Tabex, 100 film-coated tablets

pharmachologic effect

The drug is an N-cholinomimetic. It has an exciting effect on the nicotinic receptors of the autonomic ganglia, has a reflex stimulating effect on the respiratory center, promotes the release of adrenaline , and increases blood pressure .

As a result, Tabex effectively reduces the body's dependence on nicotine . Under the influence of the drug, the taste of smoking becomes unpleasant for a person. Gradually the desire to smoke decreases. The drug helps reduce withdrawal syndrome , which is associated with quitting nicotine.

In general, the effect of cytisine is close to the mechanism of action of nicotine. This allows you to gradually stop smoking and significantly reduce the intensity of withdrawal symptoms.

Pharmacodynamics

The alkaloid cytisine, which is the active substance of the drug, has an n-cholinomimetic effect; excites the ganglia of the autonomic nervous system, reflexively stimulates the respiratory center, causes the release of adrenaline from the adrenal medulla, and increases blood pressure.

While closely similar to the mechanism of action of nicotine, cytisine has much lower toxicity and a greater therapeutic index.

Cytisine competitively inhibits the interaction of nicotine with the corresponding receptors, which leads to a gradual decrease and disappearance of nicotine addiction.

Pharmacodynamics and pharmacokinetics

The pharmacokinetics of Tabex have not been studied in humans. Wikipedia indicates that data on the pharmacokinetics of the drug appeared as a result of animal studies. The substance Cytisine is absorbed from the gastrointestinal tract quickly, but not completely. In mice, after oral administration of the drug, the degree of resorption is 42%, in rabbits - 34%. When administered orally, the highest concentration in mice was achieved after 2 hours, in rabbits - after 35 minutes. The maximum plasma concentration of cytisine is observed in the kidneys , liver , and adrenal glands .

The half-life of the drug taken intravenously in mice is 200 minutes, 18% of the dose taken orally was eliminated in mice over 24 hours. In rabbits, the half-life after intravenous administration is 37 minutes.

Tabex contains cytisine , the effect of which on the body is similar to that of nicotine.

Contraindications for Tabex

The drug should not be taken by those who have hypersensitivity to cytisine or other components of this drug. Contraindications to Tabex are observed in those people who suffer from certain physical and mental illnesses. In particular, contraindications for smoking pills are observed in the following diseases:

• acute form of myocardial infarction ;
• arrhythmias;
• angina pectoris;
• circulatory disorders in the brain;
• bleeding from large vessels;
• atherosclerosis;
• arterial hypertension;
• exacerbation of duodenal and gastric ulcers ;
• pulmonary edema;
• bronchial asthma.

Doctors prescribe Tabex and its analogues with caution to patients with schizophrenia , coronary heart disease , diabetes mellitus , chromaffin tumors of the adrenal glands , gastroesophageal disease , hyperthyroidism , as well as patients with renal and liver failure .

For children and people over 65 years of age, the drug is prescribed only after assessing how the benefits and potential risks compare.

Tabex 1.5 mg 100 pcs. pills

pharmachologic effect

N-cholinomimetic.

Composition and release form Tabex 1.5 mg 100 pcs. pills

Film-coated tablets - 1 tablet:

• active substance: cytisine - 1.5 mg;
• excipients: lactose monohydrate - 28 mg; MCC - 67.5 mg; talc - 2 mg; magnesium stearate - 1 mg;
• film shell: Opadry II brown 8 F 26948 - 3 mg: partially hydrolyzed polyvinyl alcohol - 1.2 mg; titanium dioxide (E171) - 0.654 mg; macrogol 3350 - 0.606 mg; talc - 0.444 mg; iron oxide yellow (E172) - 0.062 mg, iron oxide red (E172) - 0.018 mg, iron oxide black (E172) - 0.016 mg.

Film-coated tablets, 1.5 mg. In bl. made of PVC film/aluminum foil, 50 pcs. 2 bl. in a cardboard insert with an appointment calendar in a cardboard pack.

Description of the dosage form

Tablets: round, biconvex, light brown film-coated.

The appearance of the fracture is white to beige.

