Diarrhea is an extremely unpleasant disorder that can take both children and adults by surprise. Stopdiar will help eliminate the cause of the disease - harmful bacteria. The drug is distinguished by a variety of dosage forms, the absence of a negative effect on the intestinal microflora and an affordable price.
Medicine Stopdiar - composition
Film-coated tablets. One tablet contains:
- active ingredient nifuroxazide 100 mg;
- excipients: talc , colloidal silicon dioxide , potato starch , gelatin , magnesium stearate ;
- film shell composition: talc , hypromellose , titanium dioxide , polyethylene glycol 20000 , quinoline yellow dye .
Suspension for oral administration, 5 ml of suspension contains:
- active ingredient nifuroxazide 220 mg;
- excipients: carbomer , sucrose , sodium hydroxide , citric acid monohydrate , 30% simethicone antifoam emulsion , methyl parahydroxybenzoate , banana flavor .
Stopdiar (susp. for intravenous administration 220 mg/5 ml 90 ml)
A country
Romania
The country of production may vary depending on the batch of goods. Please check with the operator for detailed information when confirming your order.
Active substance
Nifuroxazide
Compound
Bottle 90 ml
Nifuroxazide 220 mg per 5 ml. Excipients: carbomer - 11 mg, sucrose - 1100 mg, sodium hydroxide - 2.2 mg, citric acid monohydrate - 0.83 mg, simethicone emulsion 30% (antifoam emulsion) - 11 mg, methyl parahydroxybenzoate - 5.5 mg, banana flavor - 4.57 mg, water - up to 5 ml. Suspension for oral administration is light yellow in color, with a banana odor. During storage, sediment may form; after shaking, it returns to the state of a homogeneous suspension.
pharmachologic effect
Nifuroxazide is an antimicrobial agent derived from nitrofuran. Blocks the activity of dehydrogenases and inhibits the respiratory chain, the tricarboxylic acid cycle and a number of other biochemical processes in the microbial cell. Destroys the microbial cell membrane, reduces the production of toxins by microorganisms. Highly active against Campylobacter jejuni, Escherichia coli, Salmonella spp., Shigella spp.; Clostridium perfringens, Vibrio cholerae, pathogenic Vibrions and Vibrio parahaemolytique, Staphylococcus spp. Weakly sensitive to nifuroxazide: Citrobacter spp., Enterobacter cloacae and Proteus indologenes. Resistant to nifuroxazide: Klebsiella spp., Proteus mirabilis, Providencia spp., Pseudomonas spp. Nifuroxazide does not disturb the balance of intestinal microflora. In acute bacterial diarrhea, it restores intestinal eubiosis. When infected with enterotropic viruses, it prevents the development of bacterial superinfection.
Indications for use
Acute bacterial diarrhea, occurring without deterioration in general condition, increase in body temperature, or intoxication.
Mode of application
The drug is used orally. Before taking the drug, shake the bottle several times so that the suspension becomes homogeneous. The drug can be taken with water. Children aged 1 to 6 months: 110 mg (1 small scoop of suspension) 2-3 times a day (interval between doses 8-12 hours). Children aged 6 months to 3 years: 110 mg (1 small scoop of suspension) 3 times a day (interval between doses 8 hours). Children aged 3 to 6 years: 220 mg (1 large scoop of suspension) 3 times a day (interval between doses 8 hours). Children aged 6 to 18 years: 220 mg (1 large scoop of suspension) 3-4 times a day (interval between doses 6-8 hours). Adults: 220 mg (1 large scoop of suspension) 4 times a day (interval between doses 6 hours). The drug Stopdiar should be used for 5-7 days, but not more than 7 days. If there is no improvement within the first 3 days of taking it, you should consult a doctor. The drug should be used only in accordance with the method of application and in the doses indicated in the instructions. If necessary, consult a doctor before using the drug.
Interaction
Concomitant use with drugs that cause the development of disulfiram-like reactions and with drugs that depress the function of the central nervous system is not recommended. If the patient is taking other medications (including over-the-counter medications), you should consult your doctor before using Stopdiar.
Side effect
Allergic reactions: skin rash, urticaria, Quincke's edema, anaphylactic shock.
Contraindications
- hypersensitivity to nifuroxazide, nitrofuran derivatives or any excipients of the drug;
- fructose intolerance, glucose-galactose malabsorption syndrome or sucrase and isomaltase deficiency; - pregnancy; — neonatal period up to 1 month; - prematurity. Use during pregnancy and lactation No teratogenic effect was detected in animal studies. However, as a precaution, taking nifuroxazide during pregnancy is not recommended. During the lactation period, it is possible to continue breastfeeding in case of a short course of treatment with the drug. You should consult your doctor.
