Caffeamine, 10 pcs., film-coated tablets

Pharmacodynamics

The effect of Caffetamine is associated with the vasoconstrictor effect of ergotamine and the improvement of brain functions under the influence of caffeine.

Ergotamine causes a vasoconstrictor effect.

Caffeine accelerates the absorption of ergotamine and enhances the effect of ergot alkaloids in the treatment of migraine. Caffeine also causes stimulation of the central nervous system, mainly the cerebral cortex, respiratory and vasomotor centers. Increases mental and physical performance, reduces drowsiness and fatigue. Caffeine has a pronounced cardiotonic effect: it increases the strength and frequency of heart contractions, and increases blood pressure during hypotension.

Caffeamine tablets 10 pcs. In Perm

Contraindications

hypersensitivity to caffetamine components;

decompensated diseases of the cardiovascular system, severe hypertension or atherosclerosis;

pregnancy;

lactation period.

With caution (relative contraindications):

sleep disturbance;

increased excitability;

anxiety disorders (agoraphobia, panic disorders);

organic diseases of the cardiovascular system (myocardial infarction, angina pectoris, atherosclerosis, paroxysmal tachycardia, ventricular extrasystole, arterial hypertension, obliterating diseases of peripheral vessels);

liver and/or kidney failure;

glaucoma (increased intraocular pressure);

elderly age.

Side effects

From the nervous system: agitation, anxiety, tremor, restlessness, headache, dizziness, convulsions, paresthesia in the extremities, increased reflexes, tachypnea, insomnia; with sudden withdrawal - inhibition of the central nervous system, increased fatigue, drowsiness.

From the cardiovascular system: palpitations, tachycardia, cardialgia, hypertension (increased blood pressure).

From the digestive system: nausea, vomiting, diarrhea.

Allergic reactions: swelling, itching.

Other: with long-term use - weakness in the legs, myalgia, Leriche syndrome (cyanosis, absence of pulse in the lower extremities, pain, distal sensory disturbance).

COFFETAMINE (tablets)

are strong, since it is necessary to increase the pressure by any available means.
At first, in such situations, I try to make do with natural remedies, that is, drink coffee or tea, or maybe snack on some chocolate. But there are days when you simply can’t do without medications and usually I start drinking the drug “Coffetamine”, which is sold in almost any pharmacy in our city, since it is a Russian drug and produces it. The cost of this drug, compared to foreign analogues, is quite low and the product will cost 88 rubles per blister containing 10 tablets.

The packaging of the product is not at all flashy and if you do not know about its effectiveness, then it is practically impossible to purchase it, since it is lost against the background of other similar products due to its design. The main and most important active agent is caffeine, which helps to increase blood pressure, as an auxiliary substance is the drug ergotamine tartrate.

Thanks to this combination, the drug not only has a positive result, but also has a strong effect on all other organs in the body, making a person irritable, disrupting sleep and doing many other unpleasant things. I did notice some side effects, the most noticeable was severe excitability, when everything was boiling inside, and I could not sit still, some kind of nervous activity occurred. I also noticed that after long-term use, diarrhea begins, which I was unable to connect with something else, since I did not introduce new foods into my diet.

There are still many contraindications for which this drug should not be taken, they are, as always, the usual, lactation and pregnancy, intolerance.

The fact is that I took the drug 1 tablet 2 times a day, sometimes increasing the number of doses up to 4 times a day. But this happened rarely, only in the most extreme cases, when the headache did not go away at all. Usually, 2 tablets a day were enough for the headache to gradually begin to subside, leaving only small unpleasant echoes in the back of the head, which could be easily tolerated and ignored, and after sleep the residual pain completely disappeared.

You can also take the product in a course to improve the situation for a while; for this purpose, it is recommended to take the drug 1 tablet 3 times a day for a week. I only took the whole course once and was pleasantly surprised by the results I got when I didn’t have any protracted migraines for a month. In other cases, I get by with a few tablets and the situation gradually improves and the pain recedes into the background. I think this product is no worse than its foreign analogues, which are sold for huge amounts of money, but give the same effect.

Interaction

Strengthens the effect of other products containing ergot alkaloids and caffeine. With the combined use of caffetamine and barbiturates, primidone, anticonvulsants - hydantoin derivatives (phenytoin), it is possible to increase metabolism and increase the clearance of caffeine.

When used together, caffeamine and cimetidine, oral contraceptives, disulfiram, ciprofloxacin, norfloxacin may reduce the metabolism of caffeine in the liver, slow its elimination and increase its concentration in the blood.

When caffeamine is used together with drugs that cause central nervous system stimulation, excessive stimulation of the central nervous system is possible.

Caffeine is an adenosine antagonist.

Mexiletine reduces caffeine excretion by up to 50%; Nicotine increases the rate of caffeine elimination.

Large doses of caffeine can cause the development of dangerous cardiac arrhythmias or a pronounced increase in blood pressure while taking MAO inhibitors (furazolidone, procarbazine, selegiline).

Caffeine reduces the absorption of calcium preparations (calcium gluconate, calcium carbonate, a combination of calcium and vitamin D) in the gastrointestinal tract.

Caffeamine reduces the effect of narcotic analgesics and sleeping pills, increases the excretion of lithium drugs (lithium carbonate) in the urine, accelerates absorption, enhances the effect, and increases the toxicity of cardiac glycosides (digoxin, celanide).

The combined use of caffeamine with beta-blockers (atenolol, metoprolol, nebivolol) may lead to mutual suppression of therapeutic effects; with adrenergic bronchodilators (clenbuterol, salbutamol, fenoterol) - to additional stimulation of the central nervous system and additive toxic effects.

Caffeine may decrease the clearance of theophylline and aminophylline, increasing the potential for additive pharmacodynamic and toxic effects.

The vasoconstrictor effect of caffeamine is enhanced by alpha-adrenergic stimulants, beta-blockers, serotonin agonists (including sumatriptan) and nicotine.

Macrolides (erythromycin, spiramycin, josamycin, midecamycin, clarithromycin, azithromycin, roxithromycin) increase the toxicity of ergotamine.

Caffeamine, 10 pcs., film-coated tablets

Overdose

Symptoms: anxiety, nervousness, irritability, insomnia, facial flushing, increased diuresis, nausea, vomiting, muscle twitching, tachycardia or arrhythmia, psychomotor agitation, tremor, hypertension, confusion, hyperreflexia, numbness in the fingers and toes, epileptic seizures.

Treatment: Caffeamine withdrawal; gastric lavage, administration of activated carbon, and, if necessary, symptomatic therapy; beta-blockers (propranolol) prevent cardiotoxic effects and normalize blood pressure.