Flemoxin solutab 250 mg 20 pcs. dispersible tablets

Pharmacodynamics and pharmacokinetics

Amoxicillin is a semisynthetic β-lactam antibiotic of the penicillin group with a broad spectrum of antimicrobial activity.

The bactericidal properties of the drug are due to the ability to suppress transpeptidase, disrupt the production of peptidoglycan (supporting protein of cell walls) during periods of division and growth, and provoke the lysis of microorganisms.

Shows activity against gram(+) aerobes, including Staphylococcus spp. (with the exception of penicillinase-producing strains) and Streptococcus spp. (including Str.pneumoniae and faecalis); gram(-) aerobes (gonococci, meningococci, Escherichia coli and Haemophilus influenzae, Proteus mirabilis; certain strains of Klebsiella, Shigella and Salmonella, as well as against H. pylori.

Ineffective against strains of Proteus P. rettgeri and vulgaris (they are indole-positive), serrations, pseudomonads, enterobacteria, Morganella morgani. Mycoplasma, rickettsia and viruses are resistant to amoxicillin.

A feature of the dosage form is that the tablets are easily dispersed in water to form a dispersion. Thanks to this, the drug is quickly and as completely as possible (more than 93% of the dose taken) absorbed from the digestive canal.

Eating does not affect the absorption of the substance. TCmax - ranging from 60 to 120 minutes. When taking dispersible tablets, the plasma concentration of amoxicillin is higher than when taking insoluble forms of the drug. The active substance is resistant to acids.

TCmax when taking 500 mg amoxicillin is 120 minutes. When taking twice as much or half as much of the drug, Cmax also changes by half.

About 20% of the administered amoxicillin dose is bound to plasma proteins. The substance in therapeutically effective concentrations penetrates well into bone tissue, mucous membranes, sputum and intraocular fluid. Its concentration in bile is 2-4 times higher than plasma concentration, in amniotic fluid - from 25 to 30% of plasma concentration in the body of a pregnant woman.

Amoxicillin passes through the BBB poorly, but in case of inflammation of the meninges, its concentration in the cerebrospinal fluid is about ⅕ of the plasma concentration.

The substance is partially metabolized; most metabolic products are inactive against pathogenic microflora.

Excretion is carried out by the kidneys. In patients with healthy kidneys, T1/2 - from 60 to 90 minutes, in children under six months of age (including premature babies and newborns) - from 3 to 4 hours. If liver function is impaired, the indicator does not change; if kidney function is impaired, it can increase to 8.5 hours (this is T1/2 of amoxicillin for anuria).

Directions for use and doses

Inside, before, during or after meals. The tablet can be swallowed whole, divided into pieces or chewed with a glass of water or diluted in water to form a syrup (20 ml) or suspension (100 ml).

Adults and children over 10 years of age (for mild to moderate infections) - 500–750 mg 2 times a day or 375–500 mg 3 times a day.

Children from 3 to 10 years old - 375 mg 2 times a day or 250 mg 3 times a day; from 1 year to 3 years - 250 mg 2 times a day or 125 mg 3 times a day. The daily dose for children (including children under 1 year of age) is 30–60 mg/kg/day, divided into 2–3 doses.

When treating severe infections, as well as for infections with hard-to-reach foci (for example, acute otitis media), a three-time dose of the drug is preferable.

For chronic diseases, relapses, severe infections: adults - 0.75–1 g 3 times a day, children - up to 60 mg/kg/day in 3 divided doses.

For acute uncomplicated gonorrhea - 3 g, once, in combination with 1 g probenecid.

For mild to moderate infections, treatment is carried out for 5-7 days, for infections caused by Streptococcus pyogenes - at least 10 days.

When treating chronic diseases and severe infections, the dose of the drug should be determined by the clinical picture of the disease. The drug is continued for 48 hours after the symptoms of the disease disappear.

For patients with creatinine Cl below 10 ml/min, the dose is reduced by 15–50%.

Indications for use of the drug

What are Flemoxin Solutab tablets for?

