Nurofen Plus, film-coated tablets, 12 pcs.
Avoid simultaneous use of the drug with the following drugs:
Acetylsalicylic acid: with the exception of low doses of acetylsalicylic acid (no more than 75 mg/day) prescribed by a doctor, since combined use may increase the risk of side effects. When administered simultaneously, ibuprofen reduces the anti-inflammatory and antiplatelet effect of acetylsalicylic acid (an increase in the incidence of acute coronary insufficiency in patients receiving small doses of acetylsalicylic acid as an antiplatelet agent is possible after starting ibuprofen).
Other NSAIDs, in particular selective COX-2 inhibitors: the simultaneous use of two or more drugs from the NSAID group should be avoided due to a possible increased risk of side effects.
Prescribe with caution simultaneously with the following drugs
Anticoagulants: NSAIDs may enhance the effect of anticoagulants, in particular warfarin.
Antihypertensives (ACE inhibitors and angiotensin II antagonists) and diuretics: NSAIDs may reduce the effectiveness of drugs in these groups. In some patients with impaired renal function (for example, dehydrated patients or elderly patients with impaired renal function), co-administration of ACE inhibitors or angiotensin II antagonists and COX-inhibiting agents may lead to deterioration of renal function, including the development of acute renal failure (usually reversible). These interactions should be considered in patients taking coxibs concomitantly with ACE inhibitors or angiotensin II antagonists. In this regard, the combined use of the above drugs should be prescribed with caution, especially in elderly people.
Patients should be prevented from dehydration and consideration should be given to monitoring renal function upon initiation of this combination treatment and periodically thereafter. Diuretics and ACE inhibitors may increase the nephrotoxicity of NSAIDs.
GCS: increased risk of gastrointestinal ulcers and gastrointestinal bleeding.
Antiplatelet agents and SSRIs: increased risk of gastrointestinal bleeding.
Cardiac glycosides: simultaneous administration of NSAIDs and cardiac glycosides can lead to worsening heart failure, a decrease in GFR and an increase in the concentration of cardiac glycosides in the blood plasma.
Lithium preparations: there is evidence of the likelihood of an increase in the concentration of lithium in the blood plasma during the use of NSAIDs.
Methotrexate: there is evidence of the likelihood of an increase in the concentration of methotrexate in the blood plasma during the use of NSAIDs.
Cyclosporine: increased risk of nephrotoxicity when NSAIDs are administered concomitantly with cyclosporine.
Mifepristone: NSAIDs should be started no earlier than 8 to 12 days after taking mifepristone as NSAIDs may reduce the effectiveness of mifepristone.
Tacrolimus: When NSAIDs and tacrolimus are coadministered, the risk of nephrotoxicity may increase.
Zidovudine: Concomitant use of NSAIDs and zidovudine may result in increased hematotoxicity. There is evidence of an increased risk of hemarthrosis and hematomas in HIV-positive patients with hemophilia who received concomitant treatment with zidovudine and ibuprofen.
Quinolone antibiotics: In patients receiving concomitant treatment with NSAIDs and quinolone antibiotics, the risk of seizures may be increased.
Myelotoxic drugs: enhance the manifestations of hematotoxicity of the drug.
Caffeine enhances the analgesic effect.
MAO inhibitors: When using codeine in patients receiving therapy with MAO inhibitors or who have received it within the previous two weeks, CNS depression or worsening of the clinical picture may occur.
Moclobemide: risk of developing hypertensive crisis.
Hydroxyzine: Concomitant use of hydroxyzine (anxiolytic) and codeine can lead to increased analgesic effects, as well as greater CNS depression, increased sedative and antihypertensive effects.
CNS depressants (sedatives): The sedative effect of codeine is enhanced by substances that depress the central nervous system, such as alcohol, anesthetics, hypnotics, sedatives, tricyclic antidepressants and antipsychotic drugs and phenothiazines.
