Nemozol suspension bottle 100mg/5ml 20ml for oral administration

Albendazole has a wide spectrum of antiparasitic (anthelminthic) action. The drug acts selectively, inhibiting the polymerization of betatubulin, and has an ovicidal effect. Active against adults and larvae of cestodes and nematodes, sexually mature trematodes. Allows you to disinfect pastures by destroying helminth eggs.

The drug disrupts microtubular function, interferes with glucose transport, has an inhibitory effect on fumarate reductase in helminths, disrupts muscle innervation and the permeability of cell membranes, which leads to paralysis and death of helminths. Albendazole affects biochemical processes, blocks the movement of secretory granules and other organelles in the muscle cells of roundworms, is effective against larval forms of cestodes Echinococcus granulosus

,
Taenia solium
, nematodes -
Strongyloides stercolatis
.

When administered orally, it is absorbed into the gastrointestinal tract and penetrates into tissues and organs. It is not detected in blood plasma, because it is quickly transformed in the liver into the primary metabolite - albendazole sulfoxide, characterized by anthelmintic activity. Excretion of the substance occurs primarily in bile or urine, unchanged or as metabolites.

At recommended doses, Albendazole is well tolerated by animals and has no sensitizing or hepatotoxic effects.

Indications

For therapeutic and prophylactic purposes for deworming small and large livestock with:

• nematodes - ascariasis, microsporidiosis, hookworm disease, enterobiasis, trichuriasis, strongyloidiasis, opisthorchiasis, giardiasis;
• cestodias;
• trematodes.

The drug is effective against neurocysticercosis - against the larval form of pork tapeworm ( Taenia solium

). It is prescribed for mixed helminthiases, and also as an adjuvant in the surgical removal of echinococcal cysts.

Nemozol suspension bottle 100mg/5ml 20ml for oral administration

A country

India
Country of manufacture may vary depending on the batch of goods. Please check with the operator for detailed information when confirming your order.

Active substance

Albendazole

Compound

The active substance is albendazole.

pharmachologic effect

The main mechanism of action of albendazole is its inhibitory effect on betatubulin polymerization, which leads to the destruction of cytoplasmic microtubules of helminth intestinal tract cells: it changes the course of biochemical processes (suppresses glucose utilization), blocks the movement of secretory granules and other organelles in the muscle cells of roundworms, causing their death. It most effectively affects the larval forms of cestodes - Echinococcus granulosus and Taenia solium, nematodes - Strongyloides stercolatis. Pharmacokinetics: Poorly absorbed in the gastrointestinal tract; unchanged form is not detected in blood plasma, because quickly turns into the primary metabolite in the liver - albendazole sulfoxide, which also has anthelmintic activity. Bioavailability when taken orally is low, about 30%. Eating fatty foods increases absorption and maximum concentration (5 times). The maximum concentration of albendazole sulfoxide is reached after 2-5 hours, 70% bound to plasma proteins, and almost completely distributed throughout the body; found in urine, bile, liver, in the wall of the cyst and cystic fluid, cerebrospinal fluid. Albendazole sulfoxide in the liver is converted into albendazole sulfone (secondary metabolite) and other oxidized products. The half-life of albendazole sulfoxide is 8-12 hours. It is excreted in the form of various metabolites in the urine. Renal excretion of albendazole and its main metabolite, albendazole sulfoxide, is insignificant; clearance does not change in patients with impaired renal function. Against the background of liver damage, bioavailability increases, maximum the concentration of albendazole sulfonide increases 2 times, the half-life is extended. Albendazole is an inducer of microsomal enzymes of the cytochrome P-450 system: it accelerates the metabolism of many drugs.

Indications for use

Nematodes (ascariasis, enterobiasis, hookworm disease, necatoriasis, trichocephalosis, etc.). Mixed helminthic infestations. Strogyloidosis, neurocysticercosis caused by the larval form of the pork tapeworm (Taenia solium); echinococcosis of the liver, lungs, peritoneum, caused by the larval form of the canine tapeworm (Echinococcus granulosus). As an adjuvant in the surgical treatment of echonococcal cysts. Giardiasis and toxocariasis.

