Magnelis b6 48mg+5mg 50 pcs. film-coated tablets

What is Magnelize B6 for?

For pregnant women in the early stages of pregnancy, starting from 3-4 weeks, the local obstetrician prescribes Magnelis at the antenatal clinic. First of all, this is due to the fact that an interesting position does not leave any woman indifferent. There is always excitement about the upcoming responsibility, concern about the health of the unborn child and how the birth will go. But expectant mothers should not take most sedative medications and herbal medications. Magnesium does a better job in this regard – it strengthens the nervous system and prevents stress.

In addition, magnesium is involved in normalizing muscle tone. When taken in a timely manner, a woman relieves herself of nagging pain in the lower abdomen, gives support to her back, and in combination with calcium, gets rid of night cramps in the calf muscles.

Magnesium deficiency interferes with normal mental functioning. Taking Magnelis B6 allows you to compensate for the lack of the mineral, thereby putting your thought processes in order. Magnelis B6 is shown to pupils of the last grades of school and college students as a dietary supplement that helps to remember large amounts of information, concentrate on important details for a long time, and cope better with learning.

Magnelis B6 instructions

Magnelis is sold in tablet form. Each dose contains 48 mg of magnesium. Absorption of the drug is ensured by 50% from the intestine after oral administration. The kidneys are mainly responsible for removing the substance. In case of severe magnesium deficiency, up to 8 tablets per day are prescribed for adults and children over 18 years of age. It is recommended to divide the reception into several doses, in equal parts.

Children under 18 years of age, weighing more than 20 kg, should not take more than 6 tablets per day. As a rule, it is recommended to take 2 tablets three times a day after meals. If magnesium deficiency is not expressed or prevention of acute deficiency of the element is required, take 1 tablet three times a day for a month.

It is recommended to take a blood test for magnesium levels a month after taking Magnelis B6 to determine whether continued therapy is required or whether the use of this supplement should be discontinued.

Magnelis B6, magnesium + vitamin B6 tab. 120 pcs

Active substance:

1 tablet contains: magnesium lactate dihydrate - 470 mg in terms of magnesium (Mg2+) - 48 mg, pyridoxine hydrochloride 5 mg.
Excipients:
Sucrose - 27.4 mg, kaolin - 41.0 mg, acacia gum - 25.0 mg, Kollidon SR [polyvinyl acetate 80%, povidone 19%, sodium lauryl sulfate 0.8%, silicon dioxide 0.2%] – 34.0 mg, magnesium stearate – 6.8 mg, carmellose sodium – 34.0 mg, talc – 6.8 mg. shell: sucrose – 166.7 mg, kaolin – 54.0 mg, gelatin – 0.9 mg, acacia gum – 4.0 mg, beeswax – 0.4 mg, titanium dioxide – 9.0 mg, talc – 15 .0 mg.

Description:

The drug Magnelis® B6 contains magnesium in an easily digestible form and vitamin B6 in therapeutic dosages. Magnelis® B6 helps eliminate magnesium deficiency and its manifestations: increased irritability, fatigue, minor sleep disturbances, cramps, pain and tingling in the muscles. Replenishing magnesium deficiency will maintain balance and metabolic processes in the nervous system, improve mood and sleep, attention and memory, and help withstand increased stress. Taking Magnelis® B6 forte replenishes magnesium deficiency during pregnancy, which creates favorable conditions for normal fetal development and pregnancy. Recommended for adults, pregnant women and children over 6 years old.

Magnelis® B6 with care for the nerves.

EFFECTIVENESS HAS BEEN PROVEN IN NUMEROUS CLINICAL STUDIES.

Advantages of Magnelis® B6.

Magnelis® B6 is a medicinal product of magnesium and vitamin B6. Contains organic magnesium salt and magnesium fixer - vitamin B6, which ensures easy and complete absorption.

Replenishes magnesium deficiency, which contributes to: - normalization of the nervous system; - improving mood and sleep, attention and memory; - helps to withstand increased emotional, mental and physical stress.

