Composition per 1 ml
Active substance: xylometazoline hydrochloride – 0.50 mg or 1.00 mg; Excipients: disodium edetate (Trilon B) – 0.50 mg, sodium chloride – 9.00 mg, benzalkonium chloride – 0.15 mg, potassium dihydrogen phosphate – 3.63 mg, sodium hydrogen phosphate dodecahydrate – 7.13 mg, purified water – up to 1 ml.
Description: transparent, colorless or slightly colored liquid.
Pharmacotherapeutic group: anticongestive agent – alpha-adrenergic agonist.
ATX code : R01AA07
What Rinostop contains
The main active component of the drug is xylometazoline hydrochloride. This substance belongs to alpha-adrenergic agonists; when applied topically, it causes a reflex vasoconstriction.
Rinostop is produced in the form of:
- nasal spray: in bottles with a dispenser spray with a capacity of 10–30 ml, with a concentration of 0.1 and 0.05% of the active substance;
- nasal drops: similar volume and concentration in bottles with a drip dispenser.
Among the auxiliary components of the product: distilled water and stabilizing additives.
Contraindications
Hypersensitivity to xylometazoline and other components of the drug, arterial hypertension, tachycardia, severe atherosclerosis, glaucoma, atrophic rhinitis, surgical interventions on the meninges (in history), conditions after transsphenoidal hypophysectomy, children's age (up to 2 years - for 0.05% spray , up to 6 years for 0.1% spray), pregnancy. Do not use during therapy with monoamine oxidase inhibitors and tricyclic antidepressants (including the period of 14 days after their discontinuation).
Carefully
With increased intraocular pressure, chronic heart failure, arterial hypertension, angina pectoris; arrhythmias; chronic renal failure; in patients with prostatic hyperplasia with clinical symptoms (urinary retention); severe atherosclerosis; with hyperthyroidism; diabetes mellitus; pheochromocytoma; tachycardia; therapy with monoamine oxidase inhibitors (MAO) (including for up to 14 days after their discontinuation) and tricyclic antidepressants, as well as other drugs that increase blood pressure; porphyria; pregnancy, during breastfeeding.
Directions for use and doses
Intranasally.
Spraying is carried out after removing the safety cap from the sprayer. The sprayer is inserted into the nose and, pressing on its base, sprays for 1 second.
For adults and children over 6 years of age (0.1% spray): one spray from a spray bottle into each nasal passage, usually 3-4 sprays per day are sufficient; should not be used more than 3 times a day.
For children aged 2 to 6 years (0.05% spray) one spray from a spray bottle into each nasal passage 1 or 2 times a day; should not be used more than 3 times a day.
Do not use the drug without a break for more than 3-5 days.
Rhinostop
STUFFY NOSE?! RINOSTOP® SPRAY – ACTIVE IN A FEW MINUTES1, COSTS INEXPENSIVE!
for adults and children from 2 years old
Advantages of the drug
- has a local vasoconstrictor effect
- due to narrowing of the blood vessels of the nasal mucosa:
- helps eliminate swelling and hyperemia (redness) of the mucous membrane
- helps relieve nasal congestion
- helps restore patency of the nasal passages and facilitate nasal breathing
Advantage of the release form
- 2 release forms provide the possibility of using the drug in people of different age groups:
- nasal spray 0.05% – 15 ml: for children from 2 to 6 years old
- nasal spray 0.1% - 15 ml: for adults and children over 6 years old
Indications for use
- acute respiratory diseases with symptoms of rhinitis (runny nose)
- acute allergic rhinitis
- sinusitis,
- eustacheitis
- hay fever
- otitis media (to reduce swelling of the nasopharyngeal mucosa)
- preparing the patient for diagnostic manipulations in the nasal passages
Rinostop is the winner of the “No. 1 Brand in Russia” award in the category of means for treating the common cold in 2022.
Side effect
With frequent and/or prolonged use - irritation and/or dryness of the nasopharyngeal mucosa, burning and paresthesia of the nasal mucosa, sneezing, hypersecretion of the nasal mucosa; swelling of the nasal mucosa, vomiting, headache, palpitations, increased blood pressure, tachycardia, arrhythmia, insomnia, blurred vision, depression (with long-term use of high doses).
Benzalkonium chloride, which is part of the drug, can cause irritation of the nasal mucosa.
Interaction with other drugs
When used concomitantly with monoamine oxidase inhibitors (during the previous 2 weeks and within 2 weeks after their discontinuation), tricyclic antidepressants or other drugs that increase blood pressure, an increase in blood pressure may occur. The drug slows down the absorption of local anesthetic drugs and prolongs their effect.
Co-administration of other vasoconstrictor drugs increases the risk of side effects.
