Miropriston is an antigestagenic drug that is widely used in gynecological practice to artificially increase the contractile activity of the uterus.
The drug is produced in Russia and supplied to obstetrics and gynecology clinics for medical termination of pregnancy or artificial induction of labor.
Pharmacodynamics and pharmacokinetics of Miropriston
The active substance of the drug mifepristone is a synthetic steroidal antigestagenic drug (blocks the action of the hormone progesterone at the receptor level) and does not have gestagenic activity. Antagonism with glucocorticosteroids , manifested due to competition at the level of interaction of the drug with receptors.
Mifepristone increases the contractile function of the myometrium, thereby stimulating, in choriodecidual cells, the release of IL-8 (interleukin-8) , increasing the sensitivity of the myometrium to prostaglandins . The result of the drug is desquamation of the decidua and, as a consequence, the release of a fertilized egg.
After taking a single dose of 600 mg, the maximum content of the active substance in the blood plasma is observed after 1.3 hours (1.98 mg/l). Bioavailability is approximately 69%.
Mifepristone in blood plasma is 98% protein albumin and acidic alpha1-glycoprotein ). The elimination of the drug, after the distribution phase, occurs slowly, with its concentration halving between 12–72 hours; after 72 hours, elimination proceeds more quickly. The half-life of the drug is usually 18 hours.
Pharmacological action of miropristone
The content of the article
Miropriston contains a synthetic steroid substance - mifepristone, which, when it enters the female body, has an antigestagenic effect: it blocks the activity of the main hormone of pregnant women - progesterone - at the receptor level. Already 80-90 minutes after taking the drug, the concentration of the active substance becomes as high as possible, while the uterus increases its activity. The tone of the uterus increases and its contractile function increases.
In addition, when a pregnant woman takes the drug, rapid destruction of the capillaries of the placenta occurs, which causes the death of the embryo. This is followed by rejection of the fetal membrane by the walls of the uterus - spontaneous termination of pregnancy occurs. Physiologically, this process resembles regular menstruation, but the bleeding is more abundant and contains clots.
At the same time, the drug does not have gestagenic activity and does not affect hormonal levels in the future. After such medical intervention, the woman’s fertility is preserved, so during the next ovulation there is a chance of becoming pregnant again.
Contraindications
- individual sensitivity to this drug;
- acute or chronic pathologies of the kidneys and liver;
- adrenal insufficiency;
- long-term therapy using glucocorticosteroids ;
- porphyria;
- anemia (with hemoglobin less than 100 g/l);
- hemostasis disorders (including previous therapy using anticoagulants );
- acute inflammatory pathology of the female genital organs;
- severe extragenital diseases;
- uterine fibroids;
- smoking (for patients over 35 years old, without consulting a doctor).
Use for abortion :
- the estimated pregnancy period is more than 42 days of amenorrhea ;
- confirmed ectopic pregnancy or suspicion of its possibility;
- unconfirmed pregnancy;
- possible pregnancy that occurred due to the use of intrauterine contraceptives ;
- possible pregnancy after discontinuation of hormonal contraceptives .
Use for initiating labor and preparing for childbirth:
- preeclampsia;
- severe gestosis
- eclampsia;
- discrepancy in the size of the fetal head and the pelvis of the woman in labor;
- post-term or premature pregnancy;
- causeless bleeding from the genitals;
- pathological position of the fetus;
- severe hemolytic disease of the fetus;
- premature discharge of amniotic fluid.
Prescribe with caution:
- for arterial hypertension ;
- for bronchial asthma ;
- for chronic obstructive diseases of the pulmonary system;
- for cardiac arrhythmias;
- with diagnosed heart failure .
Side effects
When taking mifepristone :
- hives;
- hyperthermia;
- dizziness;
- headache;
- general weakness;
- feeling of discomfort in the lower abdomen;
- nausea and vomiting.
During the procedure of medical abortion :
- pain in the lower abdomen;
- bleeding from the genital tract;
- inflammatory processes of the uterus and its appendages.
Where to buy Miropriston for medical abortion in St. Petersburg, price
Miropriston is not sold through the pharmacy chain in St. Petersburg. The drug is supplied exclusively to medical institutions of the appropriate profile for its use directly in the process of artificial induction of labor or medical termination of pregnancy. For example, have a medical abortion at the Diana Clinic, at 10 Zanevsky Prospekt. The cost of a set of services, including abortion pills, an appointment with a gynecologist and a comprehensive ultrasound of the female organs is 3,500 rubles.
Instructions for Miropriston (Method and dosage)
The drug Miropriston in the form of tablets is taken orally. The drug should be prescribed and used only in specialized medical institutions that have trained and trained personnel, as well as the necessary diagnostic and treatment equipment.
