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Manufacturers: Schering AG, PL
Active ingredients
- Levonorgestrel
Disease class
- Monitoring contraceptive use
Clinical and pharmacological group
- Not indicated. See instructions
Pharmacological action
- Contraceptive
- Progestin
Pharmacological group
- Estrogens, gestagens; their homologues and antagonists
pharmachologic effect
Contraceptive. Microlut is a progestin, low-dose medication that is used to prevent pregnancy. Daily, regular use of levonorgestrel provides reliable contraceptive action, which is achieved through the complex influence of several mechanisms at once. The leading role is given to the peripheral gestagenic effect. The active substance can increase the viscosity of mucus, which is located in the cervix (cervical/cervical mucus), which prevents sperm from entering the uterine cavity. The active substance is capable of inhibiting endometrial proliferation , which prevents the fertilized egg from implanting to the uterine wall.
Microlute is able to block the release of follicle-stimulating and luteinizing releasing factors of the hypothalamus . While taking the medication, there is a suppression of the production of pituitary gonadotropic hormones, which in turn inhibits the ovulation process. With regular use, the volume of menstrual bleeding noticeably decreases and menstrual pain (including premenstrual pain) is eliminated.
Contraindications
- neoplasms in the hepatic system;
- vaginal, uterine bleeding of unknown origin;
- sickle cell anemia;
- diabetes mellitus with various vascular complications;
- thromboembolic processes;
- herpetic infection;
- hemolytic anemia;
- history of stroke
- malignant neoplasms of the mammary gland, suspicion of them;
- individual hypersensitivity;
- hormone-dependent endometrial/breast cancer;
- period of gestation.
Relative contraindications:
- history of ectopic pregnancy
- pathology of the renal system;
- violation of the patency of the fallopian tubes;
- diabetes mellitus without complications;
- epilepsy;
- migraine;
- tuberculosis.
Microlut tab. 0.03 mg 35pcs - Instructions
Compound
The main active substance is levonogestrel.
Other ingredients: calcium carbonate, glycol montanate, lactose monohydrate, macrogol 6000, magnesium stearate, corn starch, povidone, purified talc, sucrose.
Release form
The medication is available in tablets placed in packages of 35 pieces each.
pharmachologic effect
Microlut contains the progestogen levonorgestrel for oral administration in a very low dose. Continuous daily dosing of 0.03 mg levonorgestrel prevents conception in several independent ways. These are basically changes in the cervical mucus that make it difficult or block sperm migration and ascent. Moreover, changes in the endometrium throughout the cycle can be considered as an effect that complicates treatment. Ovulation is not suppressed in most women, but Microlut may reduce peak mid-cycle gonadotropin levels and corpus luteum function, which may contribute to contraceptive effects. The pregnancy rate with progestogen-only oral contraceptives is slightly higher than with combined progestogen-estrogen oral contraceptives. However, if taken correctly (without missing pills), the chance of getting pregnant is very low.
Pharmacokinetics
Rapidly absorbed from the gastrointestinal tract, tmax is 2 hours. Highly bound to plasma proteins. T1/2 - 26 hours; metabolism occurs in the liver. Excreted in the form of metabolites in urine and feces.
Indications for use
Microlute is used to prevent pregnancy.
Contraindications
Microlut should not be used if any of the following conditions exist:
- established or suspected pregnancy;
- active venous thromboembolic disease;
- arterial and cardiovascular diseases, present or in history;
- diabetes mellitus with vascular damage;
- presence or history of severe liver disease associated with impaired liver function;
- presence or history of liver tumors (benign or malignant);
- known or suspected sex hormone-dependent malignancies, such as breast;
- vaginal bleeding of an undiagnosed nature;
- hypersensitivity to constituent substances.
Side effects
Most often, the medication can cause gastrointestinal disorders (nausea, loss of appetite, vomiting, diarrhea), dizziness and headache, migraine, depression, allergic reactions, amenorrhea.
