Compound
The drug tablets contain the active component pyrantel , as well as additional components: methyl parahydroxybenzoate, gelatin, acacia gum, starch, sodium carboxymethyl starch, talc, magnesium stearate, propyl parahydroxybenzoate, colloidal silicon dioxide.
Pyrantel suspension contains the active component pyrantel , as well as additional components: sucrose, xanthan gum, sorbic acid, polysorbate 80, methyl parahydroxybenzoate, sorbitol solution 70%, propyl parahydroxybenzoate, flavorings, purified water.
Side effects
During treatment, the following side effects may occur:
- nervous system: drowsiness , headache , dizziness , insomnia ;
- digestive system: vomiting, diarrhea , periodic abdominal cramps , anorexia , tenesmus ;
- skin and subcutaneous tissue: urticaria , rash ;
- hepatobiliary system: increased levels of liver enzymes;
- other manifestations: feeling of weakness, increased fatigue.
Instructions for use of Pirantel (Method and dosage)
The product is used according to doctor's indications.
Pyrantel suspension, instructions for use
The suspension for children is used according to indications; it must be shaken before taking. Patients with ascariasis and enterobiasis are prescribed an average dose of 10–12 mg per 1 kg of weight in one dose. Children after 6 months should receive syrup at a dose of 2.5 ml per 10 kg of weight in one dose. Adult patients (up to 75 kg) receive 15 ml per dose. If a person’s weight exceeds 75 kg, you need to drink 20 ml of the product at one time.
To improve the effectiveness of the treatment of enterobiasis, you should very carefully adhere to all the rules of personal hygiene. It is recommended to conduct another course of therapy after three weeks.
For patients with hookworm in endemic areas or with severe infestation, the drug is prescribed based on a dosage of 20 mg per 1 kg of weight for 2 or 3 doses, treatment lasts 2-3 days.
The dosage per day is calculated as follows:
- children after 6 months receive 5 ml of syrup per 10 kg of weight;
- with a weight of up to 75 kg - 30 ml of syrup per day;
- with a weight of 75 kg - 40 ml of syrup per day.
Under conditions of mild infestation of Ankylostoma duodenale, sometimes it is enough to take a single dose of 10 mg per 1 kg.
Pirantel tablets, instructions for use
Adults are usually prescribed Pirantel in tablets. It should be taken before or during the use of food. The tablet is chewed and washed down with plenty of liquid.
How to take Pirantel for children depends on their body weight and age:
- at the age of 2-6 years, 250 mg of the drug is indicated;
- at the age of 6-12 years - 500 mg;
- children over 12 years of age and adult patients weighing up to 75 kg - 750 mg;
- adults whose weight exceeds 75 kg - 1000 mg.
If only infection with a human nematode is noted, you should take Pyrantel 5 mg per 1 kg of weight in one tablet.
For patients with enterobiasis and ascariasis, as well as with mixed infestations, the dose intended for the entire course is administered once (10 mg per 1 kg).
Patients with hookworm disease are advised to take the same dose for three days.
In case of massive infestations of Necator americanus, a dose of 20 mg/kg is indicated for two days.
You should ask your doctor for more information about how many days to take the drug, how to take tablets and suspension for adults and children for treatment, as well as for prevention for adults and children.
Pyrantel 250mg/5ml 15ml oral suspension Poland
pharmachologic effect
Anthelmintic. Causes neuromuscular blockade of sensitive helminths. Active against Enterobius vermicularis, Ancylostoma duodenale, Necator americanus and, to a lesser extent, Trichocephalus trichiurus. It affects both sexually mature and immature individuals of both sexes.
Composition and release form Pirantel 250mg/5ml 15ml suspension for oral administration Poland
Suspension - 5 ml: pyrantel (in the form of embonate) 250 mg.
15 ml - dark glass bottles (1) complete with measuring cap - cardboard packs.
Directions for use and doses
For ascariasis and enterobiasis, use a single dose of 10 mg/kg. When necatoriasis is combined with ascariasis or other combined helminthic lesions, use for 3 consecutive days at a dose of 10 mg/kg/day or for 2 days at a dose of 20 mg/kg/day.
