Panangin Forte is a Hungarian drug produced by the Gedeon Richter company. The medicine is used to improve the metabolic processes of myocardial tissue, treat diseases such as arrhythmia, atherosclerosis, arterial hypertension, and as an auxiliary therapy for coronary heart disease, accompanied by attacks of angina and other symptoms. Panangin forte contains a higher concentration of active components in its composition, unlike classic Panangin, therefore it acts more efficiently and quickly.
Description of the drug and its composition
The product is produced in the form of oval tablets, their surface is slightly glossy, biconvex. The color is white or grayish-white, odorless. The medicine is available in blisters placed in cardboard packaging. One package of the product contains 60 capsules. Each tablet is engraved “A83”.
Like the classic remedy, Panangin Forte includes potassium, magnesium and auxiliary components. The tablet core consists of potassium (316 mg) and magnesium (280 mg). The capsule shell consists of macrogol-6000, butyl methacrylate copolymer, titanium dioxide.
Compound
1 film-coated tablet contains:
280 mg magnesium aspartate (as 350 mg magnesium aspartate tetrahydrate);
316 mg potassium aspartate (as 332.6 mg potassium aspartate hemihydrate);
excipients: silicon dioxide colloidal povidone K-30; potato starch; magnesium stearate talc corn starch;
film shell: macrogol 6000; titanium dioxide (E 171) main copolymer of butylated methacrylate (eudragit E); talc.
Properties of Panangina forte
Thanks to the use of the medicine, it is possible to have a positive effect on the cardiovascular system and the entire body as a whole. Potassium and magnesium are valuable components that play a critical role in the formation of connections between intracellular structures and macromolecules in the mechanism of contractility of human muscle tissue. When the balance of potassium, sodium, magnesium and calcium ions in the body is disturbed, the functioning of the myocardium deteriorates, which leads to the development of hypertension, atherosclerosis, arrhythmias, cardiac conduction disorders and other heart failures.
Panangin Forte helps to establish metabolic processes, improves the contractile function of the heart muscle, and restores the tone of the nerve and muscle structures of the myocardium. In addition, the magnesium content in the preparation helps improve the enzyme reactions of the heart, which ensures normal contractility of the organ and reduces the heart's need for oxygen. Magnesium also prevents the development of coronary disease and is an excellent prevention of many complications in heart and vascular diseases.
Who is Panagin recommended for?
Panangin. Pills
Panangin is recommended for medicinal purposes:
- For cardiac arrhythmia (irregular heart rhythm) caused by electrolyte disturbances, mainly due to potassium deficiency in the blood
- For heart rhythm disturbances caused by intoxication with digitalis products
- For atrial rhythm disturbances
- For ventricular rhythm disturbances
- For coronary insufficiency
- For arterial hypertension
For disorders of myocardial metabolism, the cause of which is impaired blood circulation through the blood vessels of the myocardium and a decrease in the concentration of potassium in the blood as a result of taking diuretics. Panangin is recommended for all healthy people over the age of 45 for the purpose of nutrition and strengthening the heart and preventing cardiovascular pathologies.
Indications for use
Taking Panangin forte is recommended for patients suffering from the following diseases:
- lack of potassium, magnesium, caused by vitamin deficiency and other conditions;
- coronary heart disease with manifestations of tachycardia and arrhythmia. For such patients, the medicine is prescribed as an auxiliary therapy in combination with treatment with other drugs;
- myocardial infarction in the acute stage to increase myocardial metabolism;
- myasthenia gravis, chronic form of heart failure;
- heart rhythm disturbances;
- arrhythmias provoked by the use of cardiac glycosides.
Panangin forte is used to treat heart disease
Self-administration of the medicine is unacceptable. The drug has a number of contraindications and is prescribed by a specialist based on the patient’s medical history and diagnosis.
Important! Patients who have previously taken Panangin should take into account when switching to Panangin Forte that the product contains an increased concentration of active ingredients.
Contraindications
Instructions for use contain a description of diseases for which the use of the drug is prohibited. These include:
- personal intolerance to the active or auxiliary components of the drug;
- serious kidney pathologies, including chronic as well as acute failure;
- excess magnesium and potassium. The use of the drug can provoke hyperkalemia, hypermagnesemia;
- any diseases accompanied by dehydration;
- violation of amino acid metabolism;
- severe cases of myasthenia gravis;
- cardiogenic shock;
- heart block;
- the patient's age is under 18 years;
- Addison's disease;
- severe liver diseases.