Mode of application

The drug is taken orally during meals. It is recommended to treat all family members simultaneously. The standard dosage for the treatment of roundworm infestation for adults and children over 2 years of age is 400 mg or 20 ml of suspension orally once; neurocysticercosis and echinococcosis: patients weighing 60 kg or more - 400 mg 2 times a day, less than 60 kg - 15 mg/kg per day in 2 divided doses; maximum daily dose - 800 mg; course of treatment: for neurocysticercosis - 8-30 days, for echinococcosis - 3 cycles of 28 days with a 14-day break between cycles. For giardiasis in children, 10-15 mg/kg once a day for 5-7 days. For toxocariasis - adults and children over 14 years of age, weight more than 60 kg - 400 mg 2 times a day for 7-14 days, less than 60 kg - 200 mg 2 times a day for 7-14 days, for children - 10 mg/kg 2 times a day 7 -14 days.

Interaction

Dexamethasone and cimetidine increase the concentration of albendazole sulfoxide in the blood.

Side effect

Impaired liver function with changes in liver function tests (weak or moderate increase in transaminase levels), inhibition of bone marrow hematopoiesis (leukopenia, granulocytopenia, agranulocytosis, thrombocytopenia, pancytopenia), fever, abdominal pain, nausea, vomiting, headache, dizziness, meningeal symptoms, increased blood pressure, acute renal failure, reversible alopecia, skin rash, itching and other allergic reactions.

Contraindications

Individual intolerance (including to other benzimidazole derivatives), damage to the retina, pregnancy.

Overdose

Treatment; symptomatic, gastric lavage, activated carbon.

special instructions

Use with caution in cases of hematopoietic disorders, liver dysfunction (before and during treatment, its functions are regularly monitored), breastfeeding. In women of childbearing age, a pregnancy test is performed before starting treatment. Reliable contraception is required during therapy. Patients with neurocystocircosis should receive appropriate therapy with steroids and anticonvulsants. Oral or intravenous corticosteroids are used to prevent a hypertensive attack during the first week of anticyst therapy. Blood tests should be performed at the beginning of each 28-day cycle and every 2 weeks during albendazole therapy. It is possible to continue treatment with albendazole if the decrease in total leukocytes and neurotrophil leukocytes is moderate and does not progress.

Dispensing conditions in pharmacies

On prescription

Medications

As of 05.2020, 23 albendazole medicinal products with different trade names were registered in the Russian Federation. You can buy albendazole in various dosage forms, for example:

