Arbidol powder for the preparation of suspension for oral administration 25mg/5ml, 100 ml

What kind of medicine is Arbidol?

The drug Arbidol is a fairly effective antiviral agent.

The medication specifically affects viruses and provokes the production of interferon in the human body.

The active component of Arbidol helps stimulate the cellular, humoral reactions of the immune system, thereby increasing resistance to viral pathologies.

Due to the mechanism of action on the body, the medicine can be called a fusion inhibitor. Taking a pharmaceutical product helps:

• reducing the incidence of complications associated with exposure to viruses
• reduces the risk of exacerbation of chronic bacterial diseases

Indications for use

Most often, doctors recommend using Arbidol for the prevention and treatment of viral diseases.

The medicine is recommended for:

• influenza type A and B
• acute respiratory viral infection
• bronchitis, pneumonia (complex therapy)
• immunodeficiency
• severe acute respiratory disease

In addition, the medication is prescribed for:

• prevention of infectious diseases after surgery
• normalization of immunity

Doctors prescribe the drug to children under 3 years of age for intestinal infections of rotavirus etiology (complex treatment).

Instructions for use of Arbidol

• Both forms are taken orally before meals.
• The dosage of the capsule form depends on the age of the patient. For children from 3 to 6 years old, doctors prescribe 50 mg; for children from 6 to 12 years old, the dosage is doubled. Persons over 12 years of age can take 200 mg of the medication.
• Arbidol is not prescribed to children under 3 years of age.
• After contact with an infected patient, you can take Arbidol for preventive purposes for 2 weeks.
• In the above-mentioned dosage, the drug is prescribed during an epidemic of viral pathologies. In this situation, the medicine should be taken twice a week, one dose, the prophylactic course should last 3 weeks.
• Doctors prescribe the tablet form to children from 3 to 6 years old one tablet (50 mg), children from 6 to 12 years old are recommended to take 100 mg of the medicine, adult patients are advised to take 200 mg.
• Depending on the situation, the doctor can select the dosage of the medication individually for each patient.

Analogues of the drug Arbidol

The medicine has structural and non-structural analogues that are not inferior in effectiveness. Similar drugs include:

• Viferon;
• Grippferon;
• Kagocel;
• Anaferon;
• Umifenovir;
• Arpeflu.

Structural analogues include Arpeflu, Umifenovir. They have the same active ingredient: umifenovir. The mechanism of action of drugs is similar to Arbidol. The drugs are produced in the form of tablets of 50 mg.

Non-structural analogues include Viferon, Kagocel, Anaferon, Grippferon.

Viferon

Viferon is an effective analogue. It is available in the form of rectal suppositories. There is also an ointment and gel form for topical use. The drug belongs to the group of cytokines. Contains interferon alpha-2b. Due to the fact that interferons enter the body from the outside, the effect of therapy is noticeable within 1-3 hours after use. The product is suitable for influenza, rotavirus, adenovirus, respiratory syncytial, herpes and other infections.

The medication can be used in children from birth, including premature babies. The medicine is suitable for lactating and pregnant women at any stage of gestation.

Grippferon

Another analogue is Grippferon. It is produced in the form of nasal drops and spray. The drug is used topically. The medicine contains interferon alpha-2b. It is allowed for children, pregnant and lactating patients.

Kagocel

Kagocel is an interferon inducer. The medicine increases the formation of the patient’s own protective antibodies. The medicine is produced in the form of tablets. The drug is approved from 3 years of age. It is prohibited to use it during pregnancy and lactation.

Anaferon

Anaferon is produced in the form of tablets and drops. The active component of the drug is antibodies to human interferon gamma. The drug enhances the functioning of immune mechanisms. The medicine can be taken by children from 1 month of age. During pregnancy and breastfeeding, the drug is prescribed only by a doctor. The medicine is indicated for herpetic rashes, acute respiratory viral infections, and influenza.

Arbidol today is one of the most frequently purchased drugs. The medication is suitable for both adults and children. It is acceptable to use during pregnancy from the 2nd trimester. The medicine is non-toxic and does not damage the kidneys and liver. Umifenovir is ideal for the treatment of coronavirus infection, influenza, herpes and other conditions. It can only be used as prescribed by a doctor, despite the availability in pharmacies.

Is Arbidol suitable for breastfeeding women?

Arbidol is a low-toxic medicine. When using it, side effects are extremely rarely observed. Unfortunately, no experiments have been conducted regarding the effect of the drug on breastfeeding. The instructions note that it is unknown how much of the substance passes into breast milk. Therefore, it is more advisable to interrupt breastfeeding during treatment.