The use of Magnelis B6 during pregnancy replenishes magnesium deficiency, which helps normalize the tone of the uterus, improve mood and sleep, and eliminate muscle cramps.

Advantages of the release form.

A wide range allows you to choose a package depending on the situation: Magnelis® B6 No. 50 to start taking; Magnelis® B6 No. 90 and No. 120 - large packages for a course of administration; The largest package of Magnelis® B6 No. 120 is more profitable and convenient for course use.

Release form:

Film-coated tablets. 120 tablets in polymer jars made of low-density polyethylene. The jars are sealed with screw-on lids made of high-density polyethylene or low-density polyethylene. Each jar is covered with a polyvinyl chloride heat-shrink tube. Each jar is placed in a cardboard box along with instructions for use.

Contraindications

Despite the undeniable benefits of restoring magnesium levels, taking the drug is contraindicated in the following cases:

• the patient's age is less than 6 years;
• if you have an individual intolerance to one of the components of the drug;
• phenylketonuria;
• severe form of renal failure.

The lactation period is also a contraindication, since magnesium passes into breast milk unhindered.

Separately, patients with type 1 and type 2 diabetes mellitus are included in the group of special patients. If taking magnesium is indicated, then the choice of this particular dosage form should be accompanied by monitoring blood sugar levels, since the tablets contain sucrose among the excipients. The presence of lactose should be a deciding factor for patients with lactose intolerance and lactase deficiency.

Magnelis B6 – heart support

Magnesium, together with potassium, are the most important microelements that ensure normal functioning of the heart muscle. Arrhythmias and tachycardias in the absence of congenital pathologies are due to a deficiency of these two components. Heart diseases are no longer considered age-related; increasingly, young patients, barely 30 years of age, are coming in with complaints of increased heart rate and uneven rhythm.

It is very important to monitor the level of magnesium in the blood from a cardiological point of view. Without magnesium, high-quality transmission of nerve impulses is impossible; the heart muscle loses the ability to relax between beats, which leads to rapid wear of the vital pump.

Magnesium for health

Magnesium is an essential trace element that is directly involved in the functioning of the nervous system. Regulates cellular metabolism, ensures the transmission of nerve impulses between muscles and the brain. A sufficient amount of this element in the body helps to more easily endure stress and shock, not experience muscle tone and spasms, and regulate mood and emotions.

Magnesium is extremely important for women's health during pregnancy. Regulates endocrine functions. Magnesium is best absorbed only in combination with vitamin B6 or pyridoxine. Therefore, it is required to be present in magnesium preparations.

The main symptoms of magnesium deficiency in the body:

• headache;
• tachycardia;
• arrhythmia;
• muscle cramps;
• irritability;
• insomnia;
• premenstrual syndrome;
• "lazy bowel" syndrome;
• anxiety and neurasthenic disorders;
• photosensitivity and sensitivity to noise;
• hypertension;
• increased level of platelets in the blood.

Where else can you find magnesium?

Proper and balanced nutrition provides the human body with all the necessary elements. That’s why it’s so important to have in your diet:

• meat
• fish
• fresh fruits;
• dairy products;
• vegetables.

Separately, we can highlight foods rich in magnesium:

• walnuts;
• millet;
• almond;
• oatmeal;
• rice;
• cashew nuts;
• cabbage;
• spinach;

The advantage of consuming magnesium with food is the high degree of absorption of the substance. But nutritionists call the heat treatment of foods the main disadvantage. For example, roasting nuts promotes the breakdown of a certain amount of nutrients, as does cooking cabbage, rice and oatmeal.

Why is it called Magnelis B6

To increase the level of absorption of magnesium, vitamin B6 is required - this is an important assistant that delivers magnesium molecules to their destination. You can buy a pack of 50 tablets for an average of 360 rubles.

Taking magnesium without adding pyridoxine will not give the desired result. Statistics show that people with high levels of anxiety who took Magnesium in combination with vitamin B6, after three weeks, noted improved sleep, an increased ability to fight back stress, ignore outbursts of aggression from others, and be calm about difficulties or personal failures. A group of subjects taking magnesium in its pure form, without an assistant in the form of pyridoxine, even after two months of taking it, did not notice any improvements in the condition of their nervous system.