To terminate an unwanted pregnancy in the early stages
Prescribe 600 mg of the drug (3 tablets of 200 mg each) once 1-1.5 hours after a meal, with a sufficient amount of water. The drug is indicated for use only in the presence of the attending physician. After taking 3 tablets of Miropriston, 36-48 hours later, the patient is prescribed Misoprostol at a dose of 400 mcg and left under the dynamic supervision of the attending physician for 2 hours. Ultrasound monitoring and repeated clinical examination are prescribed 10-14 days after starting Mifepristone . If necessary, the level of human chorionic gonadotropin is determined in order to confirm a successful medical abortion.
If the effect of therapy is negative or incomplete (continuing pregnancy or incomplete abortion), vacuum aspiration with further histological studies is recommended on the 14th day after taking the drugs.
For preparation and artificial induction of labor
The drug Miropriston is prescribed as tablets to induce labor in a dose of 200 mg (1 tablet) once (only in the presence of the attending physician). After a day (24 hours), 200 mg of Miropriston is re-prescribed. The condition of the birth canal is assessed 48-72 hours after taking a second dose of the drug. If necessary, prostaglandins and Oxytocin .
When to take miropristone
Miropriston is used in medical institutions under the supervision of a doctor for the following purposes:
- As part of a medical regimen for terminating pregnancy for up to 42 days from the last menstruation, there is a medical abortion.
- To stimulate the labor process during full-term pregnancy.
- Composition and release form
- The active ingredient of the drug is mifepristone. The tablets also contain carboxymethyl starch and microcrystalline cellulose, and talc is added.
- The drug is produced in the form of tablets, sold in cardboard boxes or polymer jars of 2, 3 or 6 pieces, depending on the purpose.
special instructions
Patients who take Miropriston to terminate an unwanted pregnancy in the early stages should have full information about the action of this drug. In particular, if there is no effect from taking the drug on days 10-14 ( continuing pregnancy or incomplete abortion ), the pregnancy must be terminated in another way recommended by the attending physician, in order to avoid the risk of developing congenital defects in the fetus.
The use of Miropriston requires the prevention of Rh alloimmunization and the appointment of other general measures that accompany abortion.
Interaction with other drugs
- If, during the period of Miropriston administration, a woman is taking a course of glucocorticosteroids, the dose of the latter medications must be increased. This is due to competition that appears at the level of mifepristone's effect on receptors.
- It is unacceptable to take Miropriston with any non-steroidal anti-inflammatory drugs.
- Pregnancy and lactation period.
Taking Miropriston during lactation requires a temporary stop in feeding for 3 days: during this period it is recommended to express milk. In the case when the drug is prescribed to stimulate the birth process, no restrictions are imposed on breastfeeding.
Reviews of Miropriston
Reviews on forums about the drug Miropriston, as a means of terminating an unwanted pregnancy, are mostly positive. Of the advantages of this drug, attention is most often paid to the possibility of abortion without surgical intervention. Disadvantages include pain in the lower abdomen , vomiting and a feeling of discomfort after taking the medicine. Side effects and undesirable consequences of using Mifepristone usually occur when taking the drug at home without consulting a doctor.
There are practically no negative reviews about Miropriston during childbirth. This drug is used in obstetric practice quite widely and successfully.
Peculiarities
The drug Miropriston belongs to the group of synthetic steroidal antigestagenic agents. The drug is produced in the form of 200 mg tablets. It is sold and used exclusively in medical institutions, which are staffed by professionals and have all the necessary equipment.
The active substance in the drug is mifepristone. This component is a synthetic steroid substance. When it enters a woman’s body, it has an antigestagenic effect. That is, it blocks the production of progesterone, which is necessary to maintain pregnancy. Additionally, taking the drug destroys the capillaries of the placenta, which leads to the death of the embryo. Against this background, the tone of the uterus and its contractility increases, which leads to spontaneous miscarriage.
The drug does not change hormonal levels after termination of pregnancy. This means that after a medical abortion, it is still possible to become pregnant during the next ovulation. This means that in order to exclude an unwanted pregnancy, you should start taking contraceptives as early as possible.
Miropriston price, where to buy
The price of Miropriston in a pharmacy (Table 0.2g N3) ranges from 535 to 692 hryvnia, depending on the medical institution.
In Ukraine, Miropriston can be purchased exclusively by prescription, with further use in a specialized clinic, under the strict supervision of the attending physician.
- Online pharmacies in UkraineUkraine
Pharmacy24
- Miropriston 0.2 g N3 tablets ZAT "Obninsk Chemical-Pharm. Company", Russia
755 UAH.order
It is important!
Before undergoing medical termination of pregnancy, the patient must undergo a full diagnostic course preceding any type of abortive intervention.
If, 14 days after the medical termination of pregnancy, the examination showed that the fertilized egg remained in the uterus or did not come out completely, mandatory vacuum aspiration with further examination of the resulting aspirate is required.
If the patient has a prosthetic heart valve or a history of infective endocarditis, pretreatment with antibiotics is necessary.