• Alben S
  - (Produced by NVC Agrovetzashchita LLC, Russia, 129329, Moscow) - a combined preparation of albendazole (250 mg) and praziquantel (25 mg) in the form of tablets for oral use. Prescribed to dogs and cats for therapeutic and prophylactic purposes for nematodes (toxocariasis, toxacaridiasis, uncinariasis, hookworm disease), cestodiasis (taeniasis, dipylidiasis, echinococcosis, diphyllobothriasis, mesocestoidosis) and giardiasis.
• HELMICIDE tablets
  - (Produced by NVC Agrovetzashchita LLC, Russia, 1229329, Moscow) - a combined preparation of albendazole (360 mg) and oxyclozanide (175 mg) in the form of tablets for oral administration. HELMICIDE tablets are used for deworming large and small cattle with the following diseases: trematodes (acute and chronic fascioliasis, paramphistomiasis, dicroceliosis); nematodes of the gastrointestinal tract (haemonchiasis, esophagostomiasis, nematodirosis, bunostomiasis, stertagiasis, habertiosis, cooperiosis, strongyloidiasis, trichostrongylosis, trichocephalosis, neoascariasis); nematodes of the lungs (dictyocaulosis, protostrongylidosis, mulleriosis, cystocaulosis); cestodoses (moniesiosis, avitellinosis, tyzaniesiosis).
• Closalben 10 and 20
  - (Produced by VIK - Animal Health LLC, Russia, 140050, Moscow region, Lyubertsy) - a combined preparation of closantel (50 mg or 100 mg, respectively) and albendazole (50 mg or 100 mg, respectively) in powder form for oral use. Prescribed to cattle, sheep, goats, deer for fascioliasis, moniesiosis, edemagenosis, dictyocaulosis, ostertagiasis, hemonchiosis, dicroceliosis, trichostrongylosis, cooperiosis, esophagostomosis, as well as for cattle hypodermatosis, estrosis and psoroptosis in sheep. Closalben 10 and 20 are approved for use during pregnancy in animals.
• Alvet
  - (Produced by LLC NITA-PHARM, 410010, Saratov) - single-drug albendazole (200 mg) in the form of granules. Prescribed for therapeutic and prophylactic purposes to cattle, sheep, horses, pigs, dogs and poultry for nematodes, cestodes, trematodes.
• Albendazole 10% granulate
  - (Produced by Domestic LLC NPK Askont+, Moscow region, Serpukhov district, Obolensk) - a single preparation of albendazole 10% in the form of granular powder for oral use for deworming farm animals and birds. Prescribed for nematodes, trematodes, cestodes.
• Albendazole suspension
  - (Produced by LLC NPP "Agropharm"; Russia, 394061, Voronezh region, Voronezh) - a single drug of albendazole in the form of a suspension for oral use, available in two concentrations of 2.5% and 10%. Albendazole suspension 2.5% is used in cattle, goats and sheep, and Albendazole suspension 10% is used in cattle for therapeutic and prophylactic purposes for nematodes, tremotodiases and cestodiases, incl. bunostomosis, cooperiosis, hemonchosis, nematodirosis, esophagostomosis, ostertagiasis, strongyloidiasis, trichostrongylosis, habertiosis, dictyocaulosis, protostrongylosis, mulleriosis, moniesiosis, avitellinosis and chronic fasciolosis.
• Febtal®-combo
  - (manufactured by Otechestvenny LLC "AVZ S-P", Sergiev Posad) - a combined anthelmintic drug of praziquantel (5 mg) and albendazole (50 mg) in the form of a suspension for oral use for nematodes and cestodiases (toxocariases, toxascariasis , uncinariasis, trichocephalosis, hookworm disease, taeniasis, dipylidiasis, echinococcosis, diphyllobothriasis, mesocestoidosis) and associative nematodo-cestodiasis infestations of dogs and cats. Febtal Combo should not be used by pregnant or lactating animals, as well as puppies and kittens under 3 weeks of age.
• REPTILIFE suspension
  - (Produced by NVC Agrovetzashchita LLC, Russia, 1229329, Moscow) - a combined preparation of albendazole (25 mg) and praziquantel (10 mg) in the form of a suspension for oral use. REPTILIFE suspension is prescribed to turtles, lizards and snakes for prophylactic and therapeutic purposes against nematodes and cestodiases. Should not be used during laying or pregnancy (viviparous reptiles).

Recommended storage conditions for the drugs are in sealed manufacturer's packaging, in a place protected from light, at a temperature of no more than 25℃. More accurate information is provided on the packaging of drug manufacturers.

Doses and method of administration

Alben S

Apply to dogs and cats individually, orally (orally). For helminthiasis, a single dose of 1 tablet per 5 kg of animal weight in the morning feeding with a small amount of food. For giardiasis and helminthiasis complicated by giardiasis, Alben S is used in a dose of 1 tablet per 10 kg of animal weight once a day for 5 days in a row.

HELMICIDE

tablets are administered to animals individually once orally (orally) in the following doses (number of tablets per animal weight):

• for fascioliasis, dicroceliosis, paramphistomiasis and ostertagiasis: for cattle - 1 tablet per 35 kg, for sheep and goats - 1 tablet per 45 kg;
• for cestodiases and nematodes (excluding ostertagiasis): for cattle - 1 tablet per 50 kg, for sheep and goats - 1 tablet per 70 kg.

Closalben 10 and 20

used for helminthiases and gadfly infestations individually or in groups once. The drug is administered as a mixture with food or force-fed in the form of an aqueous suspension from a bottle. For psoroptosis in sheep, Closalben 10 and 20 are used twice with an interval of 7 days, and for prophylactic purposes - once.