Directions for use and doses

Inside, whole, with a sufficient amount of liquid. Do not exceed recommended doses. It is advisable to start taking the drug after the patient has committed to complete smoking cessation.

The drug should be used according to the following scheme: from the 1st to the 3rd day - 1 tablet. 6 times a day (every 2 hours), gradually reducing the number of cigarettes smoked. The tablet should be taken between smoking episodes to lengthen the intervals between smoking cigarettes in order to reduce their consumption as much as possible. The dosage interval every 2 hours must be observed. If the result is unsatisfactory, treatment should be stopped and after 2-3 months it can be started again.

If the effect is good, treatment is continued according to the following scheme: from the 4th to the 12th day - 1 tablet. every 2.5 hours; from the 13th to the 16th day - 1 tablet. every 3 hours; from the 17th to the 20th day - 1 tablet. every 5 hours; from the 21st to the 25th day - 1-2 tablets. in a day.

It is strongly recommended to quit smoking no later than the 5th day from the start of treatment. A combination of drug therapy with consultations, incl. with measures of psychological support for the patient, significantly increases the effectiveness of treatment.

Pharmacodynamics

The alkaloid cytisine, which is the active substance of the drug, has an n-cholinomimetic effect; excites the ganglia of the autonomic nervous system, reflexively stimulates the respiratory center, causes the release of adrenaline from the adrenal medulla, and increases blood pressure.

While closely similar to the mechanism of action of nicotine, cytisine has much lower toxicity and a greater therapeutic index.

Cytisine competitively inhibits the interaction of nicotine with the corresponding receptors, which leads to a gradual decrease and disappearance of nicotine addiction.

Pharmacokinetics

Pharmacokinetic studies have not been conducted in humans.

Indications for use Tabex 1.5 mg 100 pcs. pills

Nicotine addiction (to facilitate smoking cessation).

Physical and psychological dependence on nicotine is considered a specific type of disease that leads to the inability to abstain from smoking, even with the understanding of its negative effects.

Contraindications

• hypersensitivity to the active or any of the excipients of the drug;
• acute myocardial infarction;
• unstable angina;
• Heart arythmy;
• recent cerebrovascular accident;
• atherosclerosis;
• severe arterial hypertension;
• lactase deficiency, galactosemia, glucose-galactose malabsorption syndrome (the drug contains lactose);
• pregnancy;
• breastfeeding period;
• age under 18 and after 65 years.

With caution: other forms of coronary heart disease (stable angina, asymptomatic (silent) myocardial ischemia, vasospastic angina, syndrome “X” (microvascular angina); heart failure, high blood pressure; cerebrovascular disease; obliterating arterial diseases, hyperthyroidism, peptic ulcer stomach, diabetes mellitus, renal or liver failure, some forms of schizophrenia, the presence of chromaffin tumors of the adrenal glands, gastroesophageal reflux disease, people with a long history of smoking and people over 40–45 years of age.The use of the drug in patients with diseases is possible only after consulting a doctor.

Application Tabex 1.5 mg 100 pcs. pills during pregnancy and breastfeeding

Tabex® should not be used by women during pregnancy and breastfeeding.

special instructions

The drug should be started only when the patient has a serious intention to quit smoking.

Persons with a long history of smoking and persons over 40–45 years of age should use Tabex® only after consultation with a doctor. When using the drug, do not exceed the recommended dose. Treatment with the drug and continued smoking may lead to increased side effects of nicotine (nicotine intoxication). The medicinal product contains the excipient lactose. Patients with rare hereditary problems of galactose intolerance, lactase deficiency (Lapp type) or glucose-galactose malabsorption should not use the drug.

Impact on the ability to drive vehicles and operate machinery. Although no negative effects on the ability to drive vehicles or operate machinery were observed during the use of the drug, due to the possible occurrence of drowsiness and other adverse reactions, caution should be exercised in these situations.

Overdose

Symptoms: nausea, vomiting, dilated pupils, general weakness, tachycardia, clonic convulsions, respiratory paralysis. Occurs when the patient does not comply with the dosage regimen and takes the drug in doses several times higher than the therapeutic ones.