Panangin Forte is prescribed to women during pregnancy with extreme caution, especially in the first 3 months of pregnancy. The decision to take medication during lactation is made solely by the attending physician if the expected benefit outweighs the risk of developing negative consequences.
Difference from classic Panangin
Many patients are interested in what is the difference between Panangin and Panangin Forte? In Latin, the word forte means strong, strengthened, durable. It is included in the name of drugs that have an enhanced effect, including an increased concentration of active components.
If we conduct a comparative analysis of the composition of Panangin and Panangin Forte, it is clear that the second version of the medicine contains a larger number of active components.
Panangin contains:
- magnesium – 175 mg;
- potassium – 166 mg.
Panangin forte contains:
- magnesium – 350 mg;
- potassium – 332 mg.
In addition to the composition, the difference from Panangin fortified drug lies in the packaging. Regular Panangin is packaged in plastic tubes. Panangin forte is produced in capsules. There is also a noticeable difference in the price of these two drugs. Panangin Forte is more expensive.
Panangin and Panangin Forte have the same composition and action
It is impossible to unequivocally answer which is better, a classic or enhanced drug. The doctor should select the remedy, taking into account the characteristics of the disease and the client’s personal preferences.
What side effects does Panangin cause?
Due to its high quality and unique action, medical workers and patients who have completed the course of the drug express positive reviews about Panangin and note its good tolerability. In rare cases, there are complaints of nausea, vomiting, discomfort and burning in the pancreas. When taking the drug in large doses over a long period of time, hyperkalemia and hypermagnesemia may develop.
Dosage and method of administration
Let's look at how to take the product. Typically, Panangin Forte is prescribed to patients 2-3 capsules throughout the day at equal intervals. The medicine cannot be chewed; it must be washed down with plain water.
Depending on the patient's condition, the doctor may adjust the dose and how long to take the drug. During therapy, the patient should not independently change the dosage or combine the drug with other medications.
Important! Take the medicine after meals, as stomach acid can reduce the effectiveness of the drug and interfere with the absorption of the active ingredients.
Side effects and symptoms of overdose
Negative phenomena can be caused by improper use or overdose of the drug. In this case, the patient’s condition is accompanied by the following symptoms:
- increased vomiting;
- the appearance of pain in the epigastric region;
- symptoms of potassium and magnesium overdose (muscle weakness, headaches, stomach pain, apathy);
- hyperemia of the skin of the face, neck;
- dysfunction of the respiratory system;
- muscle cramps;
- feeling of thirst.
The development of an overdose is indicated by the following manifestations:
- heart rhythm disturbances;
- fast fatiguability;
- feeling overwhelmed;
- muscle weakness;
- feeling of goosebumps running through the body;
- disturbance of consciousness.
If used incorrectly, there is a risk of overdose
In especially severe cases, lethargic sleep and coma may develop. Treatment is usually carried out with symptomatic therapy, sometimes hemodialysis is necessary.
Special instructions and drug interactions
The drug is prescribed by the attending physician if the patient has indications. Special instructions include the following:
- during pregnancy, treatment is carried out under the close supervision of a specialist. Panangin forte is used only when necessary;
- since the active components of the medication are able to penetrate into mother’s milk, the drug is not used during lactation;
- The drug is not prescribed to patients with elevated potassium concentrations in the blood;
- Do not combine Panangin Forte with alcohol;
- There is no data on the effect of the drug on the ability to drive vehicles and operate complex mechanisms.
Drug interactions:
- simultaneous use of Panangin forte with potassium-sparing diuretics, beta-blockers, ACE inhibitors, non-steroidal anti-inflammatory drugs increases the risk of potassium overdose;
- when treated with anesthetics, magnesium may have a negative effect on the central nervous system;
- therapy with enveloping and astringent drugs reduces the effectiveness of Panangin Forte.
These and other features of the drug should be taken into account when prescribing the medicine. Failure to comply with special instructions and contraindications of the drug can lead to the development of serious consequences.
Panangin forte 60 pcs. film-coated tablets
pharmachologic effect
Potassium and magnesium preparation.