Diuretics and antihypertensive agents: The antihypertensive effects of diuretics and antihypertensive agents may be enhanced when used concomitantly with opioid pain relievers.
Antidiarrheals and motility suppressants: Concomitant use of codeine and antidiarrheals and motility suppressants, such as loperamide and kaolin, may increase the risk of severe constipation.
Antimuscarinics: Concomitant use of antimuscarinics or drugs with muscarinic effects, such as atropine and some antidepressants, may increase the risk of severe constipation, which in turn may lead to severe paralytic ileus and/or urinary retention.
Muscle relaxants: The respiratory depression effects caused by muscle relaxants may be additive to the major respiratory depression effects associated with opioid analgesics.
Quinidine: May inhibit the analgesic effect of codeine.
Mexiletine: Codeine may delay the absorption of mexiletine, and thereby reduce the antiarrhythmic effect of the latter.
Metoclopramide, cisapride and domperidone: Codeine may suppress the gastrointestinal effects of metoclopramide, cisapride and domperidone.
Cimetidine: Cimetidine inhibits the metabolism of opioid painkillers, resulting in increased plasma concentrations.
Naloxone: Naloxone inhibits the analgesic, CNS, and respiratory depressant effects of opioid pain medications.
Naltrexone also blocks the therapeutic effects of opioids.
Impact on laboratory test results: Opioid painkillers affect the results of a number of laboratory tests, including determination of plasma concentrations of amylase, lipase, bilirubin, alkaline phosphatase, LDH, ALT and AST.
Opioids may also interfere with examinations because they slow gastric emptying, and hepatobiliary imaging using disophenine, a technetium Tc 99m opioid, may cause contraction of the sphincter of Oddi and increased bile duct pressure.
Content:
- How does the compound affect the human body?
- Forms of release of drugs containing codeine
- What medications contain codeine 3.1. Codelac 3.2. Terpicode 3.3. Solpadeine 3.4. Tetralgin 3.5. Nurofen Plus 3.6. Panadeine
Codeine medications have been used by doctors for decades. They are prescribed if you have a dry, unproductive cough or severe pain. Today they are sold in pharmacies only by prescription. This is due to the fact that codeine in medications has a pronounced psychotropic effect.
How does the compound affect the human body?
Typically, pulmologists and therapists use the properties of codeine in their work. The component relieves coughing attacks, but does not treat the inflammatory disease. It only removes the signs. This effect of drugs containing codeine is explained by the fact that it affects certain parts of the brain. The component also inhibits the functioning of receptors responsible for the occurrence of pain. Due to this, it eliminates pain and quickly normalizes the patient’s well-being (but for a short period of time).
Codeine-based medications stimulate opiate receptors. If taken in low dosages, the effect on the central and peripheral nervous system will be gentle. If the therapeutic dose is repeatedly exceeded, the medication exhibits narcotic properties. Then the person feels the effect of euphoria. He relaxes and feels at peace. Doctors are even aware of cases of short-term loss of consciousness after consuming codeine compounds.
What medications contain codeine?
Before listing which medications contain codeine, we note that treatment with them is permissible only if the following conditions are met:
- the medicine was prescribed by a doctor;
- the patient strictly adheres to the daily dosage and timing of drug therapy;
- There are no contraindications to taking the pills.
The most common drugs containing codeine are:
- Codelac;
- Terpincode;
- Solpadeine;
- Tetralgin;
- Nurofen Plus;
- Panadeine.
Let's talk about each in more detail.
Codelac
Antitussive. Used to reduce the intensity and frequency of cough. Enhances the production of bronchial secretions and makes sputum less viscous. Shows weak anti-inflammatory and antispasmodic properties. This combined effect is explained by the inclusion in Codelac of not only codeine, but also licorice root, sodium bicarbonate, and Thermopsis lanceolata herb.
The remedy may cause:
- nausea, vomiting;
- constipation;
- headache;
- lethargy and drowsiness;
- allergic rashes.