It must be remembered that you can draw conclusions about taking magnesium no earlier than 2 weeks after starting treatment, since such therapy has a cumulative effect. Within 14 days, the drug will replenish the deficiency of the substance, and only starting from the third week can you reduce the dose and observe the results of treatment.

Children under 6 years of age are advised to take a liquid form of magnesium in the form of a solution. It is taken 10 mg twice a day for the first two weeks. Starting from the third week, take 5 mg twice a day for two to three months. Magnesium is prescribed to children as prophylaxis and general strengthening therapy before the period of adaptation to a preschool institution.

The role of magnesium in a woman’s life

Magnesium is one of the most important microelements, ranking second in content in the cell after potassium. The biological role of magnesium is multifaceted, since it is an essential element of many biochemical processes, such as stabilization of DNA in the processes of mitosis and meiosis, activation of more than 300 enzymes: creatine kinase, adenylate cyclase, phosphofructokinase, K-Na-ATPase, enzymes of protein synthesis, glycolysis, transmembrane ion transport . Magnesium takes an active part in the process of neuromuscular excitability and affects the processes of thermoregulation of the body [1].

Magnesium is indispensable in carbohydrate, protein and lipid metabolism, nucleic acid synthesis; there are at least 500 magnesium-dependent proteins in the human body. It is involved in maintaining the normal function of the nervous and cardiovascular systems; magnesium plays a special role in the processes of membrane transport of calcium and sodium ions in electrically excitable tissues, and its deficiency leads to destabilization of membranes. The effect of magnesium on the cardiovascular system is twofold: participation in the process of blood coagulation as an antithrombotic factor and a direct effect on the heart muscle, since it is a powerful vasodilator, stabilizing the functioning of calcium channels and the rhythm of myocardial contractions [2, 3].

Magnesium is a physiological antagonist of calcium, competing with it on the cell membrane and taking part in the relaxation of muscle fibers. The role of magnesium in osteogenesis is known, since it maintains a normal level of calcium in the bones, promotes the renewal of calcium in them, prevents calcium loss and is extremely necessary for stabilizing energy processes in bone tissue [4, 5].

It has been established that some proteins in osteogenesis are magnesium-dependent, bind fibroblast growth factors and trigger the initial intracellular signal, the synthesis of the signal molecule phosphatidylinositol triphosphate. Consequently, magnesium not only maintains the stability of calcium in the bone, but also, as an independent microelement, ensures osteogenesis and contributes to the physiological strength of bone tissue [6].

The most important causes of magnesium deficiency are:

1. Reduced magnesium consumption: reduced content in “civilized food”, diet courses, alcoholism, parenteral nutrition with a low Mg content.
2. Reduced intestinal resorption: prolonged diarrhea, malabsorption syndrome, inflammatory enteropathies, condition after intestinal resection, reduced resorption due to high calcium intake, protein-rich foods, high fat content in food, large amounts of alcohol.
3. Increased need for magnesium: pregnancy and breastfeeding, increased physical activity (sweating), growth period, recovery period, stress.
4. Increased excretion of magnesium: gastrointestinal disorders - vomiting, prolonged diarrhea, abuse of laxatives; renal diseases - nephrotic syndrome, Barter's syndrome, renal salt loss, renal acidosis; chronic alcoholism, diabetes mellitus, diuretic and cytostatic therapy, anti-tuberculosis drugs.
5. Endocrine disorders: hyperthyroidism, hyperparathyroidism.

In recent years, the frequency of detection of magnesium deficiency among people with various pathological diseases and conditions has been increasing in the world, which proves its connection with a wide range of diseases and pathological conditions associated with endothelial dysfunction, impaired apoptosis, metabolic and hypertensive syndromes, connective tissue pathology, pregnancy, premenstrual and menopausal syndrome, immunity problems [2, 7–10].

According to the International Classification of Diseases (ICD-10), the diagnosis of “magnesium deficiency” is coded as E61.3.