Pharmacokinetics
Practically not absorbed from the gastrointestinal tract. After taking a single dose of 10 mg/kg, the plasma concentration is 0.005-0.13 mcg/ml and is achieved within 1-3 hours. It is partially metabolized in the liver to N-methyl-1,3-propanediamine. It is excreted unchanged through the intestines (about 93%), 7% is excreted by the kidneys unchanged or as a metabolite.
Indications for use Pirantel 250mg/5ml 15ml oral suspension Poland
Ascariasis, hookworm disease, necatoriasis, trichocephalosis.
Contraindications
Pregnancy, hypersensitivity to pyrantel, myasthenia gravis (treatment period).
Use of Pyrantel 250 mg/5 ml 15 ml oral suspension Poland during pregnancy and lactation
Pyrantel is contraindicated for use during pregnancy.
If it is necessary to use it during lactation, the issue of stopping breastfeeding should be decided.
Use in children
Prescribe with caution to children under 6 months of age.
special instructions
Use with caution in case of liver failure.
After taking pyrantel, laxatives are not prescribed.
In case of enterobiasis, simultaneous treatment of all persons living together should be carried out. After completion of treatment, it is necessary to conduct a control stool examination for the presence of parasite eggs.
Prescribe with caution to children under 6 months of age.
Side effects Pirantel 250mg/5ml 15ml oral suspension Poland
From the digestive system: nausea, vomiting, diarrhea, anorexia, increased activity of liver transaminases.
From the central nervous system and peripheral nervous system: headache, hallucinations, confusion, paresthesia, dizziness, drowsiness or insomnia.
Dermatological reactions: skin rash, urticaria.
Other: hearing impairment, hyperthermia.
Drug interactions
Should not be administered concomitantly with piperazine (decreased effect).
With simultaneous use, pyrantel increases the concentration of theophylline in plasma.
Overdose
In case of an overdose of the drug, the patient may experience the following negative manifestations: nausea, vomiting , diarrhea , anorexia . But it should be borne in mind that pyrantel is poorly absorbed in the body, which is why signs of intoxication appear very rarely even with a significant overdose. If there is such a need, gastric lavage is prescribed; there is no specific antidote. It is important to monitor the functions of blood vessels, heart, and respiratory system.
special instructions
The drug is prescribed with caution to people who have impaired liver function. During therapy, you should not abstain from eating or take laxative medications. This does not determine how quickly the drug works.
The drug is prescribed for simultaneous administration to all members of the family who live together. You should consider how to give the suspension or tablets to your child and follow the instructions. After completion of the study, the patient's stool is examined.
To prevent re-infection, it is important to carefully adhere to hygiene rules.
Sometimes during treatment, weakness, drowsiness , and dizziness . This should be taken into account when driving or when working with precision mechanisms.
The drug is not prescribed to people undergoing treatment for myasthenia gravis .
How long the drug takes to work depends on the diagnosis and the individual characteristics of the course of the disease.
How worms after using the drug depends on the disease.
Pyrantel is also used to treat animals. The dosage for cats and the dosage for dogs should only be determined individually by a veterinarian.
Pyrantel oral suspension 250 mg/5 ml, 15 ml bottle (Ozone - Atoll)
Registration Certificate Holder
ATOLL (Russia)
Dosage form
Medicine - Pyrantel
Description
Oral suspension
light yellow in color, with a characteristic odor; separation into a liquid layer and sediment is allowed; after shaking, a homogeneous suspension is formed.
5 ml
pyrantel pamoate 721 mg, which corresponds to the content of pyrantel 250 mg
Excipients
: sodium benzoate - 15 mg, carmellose sodium - 15 mg, sorbitol 70% (non-crystallizing) - 3605 mg, glycerol - 303.5 mg, magnesium aluminum silicate - 16.5 mg, polysorbate 80 - 10 mg, povidone K25 - 100 mg, citric acid monohydrate - 1.5 mg, simethicone emulsion - 2.5 mg, fruit flavoring - 2.5 mg, water - up to 5 ml.
5 ml - bottles (1) complete with a measuring cup or measuring spoon - cardboard packs. 10 ml - bottles (1) complete with a measuring cup or measuring spoon - cardboard packs. 15 ml - bottles (1) complete with a measuring cup or measuring spoon - cardboard packs. 25 ml - bottles (1) complete with a measuring cup or measuring spoon - cardboard packs.
Indications
- ascariasis;
- enterobiasis;
- hookworm disease (including necatoriasis).