But still, some doctors prescribe the drug during lactation, until a negative effect on the child has been recorded.

Arbidol tablets

Registration number: LSR-003900/07

Trade name of the drug: Arbidol®

International nonproprietary name: Umifenovir

Chemical name: 6-Bromo-5-hydroxy-1-methyl-4-dimethylaminomethyl 2-phenylthiomethylindole-3-carboxylic acid ethyl ester hydrochloride monohydrate.

Dosage form: film-coated tablets.

Compound

One tablet contains: active ingredient: umifenovir hydrochloride monohydrate – 51.75 mg (in terms of umifenovir hydrochloride – 50.00 mg);

Excipients:

core: potato starch - 31.860 mg, microcrystalline cellulose - 57.926 mg, povidone (povidone K30) - 8.137 mg, calcium stearate - 0.535 mg, croscarmellose (croscarmellose sodium) - 1.542 mg;

shell:

Opadry 10F280003 White (Opadry 10F280003 WHITE) - 6,000 mg, [Hypromellose (hydroxypropyl methylcellulose 2910) - 3.54 mg, macrogol (polyethylene glycol) - 0.48 mg, polysorbate-80 (Tween-80) - 0.06 mg, titanium dioxide - 1.92 mg.

Description

Film-coated tablets from white to off-white with a creamy tint, round, biconvex. On the fracture it is white to white with a greenish-yellowish or creamy tint.

Pharmacotherapeutic group: antiviral agent.

ATX code: J05AX13

Pharmacological properties

Pharmacodynamics. Antiviral agent. Specifically suppresses in vitro influenza viruses A and B (Influenzavirus A, B), including highly pathogenic subtypes A(H1N1)pdm09 and A(H5N1), as well as other viruses that cause acute respiratory viral infections (ARVI) (coronavirus associated with severe acute respiratory syndrome (SARS), rhinovirus (Rhinovirus), adenovirus (Adenovirus), respiratory syncytial virus (Pneumovirus) and parainfluenza virus (Paramyxovirus)). According to the mechanism of antiviral action, it belongs to fusion inhibitors, interacts with the hemagglutinin of the virus and prevents the fusion of the lipid membrane of the virus and cell membranes. It has a moderate immunomodulatory effect and increases the body's resistance to viral infections. It has interferon-inducing activity - in a study on mice, the induction of interferons was noted after 16 hours, and high titers of interferons remained in the blood up to 48 hours after administration. Stimulates cellular and humoral immune responses: increases the number of lymphocytes in the blood, especially T cells (CD3), increases the number of T helper cells (CD4) without affecting the level of T suppressors (CD8), normalizes the immunoregulatory index, stimulates the phagocytic function of macrophages and increases number of natural killer (NK) cells.

Therapeutic effectiveness for viral infections is manifested in a decrease in the duration and severity of the disease and its main symptoms, as well as in a decrease in the incidence of complications associated with viral infection and exacerbations of chronic bacterial diseases.

Refers to low-toxic drugs (LD50>4 g/kg). Does not have any negative effects on the human body when administered orally in recommended doses.

Pharmacokinetics. Quickly absorbed and distributed throughout organs and tissues. The maximum concentration in blood plasma when taken at a dose of 50 mg is achieved after 1.2 hours, at a dose of 100 mg - after 1.5 hours. Metabolized in the liver. The half-life is 17-21 hours. About 40% is excreted unchanged, mainly with bile (38.9%) and in small amounts by the kidneys (0.12%). During the first day, 90% of the administered dose is eliminated.

Indications for use

Prevention and treatment in adults and children: influenza A and B, other acute respiratory viral infections.

Complex therapy of acute intestinal infections of rotavirus etiology in children over 3 years of age.

Complex therapy of chronic bronchitis, pneumonia and recurrent herpes infection.

Prevention of postoperative infectious complications.

Contraindications

Hypersensitivity to umifenovir or any component of the drug, children under 3 years of age. First trimester of pregnancy.

Carefully

Second and third trimesters of pregnancy.

Use during pregnancy and breastfeeding

In animal studies, no harmful effects on pregnancy, embryonic and fetal development, labor or postnatal development were identified.

The use of Arbidol® in the first trimester of pregnancy is contraindicated. In the second and third trimester of pregnancy, Arbidol® can be used only for the treatment and prevention of influenza and if the expected benefit to the mother outweighs the potential risk to the fetus. The benefit/risk ratio is determined by the attending physician.

