Cycloferon is an antiviral agent with a broad spectrum of action.

Indications for use

The use of Imet is indicated for the symptomatic treatment of pain of mild to moderate intensity:

• Diseases of the musculoskeletal system: osteoarthritis, rheumatoid arthritis, ankylosing spondylitis and other inflammatory and degenerative pathologies; psoriatic arthritis, articular syndrome with exacerbation of gout;
• Bursitis, tendovaginitis;
• Post-traumatic pain in joints and muscles;
• Toothache and headache;
• Acute respiratory viral infections (as part of complex therapy);
• Algodismenorrhea, adnexitis;
• Feverish conditions of various origins.

Contraindications

• Severe renal and/or liver dysfunction;
• Severe form of cardiovascular failure;
• Peptic ulcers, hemorrhage, including a history;
• Functional disorders of the hematopoietic system associated with a tendency to active bleeding, including gastrointestinal and cerebrovascular bleeding;
• Aspirin triad (history);
• Concomitant use of selective cyclooxygenase-2 inhibitors or other non-steroidal anti-inflammatory drugs;
• Age up to 12 years;
• III trimester of pregnancy;
• Hypersensitivity to the components of the drug and other non-steroidal anti-inflammatory drugs.

It is recommended to prescribe Imet with caution to: elderly patients due to the increased risk of bleeding, including death; with systemic lupus erythematosus, arterial hypertension, mixed collagenosis, cardiovascular failure, impaired renal and liver function; in the first and second trimesters of pregnancy, during breastfeeding; immediately after surgery.

Using liniment

Liniment is used topically. Rules of use for various conditions:

• herpes - applied to damaged skin 1-2 times a day for 5 days; for herpetic lesions of the genital organs, it is recommended to apply to the vaginal mucosa once for 5 days.
• bacterial or nonspecific vaginosis - intravaginally 5-10 ml 1-2 times a day; course therapy is 10-15 days; it is allowed to soak a tampon with liniment and then insert it into the vagina; The medication can be used with other local remedies (vaginal tablets and suppositories).

To introduce liniment intravaginally, you need to open the tube and pierce the tube membrane. Next, you should take a disposable syringe with a needle, draw up 5-10 ml of medicine, and remove the needle. Next, it is recommended to lie on your back and insert the medication into the vagina by pressing on the syringe plunger. To ensure that the medicine remains in the vaginal cavity, a cotton swab should be placed for 2-3 hours. Course therapy can last up to 15 days. If necessary, treatment is repeated after 2 weeks.

The external preparation can be used for periodontitis. Before applying the antiviral liniment, it is recommended to rinse the periodontal pockets. Next, liniment is applied using a cotton swab. Dose calculation: 1.5 ml per 1 gum. Rubbing the drug in is not recommended. It is advisable to apply the medicine 1-2 times a day. The intervals between uses are 10-12 hours. The duration of treatment is up to 2 weeks. A second course of therapy is carried out after 2 weeks.

Directions for use and dosage

The tablets are taken orally, without chewing, during or immediately after meals, with a sufficient amount of water.

The dose and duration of use are prescribed by the doctor individually, taking into account the clinical indications and the patient’s condition.

Recommended daily dosage:

• Pain syndrome of weak and moderate intensity: 200-400 mg 2-3 times a day with an interval between doses of at least 4 hours;
• Feverish conditions of various origins: 200-400 mg 1 time per day, if necessary, repeated administration is allowed after 4 hours.

The maximum daily dose for patients over 15 years of age is 1200 mg, for children over 12 years of age – 1000 mg.

For elderly patients, no dose adjustment is required.

Instructions for use of Cycloferon tablets

The medication is indicated for use orally. You should take the tablets half an hour before meals. The tablet form should not be chewed, as it has a protective coating that does not allow the active substance to be destroyed by gastric juice. The tablet shell dissolves only in the intestinal cavity, which increases the effectiveness of the drug.

Take the tablet with 50 ml of water. Depending on age, different dosages are used:

• adults - single dose 450-600 mg;
• 7-11 years of age - single dosage 300-450 mg;
• 4-6 years - single dose 150 mg.

Repeated course therapy is carried out 14-21 days after the end of the first course.

Side effects

• From the gastrointestinal tract: nausea, epigastric pain, vomiting, dry mouth, heartburn, flatulence, indigestion, diarrhea or constipation; possible - ulcerative lesions of the stomach and duodenum (including with perforation and bleeding), gastrointestinal bleeding, ulcerative stomatitis, exacerbation of colitis and Crohn's disease, esophagitis, gastritis, pancreatitis; in isolated cases – duodenitis;
• From the cardiovascular system: heart failure, arrhythmia, arterial hypertension; possible – development of myocardial infarction (when taking high doses);
• From the nervous system: dizziness, headache, sleep disturbances, irritability, increased fatigue; possibly depression, emotional lability, feelings of causeless anxiety and other psychotic reactions; in isolated cases – convulsions, psychomotor agitation;
• From the hematopoietic system: thrombocytopenia, anemia, pancytopenia, agranulocytosis, leukopenia; in patients with impaired function of the hematopoietic system - erosive lesions of the oral mucosa, sore throat and/or muscle pain, increased body temperature, depression; possible - hematomas, skin hemorrhages, nosebleeds and other bleeding of unknown etiology;
• From the hepatobiliary system: functional liver disorders, toxic liver damage, hepatitis, acute liver failure, hepatorenal syndrome;
• From the senses: blurred vision (with long-term use), including dryness of the mucous membrane and color perception of the eye, decreased clarity of vision; possible – hearing impairment, tinnitus;
• From the genitourinary system: edema (mainly in patients with arterial hypertension and/or renal failure), necrosis of the renal papillae, interstitial nephritis, hyperuricemia, nephrotic syndrome, polyuria, cystitis, oliguria; in isolated cases - hematuria, glomerulonephritis;
• Allergic reactions: itching, skin rash, rhinitis, erythema multiforme, urticaria, anaphylactoid reactions, including swelling of the tongue and larynx, arterial hypotension, anaphylactic shock; possible – development of bronchospasm and bronchial asthma in patients with increased individual sensitivity;
• From the skin: dry skin, Stevens-Johnson syndrome, alopecia, Lyell's syndrome, photosensitivity;
• Other: arterial thromboembolism, stroke (with long-term use in high doses).

