What medications require a prescription and how long it lasts: prescription drugs, antibiotics

What are the types of prescription drugs?

The state restricts the sale of drugs that cannot be used uncontrolled. These are: • anabolic steroids; • combination medications listed in paragraphs 4 and 5 of the Order of the Ministry of Health and Social Development dated May 17, 2012 No. 562N (for example, Ascoril); • medicines containing narcotic or psychotropic substances, the circulation of which is limited in Russia. Antibiotics, despite numerous initiatives, are still available freely. The Ministry of Health has not yet found any grounds to restrict their sale. You cannot buy such products in a pharmacy without a properly documented medical prescription. However, a prescription form must also be presented to purchase preferential medications and products that are subject to subject-quantitative accounting by virtue of Order of the Ministry of Health dated April 22, 2014 No. 183n. The law provides for several types of forms.

Salbutamol aerosol 100mcg/dose 12ml 200dose fl binnopharm

The drug Salbutamol aerosol for inhalation dosed 100 mcg/dose is intended for inhalation administration only. Only a doctor can decide whether to increase the dose or frequency of use of the drug.

It is not recommended to use the drug more than 4 times a day. The need for frequent use of maximum doses of the drug or a sudden increase in dose indicates a worsening of the disease.

Relieving an attack of bronchospasm: the recommended dose is 100-200 mcg (1-2 inhalations).

Why are recipes needed?

Based on the main types of drugs that are dispensed only upon presentation of prescription forms, we can formulate the main tasks of using the latter: • control of the sale of psychotropic and narcotic substances restricted in circulation; • control of the use of combination drugs containing small doses of psychotropic and narcotic substances (for example, mild painkillers); • accounting for the use of benefits by pensioners, disabled people of the first group, and disabled children; • subject-quantitative accounting of individual medications.

This measure can be considered as a way to prevent drug addiction and prevent crimes in the field of pharmaceuticals. Additionally, it helps monitor the supply of medicines to people in need.

What does a doctor's prescription look like?

Now the prescription of medications is regulated by the Procedure established by Order of the Ministry of Health dated January 14, 2019 No. 4n.

The following forms of prescription forms : • 148-1/у-88. Designed for the sale of anabolic steroids, combination drugs (clause 5), restricted narcotic and psychotropic drugs, as well as medicines subject to registration. • 148-1/у-04 (l). Used to dispense medications free of charge or provide a discount to people with benefits. • 107-1/у. Used for the sale of combination drugs (clause 41). Order No. 4n will be valid until March 1, 2022 - after that it will lose force. It will be replaced by the Procedure contained in the Order of the Ministry of Health dated November 24, 2021 No. 1094n. It will contain the numbers of prescription forms and their basic details. They will look the same as before, since the OKUD codes remain the same.

Salbutamol and breastfeeding

At the moment, there is no information regarding the presence of Salbutamol in breast milk, its effect on the infant, or its effect on milk production.
The benefits of breastfeeding for the development and health of the baby should be considered with the mother's clinical need for Salbutamol, as well as any possible side effects of this drug.

If there is a strong need to use Salbutamol, it is recommended to stop breastfeeding while taking the medication.

Sources

Albuterol: warning about pregnancy and breastfeeding. / Drugs.com (English)
SALBUTAMOL 1MG / ML NONBULIZING SOLUTION / Drugs.com (English)
Salbutamol / State register of medicinal products of Ukraine

Details of form 148-1/u-88

The header of the form (on the left) should contain a stamp of the medical institution, on the right - a link to the regulatory act that approved the form.

In the body of the document (on the front side) indicate: • its series, number, date of issue; • age (adult or child); • last name and initials (IO) of the patient, his date of birth; • patient's address or medical record number; • surname and initials (IO) of the attending physician; • name of the drug, release form, quantity, dosage. The principles for filling out the prescription form have been adjusted compared to the edition almost ten years ago. Then, instead of the date of birth, the age of the recipient was indicated, and the name and patronymic of the patient and doctor were written in full.