Overdose
Overdose symptoms are not known. In case of overdose, symptomatic treatment should be carried out.
special instructions
When treating diarrhea, rehydration therapy must be carried out simultaneously with nifuroxazide therapy. Treatment of diarrhea in children under 3 years of age is recommended under medical supervision. In case of bacterial diarrhea with signs of systemic damage (deterioration of general condition, increased body temperature, symptoms of intoxication or infection), you should consult a doctor to decide on the use of systemic antibacterial drugs. If symptoms of hypersensitivity occur (shortness of breath, rash, itching), you should stop taking the drug. Alcohol consumption is prohibited during therapy. The drug Stopdiar contains sucrose. Patients with rare hereditary disorders of fructose tolerance, glucose-galactose malabsorption, or sucrase and isomaltase deficiency should not take this drug. Due to the content of methyl parahydroxybenzoate, Stopdiar may cause allergic reactions (possibly delayed). 1 small measuring spoon of suspension contains 0.09 XE, 1 large measuring spoon of suspension contains 0.18 XE. The daily dose of the suspension for children aged 1 month to 3 years contains 0.27 XE. The daily dose of the suspension for children aged 3 to 6 years contains 0.54 XE. The maximum daily dose of the suspension for children aged 6 to 18 years contains 0.72 XE. The daily dose of the suspension for adults contains 0.72 XE. Effect on the ability to drive vehicles and machinery The drug does not affect the ability to drive vehicles and machinery.
Pharmacodynamics and pharmacokinetics
The active ingredient Stopdiar nifuroxazide belongs to the group of nitrofurans and, when taken orally, has an antibacterial effect on pathogenic and opportunistic microorganisms that cause intestinal infections. Nifuroxazide is active against gram-positive ( staphylococci, streptococci ) and gram-negative ( salmonella , shigella , klebsiella , Escherichia coli ) bacteria, which are most often the causative agents of intestinal infections.
The action of Stopdiar is associated with the suppression of the action of enzymes involved in the cellular metabolism of infectious agents. Due to metabolic disorders, bacterial cell membranes are destroyed and the cells die.
The activity of Stopdiar against infectious agents does not decrease even with a long course of treatment. At the same time, it does not destroy the beneficial intestinal microflora, therefore, after its use, it takes less time to restore the digestive process than when using antibiotics. The effect of the drug does not depend on the acidity in the intestines.
After ingestion of capsules or suspensions, the active substance is practically not absorbed in the intestines, does not enter the blood and does not have a systemic effect on the body. It acts directly in the intestines and is then excreted from the body naturally through feces.
Mechanism of action of the drug
Due to nifuroxazide, Stopdiar has an antibacterial effect against pathogens of intestinal infections - pathogenic or opportunistic microorganisms.
The medication inhibits the action of enzymes involved in the metabolism of infectious agents at the cell level. As a result of the destruction of cell membranes, bacteria die.
Stopdiar is active against infectious agents during long courses of treatment and does not have a negative effect on the intestinal microflora. The substance is not an antibiotic, so restoration of the gastrointestinal tract after treatment does not take much time.
The main component does not enter the bloodstream, is minimally absorbed in the intestines, and has no systemic effect on the body. The drug gives a therapeutic effect in the intestines and is eliminated from the body naturally.
Contraindications for the use of Stopdiar
Contraindications for the use of tablets:
- allergies to drugs from the group of 5-nitrofuran derivatives ;
- increased sensitivity of the body to other components of the drug;
- age up to seven years.
Contraindications for use of the suspension:
- allergies to drugs from the group of 5-nitrofuran derivatives ;
- increased sensitivity of the body to other components of the drug;
- age up to two months;
- prematurity.
It is recommended to take the medicine with caution during pregnancy and breastfeeding , since clinical trials have not been conducted on these categories of patients.
Side effects of Stopdiar
The drug is usually well tolerated by all patients and only in isolated cases does its side effects appear:
- from the stomach and intestines - transient abdominal pain, nausea may appear, and symptoms of diarrhea will intensify; this does not require interruption of the course of treatment;
- allergic reactions - urticaria , Quincke's edema , breathing problems. In such circumstances, you should stop taking the drug immediately.
special instructions
When treating with Stopdiar, it is important to drink enough fluid to replenish fluid loss due to diarrhea.