In addition, undesirable effects of using Imet can be an exacerbation or development of infectious diseases: necrotizing fasciitis, aseptic meningitis (symptoms - stiff neck, hyperthermia, nausea, headache, vomiting, impaired consciousness).

Undesirable effects

According to the instructions, side effects from the tablet drug occur very rarely. When using the systemic form (tablets), an allergic reaction in the form of rashes or hives may occur. Angioedema occurs extremely rarely. If any unwanted effects occur, you should consult a doctor.

The local form (liniment) may cause burning and redness at the site of application. These symptoms are mild and do not require discontinuation of treatment with Cycloferon. If local reactions intensify, you should see a doctor to adjust your therapy.

Cycloferon 5 ml ointment

special instructions

Elderly patients should be prescribed a minimum single dose at the beginning of treatment; if necessary and normal tolerability of the drug, it can be gradually increased.

If allergic reactions develop, the patient should stop taking it and immediately consult a doctor for advice.

With long-term use of Imet, regular monitoring of hemograms and renal function is recommended.

If gastrointestinal bleeding develops, the signs of which are severe pain in the epigastric region, vomit the color of coffee grounds, black stools, you must stop taking the drug and consult a doctor.

If an infectious pathology worsens or a new infection develops while using ibuprofen, the patient should consult a doctor to prescribe antibacterial therapy.

During the period of use of Imeta, patients are advised to refrain from performing potentially hazardous types of work, including driving vehicles and machinery.

Cycloferon: dosage regimen for adults

For respiratory pathologies, it is recommended to take the medicine in a single dose on the 1st, 2nd, 4th, 6th, 8th day (20 tablet forms are required). Therapy should be started when the first signs of the disease appear. This will increase the effectiveness of treatment. If the disease is severe, you need to drink 900 mg on the first day of therapy, and then take a standard single dose on the remaining days. To alleviate the condition, it is recommended to use cough and fever medications along with Cycloferon.

Herpetic infection is treated according to the following scheme: single dosage on days 1, 2, 4, 6, 8, 11, 14, 17, 20, 23. For therapy you will need 40 tablet forms.

Adults can use Cycloferon to prevent respiratory diseases. It is better to check the treatment regimen with your doctor.

Cycloferon, 150 mg, enteric-coated tablets, 20 pcs.

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Price from 377₽

Cycloferon, 150 mg, enteric-coated tablets, 10 pcs.

Polisan, Russia

Price from 191₽

Cycloferon, 5%, liniment, 5 ml, 1 pc.

Polisan, Russia

Price from 164₽

There are contraindications. Specialist consultation is required.

How to take Cycloferon for HPV

The causative agent of HPV can have low or high oncogenicity (the ability to cause cancer). Weakly oncogenic microorganisms can provoke warts on the skin. Strongly oncogenic strains more often cause the formation of genital warts.

For warts, Cycloferon tablets can be used for 2 weeks. For HPV affecting the genital organs, the injection form of the drug is most often indicated. If HPV symptoms appear, you should visit a dermatologist (as well as a urologist or gynecologist if the genital organs are affected). The doctor will tell you whether you can take Cycloferon and prescribe the correct therapy. You should not treat the disease yourself.

Drug interactions

When taken simultaneously, Imet reduces the antihypertensive effect of amlodipine, captopril, angiotensin-converting enzyme (ACE) inhibitors and beta-blockers; pharmacological effect of furosemide, hypothiazide, hydrochlorothiazide and other diuretics.

The drug enhances the effect of anticoagulants, increasing the risk of gastrointestinal bleeding.

Ibuprofen in combination with lithium preparations, phenytoin, digoxin helps to increase the level of their concentration in the blood plasma.

When taken simultaneously, the drug displaces indirect anticoagulants, sulfonylurea derivatives, oral hypoglycemic agents and hydantoin derivatives from their bonds with blood plasma proteins; increases the toxic effect of methotrexate and baclofen.

With simultaneous use of Imeta:

• Cholestyramine – helps reduce the absorption of ibuprofen in the gastrointestinal tract;
• Warfarin – promotes the development of microhematuria and hematomas, increasing the period of bleeding;
• Acetylsalicylic acid - reduces the plasma concentration of ibuprofen;
• Magnesium hydroxide – increases the initial absorption of ibuprofen in the gastrointestinal tract;
• Glucocorticosteroids - increase the likelihood of developing side effects from the digestive system.

Pharmacological properties of the drug Imet

Ibuprofen is an NSAID whose action is associated with inhibition of prostaglandin synthesis. It reduces pain, swelling and fever caused by inflammation. In addition, ibuprofen inhibits platelet aggregation caused by ADP and collagen. When administered orally, ibuprofen is partially absorbed in the stomach and completely absorbed in the small intestine. Undergoing biotransformation in the liver (hydroxylation, carboxylation), pharmacologically inactive metabolites are completely excreted, mainly by the kidneys (90%), and are also excreted through the hepatobiliary system. The half-life in healthy people and in patients with liver and/or kidney diseases is 1.8–3.5 hours. Plasma protein binding after oral administration is 99%. Peak serum concentrations after oral administration are achieved within 1–2 hours.