Contraindications for use
- hypersensitivity to pyrantel and other components of the drug;
- myasthenia gravis;
- liver failure;
- children under 6 months.
Carefully:
children's age from 6 months to 6 years and body weight less than 10 kg.
pharmachologic effect
An anthelmintic drug that causes a neuromuscular blockade of helminths sensitive to it and ensures their expulsion without exciting or stimulating the migration of affected worms. It affects both sexually mature and immature individuals of both sexes. Active against Enterobius vermicularis, Ascaris lumbricoides, Ancylostoma duodenale, Necator americanus.
Drug interactions
The simultaneous use of levamisole and piperazine is not recommended. Increases the concentration of theophylline in plasma.
Dosage regimen
For oral administration.
The suspension is shaken before use.
1 ml of suspension contains 50 mg of pyrantel.
Pyrantel can be taken at any time of the day, not necessarily on an empty stomach. Before and after taking the drug, laxatives are not used.
Ascariasis, enterobiasis:
For enterobiasis, as well as mixed invasions (enterobiasis and ascariasis), the dose intended for the entire course (at the rate of 10 mg/kg body weight) is applied once.
Children from 6 months to 2 years:
2.5 ml suspension (125 mg);
Children from 2 years of age weighing more than 12 kg to 6 years of age:
5 ml suspension (250 mg);
Children from 6 to 12 years old:
10 ml suspension (500 mg);
Children over 12 years of age and adults weighing less than 75 kg:
15 ml suspension (750 mg);
Adults weighing more than 75 kg
: 20 ml suspension (1000 mg).
To prevent re-infection, it is recommended to repeat the drug after 3 weeks.
For isolated ascariasis - 5 mg/kg once.
Hookworm:
In endemic areas, in case of infection with Necalor americanus or in case of severe infection with Ancylostoma duodenale, the dosage is 20 mg/kg/day (in one or two doses) for two to three days.
In case of infection with Ancylostoma duodenale outside endemic zones (it occurs more easily), a dose of 10 mg/kg is used at a time.
Overdose
Symptoms:
increased dose-dependent side effects.
Treatment:
symptomatic therapy.
Side effect
From the gastrointestinal tract:
nausea, vomiting, abdominal pain, diarrhea, loss of appetite, increased activity of “liver” transaminases.
Allergic reactions:
itching, urticaria, skin rash.
From the nervous system:
headache, dizziness, weakness, drowsiness, insomnia, hallucinations, confusion, paresthesia.
From the organ of hearing and labyrinthine disorders:
hearing impairment.
Other:
hyperthermia.
special instructions
No special preparation or diet is required when using the drug Pirantel.
If you have existing liver diseases, you must notify your doctor. It should be remembered that before using the drug Pirantel, like any other anthelmintic drug, you should thoroughly clean the room, wash children's toys, take a shower before and after bedtime, and change your underwear. It is advisable to iron bed linen with a hot iron during the days of treatment and for several days after taking the drug. To avoid re-infection, it is necessary to strictly follow the rules of hygiene: wash your hands, trim and clean your nails, avoid scratching in the perineal area, change bedding and underwear daily. Thorough cleaning of living quarters and clothes to destroy helminth eggs serves to prevent reinfection. Treatment of all persons living together is recommended at the same time. Infection often may not cause any symptoms. After completion of treatment, it is necessary to conduct a control stool examination for the presence of helminth eggs. Impact on the ability to drive vehicles and operate machinery
During the treatment period, you should refrain from driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.
Storage conditions
The drug should be stored in a place protected from light and out of reach of children at a temperature not exceeding 25°C.
Best before date
Shelf life: 3 years. Do not use the drug after the expiration date.
Use during pregnancy and breastfeeding
Restrictions during pregnancy - With caution. Restrictions during breastfeeding - Contraindicated. During pregnancy, use only if the expected benefit to the mother outweighs the potential risk to the fetus. If it is necessary to use the drug during lactation, breastfeeding should be stopped.
Use for liver dysfunction
Restrictions for liver dysfunction - Contraindicated.
The use of the drug in patients with liver failure is contraindicated.
Use in children
Restrictions for children - With caution.
The use of the drug in children under 6 months of age is contraindicated.
Use the drug with caution in children aged 6 months to 6 years and weighing less than 10 kg.
