract are instantly irritated at the slightest fluctuations in the ciliated epithelium, causing a cough that easily expels liquid sputum along with the pathogen.
Ambroxol for children
The most common childhood diseases are diseases of the bronchi and lungs , which are usually accompanied by stagnation of sputum in the bronchi . Timely excretion of sputum is an indispensable condition for the normal functioning of the respiratory system , as well as the key to their recovery from diseases.
Ambroxol syrup for children is one of the latest developments in the field of pharmacy. Like other dosage forms of Ambroxol, the drug has proven itself to be an effective remedy for sputum , so pediatricians recommend it for the treatment of even very young patients.
The dose and dosage form of the drug for children is selected depending on age (the dose varies from 15 mg to 45 mg per day).
Ambroxol and its analogues
The active ingredient Ambroxol is disguised under different brands:
- Ambrobene;
- Lazolvan;
- Orvis Broncho;
- Thoraxol;
- Asterisk Broncho;
- Halixol.
Knowing the name of the active substance, it is easier to find a cheap analogue in the pharmacy, so as not to spend unreasonably large sums on the same thing, but under a different name.
Ambroxol, like drugs under other trade names, is sold in different forms: from tablets to solutions that are taken orally or used as an additive to an inhaler.
Ambroxol during pregnancy
During pregnancy , the drug is contraindicated only in the first trimester. In the second and third trimesters, it is allowed to be prescribed, taking into account the benefits for the expectant mother and the potential risks for the developing fetus.
On forums, many are interested in why doctors recommend this particular drug during pregnancy. There is evidence that in cases where a woman takes tablets or syrup during pregnancy , the synthesis of pulmonary surfactant .
Interesting results were noted when using the drug in the treatment of respiratory system in unborn children. The ability of the drug to pass well through the placental barrier allows it to be used in cases where the child, for one reason or another, begins to accumulate mucus in the bronchi or lungs .
If treatment with the drug is necessary during breastfeeding , the issue of stopping the latter should be decided, since the active substance Ambroxol is excreted in milk.
Ambroxol for children: Komarovsky
Popular pediatrician Evgeny Komarovsky reminds parents that during periods of illness it is especially important for a child to drink plenty of fluids, which will ensure natural maintenance of high-quality sputum production.
Adding Ambroxol to the inhaler requires special attention: taking it at night is strictly contraindicated. Otherwise, the child will cough all night, depriving himself and the whole family of sleep.
It is important to remember that Ambroxol is not a cough suppressant. This is a cough stimulant. In other words, taking the drug in any dosage form will lead to increased and more frequent coughing, which ensures timely removal of mucus from the lower respiratory tract.
Reviews about Ambroxol
The drug Ambroxol is a very popular drug that allows you to effectively treat respiratory diseases . It normalizes the functioning of bronchial cilia , thins accumulated mucus and activates its elimination.
The use of an inhalation solution, injection solution, syrup or Ambroxol tablets - reviews are proof of this - enhances the formation of an agent that clears mucus from the bronchi and lungs, and also prolongs its action.
Reviews of Ambroxol syrup indicate that this drug has virtually no drawbacks. It effectively eliminates unpleasant symptoms of the disease, relieves inflammation and stimulates the synthesis of immunoglobulin , which in turn helps strengthen local immunity.
Another advantage of the drug is its price - both tablets and syrup for children belong to the category of inexpensive medicines.
Ambroxol price
The average price of Ambroxol in tablet form in Ukraine is 3.8 UAH. The price of Ambroxol syrup is from 11 to 75 UAH (depending on the manufacturer). The cost of the inhalation and oral solution also varies depending on which pharmaceutical company makes it.
The average price of Ambroxol tablets in Russia is 20 rubles; syrup for children can be purchased for an average of 30-50 rubles per bottle.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Ambroxol-Akrikhin tab.
30 mg 20 pcs JSC "AKRIKHIN" 132 rub. order - Ambroxol Welfarm tab. 30 mg 30 pcs. Welfarm LLC
RUB 133 order
- Ambroxol tablets 30 mg 20 pcs. Ozon Pharm LLC
33 rub. order
- Ambroxol solution for internal use. approx. and ing 7.5 mg/ml 40 mlOzon LLC
120 rub. order
- Codelac Broncho + ambroxol 20 mg, tablets 10 pcs. JSC Pharmstandard (ICN) Leksredstva Kursk
RUB 139 order
Pharmacy Dialogue
- Ambroxol (tab. 30 mg No. 20)Update of PFC CJSC
97 RUR order
- Ambroxol (solution for intravenous/inhalation 7.5 mg/ml 4 ml No. 10+ solution)Update of PFC JSC
119 RUR order
- Ambroxol-ALSI (tab. 30 mg No. 30) Alsi Pharm
43 RUR order
- Ambroxol Welfarm (tab. 30 mg No. 30) Welfarm LLC
127 RUR order
- Ambroxol (syrup 15mg/5ml 100ml)Hemofarm
81 RUR order
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Pharmacy24
- Ambroxol 30 mg tablets PrAT" Pharmaceutical company "Darnitsa", Ukraine
11 UAH. order - Ambroxol syrup 30 mg/5 ml 100 ml PAT NEC "Borshchagivsky chemical and pharmaceutical plant", Kiev, Ukraine
27 UAH order
- Ambroxol 30 mg No. 20 tablets Ternopharm TOV, Ternopil, Ukraine
7 UAH order
- Ambroxol 0.03 g No. 20 tablets PAT NEC "Borshchagivsky chemical and pharmaceutical plant", Kiev, Ukraine
7 UAH order
- Ambroxol 0.03 g No. 20 tablets PAT "Khimpharmzavod" Chervona Zirka", Kharkov, Ukraine
8 UAH order
PaniPharmacy
- Ambroxol liquid Ambroxol forte syrup 30mg/5ml 100ml Ukraine, Zdorovye LLC
31 UAH order
- Ambroxol liquid Ambroxol syrup 15mg/5ml 100ml Ukraine, Borshchagovsky Chemical Plant PJSC
27 UAH order
- Ambroxol tablets Ambroxol tablets. 0.03g No. 20 Ukraine, Lekhim-Kharkov CJSC
8 UAH order
- Ambroxol liquid Ambroxol syrup 15mg/5ml 100ml Ukraine, Ternopharm LLC
23 UAH order
- Ambroxol tablets Ambroxol tablets. 0.03g No. 20 Ukraine, Kiev Vitamin Plant PJSC
12 UAH order
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