Antigrippin-Express
Ethanol enhances the sedative effect and promotes the development of acute pancreatitis.
Antidepressants, antiparkinsonian drugs, antipsychotic drugs (phenothiazine derivatives) increase the risk of side effects (urinary retention, dry mouth, constipation).
Glucocorticosteroids increase the risk of developing glaucoma; with long-term use, they deplete ascorbic acid reserves.
Inducers of microsomal liver enzymes (barbiturates, phenytoin, phenylbutazone, rifampicin, zidovudine, carbamazepine, tricyclic antidepressants), ethanol and hepatotoxic drugs increase the production of hydroxylated active metabolites, increasing the risk of developing severe intoxications with small overdoses.
Barbiturates and primidone increase the excretion of ascorbic acid in the urine.
Inhibitors of microsomal oxidation (including cimetidine) reduce the risk of hepatotoxicity.
With long-term combined use with other non-steroidal anti-inflammatory drugs, the risk of developing “analgesic” nephropathy and renal papillary necrosis, and the onset of end-stage renal failure increases.
Diflunisal increases plasma concentrations of paracetamol by 50%, increasing hepatotoxicity.
Long-term use in high doses concomitantly with salicylates increases the risk of developing kidney or bladder cancer.
When used simultaneously with acetylsalicylic acid (ASA), the absorption of ascorbic acid decreases (by about 30%) and its excretion in urine increases, and the excretion of ASA decreases.
Myelotoxic drugs increase the manifestations of hematotoxicity of the drug.
Drugs of the quinoline series, calcium chloride, when used for a long time, deplete reserves of ascorbic acid; oral contraceptives, fresh juices and alkaline drinks reduce its absorption and assimilation.
Paracetamol, which is part of the drug, reduces the effectiveness of uricosuric drugs; when taken in high doses, it increases the effect of anticoagulant drugs.
Ascorbic acid increases the concentration of benzylpenicillin and tetracyclines in the blood, and at a dose of 5 sachets per day increases the bioavailability of ethinyl estradiol; improves the absorption of iron preparations in the intestine, can increase the excretion of iron when used simultaneously with deferoxamine; reduces the effectiveness of heparin and indirect anticoagulants; increases the risk of developing crystalluria during treatment with salicylates and short-acting sulfonamides, slows down the excretion of acids by the kidneys and increases the excretion of drugs that have an alkaline reaction (including alkaloids); reduces the blood concentration of oral contraceptives; increases the overall clearance of ethanol, which in turn reduces the concentration of ascorbic acid in the body; reduces the therapeutic effect of antipsychotic drugs - phenothiazine derivatives, tubular reabsorption of amphetamine and tricyclic antidepressants; when used simultaneously, it reduces the chronotropic effect of isoprenaline; with long-term use or use in high doses, it may interfere with the interaction of disulfiram and ethanol; in high doses increases the excretion of mexiletine by the kidneys.
Antigrippin-Express lemon 13.1g No. 9 por.d/prig.r-ra pr/vn in Izhevsk
Ethanol enhances the sedative effect and promotes the development of acute pancreatitis.
Antidepressants, antiparkinsonian drugs, antipsychotic drugs (phenothiazine derivatives) increase the risk of side effects (urinary retention, dry mouth, constipation).
GCS increase the risk of developing glaucoma; with long-term use, they deplete ascorbic acid reserves.
Inducers of microsomal liver enzymes (barbiturates, phenytoin, phenylbutazone, rifampicin, zidovudine, carbamazepine, tricyclic antidepressants), ethanol and hepatotoxic drugs increase the production of hydroxylated active metabolites, increasing the risk of severe intoxication with a minor overdose.
Barbiturates and primidone increase the excretion of ascorbic acid in the urine.
Inhibitors of microsomal oxidation (including cimetidine) reduce the risk of hepatotoxicity.
With long-term combined use with other NSAIDs, the risk of developing analgesic nephropathy and renal papillary necrosis, and the onset of end-stage renal failure increases.
Diflunisal increases plasma concentrations of paracetamol by 50%, increasing hepatotoxicity.
Long-term use in high doses concomitantly with salicylates increases the risk of developing kidney or bladder cancer.
When used simultaneously with acetylsalicylic acid (ASA), the absorption of ascorbic acid is reduced by approximately 30% and its excretion in the urine increases, and the excretion of ASA is reduced.
Myelotoxic drugs increase the manifestations of hematotoxicity of the drug.
Quinoline drugs and calcium chloride, when used for a long time, deplete ascorbic acid reserves, and oral contraceptives, fresh juices and alkaline drinks reduce its absorption and assimilation.
Paracetamol, which is part of the drug, reduces the effectiveness of uricosuric drugs; when taken in high doses, it increases the effect of anticoagulant drugs.
Ascorbic acid increases the concentration of benzylpenicillin and tetracyclines in the blood.