• bacterial infections of the external respiratory system: sore throat , pneumonia , bronchitis , pharyngitis , sinusitis , acute inflammation of the middle ear ;
• infections of the genitourinary system: pyelonephritis , pyelitis , cystitis , urethritis , cervicitis , endometritis ;
• infections of the skin and/or soft tissues: impetigo , erysipelas , secondary infected dermatoses;
• bacterial infections of the digestive system and abdominal infections: angiocholitis , peritonitis , typhoid fever , cholecystitis , salmonellosis , dysentery , salmonella carriage (if they are caused by bacteria sensitive to Flemoxin).

Flemoxin - what is it used for in pediatrics?

Flemoxin Solutab is the drug of the penicillin group most commonly used in pediatric practice. Most often it is prescribed for bacterial infections of the respiratory system.

Practical application experience proves the high effectiveness of Flemoxin for sinusitis , acute non-purulent otitis media , bronchitis , bronchopneumonia , tonsillitis , and sore throat .

The drug is safe, well tolerated by young patients of any age and, just as important, when it comes to treating children, it has excellent organoleptic properties.

Contraindications

Flemoxin is not prescribed for hypersensitivity to amoxicillin, other β-lactams or auxiliary components of the tablets.

Relative contraindications for the antibiotic Flemoxin Solutab:

• lymphocytic leukemia;
• Infectious mononucleosis;
• renal failure;
• history of gastrointestinal pathology (especially colitis associated with the use of antibiotics);
• pregnancy;
• lactation;
• breastfeeding period;
• polyvalent hypersensitivity to chemicals foreign to the body (xenobiotics).

Side effects

Side effects appear as:

• nausea, changes in taste, diarrhea, vomiting, moderate increases in liver enzyme activity (sometimes), hemorrhagic and pseudomembranous colitis (extremely rare);
• interstitial nephritis (extremely rare);
• hemolytic anemia , neutropenia , agranulocytosis , thrombocytopenia .

When using the drug in the form of dispersible tablets, no adverse effects from the nervous system were observed.

The use of the drug may be accompanied by the development of hypersensitivity reactions, which are expressed in the form of a rash (mainly specific maculopapular), exudative erythema multiforme (rarely), angioedema and anaphylactic shock (in exceptional cases).

Flemoxin Solutab tablets, instructions for use

How should adults take Flemoxin tablets?

The drug is taken orally, without reference to the time of meal.

The tablet can be dissolved in 20 ml of water to obtain a syrup or in 100 ml of water to obtain a suspension; it can be swallowed whole or taken in crushed form.

For mild and moderately severe infections, 250 mg tablets are taken in 2-3 pieces. 2 times a day, 500 mg tablets - 1-1.5 pcs. 2 r./day, 1000 mg tablets - half 3 r./day.

When treating severe diseases, as well as infections with hard-to-reach foci, it is preferable to take the drug three times a day.

The daily dose of antibiotic for severe infections, relapses and chronic pathologies is 1.5-2 tablets. 500 mg 3 times/day.

For acute acute gonorrhea , a single dose of Flemoxin with probenecid (dose, 3 and 1 g, respectively).

For severe infections and chronic pathologies, the treatment regimen is selected taking into account the characteristics of the clinical picture of the disease.

In case of kidney damage, in which the Clcr value is in the range from 15 to 40 ml/min, the interval between tablet doses should be increased to 12 hours. If Clcr does not exceed 10 ml/min, the dosage of amoxicillin should be reduced by 15-50%. For anuria, the highest daily dose of amoxicillin is 2 g.

How should children take Flemoxin tablets?

Children's Flemoxin is a tablet with a dosage of amoxicillin of 125 and 250 mg. The instructions for children indicate that it is more convenient for a younger child to give a syrup or suspension; older children can swallow the tablet whole or after chewing it.

The instructions for using Flemoxin for children over 10 years of age are similar to those for adults: for mild and moderately severe infections, the child is given 3-4 tablets. 125 mg 3 times/day.