Salbutamol Aerosol for inhalation dosed 100 mcg/dose 90 doses, 12 ml

Registration Certificate Holder

ALTAIVITAMINS (Russia)

Dosage form

Medicine - Salbutamol AV (Salbutamol AV)

Description

Aerosol for inhalation dosed

in the form of a white or white with a yellowish suspension, located in a cylinder with a metering valve and a sprayer; When sprayed 5 doses onto glass it leaves a white stain.

1 dose

salbutamol sulfate 120 mcg, which corresponds to the content of salbutamol 100 mcg

Excipients

: ethanol (ethyl alcohol 95%) - 2.363 mg, oleic acid - 0.044 mg, tetrafluoroethane (Solkane® 134a) - 25.473 mg.

300 doses (11 g) - aluminum aerosol cans with a dosing valve (1) complete with a spray nozzle - cardboard packs.

Indications

Prevention and relief of bronchospasm in all forms of bronchial asthma. Reversible airway obstruction in chronic bronchitis and emphysema, broncho-obstructive syndrome in children.

Threatened premature birth with contractile activity of the uterus; childbirth before 37-38 weeks of pregnancy; isthmic-cervical insufficiency, a decrease in fetal heart rate depending on uterine contractions during periods of cervical dilatation and expulsion. For preventive purposes during operations on the pregnant uterus (application of a circular suture in case of insufficiency of the internal os of the uterus).

Contraindications for use

Threat of miscarriage in the first and second trimesters of pregnancy, premature placental abruption, bleeding or toxicosis in the third trimester of pregnancy; children under 2 years of age; hypersensitivity to salbutamol.

pharmachologic effect

Beta-adrenergic agonist with a predominant effect on β2-adrenergic receptors (localized, in particular, in the bronchi, myometrium, blood vessels). Prevents and relieves bronchospasm; reduces resistance in the respiratory tract, increases the vital capacity of the lungs. Prevents the release of histamine, a slow-reacting substance from mast cells and neutrophil chemotaxis factors. Compared to other drugs in this group, it has a less pronounced positive chrono- and inotropic effect on the myocardium. Causes expansion of the coronary arteries, practically does not reduce blood pressure. It has a tocolytic effect, reducing the tone and contractile activity of the myometrium.

Drug interactions

With simultaneous use of salbutamol with non-cardioselective beta-blockers, mutual suppression of therapeutic effects is possible; with theophylline - the risk of developing tachycardia and arrhythmia, in particular supraventricular extrasystole, increases.

With the simultaneous use of salbutamol and xanthine derivatives, corticosteroids or diuretics, the risk of developing hypokalemia increases.

Dosage regimen

Orally as a bronchodilator for adults and children over 12 years of age - 2-4 mg 3-4 times a day, if necessary, the dose can be increased to 8 mg 4 times a day. Children aged 6-12 years - 2 mg 3-4 times a day; children 2-6 years old - 1-2 mg 3 times a day.

When administered by inhalation, the dose depends on the dosage form used, the frequency of use depends on the indications and the clinical situation.

As a tocolytic agent, it is administered intravenously in a dose of 1-2 mg.

Side effect

From the cardiovascular system:

transient dilatation of peripheral vessels, moderate tachycardia.

From the side of the central nervous system:

headache, dizziness, nausea, vomiting.

From the side of metabolism:

hypokalemia.
Allergic reactions:
in isolated cases - angioedema, allergic reactions in the form of skin rash, urticaria, arterial hypotension, collapse.

Other:

tremor of the hands, internal trembling, tension; rarely - paradoxical bronchospasm, muscle cramps.

special instructions

Use with caution for tachyarrhythmias and other heart rhythm disorders, arterial hypertension, myocarditis, heart defects, aortic stenosis, diabetes mellitus, thyrotoxicosis, glaucoma, acute heart failure (subject to careful medical supervision).

Increasing the dose or frequency of taking salbutamol should be done under the supervision of a physician. Reducing the interval is possible only in exceptional cases and must be strictly justified.

When using salbutamol, there is a risk of developing hypokalemia, therefore, during treatment in patients with severe bronchial asthma, the level of potassium in the blood should be monitored. The risk of hypokalemia increases with hypoxia.