At a dose of 5 sachets/day, ascorbic acid increases the bioavailability of ethinyl estradiol.
Ascorbic acid improves the absorption of iron preparations in the intestines. When used simultaneously with deferoxamine, it may increase iron excretion.
Ascorbic acid reduces the effectiveness of heparin and indirect anticoagulants.
When treated with salicylates and short-acting sulfonamides, ascorbic acid increases the risk of developing crystalluria, slows down the excretion of acids by the kidneys and increases the excretion of drugs that have an alkaline reaction (including alkaloids).
Ascorbic acid reduces the blood concentration of oral contraceptives.
With simultaneous use, ascorbic acid increases the overall clearance of ethanol, which in turn reduces the concentration of ascorbic acid in the body.
Ascorbic acid reduces the therapeutic effect of antipsychotic drugs - phenothiazine derivatives, tubular reabsorption of amphetamine and tricyclic antidepressants.
When used simultaneously, ascorbic acid reduces the chronotropic effect of isoprenaline.
With long-term use or when used in high doses, ascorbic acid may interfere with the interaction of disulfiram and ethanol.
When used in high doses, ascorbic acid increases the excretion of mexiletine by the kidneys.
Antigrippin express powder for preparing solution for internal use raspberry 13.1g N 9
Description of the dosage form
Powder from white to white with a yellowish tint with a characteristic odor (lemon); from white with a pinkish tint to pink with a characteristic odor (raspberry); from white to white with a pinkish tint with a characteristic odor (black currant). The presence of loosely packed lumps is allowed.
An aqueous solution of the drug, obtained by dissolving the contents of the sachet in 200 ml of warm water: opalescent, colorless to yellowish in color with a characteristic lemon odor (lemon); from light pink to red-pink color with a characteristic raspberry (raspberry) smell; lilac-red to violet in color with a characteristic smell of black currant (black currant).
Pharmacological action - anti-cold, antihistamine, antipyretic, analgesic.
| Powder for preparing a solution for oral administration (lemon, raspberry, black currant) | 1 pack |
| active substances: | |
| paracetamol | 0.5 g |
| ascorbic acid | 0.2 g |
| pheniramine maleate | 0.025 g |
| excipients: soluble saccharin (sodium saccharinate dihydrate) - 0.02 g; citric acid (citric acid monohydrate) - 0.2 g; natural lemon flavoring - 0.6 g (lemon); or natural lemon flavoring - 0.1035 g; flavoring identical to natural raspberry - 0.215 g; food coloring raspberry - 0.0015 g; or natural lemon flavoring - 0.1020 g; flavoring identical to natural black currant - 0.215 g; food coloring carmoisine - 0.00075 g; black shiny food coloring (black currant) - 0.00025 g; sugar (sucrose) - up to 13.1 g |
Indications of the drug Antigrippin-Express
symptomatic treatment of colds (influenza, acute respiratory viral infections), accompanied by fever and runny nose;
allergic rhinitis, nasopharyngitis.
Contraindications
- hypersensitivity to paracetamol, ascorbic acid, pheniramine or any other component of the drug;
- erosive and ulcerative lesions of the gastrointestinal tract (in the acute phase);
- liver failure;
- angle-closure glaucoma;
- urinary retention associated with prostatic hyperplasia;
- blood diseases (sideroblastic anemia, thalassemia, leukopenia, thrombocytopenia);
- portal hypertension;
- diabetes;
- deficiency of glucose-6-phosphate dehydrogenase;
- hyperoxaluria;
- kidney stone disease;
- sucrase/isomaltase deficiency, fructose intolerance, glucose-galactose malabsorption (the dosage form contains sucrose);
- pregnancy;
- breastfeeding period;
- children under 18 years of age (since the content of ascorbic acid in the daily dose of the drug (400 and 600 mg) exceeds the permitted maximum daily dose for children - 300 mg).
With caution: renal failure; congenital hyperbilirubinemia (Gilbert, Dubin-Johnson and Rotor syndromes); viral hepatitis; alcoholic hepatitis; hemochromatosis; elderly age. If the patient has one of the listed diseases, be sure to consult a doctor before taking the drug.
Use during pregnancy and breastfeeding
The drug is not recommended for use during pregnancy and breastfeeding.
Directions for use and doses
Inside.
Pour the contents of the sachet into a mug. Fill with warm water. Stir until dissolved and serve warm.
Adults and children over 18 years old: 1 pack. 2–3 times a day. The interval between doses of the drug should be at least 4 hours, and in case of severe renal failure (Cl creatinine less than 10 ml/min), the interval between the first and second dose should be at least 8 hours.
The drug should not be taken for more than 3 days as an antipyretic and for more than 5 days as an analgesic.
Conditions for dispensing from pharmacies Without a prescription.
Storage conditions for the drug Antigrippin-Express At a temperature not exceeding 25 °C.