It is not known whether Arbidol® passes into breast milk in women during lactation. If you need to use Arbidol®, you should stop breastfeeding.

Directions for use and doses

Inside, before meals.

Single dose (depending on age):

The drug should be taken from the moment the first symptoms of influenza and other acute respiratory viral infections appear, preferably no later than 3 days from the onset of the disease.

If, after taking the drug Arbidol® for three days during the treatment of influenza and other acute respiratory viral infections, the severity of the symptoms of the disease, including high temperature (38 ° C or more), then you must consult a doctor to assess the validity of taking the drug.

Use the drug only according to the indications, method of administration and in the doses indicated in the instructions.

When treating influenza and ARVI, concomitant symptomatic therapy is possible, including taking antipyretic drugs, mucolytics and local vasoconstrictors.

Side effect

The drug Arbidol® is a low-toxic drug and is usually well tolerated.

Side effects are rare, usually mild or moderate and transient.

The frequency of adverse drug reactions is determined in accordance with the WHO classification: very often (with a frequency of more than 1/10), often (with a frequency of at least 1/100, but less than 1/10), infrequently (with a frequency of at least 1/1000, but less than 1/100), rare (with a frequency of at least 1/10,000, but less than 1/1000), very rare (with a frequency of less than 1/10,000), frequency unknown (cannot be determined from available data)

Immune system disorders: rarely - allergic reactions.

If any of the side effects indicated in the instructions get worse, or you notice any other side effects not listed in the instructions, tell your doctor.

Overdose

Not marked.

Interaction with other drugs

When prescribed with other drugs, no negative effects were noted.

No special clinical studies have been conducted to study the interaction of the drug Arbidol® with other drugs.

There was no evidence of undesirable interactions with antipyretic, mucolytic and local vasoconstrictor drugs in a clinical study.

special instructions

It is necessary to follow the regimen and duration of taking the drug recommended in the instructions. If you miss taking one dose of the drug, the missed dose should be taken as early as possible and continue taking the drug according to the started regimen. If, after taking the drug Arbidol® for three days during the treatment of influenza and other acute respiratory viral infections, the severity of the symptoms of the disease, including high temperature (38 ° C or more), then you must consult a doctor to assess the validity of taking the drug.

Impact on the ability to drive vehicles and machinery

It does not exhibit central neurotropic activity and can be used in medical practice by people of various professions, incl. requiring increased attention and coordination of movements (transport drivers, operators, etc.).

Release form

Film-coated tablets, 50 mg.

10 tablets in a blister pack.

1, 2, 3 or 4 blister packs along with instructions for use in a cardboard pack.

Best before date

3 years.

Do not use after the expiration date stated on the packaging.

Storage conditions

At a temperature not higher than 25°C.

Keep out of the reach of children

Conditions for dispensing from pharmacies Dispensed without a prescription.

Marketing authorization holder/organization receiving consumer complaints

PJSC OTCPharm, Russia, 123317, Moscow, st. Testovskaya, 10 Tel. Fax

, 305022, Russia, Kursk, st. 2nd Aggregatnaya, 1a/18, tel./fax: (4712) 34-03-13

What is stronger Arbidol or Anaferon

The homeopathic remedy Anaferon is prescribed for colds; it is also suitable for strengthening the immune system. However, the drug does not have an antiviral effect. When treating pathologies, its use is effective only in the initial stages of the disease.

The drug Arbidol perfectly fights viruses, so in case of viral diseases it is better to opt for it, it is more effective.

Both medications are recommended to be taken together with other medications if a person suffers from a serious illness. But Anaferon and Arbidol are excellent for use for preventive purposes, as they do not harm the body.

Before starting to take Arbidol, it is recommended that you carefully read the instructions included with the drug.

Is it permissible during COVID-19?

Umifenovir is recommended for use both for the treatment of coronavirus infection and for the prevention of infection with Covid-19. As a preventive measure, the drug is ideal because it prevents the virus from entering cells, even if there has been contact with a sick person. Coronavirus can be present in the blood for up to 2 weeks or more without penetrating into cells. This explains the long incubation period (asymptomatic). For preventive purposes, it is recommended to take Arbidol for 2 weeks, which will prevent the virus from entering cells and its further reproduction.

It makes sense to prescribe the drug for the treatment of coronavirus infection, as it stops further reproduction of viruses. The medicine relieves symptoms and prevents complications. Arbidol copes well with mild forms of COVID-19.