Terpicode
Source of sodium bicarbonate, terpin hydrate, codeine. Acts as a weak analgesic. Slightly depresses respiratory activity. May cause nausea, vomiting, miosis. It has sedative properties, calms, and normalizes sleep. As a result of taking the medication, the secretion of the bronchial glands increases and expectoration of sputum is stimulated.
The instructions for use indicate that Terpicode helps with:
- emphysema;
- bronchitis;
- bronchopneumonia.
It can be taken for pathologies of the respiratory tract and lungs. The drug is contraindicated for children under two years of age, pregnant women, breastfeeding women, and persons with bronchial asthma.
Solpadeine
The drug contains codeine, caffeine, paracetamol. Reduces cough, analgesizes. Doctors prescribe Solpadeine for neuralgia, toothache and headache, muscle spasms, sprains, and bruises. It can also be used in the symptomatic treatment of colds, flu, sinusitis, and fever.
Tetralgin
Made from codeine, caffeine, metamizole sodium and phenobarbital. A combined medicine that has a muscle relaxant, hypnotic, antitussive and analgesic effect. Helps cope with migraines, myalgia, arthralgia, algodismenorrhea, neuralgia, and ARVI symptoms.
During therapy, sometimes adverse reactions occur such as:
- allergic skin rashes;
- drowsiness;
- dizziness;
- vomiting, constipation;
- granulocytopenia;
- agranulocytosis;
- leukopenia.
The manufacturer warns that long-term treatment with the drug leads to the development of addiction.
Nurofen Plus
Analgesic combination medication. Contains ibuprofen. It is prescribed for pain syndromes, neuralgia, painful menstruation, muscle and rheumatic pathologies.
The medicine has a fairly large list of contraindications. It can cause a huge number of side effects, for example:
- hematopoietic disorders;
- anaphylactic reactions;
- allergies;
- decreased appetite;
- hallucinations;
- depression of the central nervous system;
- nightmares;
- headache;
- convulsions;
- increased intracranial pressure;
- diplopia, decreased visual acuity;
- discomfort in the abdomen;
- hepatitis, jaundice;
- biliary colic.
Panadeine
A medicine containing codeine and paracetamol. Indications for use are:
- headache;
- migraine;
- neuralgia;
- arthritis;
- toothaches;
- fever;
- flu;
- colds.
It should not be used by children under seven years of age or with individual intolerance to any of the components.
To avoid health problems, do not take medications containing codeine unless directed by a doctor. If it is possible to replace the drug with a safer analogue, do so. If you still drink codeine, then follow the dosage and in no case exceed the duration of treatment.
Literature:
- Medicines in the neurological clinic: handbook. for doctors / E. I. Gusev, A. S. Nikiforov, A. B. Gekht. — 2nd ed., erased. - Moscow: MEDpress-inform, 2006 (M.: Printing house "News"). — 405 p.
- Basics of pharmacology. Workshop: textbook / V. A. Astafiev. — Moscow: KNORUS, 2022. — 212 p.
- Current problems of the drug situation among young people: status, trends, prevention / [ed. : Sheregi F. E. et al.] ; Ministry of Education and Science of Russia. Federation, Center of Sociol. research — M.: Center for Social Sciences. forecasting, 2004. – 499 p.
Forms of release of drugs containing codeine
Codeine-containing medications are produced in the form of:
- tablets;
- drops;
- syrups.
The first form is the most common. Pills are prescribed for:
- migraines;
- toothache;
- pain syndrome after surgery.
In all these cases, the tablets include not only codeine, but also aspirin or paracetamol. The provided therapeutic effect manifests itself quickly and lasts for several hours.
People who often suffer from bronchitis with elements of obstruction clearly know which medications contain codeine. They use such compositions to cure debilitating coughing attacks and obtain an expectorant effect.
There are products on sale with codeine that are indicated for treating indigestion, relieving nervous tension, and normalizing sleep. No such medication should be used without first consulting a specialist.
