Pharmacological properties
Antimicrobial agent, nitrofuran derivative. Blocks the activity of dehydrogenases and inhibits the respiratory chain, the tricarboxylic acid cycle and a number of other biochemical processes in the microbial cell. Destroys the microbial cell membrane, reduces the production of toxins by microorganisms. Highly active against Campilobacter jejuni, Escherichia coli, Salmonella spp., Shigella spp., Clostridium perfringens, Vibrio cholerae pathogenic Vibrions and Vibrio parahaemolyticus, Staphylococcus spp.
Weakly sensitive to nifuroxazide: Citrobacter spp., Enterobacter cloacae and Proteus indologenes. Resistant to nifuroxazide: Klebsiella spp., Proteus mirabilis, Providencia spp., Pseudomonas spp.
Does not disturb the balance of intestinal microflora. In acute bacterial diarrhea, it restores intestinal eubiosis. When infected with enterotropic viruses, it prevents the development of bacterial superinfection.
Pharmacokinetics
After oral administration, nifuroxazide is practically not absorbed from the digestive tract and exerts its antibacterial effect exclusively in the intestinal lumen. Nifuroxazide is excreted by the intestines: 20% unchanged, and the remaining amount of nifuroxazide is chemically modified.
What threat does diarrhea pose?
Pathogenic microorganisms, entering the gastrointestinal tract in large quantities, begin to multiply quickly. During their life, toxins are released, which lead to inflammation of the intestinal mucosa and disruption of its function - the absorption of water and nutrients. Microbes, destroying beneficial microflora in the body, aggravate the course of the disease.
Microbes destroy beneficial microflora in the body
Diarrhea poses the main threat - dehydration, especially in children; due to physiological characteristics, they quickly lose critical volumes of fluid. Violation of the water-salt balance is fraught with the development of irreversible pathological processes, therefore, when the first signs of diarrhea occur, it is necessary to drink plenty of fluids - this is one of the main stages of treatment.
Directions for use and doses
Inside. For dosing, a double-sided measuring spoon is used, with a volume of 2.5 ml on one side and 5 ml on the other side. The suspension must be shaken well before use.
Children aged 1-6 months: 2.5 ml 2 or 3 times a day (with an interval of 8-12 hours).
Children aged 6 months to 3 years: 2.5 ml 3 times a day (interval between doses 8 hours).
Children aged 3 to 6 years: 5 ml 3 times a day (interval between doses is 8 hours). Children from 6 to 18 years old: 5 ml 3-4 times a day (interval between doses 6-8 hours).
Adults: 5 ml 4 times a day (interval between doses 6 hours).
The duration of treatment is 5-7 days, but not more than 7 days. If there is no improvement within the first three days, you should consult a doctor. The drug should be used according to the method of application and in the doses indicated in the instructions. If necessary, you should consult your doctor before using the drug.
Ecofuril Oral suspension 200 mg/5 ml 90 ml bottle
Registration Certificate Holder
ABVA RUS (Russia)
Dosage form
Medicine – Ecofuril® (Ecofuril)
Description
Oral suspension
yellow, homogeneous, with a characteristic odor.
5 ml
nifuroxazide 200 mg
Excipients
: maltitol - 350 mg, lactulose - 300 mg, povidone K90 - 25 mg, xanthan gum - 20 mg, banana flavor - 10 mg, methyl parahydroxybenzoate - 5 mg, sodium citrate dihydrate - 0.015 mg, anhydrous citric acid - 0.001 mg, purified water - until a suspension of 5 ml is obtained.
90 ml - Dark glass bottles with a capacity of 100 ml (1) complete with a dosing spoon - cardboard packs.
Indications
Acute diarrhea of bacterial origin (in the absence of suspicion of invasion).
Contraindications for use
Hypersensitivity to nitrofuran derivatives.
Do not use in newborns (under 1 month of age) and premature infants.
pharmachologic effect
A broad-spectrum antimicrobial agent for the treatment of gastrointestinal infections (intestinal antiseptic), a nitrofuran derivative. In high doses it has a bactericidal effect, in lower doses it has a bacteriostatic effect.
Active against gram-positive bacteria: Staphylococcus spp., Streptococcus spp.; gram-negative bacteria: Salmonella spp., Shigella spp., Proteus spp.
Drug interactions
Concomitant use of ethanol may cause hypersensitivity symptoms.
Dosage regimen
Adults - 200 mg 4 times a day. Children aged 1 month to 2.5 years - 100 mg 2-3 times a day; over 2.5 years - 200 mg 3 times a day. The duration of treatment is no more than 7 days.
Side effect
Maybe:
allergic reactions.
special instructions
The use of nifuroxazide does not eliminate the need for rehydration therapy if there are symptoms of dehydration.
Before use in children older than 1 month, congenital deficiency of enzymes that break down sucrose should be excluded.
Use during pregnancy and breastfeeding
Restrictions during pregnancy - No restrictions. Restrictions when breastfeeding - No restrictions.
It is possible to use nifuroxazide during pregnancy and lactation (breastfeeding) according to indications.
Use in children
Restrictions for children - With caution.