Overdose
In case of an overdose or accidental ingestion of the drug, the following symptoms may develop: nausea, vomiting, cyanosis, fever, tachycardia, arrhythmia, increased blood pressure, shortness of breath, mental disorders, depression of the central nervous system (drowsiness, decreased body temperature, bradycardia, decreased blood pressure, respiratory arrest and coma).
Treatment: symptomatic: in case of accidental ingestion - gastric lavage, taking activated charcoal.
special instructions
Long-term use and overdose of the drug should be avoided, especially in children. Avoid contact of the drug with the eyes. To avoid the spread of infection, it is necessary to use the drug individually.
Impact on the ability to drive vehicles and machinery . After long-term use of cold remedies containing oxymetazoline, and in doses higher than recommended, a general effect on the cardiovascular system cannot be excluded.
system and the central nervous system. In these cases, it is recommended to be careful when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.
When should you use Rinostop?
Indications for using the nasal solution include:
- acute rhinitis with nasal congestion;
- vasomotor, allergic and other types of runny nose, accompanied by swelling of the mucous membranes and impaired nasal breathing;
- for sinusitis, sinusitis and other sinusitis with congestion and swelling of the nasal sinuses;
- with inflammation and swelling of the auditory tube;
- in preparation for diagnostic procedures before treatment with an otolaryngologist.
Rinostop is not a long-acting drug. It must be used once or in short courses over several days. Otherwise, the risk of side effects and complications increases.
Rinostop price
Rinostop price in Moscow:
- Rinostop nasal drops 0.1% and 0.05% 10 ml - 21 - 25 rubles;
- nasal spray 0.1% And 0.05% 15 ml - 56 - 65 rubles.
Rinostop tablets, produced by the pharmaceutical company Bosnalek (Bosnia and Herzegovina) are not synonymous with Rinostop drops and spray, as they have a different composition.
- Online pharmacies in RussiaRussia
ZdravCity
- Rinostop Extra 0.05% 15 mlPharmstandard-Leksredstva OJSC
RUB 147 order - Rinostop Double relief for runny nose 6+, nasal spray + xylometazoline, 15 mlPharmstandard-Leksredstva OJSC
RUB 154 order
- Rinostop Aqua Baby for children 0+ for runny nose, nasal spray, 100% sea water 125 mlLaboratory De La Mer
RUB 339 order
- Rinostop 0.05% 15 mlPharmstandard-Leksredstva OJSC
95 rub. order
- Rinostop 0.1% 15 mlPharmstandard-Leksredstva OJSC
96 RUR order
Rinostop's analogs
Level 4 ATX code matches:
Xymelin Eco
Xymelin
Nazivin
Galazolin
Lazorin
Nazivin Sensitive for children
Otrivin
Naphthyzin
Sanorin
Knoxprey
For the nose
Lazolvan Rino
Afrin
Rhinorus
Eucazoline Aqua
Rinazolin
Grippostad Reno
Farmazolin
Xylometazoline
Nazol Advance
Analogues are drugs from different drug groups that are used to treat the same diseases. Analogues of Rinostop - drugs that relieve swelling of the nasal mucosa: naphazoline ( Naphthyzin , Sanorin ), Oxymetazoline ( Nazivin , Nazol , Knox-spray ), phenylephrine ( Nazol Baby ), tetrizoline ( Tetrin ), tramazolin ( Lazolvan Rino ), dimethindene + phenylephrine.
Pharmacodynamics and pharmacokinetics
The active substance of Rinostop, xylometazoline, belongs to the group of alpha-adrenergic agonists with local vasoconstrictor effects. Alpha adrenergic agonists are drugs that stimulate alpha adrenergic receptors , located in the walls of blood vessels and reacting to adrenaline , norepinephrine and other substances with a similar effect.
When applied to the mucous membrane of the nasal cavity, the drug causes a narrowing of the blood vessels located in it, but is almost not absorbed into the blood and does not have a general (systemic) effect on the human body. This helps to reduce blood flow in the veins and significantly reduce the perspiration of the liquid part of the blood through the walls of blood vessels. As a result, swelling of the mucous membrane is quickly relieved and nasal breathing is restored. The amount of nasal discharge also decreases. Eliminating swelling in the nasal cavity also improves the condition of the hearing aid.
At the same time, the drug does not have a negative effect on the mucous membrane, including its ciliated epithelium, which cleanses the nasal cavity of foreign particles. Long-term use of drops or spray (more than 5-7 days in a row) can lead to paresis of the smooth muscles of blood vessels and their prolonged dilation, accompanied by persistent swelling and nasal congestion.
The effect of the drug begins a couple of minutes immediately after it has been applied to the mucous membrane of the nasal cavity and can last for several hours.