Flemoxin Solutab for children over 3 years of age is prescribed to take 3 tablets. 125 mg 2 times/day. or 2 tablets. 125 mg 3 times/day.

For children under 3 years of age, according to the instructions for use, Flemoxin Solutab 125 mg, two tablets given 2 times a day. or one 3 rubles/day.

The dosage of Flemoxin Solutab for children, which contains 250 mg of amoxicillin, is as follows:

• 2-3 tab. 2 rubles/day — patients over 10 years of age;
• 1 tab. 3 rubles/day — patients 3-10 years old;
• 1 tab. 2 rubles/day or 0.5 tab. 3 rubles/day - patients under three years of age.

The daily dose of Flemoxin Solutab for children of all age groups (including children of the first year of life) is from 30 to 60 mg/kg, divided into 2 or 3 doses. If the disease is severe or the pathological focus is difficult to reach, it is preferable to take the drug 3 times a day.

For severe infections (including those with hard-to-reach lesions), the recommended dose of antibiotic is 60 mg/kg/day, divided into three doses.

Duration of treatment

The duration of the course for mild and moderately severe infections is from 5 days to 1 week. If the causative agent of the infection is Str. pyogenes, treatment lasts at least 10 days.

For severe infections, medication should be continued for 48 hours after symptoms disappear.

Antibiotic Flemoxin Solutab for sore throat

Sore throat is a common acute infectious disease, the local manifestations of which are damage to the tonsils (mainly the first and second tonsils). The most common causative agents of sore throat are B-hemolytic streptococci of group A. Staphylococci provoke it much less often.

Untreated or undertreated tonsillitis is complicated by paratonsillitis , nephritis , myocarditis , paratonsillar abscess , and tonsillogenic sepsis .

Given the bacterial nature of the disease, timely use of antibiotics is very important. If in case of catarrhal tonsillitis, in some cases, local antibiotics are enough for the patient, then in case of follicular and lacunar tonsillitis, the doctor must prescribe systemic drugs.

Research results and practical experience have shown that the most effective remedies for angina are drugs of the penicillin group.

The advantages of Flemoxin over analogues are:

• unique dosage form (Solyutab);
• the presence of tablets with a “children’s” dosage of the active substance;
• the possibility of using the drug without being tied to the time of meals.

For adults with sore throat, it is recommended to take the drug 2 times a day. 500-700 mg each. For angina in children, children's Flemoxin Solutab is used - tablets with a minimum dosage of the active substance. The dose is selected by the doctor depending on the patient’s age and the characteristics of the disease.

After the symptoms of sore throat are relieved (body temperature decreases, pustules on the tonsils disappear, sore throat goes away, the condition of the lymph nodes normalizes), taking Flemoxin should be continued for at least two more days.

If treatment is stopped immediately, the risk of disease recurrence is high. Moreover, the symptoms may appear with a vengeance.

Use of the drug for sinusitis

Sinusitis is an inflammation of the paranasal sinuses.

The use of an antibiotic for sinusitis is advisable if the disease is caused by bacteria sensitive to its action. When associated with a viral or fungal infection, as well as allergic sinusitis , antibiotic therapy is not only ineffective, but can also aggravate the course of the disease.

Acute bacterial sinusitis manifests itself first:

• hyperthermia (febrile temperature or higher);
• violation of nasal respiration and phonation;
• soreness and swelling of the skin in the projection of the maxillary cavities;
• decreased sense of smell;
• the presence of pain radiating to different parts of the face (the pain gradually loses its specific location);
• symptoms of general intoxication (sleep disturbances, headache, joint pain, etc.);
• the characteristic color of the pathological secretion discharged from the sinuses (its color in bacterial infections usually varies from yellow to dark green).

The selection of an antibiotic is carried out taking into account:

• the results of a microbiological study of biomaterial taken from the paranasal sinuses and a rapid test for staining of the pathogen using the Gram method;
• characteristics of the patient’s body;
• possible allergic reactions to the drug;
• presence of concomitant diseases.