Compatibility with other medications
It is not recommended to combine the medication with:
- medicines used to treat tuberculosis;
- antibiotics known as macrolides;
- medicines used to treat fungal infections;
- medicines used to treat HIV;
- some medicines used to treat hepatitis C virus (HCV);
- medicines used to treat epilepsy;
- antibiotics;
- cyclosporine, immunosuppressants;
- certain medications used to treat high blood pressure, chest pain, or irregular heartbeat;
- medicinal herbs containing St. John's wort;
- grapefruit juice.
Application and dosage
You need to take the medication one tablet a day at the same time every day. An interval of exactly 24 hours should be maintained between taking tablets. This interval should not be exceeded by more than 3 hours.
The day of the week is indicated on each blister pack. You should start taking it with the first tablet from the blister, corresponding to the day of the week.
Follow the direction of the arrows on the blister pack until all tablets have been taken. The day of the week is indicated on each blister pack.
The tablets must be taken for 28 consecutive days. There is no break between packs. This means that when the first package is finished, the next one must be started without interruption.
Overdose
There have been no reports of serious adverse effects from overdose. Symptoms that may occur in this case are nausea, vomiting and slight vaginal bleeding. There are no antidotes, further treatment should be symptomatic.
special instructions
A complete medical history and physical and gynecological examination should be obtained before starting or resuming use of Microlut. The frequency and nature of these assessments should be based on established rules of thumb and tailored to the individual woman, but should generally include special attention to blood pressure, breast, abdomen and pelvic organs, and should also include cervical cytology.
Use during pregnancy and breastfeeding
Taking the medication is prohibited.
Impact on the ability to drive vehicles and operate machinery
No special precautions are required.
Terms of sale
As prescribed by the doctor.
Storage conditions
In a dry, cool place, with limited access for children.
Side effects
- engorgement of the mammary glands;
- menstrual irregularities ( amenorrhea , irregular/frequent bleeding);
- allergic responses;
- depressed mood;
- nausea;
- skin changes ( hirsutism , acne );
- dizziness;
- vomit;
- deterioration of tolerance to contact lenses;
- change in vaginal secretion;
- decreased libido ;
- headache;
- change in body weight;
- diarrhea.
Dragee Microlut
Instructions for medical use of the drug
Description of pharmacological action
Increases the viscosity of cervical mucus, which prevents the penetration of sperm into the uterine cavity, blocks the release of releasing factors (luteinizing and follicle-stimulating) of the hypothalamus, inhibits the secretion of gonadotropic hormones by the pituitary gland, and thus inhibits ovulation; prevents endometrial proliferation, reduces the volume of menstrual bleeding, eliminates pre- and menstrual pain.
Indications for use
Prevention of unwanted pregnancy, incl. as an additional remedy for women using non-hormonal methods of contraception, as well as in the presence of contraindications to the use or poor tolerance of gestagen-estrogenic drugs.
Release form
dragee 0.03 mg; blister 35, box (box) 1;
Pharmacodynamics
Increases the viscosity of cervical mucus, which prevents the penetration of sperm into the uterine cavity, blocks the release of releasing factors (luteinizing and follicle-stimulating) of the hypothalamus, inhibits the secretion of gonadotropic hormones by the pituitary gland, and thus inhibits ovulation; prevents endometrial proliferation, reduces the volume of menstrual bleeding, eliminates pre- and menstrual pain.
Use during pregnancy
Contraindicated during pregnancy. Can be used during breastfeeding (due to the low dose of the hormonal agent, it is practically not excreted in breast milk).
Contraindications for use
Hypersensitivity, pregnancy, severe liver dysfunction, liver tumors and thromboembolic processes (including a history), diabetes mellitus with vascular complications, hormone-dependent breast or endometrial cancer, vaginal bleeding of unknown etiology.