Treatment: gastric lavage, administration of activated charcoal, infusion of water-salt solutions, as well as 5 or 10% glucose solution, administration of anticonvulsants, cardiotonics, respiratory analeptics and other symptomatic agents. Respiratory function, blood pressure and heart rate should be monitored.

Side effects Tabex 1.5 mg 100 pcs. pills

The drug is usually well tolerated, the observed side effects are mild or moderate. Most of them appear at the beginning of treatment and go away on their own. Most often they are associated with quitting smoking and are manifested by dizziness, headache and insomnia.

At recommended doses, Tabex® does not cause serious adverse effects.

The following side effects are possible

From the cardiovascular system: tachycardia, slight increase in blood pressure, palpitations.

From the central nervous system: headache, dizziness, insomnia or drowsiness, increased irritability.

From the respiratory system: shortness of breath.

From the gastrointestinal tract: dry mouth, nausea, abdominal pain, constipation, diarrhea, changes in taste and appetite.

Musculoskeletal and connective tissue disorders: muscle pain.

Metabolism and nutrition: weight loss, increased sweating.

Other: chest pain.

Drug interactions

After smoking cessation, the side effects of theophylline, ropinirole, clozapine and olanzapine may increase.

With simultaneous use of the drug Tabex® with acetylcholine, carbachol, galantamine, pyridostigmine, rivastigmine, distigmine, it is possible to increase cholinomimetic side effects (salivation, lacrimation, bronchial secretion with cough and the risk of an asthma attack, constriction of the pupil, colic, nausea, vomiting, frequent urination, increased muscle tone or sudden muscle contractions).

The use of Tabex® simultaneously with lovastatin, simvastatin, fluvastatin, pravastatin, etc. increases the risk of muscle pain.

The simultaneous use of Tabex® with antihypertensive drugs (propranolol, etc.) may weaken their effect.

Side effects of Tabex

Side effects of tablets can occur in a number of body systems. Reviews of the side effects of the drug indicate that the drug may have the following side effects:

• a feeling of dry mouth , diarrhea , constipation , nausea , changes in taste and fluctuations in appetite - from the digestive system;
• dizziness and headaches , drowsiness or insomnia , periodic increase in irritability - from the nervous system;
• tachycardia , increased blood pressure, shortness of breath , pain in the chest - from the cardiovascular system.

In addition, there may be a decrease in body weight , myalgia , high sweating , and allergic manifestations.

As a rule, side effects disappear on their own. If the side effects of Tabex worsen, you should definitely consult a specialist.

Instructions for use of Tabex (Method and dosage)

The instructions for Tabex suggest a specific method of using the tablets. Initially, 1 tablet is prescribed five times a day, later the dose should be reduced to 1-2 tablets per day. Treatment with this drug lasts from 20 to 25 days. The method of using Tabex must be approved by a doctor in each individual case. It is advisable to find out in more detail how to take Tabex from the specialist who prescribes the treatment. If the patient continues to take the pills correctly, but there is no effect, it is necessary to undergo treatment again after 2-3 months.

When advising the patient how to take the pills, the doctor also warns that smoking must be completely stopped no later than five days after the start of treatment.

Compound

Overdose

In case of overdose, a person may experience the following symptoms:

• nausea and vomiting ;
• convulsions;
• general feeling of weakness;
• tachycardia , increased heart rate ;
• respiratory paralysis.

If such symptoms appear, it is necessary to completely stop treatment with the drug.

Patients trying to quit smoking with the help of this drug, and who have exceeded the dose of taking it, need to rinse the stomach, if necessary, administer infusion solutions , drugs against seizures and other drugs that relieve symptoms. It is important to closely monitor your heart rate and blood pressure.

special instructions

The drug should be started only when the patient has a serious intention to quit smoking.

Treatment with the drug and continued smoking may lead to increased side effects of nicotine (nicotine intoxication).

The drug contains an excipient - lactose. Patients with rare hereditary problems of galactose intolerance, lactase deficiency (Lapp type) or glucose-galactose malabsorption should not use the drug.

Impact on the ability to drive vehicles and operate machinery. Does not affect.