Do not use in newborns (under 1 month of age) and premature infants. Children aged 1 month to 2.5 years are prescribed 100 mg 2-3 times a day; over 2.5 years - 200 mg 3 times a day. The duration of treatment is no more than 7 days.
special instructions
When treating diarrhea, rehydration therapy must be carried out simultaneously with nifuroxazide therapy. Treatment of diarrhea in children under 3 years of age should be carried out under medical supervision. In case of bacterial diarrhea with signs of systemic damage (deterioration of general condition, increased body temperature, symptoms of intoxication or infection), you should consult a doctor to decide on the use of systemic antibacterial drugs.
If symptoms of a hypersensitivity reaction appear (skin rash and itching, difficulty breathing, shortness of breath), you should stop taking the drug.
Due to the content of methyl parahydroxybenzoate, the drug may cause allergic reactions (possibly delayed).
Drinking alcohol during therapy with nifuroxazide is prohibited.
Impact on the ability to drive vehicles and perform work that requires increased concentration and speed of psychomotor reactions
The drug does not have a negative effect on the ability to drive vehicles and/or other mechanisms.
Causes
In order to effectively cope with diarrhea, it is necessary to identify the cause of this pathology.
One of the most common types is infectious diarrhea. Pathogenic bacteria enter the intestines when eating spoiled or poor-quality food and contaminated water.
Traveling abroad can cause diarrhea
Traveling abroad, especially to warm countries, or changing your permanent place of residence can also be possible causes of loose stools. This type of diarrhea is classified as traveler's diarrhea. In order not to spoil the impressions of a long-awaited vacation, it is recommended to adhere to certain rules: be careful when choosing unfamiliar food, drink bottled water, do not forget about personal hygiene, use hand sanitizer if necessary, and also be sure to take medicines for diarrhea with you on your trip.
To prevent diarrhea from taking you by surprise, it is good to have a modern and convenient antidiarrheal drug on hand. Ecofuril is a remedy for the treatment of diarrhea, aimed at eliminating the root cause of the disease and its symptoms. An antimicrobial active substance in combination with a prebiotic eliminates not only the cause of the infection that caused diarrhea, but also promotes the development of its own beneficial microflora.
Non-infectious diarrhea is often a consequence of chronic inflammation of the intestinal mucosa (enterocolitis), irritable bowel syndrome. Frequent stressful situations can also provoke chronic intestinal diseases and can cause loose stools.
Diarrhea not only disrupts your normal routine, but can also lead to even more serious health problems.
Which drugs to choose for the treatment of diarrhea?
The pharmacy offers a huge number of drugs for the treatment of diarrhea. To understand which drug may be right for you, you need to ask a few simple questions:
- How does it work: on the cause or symptoms?
- How does the drug affect the microflora (does it contain a prebiotic or not)?
- Is it suitable for the whole family (“for children”, “adults”, “release form”, etc.)?
Not all medications for diarrhea can be prescribed to children
When selecting medications for diarrhea, you should be careful, since not all of them can be prescribed to children. Some of them have contraindications and restrictions for use in children, so it is important to first read the instructions for the drug.
Treatment methods
Treatment of diarrhea always involves complex therapy, including several groups of drugs acting in different directions.
Antimicrobial agents are the main group of drugs in the treatment of infectious diarrhea, acting directly on the bacteria that cause poisoning. It is recommended to use drugs of the nitrofuran series, which quickly and effectively cope with most pathogens of intestinal infections, are not absorbed and do not have a systemic effect (which is very important in the presence of concomitant diseases or in children), and do not suppress the growth of intestinal microflora. One of these drugs is Ecofuril, which, in addition to the antimicrobial component, contains a prebiotic. "Ecofuril" not only eliminates the cause of the infection that caused diarrhea, but also promotes the development of its own beneficial microflora. It should be noted that the sooner treatment of diarrhea with antimicrobial drugs is started, the faster the effect will occur.
Pro- and prebiotics contain cultures of lacto- and bifidobacteria or a substrate for their rapid growth and development. With diarrhea, the amount of normal microflora in the body decreases; preparations rich in lacto- and bifidobacteria help restore balance in the gastrointestinal tract and normalize digestion. Prebiotics can be prescribed in the second stage of therapy, after antimicrobial drugs, as a restorative treatment. However, the effectiveness of treatment increases with the combined use of antimicrobial drugs and prebiotics.
Electrolytes. Violation of the water-salt balance leads to the loss of a large amount of minerals. Electrolytes are mandatory in the treatment of diarrhea. You can fill the deficiency of substances with the help of special medications. Ready-made mixtures are available in pharmacies and are extremely easy to use. Before use, they must be diluted in water and taken often in small portions, along with plenty of fluids.
Sorbents. Enterotoxins are the main cause of bloating and diarrhea. When they enter the gastrointestinal tract, they have a toxic effect on the body. Adsorbents have the property of selective absorption, and like a sponge, they actively absorb waste products of pathogenic microorganisms. However, the effect of using sorbents is short-term; upon completion of their action, the symptoms of intestinal disorder return again.
Symptomatic remedies are antispasmodics and drugs that reduce intestinal motility. By relaxing the intestines, antispasmodics reduce the severity of pain. Drugs that inhibit intestinal motility reduce the contractile activity of the intestine and reduce the speed of movement of feces through it. This reduces the severity of diarrhea and pain. These groups of drugs are also not treatment. As soon as their effect wears off, all the symptoms return again. Moreover, agents that inhibit peristalsis are not recommended for infectious diarrhea, especially those occurring with an increase in body temperature, since they slow down the elimination of pathogens from the body.
