Doppelhertz Active Lecithin-complex capsules 1G N30

pharmachologic effect

The dietary supplement strengthens the human nervous system, as well as improves brain function.

Lecithin is a very important element involved in the functioning of the nervous system and brain. It is also involved in the production of cell membranes and is a component of nervous tissue.

Lecithin contains such important components as linoleic acid and choline, which are involved in the transport of fatty substances and in the conduction of nerve impulses. It takes part in a number of important processes occurring in the body.

Lecithin also reduces cholesterol and provides a lipotropic effect. Under its influence, oxidation processes are activated, fat metabolism is normalized, the absorption of a number of vitamins is improved, and the body's resistance increases.

Lecithin promotes the production of hemoglobin , red blood cells, and is involved in the production of acetylcholine. This substance also helps to normalize body weight.

Vitamin B1 is important for metabolic processes in nerve cells and reduces the degree of pain in neurological diseases.

Vitamin B2 is necessary for cellular respiration; it promotes the active absorption of oxygen by tissues.

Vitamin B6 is involved in a number of important biochemical reactions, improves the body’s natural defense mechanisms against pathogenic bacteria and viruses, and activates memory and brain activity.

Vitamin B12 improves hematopoiesis and is important for normalizing the functions of the nervous system. It is involved in the production of myelin.

Nicotinamide is involved in the regulation of metabolic processes. Reduces the content of triglycerides and cholesterol, improves the functioning of the nervous system, and has a beneficial effect on the skin.

Vitamin E improves the functioning of the gonads, increases overall vitality, and stimulates the activity of the heart muscle. A lack of this vitamin in the body leads to neurological disorders and negative changes in the hematopoietic system.

Folic acid is very important for the process of production of new cells, is involved in protein metabolism, in the process of development and growth of the body as a whole.

The effect of lecithin on the neurological status of children

Lecithin is a wise addition to any Balch PA diet

Lecithin (from the Greek lekithos - egg yolk), isolated in France by Gobley M. back in 1850 and initially called “essential lipids”, is a complex of phospholipids (choline, phosphatides, inositol) and serves as one of the main sources of nutrition for the nervous system. systems. The peripheral nervous system is 17% lecithin, and the brain is 30%. Lecithin components are essential for the human body, and their deficiency is accompanied by dysfunction of the nervous, cardiovascular and other systems. This is due not only to the fact that lecithin is present in all tissue cells, but also to its role in biological membranes.

Lecithin accelerates oxidative processes, improves brain and cardiovascular system function. It promotes better absorption of fat-soluble vitamins (A, D, E and K), increases the body’s resistance to toxic substances, etc. Virtually all cells of the body need lecithin, which is part of the B complex of vitamins [1–3].

Neurologists are well aware that lecithin is necessary for the production of acetylcholine (a neurotransmitter), which ensures optimal functioning of the nervous system, and also takes part in the conduction of nerve impulses (neurotransmission). In addition, lecithin is one of the main components in the formation of myelin. Lecithin is also associated with the neuroendocrine system; lecithin and choline are essential for the production of a number of hormones and the normal metabolism of fats and cholesterol.

The biological properties of lecithin of plant origin are more effective than those of lecithin of animal origin. According to the definition of the computer encyclopedia "Wikipedia", soy lecithin is a food additive that has the properties of a surfactant - an emulsifier. Soy lecithin contains oil, phospholipids, vitamins A (retinol), E (tocopherol), etc.

The lack of an adequate supply of the phospholipid complex is accompanied by disturbances in the utilization of all fat-soluble vitamins, which is fraught with the risk of developing diseases such as rickets (vitamin D deficiency), osteoporosis, immunodeficiency states (secondary), disorders of the blood coagulation system and the functions of the gonads; Possible delay in physical development [3].

Manifestations of lecithin deficiency in children are quite diverse and variable. In children of the first years of life, due to lecithin deficiency, intracranial hypertension may occur, delayed psychomotor and speech development, behavioral disorders (psycho-emotional imbalance), decreased ability to concentrate, and memory impairment.