Terms of sale
The drug is available with a prescription.
Pyrantel's analogs
Level 4 ATC code matches:
Helmintox
Analogues of this remedy are the following drugs: Nemotsid , Helmintox , Pyrantel pamoate , which contain a similar active ingredient.
Medicines have a similar effect on the body: Vermox , Biltricid , Vormin , Dekaris , etc.
Which is better: Decaris or Pirantel?
Decaris is an anthelmintic agent that has a similar effect. The drug Dekaris has more contraindications, side effects are almost the same as when using Pirantel. It is believed that Pirantel is more preferable for treating children.
Which is better: Vermox or Pyrantel?
Vermox is a broad-spectrum drug. It is especially effective against enterobiasis and trichuriasis . Which of the two drugs is preferred should be determined taking into account individual characteristics.
Which is better: Nemozol or Pirantel?
Nemozol is a drug with a wide spectrum of effects; it eliminates most known types of parasites. But only a doctor should select the medicine.
Pyrantel (suspension)
- Precautionary measures The medicine contains sorbitol. Patients with rare hereditary diseases - fructose intolerance - should not take this medicine. The drug should be prescribed with caution to patients with impaired liver function and children under 2 years of age. During the treatment of myasthenia gravis, Pirantel should not be prescribed. The drug can be used at any time of the day (not necessarily on an empty stomach). The use of the drug does not require the simultaneous administration of laxatives. For enterobiasis, the drug should be prescribed to all family members. To prevent re-infection, it is necessary to strictly follow the rules of hygiene (wash hands, trim and clean nails, avoid scratching the perineal area, change bedding and underwear daily). 14 days after use it is necessary to conduct a control parasitological study. Pyrantel suspension is more effective against infection with duodenal hookworm (Ancylostoma duodenale) than with American hookworm (Necator americanus). The drug contains 2.6% ethanol (ethyl alcohol), that is, up to 31.25 mg in 1 ml. This must be taken into account by pregnant women and nursing mothers, children, as well as patients at high risk, incl. with liver diseases and epilepsy. It is dangerous to use in patients suffering from alcoholism. In young children (up to 2 years) and children aged 2-5 years, the use of a medicinal product containing ethanol must be justified. Considering the immaturity of enzymatic systems, the potential for ethanol accumulation, and the lack of information about potential toxicity, the benefits of use must outweigh the risks.
Use of the drug in elderly people There is no information on the effect of age on the effect of pyrantel in geriatric patients.
Pregnancy and lactation Data on the use of pyrantel during pregnancy in humans are insufficient to exclude all possible risks. The drug can be used during pregnancy only if absolutely necessary, after a careful assessment by the doctor of the balance of benefit to the mother and risk to the fetus. Breastfeeding should be stopped during treatment.
Effect on the ability to drive vehicles and operate machinery In some cases, dizziness may occur while taking the drug, so care should be taken when performing work that requires rapid psychomotor reactions.
Pirantel price, where to buy
The price of Pirantel suspension 15 ml is, on average, 60 rubles. The cost may be slightly lower or higher. The price of Pyrantel tablets depends on the packaging and manufacturer. On average, buy a pack of 3 tablets. possible at a price of 30 to 40 rubles.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Pyrantel Susp.
for internal approx. 250mg/5ml 15mlPharmaceutical plant POLFARMA JSC Medan Department in Sieradz 62 rub.order
Pharmacy Dialogue
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Pharmacy24
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PaniPharmacy
- PYRANTEL liquid Pyrantel suspension 0.25g 15ml Poland, Medana Pharma SA
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Directions for use and doses
Inside, during or after meals.
Enterobiasis, ascariasis and mixed invasions: once 10 mg/kg.
| Age | Drug dose, mg | Number of measures (1 measure=5 ml) |
| Children 6 months – 2 years | 125 | 1/2 scoop = 2.5 ml |
| Children 2 years – 6 years | 250 | 1 measure = 5 ml |
| Children 6 years – 12 years | 500 | 2 measures = 10 ml |
| Children over 12 years of age and adults weighing less than 75 kg | 750 | 3 measures = 15 ml |
| Adults weighing more than 75 kg | 1000 | 4 scoops = 20 ml |
Hookworm: 10 mg/kg/day for 3 days.
Necatoriasis: 20 mg/kg for 2 days (for severe forms).