• for gadfly infestations and helminthiasis, Closalben 20 at the rate of 40 mg per 1 kg of animal weight, and Closalben 10 at the rate of 80 mg per 1 kg of animal weight.
• for sheep psoroptosis: Closalben 20 – 100 mg/kg animal weight, and Closalben 10 – 200 mg/kg animal weight.

Alvet

administered orally individually or in a group method once, adding to the feed of cattle, sheep, pigs, horses and dogs, and poultry - twice. For group administration, a portion of the drug for a group of no more than 150 sheep is thoroughly mixed with feed (at the rate of 50-100 g of feed per animal).

• for monienosis, pulmonary and gastrointestinal nematodes: for cattle - at a dose of 3.75 g per 100 kg of animal weight (7.5 mg/kg according to the DV), sheep - 2.5 g per 100 kg of animal weight (5.0 mg/kg according to DV);
• for chronic fascioliasis: for cattle - at a dose of 5.0 g per 100 kg of animal weight (10.0 mg/kg according to DV), for sheep - at a dose of 3.75 g per 100 kg of animal weight (7.5 mg/kg according to DV);
• for horses with parascariasis, strongylidosis (alfortiosis, delafondiosis), anoplocephalosis and cyathostomosis, use individually at a dose of 3.75 g per 100 kg of animal weight (7.5 mg/kg according to the DV);
• in pigs, the drug is used for ascariasis and esophagostomiasis in a group method with concentrated feed in the morning feeding at a dose of 5.0 g per 100 kg of animal weight (10.0 mg/kg according to the DV). The drug, in a dose designed for a group of no more than 50 pigs, is mixed with half the daily feed intake;
• for dogs, the drug is used individually for nematodes at a dose of 0.375 g per 10 kg of animal weight (7.5 mg/kg according to the DV), for cestodes at a dose of 0.75 g per 10 kg of animal weight (15 mg/kg according to the DV);
• For farm poultry, the drug is used for ascariasis and heterokidosis for 2 days in a row in a group method - by adding it to the mixed feed in the morning feeding at a dose of 0.5 g per 10 kg of bird weight (10.0 mg/kg according to the DV).

Albendazole 10%

The granulate is used individually or in groups mixed with food. Cattle, sheep, horses and poultry twice. The drug is administered in the following doses:

• for gastrointestinal and pulmonary nematodes of cattle - 75 mg/kg body weight; sheep - 50 mg/kg body weight. When administering albendazole to sheep in a group, the drug is dosed per group of no more than 150 heads, mixing it with feed - 50-100 g of feed per individual;
• for chronic fascioliasis in cattle - 100 mg/kg body weight; sheep - 75 mg/kg body weight;
• for esophagostomiasis and ascariasis in pigs, the drug is mixed with half the daily norm of concentrated feed at a dose of 100 mg/kg of animal weight. Medicinal food is created for a group of no more than 50 animals and is introduced into the morning feeding;
• for anoplocephalidosis and cyathostomosis, parascariasis, strongyliasis, delafondiosis, alfortiosis, horses, the drug is administered individually - 75 mc/kg body weight;
• for ascariasis, heteracidosis and mixed ascariasis-heteracidosis, birds choose the group method. According to the instructions for use of albendazole, the medicine is administered in mixture with feed for 2 days in a row in the morning at a daily dose of 100 mg/kg of bird weight.

Albendazole

the suspension is administered once, individually, orally using a syringe dispenser:

• for moniesiosis, gastrointestinal and pulmonary nematodes in cattle - 3 ml per 10 kg (7.5 mg/kg weight according to the DV), small cattle - 2 ml per 10 kg of weight (5 mg/kg weight according to the DV) ;
• in the treatment of chronic fascioliasis in cattle - 4 ml per 10 kg of weight (10 μg of weight according to the DV), small cattle - 3 ml per 10 kg of weight (7.5 mg/kg of weight according to the DV);
• for esophagostomiasis and ascariasis in pigs - 2 ml per 10 kg of weight (5 mg/kg of weight according to the DV).