If the cause of the disease is staphylococci, streptococci or Haemophilus influenzae, it is considered most preferable to prescribe drugs of the penicillin group to the patient.

The use of amoxicillin for bacterial sinusitis (including complicated forms of the disease) gives a pronounced positive effect already in the first 7 days of treatment: the patient’s symptoms of intoxication and pain in the paranasal sinuses decrease/disappear, the temperature decreases and nasal breathing becomes easier.

The effectiveness of Flemoxin Solutab is explained by the fact that this drug:

• affects a large number of strains of infectious agents;
• quickly and in high concentrations absorbed from the digestive tract;
• resistant to gastric juice;
• Available in an easy-to-use form.

Flemoxin solutab 250 mg 20 pcs. dispersible tablets

pharmachologic effect

A bactericidal, acid-resistant, broad-spectrum antibiotic from the group of semisynthetic penicillins.

Composition and release form Flemoxin solutab 250 mg 20 pcs. dispersible tablets

Soluble tablets - 1 tablet:

• active ingredients: amoxicillin (in the form of amoxicillin trihydrate) - 125/250/500/1000 mg;
• excipients: dispersible cellulose; MCC; crospovidone; vanillin; tangerine flavor; lemon flavoring; saccharin; magnesium stearate.

There are 5 pcs in a blister; there are 4 blisters in a box (125, 250, 500, 1000 mg) or 7 pcs in a blister; There are 2 blisters in a box (125 mg).

Description of the dosage form

Dispersible tablets are white to light yellow in color, oval in shape with the company logo and digital designation on one side and a score dividing the tablet in half on the other side.

Digital designation:

• Flemoxin Solutab® (125 mg) - “231”;
• Flemoxin Solutab® (250 mg) - “232”;
• Flemoxin Solutab® (500 mg) - “234”;
• Flemoxin Solutab® (1000 mg) - “236”.

Characteristic

A bactericidal, acid-resistant, broad-spectrum antibiotic from the group of semisynthetic penicillins.

Directions for use and doses

Inside.

Adults and children over 10 years old - 500-750 mg 2 times a day or 375-500 mg (up to 1 g for severe infections) 3 times a day (maximum daily dose - 6 g), children from 3 to 10 years - 375 mg 2 times or 250 mg 3 times a day, up to 1 year - 125 mg 2 times or 100 mg 3 times a day.

The daily dose for children is 30 mg/kg (up to 60 mg/kg), frequency of administration is 2–3 times.

For acute gonorrhea - 3 g once in combination with 1 g probenecid (repeated administration is recommended for women).

For patients with creatinine Cl below 10 ml/min, the dose is reduced by 15–50%; for anuria, the dose should not exceed 2 g per day.

The average course is 5–7 days (for streptococcal infections - at least 10 days).

Pharmacodynamics

Active against such gram-positive and gram-negative microorganisms as Streptococcus pyogenes, Streptococcus pneumonia, Clostridium tetani, C.welchii, Neisseria gonorrhoeae, Neisseria meningitidis, Staphylococcus aureus (not producing beta-lactamase), Bacillus anthracis, Listeria monocytogenes, Helicobacter pylori. Less active against Enterococcus faecalis, Escherichia coli, Proteus mirabilis, Salmonella typhi, Shigella sonnei, Vibrio cholerae. Not active against microorganisms producing beta-lactamases, Pseudomonas spp., indole-positive Proteus spp., Serratia spp., Enterobacter spp.

Pharmacokinetics

Suction

After oral administration, it is absorbed quickly and almost completely (about 93%), acid-stable. After oral administration at a dose of 500 mg, the Cmax of the active substance in plasma is 5 mcg/ml and is observed in the blood plasma after 2 hours. When the dose of the drug is increased or decreased by 2 times, Cmax in the blood plasma also changes by 2 times. Food intake has virtually no effect on the absorption of the drug.

