Stopdiar suspension orally 220 mg/5 ml 90 ml
Compound
Active substance: nifuroxazide 220 mg. Excipients: carbomer, sucrose, citric acid monohydrate, sodium hydroxide, methyl parahydroxybenzoate, 30% simethicone emulsion (antifoam emulsion), banana flavor, water.
Pharmacokinetics
After oral administration, nifuroxazide is practically not absorbed from the gastrointestinal tract and exerts its antibacterial effect exclusively in the intestinal lumen. Nifuroxazide is excreted through the intestines: 20% unchanged, and the rest of nifuroxazide in a chemically modified form.
Indications for use
Acute bacterial diarrhea, occurring without deterioration in general condition, increase in body temperature, or intoxication.
Contraindications
- Hypersensitivity to nifuroxazide, nitrofuran derivatives or any excipients of the drug;
- fructose intolerance, glucose-galactose malabsorption syndrome or sucrase and isomaltase deficiency;
- pregnancy;
- neonatal period up to 1 month;
- prematurity.
Directions for use and doses
The drug is used orally.
Before taking the drug, shake the bottle several times so that the suspension becomes homogeneous. The drug can be taken with water.
- Children aged 1 to 6 months: 110 mg (1 small scoop of suspension) 2-3 times a day (interval between doses 8-12 hours).
- Children aged 6 months to 3 years: 110 mg (1 small scoop of suspension) 3 times a day (interval between doses 8 hours).
- Children aged 3 to 6 years: 220 mg (1 large scoop of suspension) 3 times a day (interval between doses 8 hours).
- Children aged 6 to 18 years: 220 mg (1 large scoop of suspension) 3-4 times a day (interval between doses 6-8 hours).
- Adults: 220 mg (1 large scoop of suspension) 4 times a day (interval between doses 6 hours).
The drug Stopdiar should be used for 5-7 days, but not more than 7 days. If there is no improvement within the first 3 days of taking it, you should consult a doctor.
The drug should be used only in accordance with the method of application and in the doses indicated in the instructions. If necessary, consult a doctor before using the drug.
Storage conditions
The drug should be stored out of the reach of children at a temperature not exceeding 25°C.
Best before date
3 years. Do not use after the expiration date stated on the package. An opened bottle should be stored for no more than 14 days.
special instructions
When treating diarrhea, rehydration therapy must be carried out simultaneously with nifuroxazide therapy.
Treatment of diarrhea in children under 3 years of age is recommended under medical supervision.
In case of bacterial diarrhea with signs of systemic damage (deterioration of general condition, increased body temperature, symptoms of intoxication or infection), you should consult a doctor to decide on the use of systemic antibacterial drugs.
If symptoms of hypersensitivity occur (shortness of breath, rash, itching), you should stop taking the drug.
Alcohol consumption is prohibited during therapy.
The drug Stopdiar contains sucrose. Patients with rare hereditary disorders of fructose tolerance, glucose-galactose malabsorption, or sucrase and isomaltase deficiency should not take this drug.
Due to the content of methyl parahydroxybenzoate, Stopdiar may cause allergic reactions (possibly delayed).
1 small measuring spoon of suspension contains 0.09 XE, 1 large measuring spoon of suspension contains 0.18 XE.
The daily dose of the suspension for children aged 1 month to 3 years contains 0.27 XE. The daily dose of the suspension for children aged 3 to 6 years contains 0.54 XE. The maximum daily dose of the suspension for children aged 6 to 18 years contains 0.72 XE.
The daily dose of the suspension for adults contains 0.72 XE.
Description
Antimicrobial agent - nitrofuran.
Use in children
Contraindicated in newborns under 1 month and premature babies.
Before prescribing the suspension to infants, it is necessary to exclude congenital deficiency of enzymes that break down sucrose.
Pharmacodynamics
Nifuroxazide is an antimicrobial agent derived from nitrofuran. Blocks the activity of dehydrogenases and inhibits the respiratory chain, the tricarboxylic acid cycle and a number of other biochemical processes in the microbial cell. Destroys the microbial cell membrane, reduces the production of toxins by microorganisms.
Highly active against Campylobacter jejuni, Escherichia coli, Salmonella spp., Shigella spp.; Clostridium perfringens, Vibrio cholerae, pathogenic Vibrions and Vibrio parahaemolytique, Staphylococcus spp.
Weakly sensitive to nifuroxazide: Citrobacter spp., Enterobacter cloacae and Proteus indologenes.
Resistant to nifuroxazide: Klebsiella spp., Proteus mirabilis, Providencia spp., Pseudomonas spp.
Nifuroxazide does not disturb the balance of intestinal microflora. In acute bacterial diarrhea, it restores intestinal eubiosis. When infected with enterotropic viruses, it prevents the development of bacterial superinfection.
Side effects
Allergic reactions: skin rash, urticaria, Quincke's edema, anaphylactic shock.
If any of these adverse reactions worsen, or the patient notices any other adverse reactions, he should inform the doctor.
Use during pregnancy and breastfeeding
In animal studies, no teratogenic effect was detected. However, as a precaution, taking nifuroxazide during pregnancy is not recommended.
During the lactation period, it is possible to continue breastfeeding in case of a short course of treatment with the drug.
You should consult your doctor.
Interaction
Concomitant use with drugs that cause the development of disulfiram-like reactions and with drugs that depress the function of the central nervous system is not recommended.
If the patient is taking other medications (including over-the-counter medications), you should consult your doctor before using Stopdiar.
Overdose
Overdose symptoms are not known.
In case of overdose, symptomatic treatment should be carried out.
Impact on the ability to drive vehicles and operate machinery
The drug does not affect the ability to drive vehicles and machinery.