Febtal®-combo

applied to animals individually, once in the morning feeding with a small amount of food or forcefully on the root of the tongue, the dose is calculated as 1 ml of suspension per 1 kg of weight.

REPTILIFE suspension

. The drug is used individually, orally (orally) using a dosing syringe at the rate of 1 ml of suspension per 1 kg of reptile weight, 2-3 times with an interval of 14 days.

I. General information

1. Trade name of the drug: Albendazole 100 (Albendasol 100).
International nonproprietary name: albendazole.

2. Dosage form: suspension for oral use.

Albendazole 100 as an active ingredient in 1 ml contains 100 mg of albendazole, and as auxiliary components - 1 mg of polysorbate 80, 1 mg of benzoic acid, 1 mg of fellow potassium, 5 mg of carboxymethylcellulose, 60 mg of glycerin and water for injection up to 1 ml. In appearance, the drug is a suspension from milky white to light gray.

3. Albendazole 100 is produced in 1,000 ml polyethylene bottles with screw caps.

4. Store the medicinal product in the manufacturer’s sealed packaging, in a dry place, protected from direct sunlight, separately from food and feed, at a temperature of 5°C to 25°C.

The shelf life of the medicinal product, subject to storage conditions in the manufacturer's closed packaging, is 2 years from the date of production. Do not use Albendazole 100 after the expiration date.

5. Albendazole 100 should be kept out of the reach of children.

6. Unused medicinal product is disposed of in accordance with legal requirements.

II. Pharmacological properties

7. Albendazole 100 is a broad-spectrum anthelmintic drug.

Albendazole, which is part of the drug, has a wide spectrum of anthelmintic action, is active against the adults and larvae of nematodes, trematodes, as well as sexually mature forms of cestodes; has an ovicidal effect, which reduces the infestation of pastures with helminth eggs.

The mechanism of action of albendazole is to disrupt the processes of glucose transport, microtubular function and reduce the activity of helminth fumarate reductase, disrupt the permeability of cell membranes and muscle innervation, which causes paralysis and death of parasites.

When administered orally, albendazole is absorbed from the gastrointestinal tract and penetrates into organs and tissues; the maximum concentration in blood serum is observed 18-25 hours after application. Albendazole is excreted from the body mainly in urine and bile in unchanged form and in the form of metabolites.

In terms of the degree of impact on the body, Albendazole 100 is classified as a moderately hazardous substance (hazard class 3 according to GOST 12.1.007-76).

III. Application procedure

8. Albendazole 100 is used in cattle, sheep, goats and pigs for the treatment and prevention of nematodes, trematodes and cestodiases, including dictyocaulosis, protostrongyliasis, hemonchiasis, ostertagiasis, trichostrongyliasis, bunostomosis, nematodirosis, cooperiosis, esophagostomiasis, habertiosis, moniesiosis, a also chronic fascioliasis.

9. The use of Albendazole 100 is not allowed for dicraceliosis and acute form of fascioliasis, during the hunting period, pregnant cows in the first third of pregnancy, pregnant sheep, goats and pregnant sows in the first half of pregnancy, as well as patients with infectious diseases and emaciated animals.

10. Albendazole 100 is administered to animals once orally, in the following doses:

— for cattle with moniesiosis, pulmonary and gastrointestinal nematodes – 0.75 ml per 10 kg of animal weight (7.5 mg per 1 kg of animal weight according to the DV); for chronic fascioliasis - 1 ml per 10 kg of animal weight (10 mg per 1 kg of animal weight according to the DV);

— sheep and goats for moniesiosis, pulmonary and gastrointestinal nematodes – 0.5 ml per 10 kg of animal weight (5 mg per 1 kg of animal weight according to the DV); for chronic fascioliasis - 0.75 ml per 10 kg of animal weight (7.5 mg per 1 kg of animal weight according to the DV);

- pigs with ascariasis and esophagostomosis - 0.5 ml per 10 kg of animal weight (5 mg per 1 kg of animal weight according to the DV).

Before use, the drug in the vial must be shaken thoroughly.