Distribution

Plasma protein binding is about 20%. Amoxicillin penetrates well into mucous membranes, bone tissue, intraocular fluid and sputum in therapeutically effective concentrations. The concentration of amoxicillin in bile exceeds its concentration in blood plasma by 2-4 times. In amniotic fluid and umbilical vessels, the concentration of amoxicillin is 25-30% of its level in the blood plasma of a pregnant woman. It penetrates poorly through the BBB, but during inflammation of the meninges, the concentration in the cerebrospinal fluid is about 20% of the concentration in the blood plasma.

Metabolism

Partially metabolized, most of its metabolites are inactive against microorganisms.

Removal

It is eliminated primarily by the kidneys, about 80% by tubular excretion, 20% by glomerular filtration. In the absence of renal dysfunction, T1/2 is 1-1.5 hours. In premature infants, newborns and children under 6 months - 3-4 hours. Pharmacokinetics in special clinical cases. T1/2 of amoxicillin does not change with impaired liver function. If renal function is impaired (Cl creatinine

Indications for use Flemoxin solutab 250 mg 20 pcs. dispersible tablets

• Infections of the respiratory tract and ENT organs (bronchitis, pneumonia, tonsillitis, acute otitis media, pharyngitis, sinusitis), genitourinary system (urethritis, cystitis, pyelonephritis, endometritis, uncomplicated gonorrhea), skin and soft tissues, gastrointestinal tract (peritonitis, enterocolitis, cholecystitis , cholangitis, typhoid fever);
• leptospirosis, listeriosis, meningitis, Lyme disease (borreliosis), prevention of endocarditis and surgical infection;
• combination therapy of gastritis and peptic ulcer (in combination with metronidazole), sepsis (in combination with aminoglycosides).

Contraindications

Hypersensitivity (including to other penicillins, cephalosporins, carbapenems), allergic diathesis, bronchial asthma, hay fever, infectious mononucleosis, lymphocytic leukemia, history of gastrointestinal diseases (especially colitis associated with the use of antibiotics).

Application of Flemoxin solutab 250 mg 20 pcs. dispersible tablets during pregnancy and breastfeeding

During pregnancy and lactation, it is used for health reasons, taking into account the expected effect for the mother and the potential risk for the fetus or child. During the course, breastfeeding is excluded.

special instructions

Hypersensitivity reactions

Before starting treatment with amoxicillin, you should pay attention to the presence of hypersensitivity reactions to penicillins, cephalosporins or other beta-lactam antibiotics in the anamnesis (see sections “Contraindications” and “Side effects”).

Severe and sometimes fatal hypersensitivity reactions (including anaphylactic reactions and severe skin reactions) have been reported in patients receiving penicillin therapy. The development of these reactions is more likely in people with a history of hypersensitivity to penicillins and in people with atopy. If an allergic reaction occurs, discontinue treatment with amoxicillin and institute appropriate alternative treatment.

Acute coronary syndrome associated with hypersensitivity (Kounis syndrome)

In rare cases, hypersensitivity reactions (acute coronary syndrome associated with hypersensitivity) have been reported during treatment with amoxicillin. If this reaction occurs, amoxicillin should be discontinued and appropriate treatment should be prescribed.

Insensitive microorganisms

For some types of infections, before prescribing amoxicillin, it is necessary to first establish the pathogen and its sensitivity to the drug, or make sure that the pathogen is likely to be treatable with amoxicillin. This particularly applies to patients with urinary tract infections and severe ear, nose and throat infections.

Convulsions

Convulsions may occur in patients with renal failure, in patients receiving high doses of the drug, as well as in patients with predisposing factors - a history of seizures, treatment for epilepsy or meningitis, etc.

Kidney failure

In patients with renal insufficiency, the dose should be adjusted according to the degree of renal insufficiency (see section "Dosage and Administration").

Skin reactions

The occurrence of generalized erythema with fever, accompanied by pustules, at the initial stage of treatment may be a symptom of OHEP (see section “Side effects”). In this case, amoxicillin should be discontinued, and its subsequent use will be contraindicated in any situation.