Classic manifestations of lecithin deficiency in children include disorders of neuropsychic development (decreased functionality of the central nervous system, increased irritability, tearfulness, etc.), disorders of cognitive functions (decrease in memory parameters, attention, thinking, academic performance), decreased motor activity (fatigue and increased fatigue), etc.

Previously, researchers from the USA have demonstrated that lecithin has the ability to improve the so-called “brain chemical activity”, having a beneficial effect on higher cortical (cognitive) functions such as memory, speech and motor skills. Subsequently, this allowed Barbeau A. (1978) to highlight the problem of using lecithin in neurology (Friedreich’s ataxia, Huntington’s chorea, etc.) [4, 5].

Since the 1980s. A number of works appeared in medical periodicals on the use of lecithin for various cognitive impairments, memory disorders, as well as in the treatment of dementia of the Alzheimer's type (Garcia CA et al., 1982; Brinkman SD et al., 1982; Kazdova E., 1984; Panijel M., 1986; Ladd SL et al., 1993; Benton D. and Donohoe RT, 2004) [6–11]. Chinese researchers Shi F. et al. (2001) reported the use of soy lecithin in the treatment of cerebral infarction [12]. Higgins JP and Flicker L. (2009) presented the latest systematic review on the use of lecithin in dementia and cognitive impairment [13]. We have also previously reported the possibility of using lecithin for other types of psychoneurological pathology in children and adolescents, including early childhood autism (ECA), psychomotor development delay (PDMR), Gilles de la Tourette syndrome, asthenoneurotic reactions, depressive neurosis, Meniere's disease, epilepsy and etc. [3, 14, 15]. It is assumed that lecithin, which is part of the myelin sheaths covering nerve fibers, can in some cases ensure the onset of remission in multiple sclerosis (MS), which often occurs in childhood (up to 18 years) [16].

It is well known that vitamins are nutrients, the use of which (vitamin prophylaxis and vitamin therapy) is an integral part of neurodietology. The combination of vitamin or vitamin-mineral complexes with biologically active substances (BAS), one of which is traditionally considered lecithin, reflects a progressive way to optimize nervous functions, somatic health and vitamin supply of children. Lecithin is necessary both for neurons and cell membranes, and for the effective utilization of vitamins entering the body.

The role of vitamin status correction in the treatment of attention deficit hyperactivity disorder (ADHD) was reported by O. A. Gromova et al. (2003) [17]. Employees of the psychoneurological department of the Scientific Center for Children of the Russian Academy of Medical Sciences in 2003–2004. in the treatment of a group of children with ADHD (32 patients aged 6–16 years), the Kinder Biovital vitamin complex (gel) with lecithin was used [3]. We emphasize that at that time drugs intended for the treatment of ADHD were not registered in the Russian Federation, and atomoxetine became available only in 2006. The vitamin complex described contains 10 g of lecithin, that is, 2 teaspoons (manufacturer’s recommendations for school children age and adults) is 200 mg. It is believed that this combined preparation, which contains the most important fat-soluble (A, D, E) and water-soluble (B1, B2, B5, B6, B12, C, nicotinamide) vitamins and soy lecithin, not only corrects vitamin status, but also has antioxidant, metabolic and immunomodulatory effects.

Observed children with ADHD were examined according to a single protocol, which included:

• physical and neurological examination;
• electroencephalographic study (EEG);
• examination on test computer systems (TCS) “Psychomat” (Russia);
• Luscher color test;
• defectological examination of children (selectively);
• routine clinical blood and urine tests.

Patients were diagnosed with ADHD based on the current International Classification of Diseases, X Revision (ICD-10) criteria, which differ slightly from the DSM-IV criteria used in the United States [18, 19].