Avoid drinking alcoholic beverages due to the risk of a disulfiram-like reaction. If you have an allergic reaction, you should stop taking the medication and consult a doctor.
The ability to drive a car or operate complex machinery is not affected.
If the patient takes several medications, then it is necessary to wait 2-3 hours between doses, since Stopdiar is able to remove another drug from the body and prevent it from being absorbed.
Instructions for use of Stopdiar (Method and dosage)
Instructions for Stopdiar : swallow the tablets without chewing and wash them down with water every 6 hours. Taking Stopdiar does not depend on diet. Adults and children over six years of age should take 200 mg (2 tablets) 4 times a day for a week.
Instructions for Stopdiar - suspension for children : the suspension is given to the child every 6 - 8 hours, without connecting it with feeding; Before use, the bottle is thoroughly shaken to ensure uniformity of the suspension, after which the suspension is dosed using a measuring spoon (1 small measuring spoon per 2.5 ml contains 110 mg of the drug, 1 large measuring spoon per 5 ml - 220 mg). Instructions for children recommend the following age-specific dosages of the drug:
- 1 – 6 months: 110 – 220 mg (1-2 scoops per 2.5 ml) twice a day;
- 6 months - 6 years: 220 mg (1 scoop per 5 ml) three times a day;
- 6 - 18 years and adults: 220 mg (1 scoop per 5 ml) four times a day.
The duration of use of Stopdiar suspension for children should not exceed one week. Treatment should be carried out under the supervision of a physician, since intestinal infection , especially in young children, often leads to dehydration and associated severe complications. Therefore, it is necessary to constantly replenish fluid loss.
How to take Stopdiar
The method and regimen of use depend on the dosage form of the drug.
In accordance with the instructions for use of Stopdiar, tablets are taken 4 times a day with an interval of 6 hours.
Adults and children over the age of seven are prescribed two pieces. The tablets cannot be crushed, they cannot be chewed, but must be swallowed whole and washed down with a sufficient amount of water. The duration of therapy is three days. If symptoms persist, you should see a doctor.
Capsules are prescribed for adults and children over 6 years old, one capsule four times a day, for children 3-6 years old, one capsule three times a day. The course of treatment is three days.
The suspension is taken in accordance with the dosages recommended by the manufacturer:
- adults and children over 6 years old – 5 ml four times a day;
- children from 6 months to 6 years – 5 ml three times a day;
- infants from 2 to 6 months – 2.5-5 ml twice a day.
Before use, the contents of the bottle must be shaken so that the substance becomes homogeneous. Duration of treatment: 5-7 days.
Analogues of Stopdiar
Level 4 ATC code matches:
Levorin
Sangviritrin
Ersefuril
Nifuroxazide
Analogs are drugs from different medicinal groups that are used to treat the same diseases. An analogue of Stopdiar is Furazolidone , a drug from the nitrofuran group, but with a different active ingredient. Furazolidone is one of the first drugs from the group of nitrofuran derivatives, which was prescribed for the treatment of intestinal infections. Its effectiveness is certainly lower than that of Stopdiar.
Synonyms for the drug are Enterofuril, Ersefuril, Diastat, Nifuroxazide . In all these drugs, the active ingredient is nifuroxazide.
Stopdiar price, where to buy
The price of one package of Stopdiar tablets in Moscow ranges from 128 to 158 rubles; Stopdiar suspensions price from 214 to 247 rubles.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Stopdiar susp.
for internal approx. 220mg/5ml 90mlGedeon Richter Romania JSC/JSC Gedeon Richter 349 rub.order - Stopdiar capsules 200 mg 12 pcs. Gedeon Richter Poland LLC
RUB 284 order
- Stopdiar tablets p.p.o. 100 mg 24 pcs. Gedeon Richter Poland LLC
RUB 214 order
Pharmacy Dialogue
- Stopdiar (caps. 200 mg No. 12) Gedeon-Richter
RUB 289 order
- Stopdiar (tablet p/o 100 mg No. 24) Gedeon-Richter
RUB 219 order
- Stopdiar (susp. for intravenous administration 220 mg/5 ml 90 ml) Gedeon-Richter
RUB 356 order
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Pharmacy24
- Stopdiar 200 mg No. 12 capsules TOV "Gedeon Richter Poland", Poland
93 UAH.order
PaniPharmacy
- Stopdiar capsule Stopdiar capsule. 200 mg No. 12 Poland, Gedeon Richter Poland
89 UAH order
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