The use of amoxicillin should be avoided in patients who are suspected of having infectious mononucleosis, since a measles-like rash (exanthema) may occur due to the use of amoxicillin for this disease.

Jarisch-Herxheimer reaction

The Jarisch-Herxheimer reaction has been observed following the use of amoxicillin in patients with Lyme disease. This reaction is associated with the bactericidal effect of amoxicillin on the causative agent of Lyme disease, the spirochete Borrelia burgdorferi. Patients should be advised that this reaction is a common side effect of antibiotic treatment for Lyme disease and usually goes away on its own.

Excessive growth of non-susceptible microorganisms

Long-term use of the drug can sometimes lead to excessive growth of microorganisms that are not sensitive to amoxicillin (superinfection).

When using almost all antibacterial drugs, the development of colitis associated with taking antibiotics is possible. Its severity can range from mild to severe (life-threatening). Therefore, it is important to consider the possibility of this diagnosis in patients who develop diarrhea during or after antibiotic use. If diarrhea develops, the patient should immediately stop taking amoxicillin, consult a doctor and begin appropriate treatment. Medicines that inhibit peristalsis are contraindicated in this situation.

Long-term treatment

During long-term therapy, it is necessary to periodically monitor the function of the hematopoietic organs, kidneys and liver. Increased activity of liver enzymes and changes in the number of blood cells were reported.

Anticoagulants

Rare cases of increased prothrombin time have been reported in patients receiving amoxicillin. When prescribing the drug simultaneously with anticoagulants, appropriate monitoring should be carried out, and the dose of oral anticoagulants may need to be adjusted to maintain the required level of blood clotting.

Crystalluria

In patients with reduced diuresis, crystalluria was very rarely observed, mainly during parenteral therapy. When using high doses of amoxicillin, it is recommended to maintain adequate fluid intake and diuresis to reduce the likelihood of developing crystalluria associated with amoxicillin use. In patients with a catheterized bladder, catheter patency should be checked regularly.

Impact on diagnostic tests

Increased levels of amoxicillin in serum and urine may interfere with some laboratory tests. Due to high concentrations of amoxicillin in urine, chemical methods often give false-positive results.

When determining glucose in urine during treatment with amoxicillin, it is recommended to use enzymatic glucose oxidase tests.

The use of amoxicillin may affect the results of the quantitative determination of estradiol in urine in pregnant women.

Impact on the ability to drive vehicles and operate machinery

Studies of the effect of amoxicillin on the ability to drive vehicles or operate other machinery have not been conducted. However, side effects may occur (for example, allergic reactions, dizziness, convulsions) that affect the ability to drive vehicles or use other machinery.

Overdose

Symptoms: nausea, vomiting, diarrhea, water and electrolyte imbalance.

Treatment: gastric lavage, administration of activated carbon, saline laxatives, correction of water and electrolyte balance.

Side effects Flemoxin solutab 250 mg 20 pcs. dispersible tablets

• Nausea, vomiting, diarrhea, pain in the anus, stomatitis, glossitis;
• agitation, anxiety, insomnia, confusion, behavior changes, headache, dizziness, convulsive reactions;
• difficulty breathing, tachycardia;
• joint pain;
• interstitial nephritis;
• dysbacteriosis, superinfection, oral or vaginal candidiasis, pseudomembranous or hemorrhagic colitis;
• moderate increase in the level of transaminases in the blood, transient anemia, thrombocytopenic purpura, eosinophilia, leukopenia, neutropenia and agranulocytosis;
• allergic reactions: exfoliative dermatitis, exudative erythema multiforme, Stevens-Johnson syndrome, anaphylactic shock, maculopapular rash, itching, urticaria, Quincke's edema, reactions similar to serum sickness.

Drug interactions

Probenecid, phenylbutazone, oxyphenbutazone, and to a lesser extent acetylsalicylic acid and sulfinpyrazone, inhibit the tubular secretion of penicillins, which leads to an increase in the half-life and an increase in the concentration of amoxicillin in the blood plasma.