All medications taken by patients during the study period, compliance, etc. were taken into account. Treatment effectiveness was assessed using three headings: “no effect,” “partial effect,” and “significant improvement.” Possible adverse reactions to the drug used (nausea, vomiting, abdominal pain, intestinal disorders, allergic manifestations), pathological laboratory changes without clinical symptoms, as well as “other symptoms” were recorded. Children's tolerance to the vitamin complex with lecithin was assessed (“unsatisfactory”, “satisfactory”, “good”).

The duration of use of Kinder Biovital gel in our observations ranged from 21 to 28 days. If necessary, the drug was provided to children to complete the planned course of treatment at home.

The assessment of the effectiveness of the multivitamin preparations used was based on data from a neurological and somatic examination, and was also clarified using the results of a TCS examination and other research methods. In 10% of observations, a significant improvement was noted, and in 90% of children - a partial effect. The presence of only a partial effect in a larger number of patients is explained by the permanent and neurochemical nature of disorders in ADHD (disorders of catecholamine metabolism are the biochemical substrate in the pathogenesis of the disease) [18].

Using TCS, we tested a number of parameters of cognitive functions: tapping with the right hand (average interval - msec, frequency of reactions - number per 1 sec); memory for numbers (average response time - msec, standard deviation of the average response time - msec, number of numbers reproduced, number of correct answers); attention by number arrangement (total search time - ms, average search time - ms, average response time - ms, total number of answers - in pieces, number of errors - in pieces); reaction to a moving object (efficiency of psychomotor activity and accuracy of hand-eye coordination). In addition to the data from examining children with ADHD using TCS, we assessed the results of the modified Luscher test (anxiety level, autonomic coefficient, deviation from the autogenic norm, etc.). A comparison of the treatment results of the observed patients was carried out with a group of children with a similar pathology who did not receive a vitamin-mineral complex with lecithin (15 patients aged 6–15 years).

The main parameters of cognitive functions that initially turned out to be deficient among the children we observed were attention, memory and motor skills. During the first testing, carried out on the third day after admission to the clinic, the perception and processing of visual stimuli in children was difficult.

Three weeks after starting to take the vitamin complex with lecithin (in an age-appropriate dosage), re-testing for TCS was carried out. At the same time, the following positive dynamics of cognitive functions were revealed: the interval (time) of motor reactions decreased by an average of 5–10%; The tempo and frequency of blows per second increased within approximately the same limits (during the tapping test). Qualitative indicators of attention also showed positive dynamics: total search time was reduced by 25–30%, average search time by 30–35%, and average response time by 15–20%. In practice, this means that the patients we observe have become better at remembering and reproducing visual information.

Data from the Luscher test, conducted simultaneously with the TCS testing described above, indicated an improvement in physical activity, vegetative support, and general well-being in children with ADHD after a course of therapy with a vitamin complex with lecithin.

The tolerability of Kinder Biovital gel with lecithin was assessed by medical staff, the patients themselves and their parents. It was satisfactory in the vast majority of observed children (adverse reactions were noted in 4% of patients and were expressed in the appearance of skin rashes, regarded as manifestations of atopic dermatitis).

The results obtained allow us to conclude that Kinder Biovital gel with lecithin should be used as part of complex treatment for ADHD to correct cognitive impairments accompanying this type of pathology. It is assumed that the achieved effect was largely due to the presence of lecithin (soy) in the Kinder Biovital gel.

The above example does not exhaust the experience of using this vitamin complex with lecithin in domestic pediatric neurology. Platonova T. N. and Yarygina S. V. (2005) presented the positive experience of its use in the therapy of 88 children of early preschool and school age with functional disorders of the nervous system (tics, neurotic reactions, logoneurosis, delayed psychomotor and/or speech development, hyperdynamic syndrome, etc.), and Korovina N.A. et al. (2006) - in the treatment of 40 patients (age 4–7 years) with emotional disorders in the form of fears [20, 21]. The positive effect of the Kinder Biovital gel with lecithin, noted in relation to parameters of psychomotor development and the emotional-behavioral sphere, was verified by researchers who used a whole battery of special tests (Denver test, verbal tests with series of speech; Ozeretskovsky test, right-left orientation, Kern test –Jerasica, Luscher test, etc.) [20]. This extensive set of psychological and neurological tests objectively confirms the effectiveness of the use of Kinder Biovital gel with lecithin for various types of psychoneurological pathology in children, which is consistent with the results of researchers from the Scientific Center for Children of the Russian Academy of Medical Sciences, who used a computerized method for testing cognitive functions in patients with ADHD. We also presented data on the role of lecithin in the diet of children with ADHD [22].