Side effects
In some cases - menstrual irregularities (frequent and/or irregular bleeding, amenorrhea), breast engorgement, headache, dizziness, nausea, vomiting, diarrhea, skin lesions (including acne and hirsutism), changes in body weight and libido, depressive states, changes in vaginal secretion, deterioration in tolerance to contact lenses, allergic reactions.
Directions for use and doses
Orally, without chewing, with a small amount of liquid. 1 tablet daily, at the same time, starting from the 1st day of menstruation (using the tablet of the corresponding day of the week from the calendar package). After completing the intake of Microlut from the first package, the next day it is continued from a new package, starting with the tablet of the corresponding day of the week.
Interactions with other drugs
Rifampicin, griseofulvin, ampicillin, tetracycline, primidone, phenytoin and barbiturates reduce the effect of levonorgestrel.
Special instructions for use
If the expected menstruation does not occur while taking the drug, pregnancy must be excluded. In case of prolonged and persistent intermenstrual bleeding, additional examination is necessary to clarify the diagnosis.
Storage conditions
List B: Under normal conditions.
Best before date
60 months
ATX classification:
G Genitourinary system and sex hormones
G03 Sex hormones and modulators of the reproductive system
G03A Systemic hormonal contraceptives
G03AC Progestogens
G03AC03 Levonorgestrel
Interaction
Medicines that can reduce the effectiveness of Microlute:
- Lamotrigine;
- Phenobarbital and other barbiturates ;
- Primidon;
- Rifampicin;
- Phenytoin.
The risk of intermenstrual bleeding increases when taking the following drugs:
- Chloramphenicol;
- Nitrofurantoin;
- Sulfamethoxypyridazine;
- Phenoxymethylpenicillin;
- Ampicillin.
The active component Levonorgestrel can reduce the effectiveness of:
- anticonvulsants;
- antihypertensive medications;
- oral anticoagulants.
It is recommended to adjust the doses of insulin and hypoglycemic drugs during treatment with Microlut. The medication promotes the accumulation of Diazepam and Chlordiazepoxide .
special instructions
Before taking contraceptives, a gynecological and partial therapeutic examination is recommended, and examination of the mammary glands is mandatory. A doctor's examination and all examinations must be completed every six months. In some patients taking the medication, the interval between menstruation and the intensity of menstrual bleeding change; The menstrual cycle itself does not change. If there is no intermenstrual bleeding for more than 6 months, you should contact your doctor to rule out pregnancy. Treatment is continued if pregnancy is not confirmed.
Keeping a special calendar, which is attached to the medication, makes it easier to track the frequency of menstruation. In the first 14 days of therapy, contraception is incomplete, so it is necessary to resort to non-hormonal, barrier methods of preventing pregnancy.
The contraceptive effect is lost if the interval between taking pills is more than a day. With diarrhea , vomiting, overweight, obesity, the contraceptive effect is lost. In the event of a sudden deterioration in auditory or visual perception, prolonged migraine, pregnancy, increased frequency of seizures , suspected thrombosis or thromboembolism , a sharp rise in blood pressure, or the appearance of jaundice the medication is discontinued. After discontinuation of the drug, the functionality of the gonads is restored quickly enough, which increases the chances of pregnancy.
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** The Drug Directory is intended for informational purposes only. For more complete information, please refer to the manufacturer's instructions. Do not self-medicate; Before starting to use the drug Microlut, you should consult a doctor. EUROLAB is not responsible for the consequences caused by the use of information posted on the portal. Any information on the site does not replace medical advice and cannot serve as a guarantee of the positive effect of the drug.
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** Attention! The information presented in this medication guide is intended for medical professionals and should not be used as a basis for self-medication. The description of the drug Microlut is provided for informational purposes and is not intended for prescribing treatment without the participation of a doctor. Patients need to consult a specialist!
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Analogs
Level 4 ATX code matches:
Eskinor-F
Exluton
Postinor
Escapelle
Implanon NKST
Charosetta
Lactinet
- Escapelle;
- Postinor;
- Mirena;
- Eskinor-F;
- Levonorgestrel.
