Description of the drug SUMAMED® for systemic use

Description of the drug SUMAMED® for systemic use

Carbamazepine

In pharmacokinetic studies conducted in healthy volunteers, azithromycin did not have a significant effect on plasma levels of carbamazepine or its active metabolite.

Oral coumarin anticoagulants

In a pharmacokinetic interaction study, azithromycin never altered the anticoagulant effect of warfarin when administered as a single 15 mg dose in healthy patients. In the post-marketing period, an increase in the anticoagulant effect of coumarin derivatives was observed when used in combination with azithromycin. Although a cause-and-effect relationship has not been established, more frequent monitoring of prothrombin time should be considered when azithromycin is used in patients taking coumarin anticoagulants.

While taking cimetidine

two hours before taking azithromycin, no changes in the pharmacokinetics of azithromycin were observed.

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Cyclosporine

In a pharmacokinetic study in healthy volunteers who received a daily dose of azithromycin 500 mg orally for 3 days and who subsequently took a single dose of 10 mg/kg cyclosporine orally, the Cmax and AUC0-5 values ​​of cyclosporine were significantly increased. Therefore, these drugs should be used simultaneously with caution. If concomitant use of these drugs is necessary, monitor cyclosporine levels and adjust the dose accordingly.

Efavirenz

Co-administration of a single dose of azithromycin 600 mg and efavirenz 400 mg per day for 7 days did not result in a clinically significant pharmacokinetic interaction.

Fluconazole

The simultaneous use of a single dose of 1200 mg of azithromycin does not change the pharmacokinetics of a single dose of 800 mg of fluconazole. The total concentration and half-life of azithromycin did not change with concomitant use of fluconazole. However, a clinically insignificant decrease in Cmax (18%) of azithromycin was noted.

Indinavir

Concomitant use of a single dose of 1200 mg of azithromycin does not have a significant effect on the pharmacokinetics of indinavir when administered at a dose of 800 mg three times daily for 5 days.

Methylprednisolone

In a pharmacokinetic study of drug interactions in healthy patients, azithromycin did not have a significant effect on the pharmacokinetics of methylprednisolone.

Midazolam

In healthy patients, simultaneous administration of azithromycin 500 mg daily for 3 days does not cause clinically significant changes in the pharmacokinetics and pharmacodynamics of midazolam when administered once 15 mg.

Nelfinavir

The simultaneous use of azithromycin (1200 mg) and nelfinavir (750 mg three times a day) leads to an increase in the concentration of azithromycin at steady state. No clinically significant side effects were identified. There is no need to adjust the dose.

Rifabutin

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Concomitant use of azithromycin and rifabutin did not affect the serum concentrations of either drug. With simultaneous use of azithromycin and rifabutin, neutropenia was observed in patients. Neutropenia is associated with the use of rifabutin; a causal relationship when taken in combination with azithromycin has not been established.

Sildenafil

There was no evidence of an effect of azithromycin (500 mg daily for 3 days) on the blood AUC and Cmax values ​​of sildenafil or its major metabolites.

Theophylline

Azithromycin did not affect the pharmacokinetics of theophylline in healthy volunteers. Concomitant use of theophylline and other macrolide antibiotics has sometimes resulted in increased serum theophylline concentrations.

Triazolam

Co-administration of azithromycin 500 mg on day 1 and 250 mg on day 2 and triazolam 0.125 mg on day 2 in 14 healthy patients did not have a significant effect on the pharmacokinetic parameters of triazolam compared with co-administration of triazolam and placebo.

Trimethoprim/sulfamethoxazole

Co-administration of trimethoprim/sulfamethoxazole DS (160 mg/800 mg) for 7 days and 1200 mg azithromycin on day 7 had no significant effect on peak concentrations and urinary excretion of trimethoprim/sulfamethoxazole. Azithromycin serum concentrations were similar to those in other studies.

Cisapride

metabolized in the liver by the enzyme CYP3A4.
Because macrolides inhibit this enzyme, concomitant administration of cisapride may result in QT prolongation, ventricular arrhythmias, and torsades de pointes
.

Data on interactions with astemizole

and
alfentanil
are absent. Caution should be exercised when these drugs are used concomitantly with azithromycin, given the potential effects described with concomitant use of the macrolide antibiotic erythromycin.

Azithromycin should not be used concomitantly with other active substances that prolong the QT interval

.

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Release form

White powder for oral suspension with banana flavor. After dilution in water it turns into a white homogeneous suspension with a banana aroma.

• 16.74 grams or 15 ml of powder in a 50 ml polyethylene bottle along with a measuring spoon and syringe in a cardboard box.
• 29.295 grams or 30 ml of powder in a 100 ml polyethylene bottle along with a measuring spoon and syringe in a cardboard box.
• 35.573 grams or 37.5 ml of powder in a 100 ml polyethylene bottle along with a measuring spoon and syringe in a cardboard box.

