Coldrex HotRem
The drug should be taken only in recommended doses!
If you suspect an overdose, even if you feel well, you must stop using the drug and consult a doctor immediately, because there is a risk of delayed serious liver damage and hospitalization may be required. Overdose is usually caused by paracetamol.
Paracetamol
Symptoms
An overdose of paracetimol may cause liver failure, which may lead to the need for liver transplantation or death.
Within 24 hours the following are possible: pale skin, loss of appetite, nausea, vomiting, abdominal pain, sweating. Clinical signs of liver damage develop, as a rule, after 24-8 hours and reach a maximum after 4-6 days. Signs of impaired glucose metabolism and metabolic acidosis may occur. Toxic effects in adults are possible after taking more than 10 g of paracetamol: increased activity of “liver” transaminases. Acute pancreatitis has been observed, usually with liver dysfunction and liver toxicity.
Acute renal failure with acute tubular necrosis, which is diagnosed by severe pain in the lumbar region, hematuria and proteinuria, can develop without severe impairment of liver function.
There are reports of cases of cardiac arrhythmia with an overdose of paracetamol.
Taking 5 g or more of paracetamol may cause liver damage in patients with the following risk factors:
- long-term treatment with carbamazepine, phenobarbital, phenytoin, primidone, rifampicin, St. John's wort preparations or other drugs that stimulate liver enzymes;
- regular consumption of alcohol in excess quantities;
- glutathione deficiency (due to malnutrition, cystic fibrosis, HIV infection, starvation, exhaustion).
At the first signs of an overdose, you should immediately consult a doctor, even in the absence of clear symptoms of poisoning. In the early period, symptoms may be limited only to nausea and vomiting and may not reflect the severity of the overdose or the risk of damage to internal organs.
Treatment
During the first hours after an expected overdose, it is advisable to administer activated carbon orally. 4 or more hours after the expected overdose, it is necessary to determine the concentration of paracetamol in the blood plasma (earlier determination of the concentration of paracetamol may be unreliable).
Treatment with acetylcysteine can be carried out up to 24 hours after taking paracetamol, however, the maximum hepatoprotective effect can be obtained in the first 8 hours after an overdose. After this, the effectiveness of the antidote drops sharply. If necessary, acetylcysteine can be administered intravenously.
In the absence of vomiting, an alternative option (if it is not possible to quickly obtain hospital care) is to prescribe methionine orally.
Treatment of patients with severe liver dysfunction 24 hours after taking paracetamol should be carried out in conjunction with specialists from a poison control center or specialized liver disease department.
Phenylephrine
Symptoms
Symptoms of a phenylephrine overdose are similar to those of side effects. In addition: irritability, headache, dizziness, insomnia, increased excitability, increased blood pressure, nausea, vomiting, reflex bradycardia. In severe cases of overdose, hallucinations, confusion, convulsions, and arrhythmias may develop. It should be borne in mind that the appearance of clinically significant symptoms of phenylephrine overdose when taking the drug is always associated with severe liver damage due to an overdose of paracetamol.
Treatment
Symptomatic therapy, for severe arterial hypertension, the use of alpha-blockers, such as phentolamine.
Ascorbic acid
Symptoms
High doses of ascorbic acid (more than 3000 mg) can cause temporary osmotic diarrhea and gastrointestinal disturbances, such as nausea and stomach discomfort. It should be borne in mind that the appearance of clinically significant symptoms of an overdose of ascorbic acid when taking the drug is always associated with severe liver damage due to an overdose of paracetamol.
Treatment
Symptomatic, forced diuresis.
Coldrex
Coldrex is a combination drug widely known in our country from a British pharmaceutical company, used for the symptomatic treatment of acute respiratory viral infections (ARVI). The key characteristic of ARVI is the species diversity of their pathogens, including influenza viruses, parainfluenza, rhinoviruses, adenoviruses, etc. Such etiological polymorphism greatly complicates the development of methods for specific treatment of these diseases. In this regard, the main emphasis must be placed on symptomatic therapy, whose action is aimed at eliminating the most unpleasant symptoms of viral infections: runny nose, cough, nasal congestion, headache and sore throat, myalgia, weakness and fever. All these facts make it advisable to use combination drugs in the drug therapy of ARVI, the components of which have different mechanisms of action, but therapeutically complement each other, providing pharmacological synergism. One of these drugs is Coldrex, which includes five active substances: paracetamol, phenylephrine, caffeine, terpene hydrate and ascorbic acid. Its composition is selected in such a way as to influence all parts of the pathological process of ARVI. The main “driving force” of Coldrex is highly purified paracetamol. Its analgesic and antipyretic properties have been mercilessly exploited by doctors for almost four decades. Unlike aspirin, it does not have an ulcerogenic (ulcerating) effect, and, unlike analgin, it does not cause blood side effects (granulocytopenia, granulocytosis). The pharmacological effect of paracetamol is due to the blockade of the synthesis of prostaglandins, mediators of pain and inflammation, however, unlike aspirin and a number of other non-steroidal anti-inflammatory drugs, this effect is not systemic, but is believed to manifest itself mainly at the level of the central nervous system, due to which the drug realizes its antipyretic effect . The analgesic effect of the drug is more complex in its development mechanism and involves not only central, but also peripheral pain pathways.