Bactericidal antibiotics (including aminoglycosides, cephalosporins, vancomycin, rifampicin) have a synergistic effect when taken simultaneously; antagonism is possible when taken with some bacteriostatic drugs (for example, chloramphenicol, sulfonamides).

Concomitant use with estrogen-containing oral contraceptives may lead to a decrease in their effectiveness and an increased risk of breakthrough bleeding).

Concomitant administration with allopurinol does not increase the frequency of skin reactions, unlike the combination of allopurinol with ampicillin.

Interaction

Phenylbutazone , probenecid , oxyphenbutazone , sulfinpyrazone (to a slightly lesser extent) and ASA inhibit the secretion of penicillin antibiotics, which leads to an increase in T1/2 and an increase in the plasma concentration of amoxicillin.

Bactericidal antibiotics (including Rifampicin , Vancomycin , cephalosporins and aminoglycosides ) have a synergistic effect when used in combination with Flemoxin.

When taken simultaneously with certain bacteriostatic agents ( sulfonamides , chloramphenicol , etc.), antagonism is possible.

Use with estrogen-containing oral contraceptives may reduce the effectiveness of the latter and increase the risk of recurrent bleeding.

Use in combination with allopurine , unlike the combination of Ampicillin with allopurine, does not increase the frequency of skin reactions.

special instructions

A history of erythroderma is not a contraindication to the use of the drug.

cephalosporins and antibiotics of the penicillin cannot be ruled out .

As with other penicillin drugs, superinfection may develop.

, characteristic of pseudomembranous colitis, during treatment with the drug is a reason to discontinue Flemoxin.

Patients with lymphocytic leukemia and infectious mononucleosis are at high risk of developing non-allergic exanthema .

Analogues of Flemoxin Solutab

Level 4 ATC code matches:
Hiconcil

Ampioks

Ampicillin Trihydrate

Ampicillin

Ospamox

Amoxicar

Penicillin

Amoxicillin

Amosin

Amoxil

Ecoball

• Amoxicillin
• Amosin
• Gramox-D
• Ospamox
• Hiconcil
• Ecoball

Drugs with a similar mechanism of action:

• Ampicillin
• Azlocillin sodium salt
• Standacillin

Which is better: Flemoxin or Flemoklav?

Flemoklav is a combined antibacterial drug produced by Astellas Pharma in the form of dispersible tablets.

The basis of the tablets is amoxicillin, but - and this is the difference between it and Flemoxin - to enhance its effect, the drug also contains clavulanate (or clavulanic acid ) - a substance that inhibits bacterial beta-lactamase enzymes.

That is, Flemoklav is active against amoxicillin-sensitive microorganisms, as well as against bacterial strains that produce some chromosomal and most plasmid β-lactamases.

Clavulanate inhibits type II, III, IV and V beta-lactamases, but is inactive against those produced by Enterobacteriaceae, Pseudomonas aeruginosa, Acinetobacter, Serration (type I beta-lactamases).

Clavulanate, which has a high affinity for penicillin antibiotics, significantly expands the spectrum of activity and, consequently, the use of amoxicillin.

Pharmacological action of the drug

The drug in question has some undoubted advantages. The first of them: Flemoxin Solutab is absorbed very quickly and almost 100% when taken orally. It is quite resistant to hydrochloric acid of gastric juice. You can take the drug regardless of meals. The concentration of amoxicillin in the blood increases to its maximum within 1-3 hours after administration. Amoxicillin, which is part of the drug, has a bactericidal effect on pathogenic microorganisms sensitive to it.

• How to take Flemoxin Solutab correctly for angina: dosages and contraindications

Reviews of Flemoxin Solutab

Flemoxin is an effective and safe remedy that treats most types of bacterial infections. The drug helps with cystitis and pyelonephritis , with sore throat , secondary infected dermatoses, and it has also earned good reviews for sinusitis .