Before mass treatments, each series of Albendazole 100 is preliminarily tested on a small group of animals (10-15 animals), which are monitored for 3 days. In the absence of side effects, the drug is administered to the entire livestock.

11. In case of an overdose of the drug, the animal may experience anorexia, impaired coordination of movement, and lethargy. In this case, the use of the drug is stopped and symptomatic treatment is prescribed.

12. The specific effects of the drug upon first taking the drug and upon its withdrawal have not been established.

13. The drug is used once. Animals do not require a special diet or use of laxatives before deworming.

14. As a rule, there are no side effects or complications when using Albendazole 100 in accordance with these instructions. If allergic reactions occur, stop using the drug and prescribe the animal antihistamines and symptomatic therapy.

15. Albendazole 100 should not be used simultaneously with other antiparasitic drugs, as well as dexamethasone and cimetidine.

16. Slaughter of animals for meat is permitted no earlier than 20 days after the use of Albendazole 100. Meat of animals forcedly killed before the expiration of the specified period can be used as feed for fur-bearing animals. Milk from dairy cows is allowed to be used for food purposes no earlier than 7 days after the last administration of the drug. Milk obtained earlier than the specified period can be used as animal feed after boiling.

IV. Personal prevention measures

17. When working with Albendazole 100, you should follow the general rules of personal hygiene and safety precautions provided for when working with medications. After finishing work, wash your hands with warm water and soap.

18. In case of accidental contact of the drug with the skin or mucous membranes of the eyes, they must be rinsed with plenty of water. People with hypersensitivity to the components of the drug should avoid direct contact with Albendazole 100. In case of allergic reactions or if the drug accidentally enters the human body, you should immediately contact a medical facility (have instructions for use of the drug or label with you).

19. Empty medicinal product containers must not be used for household purposes; they must be disposed of with household waste.

Place of manufacture: Wuqi Intersection, Shijiazhuang, Hebei Province, 050041, China.

The instructions were developed by Gordonos, 7B, Agios Georgios Chavouzas, PC 3070, Limassol, Cyprus in collaboration with Hebei Yuanzheng Pharmaceutical Co., Ltd., Wuqi Intersection, Shijiazhuang, Hebei Province, 050041, China.

Waiting times for livestock products

For the drug Alben S there is no waiting period for livestock products.

HELMICIDE tablets – obtaining meat products is permitted no earlier than 21 days after deworming. When slaughtered earlier than the established deadline, the meat is used as feed for fur-bearing animals. Milk from dairy animals cannot be used for food purposes for 4 days after deworming. Milk obtained earlier than the established period can be used in animal feed after boiling.

Closalben 10 and 20 – production of meat products is permitted no earlier than 20 days after the end of taking the drug. Animal meat obtained before the end of the specified period is used to feed fur-bearing animals. Closalben 10 and 20 should not be given to dairy animals whose milk is intended for human consumption.

Alvet - slaughter of animals for meat is permitted no earlier than 20 days, birds - no earlier than 5 days after taking the drug. Meat from animals killed before the end of this period can be used as feed for fur-bearing animals. Milk from dairy animals must not be consumed for 4 days after taking Alvet. Milk obtained before the expiration of this period, after heat treatment, can be used to feed animals.

Albendazole 10% granulate - obtaining animal meat is allowed no earlier than 20 days, poultry meat - no earlier than 5 days after taking the drug. Meat products received before the end of the specified period are permitted for use as feed for fur-bearing animals. Milk can be used for food no earlier than 4 days after administration of the drug to dairy animals. Before this period expires, milk can be used as animal feed after boiling.

Albendazole suspension - slaughter of animals for meat after taking the drug is permitted no earlier than 20 days. Meat from animals killed ahead of schedule is allowed to be used to feed fur-bearing animals. Milk from dairy animals cannot be used for food purposes within 7 days after taking Albendazole suspension. Milk obtained earlier than the established deadline can be used as animal feed after heat treatment.

There are no waiting periods for the drug Febtal®-combo for livestock products.

REPTILIFE suspension is not intended for use in productive animals.