Apparently, the inclusion of lecithin gel in Kinder Biovital makes it possible to potentiate the utilization and clinical effect of their vitamin ingredients, and also to count on the implementation of a number of neuromodulatory properties inherent in lecithin as such.

Vitamins are the most important tool in neuronutrition [23–25]. The relationship between the central nervous system, lecithin and vitamin status is completely obvious and beyond doubt [25]. Meck WH et al. (2008) from the USA believe that choline (as part of lecithin), which a child receives during the first year of life, is of decisive importance for the development of memory, determining its capacity and resistance to subsequent disorders [26]. Apparently, it is no coincidence that breast milk contains 100 times more lecithin than the mother’s circulatory system.

Previously, Cott A. (1977) successfully used lecithin to enhance memory, attention and its consolidation in children unable to learn (autism, schizophrenia, etc.), achieving a 50% improvement [27].

Lecithin in the presence of pantothenic acid (vitamin B5) is transformed into acetylcholine. It is this neurotransmitter that is considered especially important for the full formation of thinking and memory processes, as well as for the activation of intellectual activity and performance.

For pediatric neurologists, it is of great importance that lecithin has a synergistic effect in relation to nootropic drugs widely used in Russia and other countries (it enhances their effect). It should also be taken into account that some drugs used in child neurology and pediatrics (phenobarbital, etc.) interfere with the absorption and assimilation of lecithin in the intestine (the need for subsidies).

In addition to the positive effect on neurological functions in diseases of the psychoneurological sphere, a number of positive effects are known that this representative of lipids has on other organs and systems of the human body (improving the functioning of the digestive tract, stimulating bile secretion, reducing cholesterol levels in the blood, detoxifying the liver/hepatoprotective effect, reducing insulin needs for diabetes, etc.). These points should not be ignored from the standpoint of somatoneurology.

Taking Kinder Biovital gel with lecithin is also indicated for healthy children and adults with increased fatigue, physical and intellectual stress, and exposure to stress. There are officially no contraindications for the use of lecithin. Balch PA (2006) emphasizes that lecithin is a wise addition to any diet [28].