Significant disorders in organs and systems due to magnesium deficiency

Clinical manifestations of magnesium deficiency affect almost all organs and systems. With severe magnesium deficiency, heart rhythm disturbances occur with the development of arrhythmias, disruption of the blood coagulation system, increased cholesterol levels in the blood and accelerated progression of atherosclerosis, headaches, decreased mental performance, irritability and depression, increased risk of bronchospastic conditions, worsened osteoporosis, impaired immune function system, urolithiasis progresses [11–14]. A lack of magnesium in the body leads to a state of increased nervous excitability of the cell, and muscle cells experiencing depolarization disorders undergo an excess of contraction processes in relation to relaxation processes [15–17].

The role of magnesium during pregnancy

During pregnancy, the need for magnesium increases 2–3 times, which is due to an increase in the weight of the uterus from 100 to 1000 g, mammary glands, total blood mass due to an increase in the number of red blood cells by 20–30%, high estrogen levels and an increase in aldosterone levels [ 2, 18–22].

Sufficient provision of the mother’s body with this important element creates the basis for full gestation and the birth of a healthy child [6, 23]. The placenta is characterized by one of the highest levels of magnesium content; it synthesizes more than 150 proteins and hormones, of which 70% are magnesium-dependent. A pregnant woman’s body’s need for magnesium often exceeds its supply, and this circumstance allows us to consider pregnancy as a physiological model of hypomagnesemia [21, 24, 25].

Magnesium deficiency during pregnancy can cause undesirable consequences on both the mother and the fetus: impaired embryo implantation, placental calcification (a consequence of impaired calcium metabolism in conditions of magnesium deficiency), prolonged threat of miscarriage, premature birth, weakness of labor, disorders dilation of the cervix and the period of expulsion during childbirth, symphysiopathy and symphysitis, preeclampsia and eclampsia [12, 16, 23, 26]. The most common manifestations of magnesium deficiency during pregnancy include calf muscle cramps, tremors, writer's cramp, increased uterine tone, and arterial hypertension [2, 17, 23, 27].

The use of inorganic magnesium salts to prolong pregnancy and in the complex therapy of preeclampsia has been well studied. However, their use can result in a number of serious and dangerous complications, such as hot flashes, nausea, headache, decreased heart rate, and acute brain damage in newborns [23, 27, 28]. Inorganic salts and magnesium oxide are poorly absorbed in the gastrointestinal tract and cause dyspepsia [18, 29].

Recently, the drugs of choice for the treatment of chronic magnesium deficiency and long-term prevention of pregnancy complications are organic magnesium salts for oral administration, which are better absorbed, easier to tolerate by patients and produce fewer adverse drug reactions from the gastrointestinal tract [4, 21, 30, 31 ].

One of the promising and most successful drugs used in the treatment and prevention of magnesium deficiency and the threat of premature birth is a preparation of organic magnesium salt, which contains 32.8 mg of elemental magnesium or 500 mg of magnesium orotate [32]. Orotic acid, which is part of the drug, is an intermediary in the biosynthesis of pyrimidines, the synthesis of glycogen and adenosine triphosphate. The effectiveness of magnesium increases when used with so-called magnesium fixatives. Orotic acid in foreign literature is classified as a “Mg-fixing agent”, which promotes the transport of Mg2+ ions into the cell [3, 27, 31, 34].

Magnesium orotate is prescribed 2 tablets 3 times a day for 7 days, then 1 tablet 2-3 times a day. The duration of the course is at least 4–6 weeks [14, 32].

The place of magnesium in the treatment of gynecological diseases

Magnesium preparations have found wide use in the treatment of various gynecological pathologies: premenstrual syndrome with a predominance of psycho-emotional stress (depression, irritability, swelling, pain and engorgement of the mammary glands) [11]. The duration of therapy should be at least 2–3 menstrual cycles and can be continued for much longer [1].

Considering that the magnesium deficiency state is accompanied by increased production of pro-inflammatory cytokines (IL-2, IL-4, IL-5, IL-6, IL-10, IL-12, IL-13, TNF-α), the inclusion of magnesium preparations in complex therapy inflammatory diseases of the genital organs is very reasonable [35–37].