Composition and release form Panangin forte 60 pcs. film-coated tablets
Tablets - 1 tablet:
- Active ingredients: potassium aspartate 316.00 mg (in the form of potassium aspartate hemihydrate 332.60 mg), magnesium aspartate 280.00 mg (in the form of magnesium aspartate tetrahydrate 350.00 mg);
- Excipients: corn starch 172.20 mg, talc 20.00 mg, magnesium stearate 8.00 mg, potato starch 6.60 mg, povidone KZO 6.60 mg, colloidal silicon dioxide 4.00 mg;
- Tablet shell: talc 7.30 mg, butyl methacrylate copolymer 6.00 mg, titanium dioxide (color index: CI 77891, E171) 5.30 mg, macrogol-6000 1.40 mg.
15 tablets in a blister made of PVC/PVDC and aluminum foil. 2, 4, 6 blisters along with instructions for use are placed in a cardboard box.
Description of the dosage form
Oval, biconvex, film-coated tablets, white or almost white, with a slightly glossy surface, engraved “A83” on one side, almost odorless. On a cross section it is white or almost white in color.
Directions for use and doses
Before use, you should consult your doctor.
Take orally, without chewing and with plenty of water.
Panangin Forte should be taken after meals, because... the acidic environment of the stomach reduces its effectiveness.
Recommended daily dose: 1 tablet 3 times a day. Maximum daily dose: 1 tablet 3 times a day.
Pharmacodynamics
The most important intracellular cations of potassium (K+) and magnesium (Mg++) play a key role in the functioning of numerous enzymes, in the formation of bonds between macromolecules and intracellular structures and in the mechanism of muscle contractility. The intra- and extracellular ratio of potassium, calcium, sodium and magnesium ions affects myocardial contractility. Endogenous aspartate acts as a conductor of ions: it has a high affinity for cells, due to the slight dissociation of its salts, ions in the form of complex compounds penetrate into the cell. Magnesium aspartate and potassium aspartate improve myocardial metabolism.
Lack of magnesium/potassium predisposes to the development of arterial hypertension, atherosclerosis of the coronary arteries, arrhythmias and metabolic changes in the myocardium.
Each tablet of the drug Panangin Forte contains 280 mg of magnesium aspartate and 316 mg of potassium aspartate, which is 2 times higher than the content of active ingredients in the drug Panangin, film-coated tablets. The daily dose of the drug Panangin Forte: 1 tablet 3 times a day, corresponds to the daily dose of the drug Panangin: 2 tablets 3 times a day. Taking a single dose of Panangin Forte in the form of one tablet makes treatment more convenient for the patient.
Pharmacokinetics
Potassium and magnesium aspartates are intensively absorbed in the intestine, mainly in the small intestine. Excreted by the kidneys.
Indications for use Panangin forte 60 pcs. film-coated tablets
To eliminate potassium and magnesium deficiency as part of combination therapy for various manifestations of coronary heart disease (including acute myocardial infarction); chronic heart failure; heart rhythm disturbances (including arrhythmias caused by an overdose of cardiac glycosides).
Contraindications
Hypersensitivity to any of the constituent components of the drug, acute and chronic renal failure, hyperkalemia, hypermagnesemia, Addison's disease, atrioventricular block I-III degree, shock (including cardiogenic) (blood pressure less than 90 mm Hg), metabolic disorders amino acids, myasthenia gravis, hemolysis, acute metabolic acidosis, dehydration state, age under 18 years (efficacy and safety have not been established). Pregnancy (especially in the first trimester of pregnancy) and the period of breastfeeding.
Application of Panangin forte 60 pcs. film-coated tablets during pregnancy and breastfeeding
Use is possible if the potential benefit to the mother outweighs the possible risk to the fetus.
Potassium and magnesium aspartate pass into breast milk. If it is necessary to take the drug during breastfeeding, breastfeeding should be stopped.
special instructions
Patients with diseases accompanied by hyperkalemia require special attention: regular monitoring of potassium levels in the blood plasma is necessary.
Overdose
The risk of symptoms of hyperkalemia and hypermagnesemia increases.
Symptoms of hyperkalemia: increased fatigue, myasthenia gravis, paresthesia, confusion, cardiac arrhythmia (bradycardia, atrioventricular block, arrhythmias, cardiac arrest).
Symptoms of hypermagnesemia: decreased neuromuscular excitability, nausea, vomiting, lethargy, decreased blood pressure.
With a sharp increase in the content of magnesium ions in the blood: inhibition of deep tendon reflexes, respiratory paralysis, coma.