Literature

1. General nutritional science: Textbook / Martinchik A. N., Maev I. V., Yanushevich O. O. M.: MEDpress-inform. 2005. 392 p.
2. Krause's food, nutrition, & diet therapy (Mahan LK, Escott-Stump S., eds.). 11 th ed. Philadelphia. Saunders/An Imprint of Elsevier. 2004. 1322 p.
3. The use of a multivitamin preparation with lecithin in neuropediatrics (a manual for doctors). M.: Publishing House "Medpraktika-M". 2005. 20 p.
4. Barbeau A. Lecithin in neurological conditions //N. Engl. J. Med. 1978. Vol. 299. P. 200–201.
5. Barbeau A. Emerging treatments: replacement therapy with choline or lecithin in neurological diseases // Can. J. Neurol. Sci. 1978. Vol. 5. P. 157–160.
6. Garcia CA, Tweedy JR, Blass JP et al. Lecithin and Parkinsonian dementia. In: Alzheimer's disease: a report of progress (Corkin S., Davis KL, Growdon JH, Usdin E. et al., eds.). New York. Raven Press. 1982, pp. 443–449.
7. Brinkman SD, Pomara N, Goodnick PJ et al. A dose-ranging study of lecithin in the treatment of primary degenerative dementia (Alzheimer's disease) // J. Clin. Psychopharmacol. 1982. Vol. 2. P. 281–285.
8. Kazdova E. Treatment of dementia with high doses of lecithin and piracetam // Activitas Nervosa Superior. 1984. Vol. 26. P. 244–245.
9. Panijel M. Therapeutische Wirksamkeit von Lecithin bei Gedachtnis-und Konzentrationsstorungen //Therapiewoche. 1986. Vol. 36. S. 5029–5034.
10. Ladd SL, Sommer SA, Laberge S., Toscano W. Effect of phosphatidylcholine on explicit memory // Clin. Neuropharmacol. 1993. Vol. 16. P. 540–549.
11. Benton D., Donohoe RT The influence on cognition of the interactions between lecithin, carnitine and carbohydrate // Psychopharmacology (Berl). 2004. Vol. 175. P. 84–91.
12. Shi F., Zhou J., Meng D. Curative effect of soybean lecithin on cerebral infarction // Zhonghua Yi Xue Za Zhi. 2001. Vol. 81. P. 1301–1303.
13. Higgins JPT, Flicker L. Lecithin for dementia and cognitive impairment (review) // The Cochrane Library. John Wiley & Sons Ltd. 2009. The Cochrane Collaboration: Issue 1. 26 p.
14. Studenikin V. M. Multivitamin preparation with lecithin: use in pediatric neurology // Treating Doctor. 2003. No. 6. P. 56–57.
15. Studenikin V.M., Balkanskaya S.V., Maslova O.I. Possibilities of using a multivitamin preparation with lecithin in pediatric neurology // Consilium medicum. Pediatrics. 2008. Extra edition. pp. 17–19.
16. Studenikin V.M., Vysotskaya L.M., Shelkovsky V.I., Bykova O.V. et al. Multiple sclerosis in children: the role of diet // Issues. children's Dietol. 2008. Volume 6. No. 6. pp. 23–28.
17. Gromova O. A., Krasnykh L. M., Limanova O. A., Kutuzova N. A., et al. Correction of vitamin status in attention deficit hyperactivity disorder // Issues. modern pediatrics. 2003. Volume 2. No. 4. pp. 33–39.
18. Attention deficit hyperactivity disorder (ADHD): etiology, pathogenesis, clinical picture, course, prognosis, therapy, organization of care (expert report). M.: CAF. 2007. 64 p.
19. American Psychiatric Association. Diagnostic and statistical manual of mental disorders (DSM-IV-TR). 4 th ed. Text rev. Washington (DC). American Psychiatric Association. 2000.
20. Platonova T.N., Yarygina S.V. Efficacy of the multivitamin complex “Kinder Biovital Gel” for minimal neurological dysfunction in preschool children // Consilium medicum. Pediatrics. 2005. Volume 7. No. 1.
21. Korovina N. A., Zakharova I. N., Naumenko L. L. Micronutrient deficiency and neuropsychic development of children // Consilium medicum. Pediatrics. 2006. Volume 8. No. 2.
22. Studenikin V.M., Balkanskaya S.V., Kurbaytaeva E.M., Shelkovsky V.I. et al. Attention deficit hyperactivity disorder (ADHD) and diet // Pediatrician’s Handbook. 2007. No. 8. pp. 18–27.
23. Combs FG Jr. (ed). The vitamins Fundamental aspects in nutrition and health. 3rd ed. Amsterdam-Boston. Elsevier Academic Press. 2008. 584 p.
24. Vitamins and minerals in nutrition and maintaining the health of children. Chapter 17. In the book: Clinical dietetics of childhood: A guide for doctors / Ed. Borovik T. E., Ladodo K. S. M.: MIA LLC. 2008. pp. 443–471.
25. Studenikin V.M., Shelkovsky V.I. Vitamin and mineral complexes for children: a tool for neurodietology // Pediatrics. G. N. Speransky. 2008. Volume 87. No. 6.
26. Meck WH, Williams CL, Cermark JM, Blusztajn JK Developmental periods of choline sensitivity provide an ontogenetic mechanism for regulating memory capacity and age-related dementia // Frontiers Integrate. Neurosci. 2008. Vol. 1 (Art. 7). P. 1–11.
27. Cott A. The orthomolecular approach to learning disabilities. San Rafael (CA). Academic Therapy Publ. 1977.
28. Lecithin. In: Prescription for nutritional healing. A practical A-to-Z reference to drug-free remedies using vitamins, minerals, herbs & food supplements (Balch PA). 4 th ed. New York. Avery/A Member of Penguin Group (USA) Inc. 2006. P. 85.