Use during pregnancy and breastfeeding

Restrictions during pregnancy - Contraindicated. Restrictions when breastfeeding - With caution.

Salbutamol is contraindicated in cases of threatened miscarriage in the first and second trimesters of pregnancy, premature placental abruption, bleeding or toxicosis in the third trimester of pregnancy.

If it is necessary to use salbutamol during pregnancy, the expected benefits of treatment for the mother should be weighed against the potential risk to the fetus. Currently, there is insufficient data on the safety of the use of salbutamol in early pregnancy. Salbutamol is excreted in breast milk, so if it is necessary to use it during lactation, the expected benefit of treatment for the mother and the possible risk for the child should also be assessed.

Use in children

Restrictions for children - Contraindicated.

Contraindicated in children under 2 years of age.

Details of form 148-1/u-04 (l)

In addition to the details placed on forms 148-1/у-88, specific data related to the preferential nature of the provision of medicines is provided: • preferential category of patients; • disease; • source of funds allocation; • % of payment; • SNILS of the patient; • patient's insurance policy. This form has a counterfoil that is filled out by a pharmacy employee. There he indicates when and what drug he released, under what trade name, etc. The reverse side is the same as that of form 148-1/у-88.

Details of form 107-1/у

Externally, the form is almost no different from 148-1/u-88 (except for the name of the form itself and the OKUD code). Visually, the difference is found only in the lower part, where there is a field for entering the number of months if the prescription was issued for a period exceeding 60 days. However, there is a significant difference between them. In 107-1/у you can enter several medicines, 148-1/у-88 involves issuing one form for one medicine. The reverse side of the document is standard. The four marks mentioned above are placed there.

Salbutamol during pregnancy: possible risks and complications

The use of Salbutamol during pregnancy is contraindicated, especially in the 2nd trimester.
The use of this drug is indicated only in extreme cases, based on the balance of benefit and risk. The safety of using Salbutamol during pregnancy has not been established. Tell your doctor if you are pregnant or planning to become a mother. It has been proven that this drug is able to penetrate the placental barrier, as evidenced by an increase in the fetal heart rate.

Beta-agonists, including this drug, may potentially affect uterine contractility.

Women with poorly or moderately controlled asthma have an increased risk of maternal preeclampsia and prematurity, low birth weight, and small for gestational age neonates. Pregnant women should be monitored closely and the dose adjusted as necessary to maintain optimal control.

In animal reproduction studies (subcutaneous administration in pregnant mice), cleft palate was detected within the maximum recommended daily inhalation dose for humans, which is 9 times less than the maximum recommended.

A study on pregnant rats showed the ability of Salbutamol to be transferred from the maternal circulation to the fetus. There is no controlled data on human pregnancy.

There is no connection between the use of Salbutamol and congenital anomalies. Excessive uterine bleeding has been reported following miscarriage due to the use of this drug. Particular caution is required for pregnant women with diabetes, since Salbutamol can provoke tachycardia as well as hyperglycemia.

Beta-agonists, including Salbutamol, may potentially affect uterine contractility.

Women with poorly or moderately controlled asthma, as well as those born prematurely and with low birth weight, have an increased risk of preeclampsia (high blood pressure combined with high levels of protein in the body). Pregnant women should be closely monitored and the dose adjusted if necessary to maintain optimal status.

How long does a prescription for medicine last?

The validity period of a prescription depends on the basis for issuing it and the form used. Form 148-1/у-88 must be purchased within 15 days after issuance. For form 148-1/u-04 (l), the period varies. As a general rule, it is 90 days. However, patients often suffer from chronic diseases that require longer treatment. For them, the period is extended to 180 days. A prescription in form 107-1/у is valid for two months from the date of issue. For chronicles, an extension is possible, but not more than a year. In this case, the doctor additionally affixes an o, which is certified by the doctor’s signature, his personal seal and the seal of the medical institution.

How to get a prescription for medicine?

