Compound
The active substance is metoclopramide hydrochloride monohydrate .
1 tablet contains 10.54 mg of this substance, which in terms of metoclopramide hydrochloride is 10 mg.
Additional substances are: silicon dioxide, potato starch, gelatin, magnesium stearate and lactose monohydrate.
1 ml of solution contains 5 mg of metoclopramide hydrochloride . Additional substances are: disodium edetate, injection water, sodium sulfite, sodium chloride.
Special instructions for the use of the drug Cerucal
Impact on the ability to drive vehicles. Even when taken as recommended, metoclopramide may significantly impair reaction time and the ability to drive or operate potentially dangerous machinery. This effect is especially pronounced with the simultaneous use of alcohol. Due to the content of sodium sulfite in the Cerucal injection solution, in some cases, mainly in patients with asthma, hypersensitivity reactions to the drug may occur, which are manifested by nausea, diarrhea, shortness of breath, an acute attack of asthma, impaired consciousness or anaphylactic shock. The severity of these reactions is purely individual; in some cases they can pose a threat to the patient’s life.
Pharmacodynamics and pharmacokinetics
The active ingredient is metoclopramide . The main substance is a blocker of serotonin and dopamine receptors. Cerucal eliminates hiccups , heartburn , accelerates gastric emptying, tones the lower sphincter of the esophagus, significantly reduces and slows down the motor activity of the esophagus, does not cause diarrhea, and accelerates the movement of food through the small intestine. The drug stimulates the release of prolactin .
After intravenous administration, the effect of the drug is felt after 1-3 minutes, when administered intramuscularly - after 10-15 minutes. The drug is metabolized in the liver. About 20% is excreted in its original state and about 80% by metabolites.
How does Cerucal work?
The medicine in tablet form is absorbed by the gastric mucosa within 20-30 minutes. The effect of using the solution intramuscularly is observed after 10–15 minutes. When administered intravenously - 1-3 minutes. Cerucal normalizes the tone of the muscular walls of the gastrointestinal tract, relaxes the spasm of the sphincter of Oddi, and improves the movement of bile. As a result, the evacuation of food masses from the small intestine is accelerated, physical discomfort and heaviness in the abdomen are reduced.
The antiemetic effect after a dose of Cerucal lasts up to 12 hours. The substances of the drug are partially metabolized in the liver. The drug does not accumulate in tissues and is completely eliminated from the body within 24 hours with the contents of the intestines and through the kidneys.
Indications for use of Cerucal
What are tablets and ampoules for?
The medicine is prescribed for hiccups, vomiting, hypotension and atony of the intestines, stomach, reflux esophagitis , biliary dyskinesia, exacerbation of ulcerative lesions of the digestive system, flatulence. What other indications exist for the use of Cerucal? To enhance peristalsis, the drug is used during X-ray contrast studies of the digestive tract.
Contraindications
Cerucal is not prescribed for bleeding in the digestive system, metoclopramide intolerance, pheochromocytoma , intestinal and gastric perforation, mechanical intestinal obstruction, pyloric stenosis , epilepsy, extrapyramidal disorders, in the presence of prolactin-dependent tumors, Parkinson's disease. For arterial hypertension, bronchial asthma, kidney and liver pathologies, in pediatrics it is prescribed with caution.
Contraindications to the use of the drug Cerucal
Hypersensitivity to the drug; pheochromocytoma; mechanical intestinal obstruction; intestinal perforation and gastrointestinal bleeding; prolactin-dependent tumors; in patients with epilepsy or in patients with increased convulsive readiness (extrapyramidal movement disorders); first trimester of pregnancy and lactation period; in newborns and children under 3 years of age. For children aged 3–14 years, as well as pregnant women in the 2nd–3rd trimester, metoclopramide is prescribed only for health reasons. For patients with reduced renal function, the drug is prescribed in reduced doses. Due to the sodium sulfite content, Cerucal injection solution cannot be prescribed to asthma patients with hypersensitivity to sulfite.
Side effects
Cerucal can cause the following side effects: diarrhea , constipation , drowsiness, dizziness, dry mouth, depression. Long-term use of high doses by elderly people causes gynecomastia, dyskinesia , parkinsonism, and galactorrhea. In case of overdose, extrapyramidal disorders , disorientation , and hypersomnia are recorded. After discontinuation of the drug, the symptoms disappear within a day.
Side effects of the drug Cerucal
Rarely, mainly when metoclopramide is used in higher doses, patients may experience fatigue, headache, dizziness, fear, anxiety and diarrhea. In some cases, mainly in children, dyskinetic syndrome (involuntary tic-like twitching of the muscles of the face, neck or shoulders) may develop. After discontinuation of the drug, these phenomena weaken within a few hours; it is possible to immediately eliminate them with the intravenous administration of biperiden (the manufacturer’s recommendations should be taken into account). For sedation, administration of diazepam is indicated. After prolonged treatment with metoclopramide, some elderly patients developed parkinsonism (tremor, muscle twitching, limited mobility) and tardive dyskinesia. After longer use of the drug, occasionally, due to stimulation of prolactin secretion, gynecomastia in men, galactorrhea or menstrual irregularities may occur; If these phenomena develop, stop taking metoclopramide. In adolescents and patients with severe renal impairment, the occurrence of side effects should be especially carefully monitored, and if they develop, the drug should be stopped immediately.
Instructions for use of Cerucal (Method and dosage)
Cerucal tablets, instructions for use
The drug is taken orally 30 minutes before meals three times a day, 5-10 mg. It is recommended to take the tablet with a large volume of liquid. The maximum daily dose is 60 mg, single dose is 20 mg.