Magnesium deficiency in the body leads to a decrease in the activity of hyaluron synthetases, an increase in the activity of hyaluronidases, which leads to disruption of the metabolism of the gel-like environment of the extracellular matrix, accelerated aging of fibroblasts, a slowdown in the synthesis of collagen and elastin fibers and a deterioration in the mechanical characteristics of tissue [1, 27, 38, 39]. The inclusion of magnesium preparations in the complex of therapeutic measures is pathogenetically indicated for patients with genital prolapse, especially in the prevention of relapses after surgery [26, 40, 41].

One of the most common causes of disturbances in menstrual and reproductive functions against the background of progressive obesity is metabolic syndrome, a particular manifestation of which is polycystic ovary syndrome [12, 42, 43]. Patients with metabolic syndrome have menstrual irregularities such as hypomenstrual syndrome, including amenorrhea, infertility, miscarriage, excess hair growth, and obesity [27].

Magnesium is known to be required for adequate glucose utilization and insulin signaling. The severity of metabolic syndrome manifestations, including insulin levels, is inversely proportional to the level of dietary magnesium intake. Non-insulin-dependent diabetes mellitus is the result of long-term metabolic disorders inextricably linked to chronic magnesium deficiency. Serum magnesium levels in women with diabetes are negatively correlated with blood lipids and the patient's fat mass [44, 45].

At earlier stages of the formation of these disorders, patients often develop asthenia, aggravating existing metabolic disorders [12, 27]. Hypomagnesemia worsens metabolic processes, creating conditions for the formation of clinically pronounced metabolic syndrome [30, 36]. Dietary measures are fundamental in the treatment of patients with metabolic syndrome. To select a diet for such patients, it is necessary to take into account the quantitative content of magnesium in food products and its bioavailability [13, 46, 47]. However, to correct a deep magnesium deficiency, dietary measures alone are not enough; there is a need to use magnesium preparations, for example its organic compound magnesium orotate. The advantages of magnesium orotate over other magnesium preparations lie in its convenient tablet form, which makes it easy to change the dosage of the drug if necessary. In addition, magnesium orotate is safe in therapeutic doses and has virtually no adverse drug reactions [4, 32].

In recent years, it has been established that the symptoms of menopausal syndrome are similar to the symptoms of magnesium deficiency: hot flashes and night sweats, a feeling of pressure in the head and body, muscle and joint pain, paresthesia, headaches, dizziness and fainting, difficulty breathing, loss of sensation in the feet and in the hands. All this justifies the need for magnesium subsidies in this period of a woman’s life. Of course, one should remember about the possibility of developing osteoporosis; it is known about the effect of magnesium preparations on supporting the normal functioning of bone tissue, supporting bone mineral density, since magnesium preserves the matrix on which calcium will rest [6, 13, 24, 48].

Thus, the problem of magnesium deficiency in obstetrics and gynecology is extremely relevant. Chronic magnesium deficiency, which often leads to serious pregnancy complications, can and should be compensated for by oral magnesium supplementation. The use of oral magnesium supplements corrects magnesium deficiency in pregnant women, reduces the risk of miscarriage and eclampsia, and prevents the development of gestational diabetes and obesity. Magnesium orotate should also be included in the complex of treatment measures for patients with metabolic syndrome, polycystic ovary syndrome, connective tissue dysplasia, premenstrual and menopausal syndromes.

Considering the need for long-term use of the drug, the safety and high bioavailability of the magnesium it contains is important; magnesium orotate fully meets all these requirements.

Determining the optimal ways to correct magnesium deficiency and actively prevent complications of magnesium deficiency states remains an important task in obstetrics and gynecology.

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A. Z. Khashukoeva1, Doctor of Medical Sciences, Professor S. A. Khlynova, Candidate of Medical Sciences Z. Z. Khashukoeva, Candidate of Medical Sciences L. A. Karelina

GBOU VPO RNIMU im. N. I. Pirogova Ministry of Health of the Russian Federation, Moscow

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