Only a medical organization has the right to issue documented prescriptions for medications that the state prohibits from dispensing uncontrollably. This may be a legal entity or an individual entrepreneur who has received a license for this type of activity. Individual entrepreneurs do not have the right to prescribe psychotropic and narcotic substances to patients, even if licensed. The prescription is signed by the employee treating the patient: • doctor; • paramedic; • midwife. Documents from the latter have legal force only if the chief physician has assigned them the powers of the attending physician in the manner prescribed by Order of the Ministry of Health and Social Development dated March 23, 2012 No. 252n.

This is the only legal way to obtain a prescription for medicine. For purchasing counterfeit documents you can be held liable under Part 3 of Article 327 of the Criminal Code.

How is an electronic prescription created?

When registering a medical prescription electronically, it is not necessary to comply with the listed forms. The main thing is that the basic details are indicated. The procedure for compiling an electronic prescription is described in detail in Section II of Appendix 3 to Order No. 4n. The necessary details are listed in paragraph 20. Let us pay attention to the main differences from the paper version: • Region code according to OKATO. Important because the electronic assignment is only valid in the territory where it is issued. • Unique number of the prescription form. It is assigned to the GIS in the healthcare sector: the authenticity of the prescription is verified using this number. • Electronic medical record number (stored in GIS). • Electronic signature of the doctor.

A distinctive feature is the QR code. Reading it at the pharmacy allows you to verify that the document is real. But even if the scanner malfunctions, it will not be possible to deceive the pharmacist: he can enter the number manually. This way he will find out whether the recipe actually exists and whether it has expired. Overall, e-prescribing has become an effective way to combat fraud. A paper form can be stolen or reproduced, but a digital form is immediately registered in GIS and linked to a specific person.

Dispensing drugs in a pharmacy

The dispensing of drugs is regulated by the Rules approved by Order of the Ministry of Health dated July 11, 2017 No. 403n.

Pharmacy workers are required to: • check the authenticity of the prescription, its validity period, and the absence of a mark on the previous dispensation; • sell prescription drugs only in the quantities specified on the form; • if the drug is not available in the required dosage, recalculate in accordance with the prescription; • if the drug is available only in a dosage exceeding that indicated in the form, do not serve the buyer until instructions are received from the attending physician; • comply with service deadlines; • place vacation notes on the form. Forms for psychotropic and narcotic drugs are stored in the pharmacy for 5 years, for combination drugs, anabolic steroids and preferential medications - for 3 years. For over-the-counter products, the pharmacist does not have the right to require a documented medical prescription. For example, antibiotics cannot be taken without medical supervision from the point of view of medicine and common sense, but not legislation. Therefore, the trading entity is obliged to sell them to everyone who applies.

Salbutamol Sopharma syrup 2mg/5ml 125ml No.1

Name

Salbutamol.

Description

Salbutamol Sopharma syrup is a drug from the group of so-called bronchodilators. It provides short-term (4-6 hours) bronchodilation, relaxing the smooth muscles of the bronchi, and promotes the expansion of the airways, relieving tension in the chest, wheezing, and facilitating breathing. Used to ease breathing and prevent asthma and other lung diseases; is acceptable for use in children and adults who are unable to use inhalants.

Contraindications

if you are allergic (hypersensitivity) to the active substance or to any of the excipients of Salbutamol Sopharma;
Salbutamol Sopharma syrup should not be used to stop uncomplicated premature labor or in cases of threatened miscarriage.

Precautionary measures

The drug Salbutamol Sopharma is not used alone or as a primary treatment for the treatment of severe or unstable asthma; not used to relieve asthmatic attacks. Tell your doctor if you have:

disease of the thyroid gland associated with an increase in its function;
heart disease, and especially those associated with heart rhythm disturbances or angina pectoris (chest pain);
treatment with other sympathomimetics;
diabetes.

Salbutamol Sopharma contains ethanol, sucrose, methyl and propyl parahydroxybenzoate. This medicine contains 3.84 vol. % ethanol, i.e. up to 0.155 g of alcohol in a dose of 5 ml, which is equivalent to 3.84 ml of beer and 1.6 ml of wine. The use of the drug in pregnant and breastfeeding women, children and risk groups such as patients with liver disease, epilepsy and alcoholism should be taken into account. The medicine contains 37.5 g of sucrose. Each 5 ml dose delivers up to 1.5 g of sucrose. If you have been told by your doctor that you have an intolerance to certain sugars, consult your doctor before using this medicine. The syrup contains methyl and propyl parahydroxybenzoate, which may cause allergic reactions (possibly delayed).