Analogs

Level 4 ATX code matches:
Cititon

Champix

Nicorette

Analogues of the drug are products in which the active ingredient is cytisine. Such products are produced in the form of tablets ( cytiton , cytisine , lobesil ), in the form of special films that are glued to the skin ( cypercuten ).

Which is better Brizantine or Tabex?

There are a number of drugs that have an effect on the smoker’s body similar to Tabex. These are Brizantine , Nicorette , Champix , etc. The drug Brizantine contains antibodies to brain-specific proteins, which helps reduce a person’s craving for nicotine. However, which is better, Brizantine or Tabex, can only be determined after an individual consultation with a doctor. The cost of the drug in Moscow is 280 rubles.

Nicorette or Tabex - which is better?

Nicorette contains nicotine, so it is used as replacement therapy in the process of quitting smoking tobacco . Nicorette comes in the form of chewing gum, so the nicotine is released and absorbed into the body gradually. The cost of the drug in the form of chewing gum in Ukraine ranges from 75 to 88 UAH.

Which is better Champix or Tabex?

The drug Champix contains varenicline , which interacts with nicotinic acetylcholine receptors. As a result, the severity of withdrawal syndrome decreases. There are different opinions about whether this drug helps you quit smoking. But its cost is higher than Tabex: in Ukraine it ranges from 335 to 336 UAH. You can find out whether pills help you quit smoking from the reviews of those who have undergone such treatment.

With alcohol

The drug cannot be combined with alcoholic beverages. When discussing compatibility with alcohol, it should be noted that alcohol negatively affects a person’s self-control. As a result, consumed alcohol can stimulate an overdose of nicotine. In addition, when taking alcohol and Tabex at the same time, a person may feel that such abuse leads to a noticeable loss of taste. In addition, the following side effects are possible:

• shortness of breath and rapid heartbeat;
• heartburn;
• increased blood pressure;
• increased craving for smoking.

Therefore, you should abstain from alcohol during the treatment process.

Reviews about Tabex

The majority of those who have been treated with this drug give positive feedback about Tabex. However, those who leave reviews about Tabex tablets note that this drug should be taken strictly according to the regimen that is described in the drug's annotation. Negative reviews on the forum are left by those who noted side effects in the form of irritability, etc. Also, those who have contraindications to taking them should not practice treatment with these pills.

Most former smokers note that with the help of this drug they were able to effectively and relatively easily get rid of this addiction.

Interaction

After smoking cessation, the side effects of theophylline, ropinirole, clozapine and olanzapine may increase.

With simultaneous use of the drug Tabex® with acetylcholine, carbachol, galantamine, pyridostigmine, revastigmine, distigmine, it is possible to increase cholinomimetic side effects (salivation, lacrimation, bronchial secretion with cough and the risk of an asthma attack, constriction of the pupil, colic, nausea, vomiting, frequent urination, increased muscle tone or sudden muscle contractions).

The use of Tabex® simultaneously with lovastatin, simvastatin, fluvastatin, pravastatin, etc. increases the risk of muscle pain.

The simultaneous use of Tabex® with antihypertensive drugs (propranolol, etc.) may weaken their effect.

Tabex price, where to buy

The average price for Tabex in Moscow for a package of 100 pieces is 540 rubles.

The price in Ukraine for a package of 100 pieces is on average 160 UAH.

You can find out how much pills cost in a particular city by visiting the websites of popular pharmacy chains. Cost may vary. The average price in Kharkov with delivery is 180 UAH, without delivery – 150 UAH. Similar offers can be seen in pharmacies in Odessa and Dnepropetrovsk - here tablets are offered at prices ranging from 150 to 170 UAH

The price of Tabex anti-smoking tablets is quite reasonable compared to other anti-smoking products. Reviews of anti-smoking pills Tabex indicate that one course of treatment is enough to get rid of this bad habit. A specialist will tell you in more detail what exactly to start with in the process of choosing an effective remedy.

Where to buy Tabex depends on the person’s place of residence. You can buy the drug in Moscow and St. Petersburg at any pharmacy. In Krasnoyarsk, Tabex is sold in many pharmacy chains; it can also be purchased in online pharmacies. The drug is sold similarly in Ukraine.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

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