Price Sumamed Forte, where to buy

The price for Sumamed Forte 30 ml (200 mg/5 ml) can reach 600 rubles in Russia.

A similar form of release in Ukraine will cost 200-300 hryvnia.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

ZdravCity

• Sumamed Forte powder for suspension.
  for internal approx. 200mg/5ml 35.37gPliva Hrvatska d.o.o RUR 555 order
• Sumamed Forte powder for suspension. for internal approx. 200mg/5ml 16.74gPliva Hrvatska d.o.o

  RUB 219 order

Pharmacy Dialogue

• Sumamed forte powder for suspension 200mg/5ml bottle 35.5mlPliva

  RUR 536 order

• Sumamed forte (portable/susp. 200 mg/5 ml fl. 16.74 g (15 ml) banana) Pliva

  RUB 218 order

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Pharmacy24

• Sumamed forte 200 mg/5 ml 1500 mg 37.5 ml suspension
  262 UAH. order
• Sumamed forte 200 mg/5 ml 600 mg 15 ml suspension Pliva Hrvatska d.o.o., Croatia

  183 UAH order

• Sumamed forte raspberry 200 mg/5 ml 37.5 ml Pliva Hrvatska d.o.o., Croatia/AT Pharmaceutical plant TEVA, Ugorshchina

  259 UAH. order

• Sumamed forte strawberry 200 mg/5 ml 30 ml powder Pliva Hrvatska d.o.o., Croatia/AT Pharmaceutical plant TEVA, Ugorshchina

  246 UAH order

• Sumamed forte 200 mg/5 ml 1200 mg 30 ml suspension Pliva Hrvatska d.o.o., Croatia

  199 UAH order

PaniPharmacy

• Sumamed forte liquid Sumamed forte powder 1500 mg for suspension 37.5 ml Croatia, Pliva

  208 UAH order

• Sumamed forte liquid Sumamed forte por. d/p susp. 200mg/5ml 37.5ml Croatia, Pliva

  216 UAH order

• Sumamed forte liquid Sumamed forte powder for the preparation of suspension for oral use 200mg/5ml 30ml Croatia, Pliva

  210 UAH. order

• Sumamed forte liquid Sumamed forte powder for suspension 200mg/5ml 15ml Croatia, Pliva

  186 UAH order

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Side effects

• Infectious lesions: candidiasis , including candidiasis of the oral and genital mucosa; pseudomembranous colitis .
• Metabolic disorders: anorexia .
• Allergic reactions: urticaria , erythema multiforme, Stevens-Johnson syndrome , skin rash, photosensitivity, angioedema , itching , anaphylactic reaction, epidermal toxic necrolysis.
• Disorders of the hematopoietic system: thrombocytopenia, leukopenia, eosinophilia, neutropenia , lymphopenia , hemolytic anemia .
• Nervous disorders: headache , paresthesia , dizziness , drowsiness , hyposthesia, insomnia , aggression, anxiety, convulsions, fainting, myasthenia gravis, psychomotor hyperactivity , deterioration of taste and smell, anxiety.
• Sensory disorders: deafness, blurred vision, tinnitus, vertigo .
• Disorders of the circulatory system: palpitations, decreased blood pressure, increased QT segment, ventricular tachycardia, arrhythmia.
• Digestive system disorders: flatulence , nausea, abdominal pain, diarrhea, dyspepsia, constipation , vomiting, gastritis, pancreatitis .
• Disorders of the hepatobiliary system: liver failure , increased bilirubin , increased transaminase activity, cholestatic jaundice, hepatitis , necrosis .
• Disorders of the musculoskeletal system: joint pain.
• Urogenital sulfur disorders: interstitial nephritis , increased concentrations of creatinine and urea in the blood, acute kidney failure.
• Other disorders: malaise, chest pain, weakness, asthenia , peripheral edema , changes in potassium levels in the blood.

Analogs

Level 4 ATC code matches:
Ecositrin

Azicine

Rovamycin

AzitRus

Safocid

Clarithromycin

Klarbakt

Azithromycin

Azitro Sandoz

Sumamed

ZI-Factor

Azitral

Azimed

Azicide

Spiramycin-vero

Zitrolide

Ecomed

Macropen

Klacid SR

Klacid

Azivon, Azivok, Azidrop, Azitral, Azilide, Azithromycin Zentiva, Azithromycin Sandoz, Sumamecin, Azithromycin, AzitRus, Azicide, Zetamax retard, Sumamox, Vero-Azithromycin, ZI-Factor, Zitnob, Zithrocin, Sumaklid, Zitrolide, Sumaside, Sumamed, Sumatrolide Solutab, Azitrox, Tremak-Sanovel, Azimicin, Hemomycin, Ecomed.