Interaction with other drugs

Tell your doctor or pharmacist if you are taking, have recently taken or may take any other medicines, including those taken without a prescription. Tell your doctor if you are taking beta blockers (such as propranolol).

Pregnancy and breastfeeding

If you are pregnant or breastfeeding, think you may be pregnant, or are planning to become pregnant, ask your doctor or pharmacist for advice before using this medicine. The use of Salbutamol Sopharma in pregnant women is not recommended due to the lack of sufficient data on the safe use of the drug in this category of patients. If you are breastfeeding and treatment with the drug is required, breastfeeding should be discontinued.

Directions for use and doses

Always take Salbutamol Sopharma exactly as prescribed by your doctor. If you are unsure about anything, ask your doctor or pharmacist. The syrup is taken orally regardless of meals. The usual dose is: Adults: 5-10 ml syrup (2-4 mg salbutamol) 3-4 times a day. If necessary, the dose can be increased to 20 ml (8 mg) 4 times a day (maximum daily dose 32 mg). Elderly patients: it is recommended to start treatment with lower doses - 5 ml of syrup (2 mg) 3-4 times a day. Use in children and adolescents Children from 2 to 6 years of age: initial dose – 2.5 ml of syrup (1 mg) 3 times a day. If necessary, the dose can be increased to 5 ml of syrup (2 mg) 3-4 times a day. Children 6-12 years of age: the minimum initial dose is 2 mg (5 ml syrup) 3 times a day. If necessary, the frequency of taking the drug can be increased up to 4 times. Children over 12 years of age: 5-10 ml of syrup (2-4 mg of salbutamol) 3-4 times a day. Children under 2 years of age: The safety, effectiveness and dosage of the drug in children under 2 years of age have not been established. If during treatment you do not feel the effect of drug treatment or there is a need for more frequent use, you should immediately contact your doctor. He will assess your condition and possibly reconsider your treatment. You should not change the dosage of the drug yourself without consulting your doctor! If you take a dose that exceeds the required dose, you may experience trembling of the limbs, increased heart rate, hyperactivity, nausea, vomiting, increased blood sugar, especially in children, decreased amount of potassium in the blood , rapid breathing. Seek advice from your healthcare professional immediately. If you miss a dose of Salbutamol Sopharma If you miss one dose, take it as soon as possible. If it is almost time for your next dose, take it as usual, skipping the forgotten dose. Do not take a double dose to make up for a missed dose. If you have any additional questions about using this medicine, ask your doctor or pharmacist.

Side effect

Like all medicines, Salbutamol Sopharma can cause side effects, although not everyone gets them. Very common (affects more than 1 in 10 patients): tremor (trembling of the limbs). Common (occurs in less than 1 in 10 patients): headache, increased heart rate, palpitations, muscle cramps. Rare (affects less than 1 in 1,000 patients): irregular heart rhythm, dilation of blood vessels in the extremities, decreased amount of potassium in the blood. Very rare (affects less than 1 in 10,000 patients): allergic reactions such as hives, angioedema (swelling of the face, lips, mouth, tongue or throat, which can make swallowing and breathing difficult), airway spasms, decreased blood pressure and collapse, hyperactivity, feeling of muscle tension. With unknown frequency (no estimate can be made from existing data). Although it is not known to what extent or how often it occurs, some patients may experience chest pain (due to cardiac problems). Notify your doctor if you experience any of the symptoms described during treatment with Salbutamol Sopharma, but do not stop using the medicine without the direction and recommendation of your doctor. If any of the side effects become serious or you notice other side effects not described in this leaflet, notify your doctor or pharmacist.

Storage conditions

Store in original packaging at a temperature not exceeding 25 °C. Keep out of the reach of children. The syrup can be used up to 1 month after opening the bottle.