The main advantage of the antibiotic is its acid resistance and high bioavailability, thanks to which amoxicillin reaches the site of its action in maximum concentration. The only downside, perhaps, is that it does not affect strains that produce β-lactamase.

Eating does not change the pharmacokinetics of amoxicillin and does not affect the efficiency of absorption of the drug; as a result, plasma concentrations reach peak values ​​within an hour or two after taking the tablet/suspension.

Flemoxin combines well with most other medications and dietary supplements, and the high safety profile of the drug allows it to be prescribed to pregnant women and children.

Reviews about Flemoxin Solutab for children are overwhelmingly good. Many mothers consider it the best antibiotic for sore throat and pharyngitis . However, as is the case with other antibacterial drugs, the effectiveness of treatment depends on how correctly the drug is selected, and for this the causative agent must be identified.

Flemoxin is destructive to most microorganisms that cause respiratory diseases, to which young children are especially susceptible, so the manufacturer also produces the drug in a special children's dosage - 125 and 250 mg.

Ease of use is also important in pediatrics: Flemoxin tablets can be eaten like candy, or dissolved in water and drunk as a drink with a pleasant fruity taste.

Medicine for sinusitis

If you have sinusitis, you should immediately consult a doctor, since it is difficult for the patient to determine the severity of the disease and choose the right medicine. Treatment varies:

• antibacterial drugs;
• preparations for the drainage of mucus from the maxillary sinuses;
• drugs that restore breathing.

The above drugs will produce a positive result if taken together. Drugs of the penicillin group - amoxicillins - act on bacteria that cause inflammation in the maxillary sinuses and kill them.

How effective is Flemoxin Solutab for sinusitis?

How much does Flemoxin Solutab cost?

The price of Flemoxin Solutab for children (with a dosage of the active substance of 125 mg) in Russian pharmacies is about 200 rubles (package No. 20). The average price of 250 mg tablets is 250 rubles, you can buy an antibiotic in 500 mg tablets for an average of 330 rubles, the cost of 1000 mg tablets is 450 rubles.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

Pharmacy Dialogue

• Flemoxin Solutab soluble tablets 250 mg No. 20Astellas/Ortat RUB
  297 order
• Flemoxin Solutab dispersible tablets. 1000 mg No. 20Astellas/Ortat

  RUB 453 order

• Flemoxin Solutab soluble tablets 500 mg No. 20Astellas/Ortat

  RUB 345 order

• Flemoxin Solutab (dissolved tablet 500 mg No. 20)Yamanouchi

  RUB 334 order

• Flemoxin Solutab tablets 500 mg No. 20Astellas Pharma

  RUB 356 order

show more

Pharmacy24

• Flemoxin Solutab 500 mg No. 20 tablets Astellas Pharma Europe B.V., Netherlands
  118 UAH.order
• Flemoxin Solutab 125 mg N20 tablets Astellas Pharma Europe B.V., Netherlands

  82 UAH order

• Flemoxin Solutab 250 mg No. 20 tablets Astellas Pharma Europe B.V., the Netherlands

  100 UAH order

• Flemoxin Solutab 1000 mg No. 20 tablets Astellas Pharma Europe B.V., the Netherlands

  163 UAH order

PaniPharmacy

• Flemoxin tablets Flemoxin solutab tablets 1000 mg No. 20 Netherlands, Astellas Pharma Europe

  181 UAH order

• Flemoxin tablets Flemoxin solutab tablets 125 mg No. 20 Netherlands, Astellas Pharma Europe

  90 UAH order

• Flemoxin tablets Flemoxin solutab tablets 500 mg No. 20 Netherlands, Astellas Pharma Europe

  125 UAH order

• Flemoxin tablets Flemoxin solutab tablets 250 mg No. 20 Netherlands, Astellas Pharma Europe

  108 UAH order

show more

Composition and release form

5 pcs in blister; there are 4 blisters in a box (125, 250, 500, 1000 mg) or 7 pcs in a blister; There are 2 blisters in a box (125 mg).