Phenylephrine is a direct beta-agonist. Causes a decrease in the lumen of arterioles, thereby relieving swelling, reducing excess formation and secretion of mucus, and relieving congestion in the nasal passages. Caffeine reinforces the analgesic potential of paracetamol, has a general tonic effect, invigorates and improves well-being. Terpin hydrate is a time-tested expectorant. It dilutes bronchial secretions and promotes their freer separation, protects the respiratory tract from blockage and makes breathing easier. It has, among other things, a weak anti-inflammatory effect. Ascorbic acid stimulates the immune system, normalizes tissue respiration processes and increases the body’s resistance to invasion by various pathogens (as is known, a bacterial infection is often “layered” on top of a viral infection).
One of the main advantages of Coldrex over its pharmacological “brothers” is the presence “under one roof” of all the medicinal ingredients required for the complex treatment of ARVI, which significantly simplifies the administration of the drug to patients. In addition, a thoughtful combination of active substances in Coldrex allows you to reduce the doses of each of them, and, therefore, reduce the risk of side effects. If you start taking Coldrex in a timely manner, the duration of the manifestation of acute symptoms of ARVI is significantly reduced. In fact, cough and increased secretion of mucus from the nose are eliminated already in the first days of the disease, creating the preconditions for further suppression of the pathological process in the respiratory tract. Taking Coldrex at the first alarming pathogenetic “bells” prevents the development of the acute phase of ARVI, thereby stopping the acute inflammatory reaction at the preclinical stage. As a result, a milder course of the disease is ensured and the negative manifestations of temperature and catarrhal reactions are leveled out. In conclusion, it should be noted that Coldrex is well tolerated by patients and rarely causes clinically significant side effects.
Coldrex Hotrem powder price, where to buy
The cost of the product in a cardboard pack for 5 sachets is about 160 rubles. And the price of Coldrex Hotrem powder in a package of 10 sachets is approximately 260 rubles.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
Pharmacy Dialogue
- Coldrex HotRem for colds and flu, lemon flavor, powder, 10 sachetsSmith Kline Beecham
RUB 355 order - Coldrex HotRem for colds and flu, lemon and honey flavor, powder, 5 sachetsSmith Kline Beecham
RUB 204 order
- Coldrex HotRem for colds and flu, lemon and honey flavor, powder, 10 sachetsSmith Kline Beecham
RUB 331 order
- Coldrex HotRem Menthol and Honey Lemon for Colds and Flu, powder, 10 sachetsSmith Kline Beecham
RUR 348 order
- Coldrex HotRem for colds and flu, lemon flavor, powder, 5 sachetsSmith Kline Beecham
RUB 197 order
show more
Pharmacy24
- Coldrex Hotrem No. 10 Lemon powder SmithKleinBeecham S.A., Spain
122 UAH order
Reviews
Those who leave reviews of Coldrex Hotrem powder report the following advantages of the drug:
- efficiency;
- fast action;
- pleasant taste;
- the presence of various flavoring additives (lemon, currant);
- convenient packaging;
- ease of use;
- possibility to buy individually;
- availability in pharmacies.
Among the disadvantages of the product, reviews indicate the presence of contraindications and side effects, as well as the high price.
Pharmacodynamics and pharmacokinetics
The medication has sympathomimetic , antipyretic , immunostimulating and analgesic effects. The features of its action depend on the properties of the components included in the composition.
The active components are excreted mainly in the urine. In addition, some ascorbic acid may be excreted in the bile. The half-life of phenylephrine is 2-3 hours, and that of paracetamol is 1-4 hours.
Interaction
When combined with barbiturates , Carbamazepine , Diphenin , Rifampicin , Zidovudine and other inducers of microsomal liver enzymes, taking the drug can cause a hepatotoxic effect .
Coldrex Hotrem should not be taken together with other products containing paracetamol . In addition, use with MAO inhibitors , tricyclic antidepressants and beta-blockers , as well as within 14 days after their discontinuation.
Side effects
When used according to the instructions, the medicine is well tolerated without side effects. In rare cases, the following negative reactions have been observed:
- digestive system and liver: increased activity of liver enzymes , vomiting, nausea, diarrhea , anorexia , dry mouth;
- nervous system: headache , insomnia , irritability, tinnitus, dizziness , tremor ;
- allergies : skin itching , rash, angioedema , urticaria , Lyell's syndrome , anaphylactic shock ;
- CVS: cardiac arrhythmia, leukopenia , thrombocytopenia , agranulocytosis , arterial hypertension , neutropenia , anemia , pancytopenia ;
- urinary system: oliguria , nephrotoxic effect , renal colic ;
- other: hyperhidrosis blood glucose levels .