Best before date

2 years. Do not use Salbutamol Sopharma after the expiration date stated on the package. The expiration date corresponds to the last day of the specified month. Medicines should not be disposed of in a sewer or household waste container. Ask your pharmacist how to dispose of your unused medications. These measures will contribute to environmental protection.

Conditions for dispensing from a pharmacy chain

On prescription.

Compound

5 ml of syrup contains: Active substance: 2 mg of salbutamol (in the form of salbutamol sulfate). Excipients: ethanol, sucrose, methyl parahydroxybenzoate (E218), propyl parahydroxybenzoate (E216), sodium citrate dihydrate, citric acid monohydrate, liquid essence “Lemon”, purified water.

Package

Transparent viscous liquid from colorless to yellow with a specific lemon odor. 125 ml of syrup in dark brown glass bottles with polyethylene caps or in dark brown polyethylene terephthalate (PET) bottles with polyethylene caps; 1 (one) bottle in a cardboard box along with a measuring cup and a leaflet.

Buy Salbutamol Sopharma syrup 2mg/5ml 125ml No. 1 in the pharmacy

Price for Salbutamol Sopharma syrup 2mg/5ml 125ml No. 1

Instructions for use for Salbutamol Sopharma syrup 2mg/5ml 125ml No. 1

How long does it take to fill a prescription?

The patient has the right to go to any pharmacy, but the necessary medications may not be available for sale. The trader then orders them from the warehouse or supplier. At the same time, as required by paragraph 6 of the Rules, he must comply with the following deadlines: • if there is a statim mark - one working day; • if there is a cito mark - two working days; • for vital medications listed in Government Order No. 2406-r dated October 12, 2019 - five working days; • for preferential medicines - 10 working days; • if there is a mark of appointment by a medical commission - 15 working days. If the assignment expires during delivery, it will not need to be reissued. The main thing is that the patient has time to present it in time.

Salbutamol-Teva aerosol. d/inhal. doses 100mcg/dose 200doses №1

Inhalation.

To relieve bronchospasm:

100 mcg (1 inhalation) 1–4 times a day. If necessary, the dose can be increased to 200 mcg (2 inhalations) 1–4 times a day.

To prevent bronchospasm:

100–200 mcg (1–2 inhalations) 15–30 minutes before physical activity or possible exposure to an allergen.

The maximum daily dose should not exceed 800 mcg (8 inhalations) per day.

At least 4 hours should pass between each dose taken.

Patient instructions for using the inhalation device

Before using the inhalation device for the first time or if it has not been used for some time, it is necessary to check its functionality by pressing the valve of the canister and releasing a dose of medication into the air.

1. Remove the protective cap from the inhalation device and make sure that the outlet tube of the inhalation device is clean. Hold the inhalation device between the index finger and thumb in a vertical position, with the thumb placed on the bottom of the inhalation device and the index finger on the metering valve of the aluminum cylinder.

2. Shake the aluminum can vigorously up and down.

3. Exhale deeply through your mouth. Press the outlet tube of the inhalation device tightly with your lips.

4. Take a slow and deep breath. At the moment of inhalation, press the dosing valve of the cylinder with your index finger, releasing the dose of Salbutamol-Teva, and continue to inhale slowly.

5. Remove the inhalation device from the mouth and hold your breath for 10 seconds or for as long as does not cause discomfort. Exhale slowly.

6. After inhalation, rinse your mouth with water, trying not to swallow the aerosol that got onto the oral mucosa during inhalation.

7. If you need to administer more than one dose of the drug, wait 1 minute and repeat all steps from step 2 to step 6.

8. Close the inhalation device with the protective cap.

There is no need to rush through steps 3 and 4. When releasing a dose of medication, it is important to inhale as slowly as possible. Before use, you can practice in front of a mirror. If you notice "steam" coming from the top of the can or from the corners of your mouth, you should start again from step 2.

Cleaning the inhaler.

The inhalation device should be cleaned at least once a week. Remove the aluminum cylinder from the inhalation device. Gently rinse the inhalation device and protective cap with warm water. Do not use hot water! Shake the inhalation device and protective cap to remove any remaining water and dry them without using heating devices.

Do not allow the aluminum cylinder to come into contact with water!