Treatment: symptomatic therapy - intravenous administration of calcium chloride at a dose of 100 mg/min, if necessary - hemodialysis.
Side effects Panangin forte 60 pcs. film-coated tablets
Possible nausea, vomiting, diarrhea, discomfort or burning sensation in the epigastric region (in patients with anacid gastritis or cholecystitis), atrioventricular block, paradoxical reaction (increased number of extrasystoles), hyperkalemia (nausea, vomiting, diarrhea, paresthesia), hypermagnesemia (redness of the face , feeling of thirst, decreased blood pressure, hyporeflexia, respiratory depression, convulsions).
If any of the side effects listed become serious, or you notice side effects not listed in this leaflet, you should consult your doctor.
Drug interactions
Pharmacodynamic interaction
When used together with potassium-sparing diuretics (triamterene, spironolactone), beta-blockers, cyclosporine, heparin, angiotensin-converting enzyme (ACE) inhibitors, and non-steroidal anti-inflammatory drugs, the risk of developing hyperkalemia up to the development of arrhythmia and asystole increases. The simultaneous use of potassium supplements with glucocorticosteroids eliminates the hypokalemia caused by the latter. Potassium reduces the undesirable effects of cardiac glycosides. Panangin Forte enhances the negative dromo- and bathmotropic effects of antiarrhythmic drugs. Magnesium reduces the effects of neomycin, polymyxin B, tetracycline and streptomycin. Anesthetics increase the inhibitory effect of magnesium preparations on the central nervous system; when used simultaneously with atracuronium, decamethonium, succinyl chloride and suxamethonium, neuromuscular blockade may be enhanced. Calcitriol increases the content of magnesium in the blood plasma, calcium supplements reduce the effects of magnesium supplements.
Pharmacokinetic interaction
Medicines that have an astringent and enveloping effect reduce the absorption of magnesium aspartate and potassium aspartate in the gastrointestinal tract, therefore it is necessary to maintain a three-hour interval between oral administration of Panangin Forte with the above medications.
What do the doctor's say
Reviews from cardiologists about the drug are mostly positive. Here are a few of them:
Antonina Vladimirovna, cardiologist “A good remedy that enriches the body with essential microelements. Like other drugs, it should be used only as prescribed by a doctor; self-medication is unacceptable. Panangin works especially well for heart pathologies, as well as in the treatment of muscular-tonic syndrome in patients over 55 years of age. Should be used with caution in patients with low blood pressure."
Anton Stanislavovich, cardiologist “I consider taking Panangin forte justified only when the lack of potassium and magnesium in the body is confirmed by laboratory tests, as well as among those patients who have signs of hypokalemia and hypomagnesemia. For example, while taking diuretics, with severe vomiting, prolonged loose stools. I would strictly not recommend drinking this medicine as a vitamin supplement. Self-medication is extremely dangerous.”
Svetlana Ivanovna, cardiologist “I prescribe Panangin to many of my patients to improve the condition of the myocardium in various cardiac pathologies, as well as to prevent complications in various conditions. I consider this remedy relatively safe if you follow the basic recommendations and do not self-medicate.”
Patient reviews
Margarita, Pyatigorsk “Saw Panangin Forte after a heart attack. The tablets are a little expensive, but the effect is worth it. The drug is sold in a large, convenient package, which was enough for me for the whole course. I don’t know if Panangin or the other medications I took worked, but the effect suited me, since after 2 weeks I was at home.”
Nadezhda, Noginsk “I have been taking diuretics for a long time to lower blood pressure. A few months ago, painful cramps appeared, the doctor prescribed me Asparkam. After 2 weeks of use, the seizures recurred. After this, the specialist recommended that I switch to the more expensive drug Panangin Forte. I completed a course of treatment and forgot about the seizures; in addition, my overall health improved.”
Marina, Moscow “I bought Panangin Forte for my mother-in-law, as she suffers from night cramps, pressure surges, and swelling of the legs. I know that this drug is prescribed in the complex treatment of many heart diseases, to normalize the heart rate. In addition to my mother-in-law, my friend is taking the medicine and is very pleased with it. There were no side effects, the condition improved after 2 weeks of use.”
Note!
Description of the drug Panangin forte table. p/o 280 mg/316 mg No. 60 on this page is a simplified author’s version of the apteka911 website, created on the basis of the instructions for use.
Before purchasing or using the drug, you should consult your doctor and read the manufacturer's original instructions (attached to each package of the drug). Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.