V. M. Studenikin , Doctor of Medical Sciences, Professor S. V. Balkanskaya , Candidate of Medical Sciences V. I. Shelkovsky , Candidate of Medical Sciences

SCCD RAMS , Moscow

special instructions

There are several points to pay attention to:

• The supplement is approved for use by people suffering from diabetes: it does not contain bread units.
• Dietary supplements are taken only after consultation with your doctor in case of exacerbation of cholecystitis.
• Patients with gallstones and pancreatitis should discuss the dosage with their physician.
• When taking the drug for a long time, simultaneous use of ascorbic acid is necessary.

Release form and composition

Doppelhertz active Lecithin-Complex is available in the form of capsules weighing 1000 mg (10 pieces in a blister, 3 blisters in a cardboard pack).

1 capsule contains:

• active ingredients: lecithin – 500 mg; vitamin E (tocopherol acetate) – 15 mg; vitamin PP (nicotinamide) – 13.5 mg; vitamin B1 (thiamine) – 2.1 mg; vitamin B2 (riboflavin) – 2.4 mg; vitamin B6 (pyridoxine) – 2.4 mg; vitamin B9 (folic acid) – 0.2 mg; vitamin B12 (cyanocobalamin) – 0.003 mg;
• auxiliary components: gelatin, glycerin, sorbitol, glycerol monostearate, red iron oxide, yellow iron oxide, soybean oil, purified water.

Overdose

Exceeding the dosages recommended by the doctor and indicated in the instructions has dangerous consequences.

Signs of acute poisoning:

• Headaches, dizziness, decreased concentration.
• Hypersalivation.
• Nausea, pain in the epigastric region.

Long-term use of high doses can lead to the following consequences:

• Decreased absorption of amino acids.
• Deterioration of memory and other intellectual functions.
• Thyroid dysfunction.

In case of acute poisoning, it is necessary to take sorbents and seek help from a medical facility.

General information

Lecithin Forte Active 1200 Doppelhertz is produced by the German company Queisser Pharma. The company appeared on the pharmaceutical market in 1897 and has more than a hundred years of successful activity. The products comply with the international GMP quality standard. Doppelgerz products began arriving in Russia in 1996.

Lecithin was discovered in 1845. In France, Gobley, a chemist, obtained it from the yolk of an egg. It is a fat-like substance consisting of phospholipids and triglycerides. Now this substance is produced from soybean and vegetable oils.

Table 1. General information.

Indications for use

The instructions for Lecithin Forte Active 1200 from Doppelhertz indicate the conditions for which this supplement can be used:

• Decreased mental and physical performance.
• Impaired liver function.
• Signs of general intoxication.
• Recovery after a heart attack.
• Prevention of atherosclerosis.
• Supporting the body during age-related changes.
• Prevention of cerebrovascular accidents.
• Violation of lipid balance in the body.

Important! The drug should not be given to a child under 16 years of age.

This supplement is not prescribed to nursing mothers and pregnant women due to the lack of data on the effects of lecithin on the growing body.

Reviews about Doppelhertz active Lecithin-Complex

Reviews about Doppelhertz asset Lecithin-Complex are mostly positive. For many users, dietary supplements are a reliable and proven remedy during periods of increased mental stress, chronic fatigue and stressful situations. In their reviews, they indicate that when taking the product, mood and the condition of the heart muscle improve, thinking processes are activated, information is easily remembered, absent-mindedness and nervousness disappear, and the quality of life improves.

Negative reviews are rarely found, the authors of which report a complete lack of tangible effect.