Cerucal injections, instructions for use
Adults and from 14 years of age are administered intramuscularly or slowly intravenously, one ampoule 1-3 per day.
Children from 2 to 14 years old need to be given injections at the rate of 0.1 mg/kg, the maximum permissible dose per day is 0.5 mg/kg.
Use of the drug Cerucal
Tablets Adults and adolescents over the age of 14 years are prescribed 10 mg orally 3-4 times a day. For children aged 3 to 14 years, the recommended single dose is 0.1 mg/kg, the maximum daily dose is 0.5 mg/kg. The tablets are taken orally, approximately 30 minutes before meals. The duration of treatment depends on the severity and course of the disease. The usual duration of treatment is 4–6 weeks. In some cases, treatment can be continued for up to 6 months. In the presence of renal failure, the dose of the drug is selected taking into account the severity of renal dysfunction. Solution for injection The injection solution is administered intramuscularly or intravenously slowly. Adults and adolescents over the age of 14 years are administered intramuscularly and intravenously 2 ml of Cerucal solution 3–4 times a day (single dose is 10 mg, daily dose is 30–40 mg of metoclopramide). For children aged 3 to 14 years, the recommended single dose is 0.1 mg/kg body weight, the maximum daily dose is 0.5 mg/kg. Prescription of metoclopramide in high doses for nausea and vomiting caused by the use of cytostatic agents: Dosage regimen 1 By short-term intravenous drip infusion (over 15 minutes), Cerucal is administered at a dose of 2 mg/kg 30 minutes before the start of the administration of the cytostatic agent, as well as after 1.5; 3.5; 5.5 and 8.5 hours after the use of a cytostatic agent. Dosage regimen 2 By continuous intravenous drip infusion, Cerucal is administered at a dose of 1 (0.5) mg/kg over an hour, starting 2 hours before the use of a cytostatic agent, then at a dose of 0.5 (0.25) mg/kg within an hour for 24 hours after using a cytostatic agent. Cerucal is used throughout the entire period of treatment with a cytostatic agent. Each short-term intravenous drip infusion is carried out within 15 minutes after the previous dilution of the dose of Cerucal in 50 ml of infusion solution. Cerucal for injection can be dissolved with isotonic sodium chloride solution or 5% glucose solution. Note Cerucal injection solution cannot be mixed with alkaline infusion solutions.
Overdose
The following phenomena are observed: hallucinations, drowsiness, irritability, convulsions, decreased level of consciousness and confusion, arrest of respiratory and cardiac activity, anxiety, extrapyramidal disorders, dysfunction of the cardiovascular system, dystonic reactions.
In case of overdose, symptomatic treatment should be used.
Interaction
Anticholinesterase drugs weaken the effect of metoclopramide. Cerucal increases the absorption of paracetamol, ampicillin , tetracycline, ethanol, levodopa , ascorbic acid. The drug reduces the absorption of cimetidine and digoxin. The simultaneous administration of antipsychotics (the risk of developing extrapyramidal disorders increases).
Interactions of the drug Cerucal
Anticholinergics may reduce the effect of metoclopramide. Metoclopramide may interfere with the absorption of other drugs. On the one hand, there may be a slowdown in the absorption of digoxin and cimetidine, on the other hand, an acceleration in the absorption of antibiotics, paracetamol and alcohol. In addition, metoclopramide may enhance the effects of alcohol and sedatives. In order to prevent a possible increase in the severity of extrapyramidal disorders, antipsychotics should not be prescribed simultaneously with metoclopramide. Metoclopramide may interfere with the action of tricyclic antidepressants, MAO inhibitors and sympathomimetic agents. Due to the content of sodium sulfite in the injection solution, thiamine (vitamin B1), taken simultaneously with Cerucal, can be quickly broken down in the body.
special instructions
According to the annotation, in some cases it is recommended to additionally use antiparkinsonian drugs, central anticholinergic blockers . It is unacceptable to consume ethanol during treatment with Cerucal. The drug affects the performance of complex activities, driving a car.
INN: Metoclopramide.
The medicine is used in veterinary medicine for cats and dogs.
Recipe in Latin:
Rp: Tab. Metoclopramidi (Cerucali) 0.01 DS 1 tab. 3 times a day before meals
Analogues of Cerucal
Level 4 ATX code matches:
Passazhix
Motinorm
Domrid
Motilium
Itomed
Metoclopramide
Domperidone
Motilak
Ganaton
Analogues of the drug are Metoclopramide , Metukal .
Cerucal price, where to buy
The price of Cerucal in 10 mg tablets is 125 rubles for 50 pieces. The cost in Ukraine is 130 hryvnia.
The price of Cerucal in ampoules of 2 ml is 230 rubles for 10 pieces.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Cerucal solution for intravenous and intramuscular injection.
5mg/ml 2ml 10 pcs. Merkle GmbH RUB 243 order - Cerucal tablets 10 mg 50 pcs. Pliva Hrvatska d.o.o.
119 RUR order
Pharmacy Dialogue
- Cerucal ampoules 10mg 2ml No. 10Merckle GmbH
RUB 215 order
- Cerucal (tab. 10 mg No. 50)Pliva
107 RUR order
show more
Pharmacy24
- Cerucal 10 mg 2 ml N10 solution for injection Merkle GmbH, Nimechchina
458 UAH.order - Cerucal 10 mg No. 50 tablets Pliva Hrvatska d.o.o., Croatia
260 UAH order
PaniPharmacy
- Cerucal ampoule Cerucal solution d/in. 10mg amp. 2ml No. 10 Hungary, Teva
441 UAH order
- Cerucal tablets Cerucal tablets. 10 mg No. 50 Croatia, Pliva
258 UAH. order
show more
