Zhenale: how to take the drug correctly if you suspect conception

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INN: Mifepristone, (Russia); Release form : 10 mg tablets, light yellow with a greenish tint, round, biconvex.

Composition: each Zhenale tablet contains:

active substance: mifepristone - 10 mg; excipients: lactose monohydrate - 123.4 mg, potato starch - 22 mg, povidone K25 - 6 mg, sodium carboxymethyl starch - 5 mg, magnesium stearate - 1.6 mg.

Pharmacodynamics

Mifepristone is a synthetic steroidal antigestagenic agent (blocks the action of progesterone at the receptor level) and does not have gestagenic activity. Antagonism with GCS was noted (due to competition at the level of communication with receptors).

Depending on the phase of the menstrual cycle, it causes an increase in the contractility of the myometrium, stimulating the release of interleukin-8 in choriodecidual cells, increasing the sensitivity of the myometrium to PG. As a result of the action of the drug, desquamation of the decidua occurs and the fertilized egg is expelled. Causes inhibition of ovulation, changes in the endometrium and prevents the implantation of a fertilized egg.

pharmachologic effect

Zhenale contains a synthetic antigestagen - mifepristone in a dosage of 10 mg. The active substance has some glucocorticosteroid activity, as a result of which the drug has special instructions and properties atypical for emergency contraception.

Zhenale is used as an option to prevent pregnancy after unprotected intercourse. This drug, as a means of emergency contraception, can be used effectively for 72 hours after an emergency.

Entering the gastrointestinal tract, zhenale reaches its maximum values ​​in the blood within 1 - 2 hours and begins to act. The medicine is excreted slowly, so when using it during lactation, breastfeeding must be stopped for a period of up to 14 days. It is the long-term presence in the body that determines the period of use of the product - up to 72 hours. While for postinor, for example, the interval is several times smaller.

How pregnancy is prevented

Genale operates on several levels. The predominant effect of one or another method depends on the day of the cycle on which the drug was taken. It looks like this in detail:

• In the case when the remedy was used before the onset of ovulation, then zhenale changes the hormonal background so that its onset is delayed. Accordingly, sperm that penetrate the uterine cavity will not be able to fertilize the egg, since it will still be in the follicle. That is why marriage is a common situation, and there is no need to worry.
• When the drug is used after ovulation, it promotes the rejection of the fertilized egg. This happens due to the fact that zhenale stimulates the production of interleukin-8, which promotes the destruction of the decidula. And it is very important, as it plays a role in attaching the fertilized egg to the wall of the uterus. Interleukin-8 also increases the sensitivity of the myometrium to prostaglandins. And they cause rhythmic contractions of the uterine walls. All this promotes the release of the fertilized egg and prevents pregnancy.
• If the drug is used at the time of ovulation, then, in addition to the above effects, it promotes endometrial atrophy in this cycle. This leads to the fact that the fertilized egg cannot attach to the wall; figuratively speaking, it has nothing to hold on to.

It is important that zhenale affects the fertilized egg. Therefore, it may have an adverse effect on the developing embryo. Due to these reasons, if the drug is taken and pregnancy still occurs, it is recommended to terminate it in another way - medication or instrumentally. Otherwise, the risk of pathologies in the fetus is high. By the way, escapelle and postinor are less safe in this regard.

Contraindications

a history of hypersensitivity to mifepristone and/or auxiliary components;

adrenal insufficiency;

acute or chronic renal and/or liver failure;

long-term therapy with glucocorticosteroids;

porphyria;

anemia;

hemostasis disorders (including previous treatment with anticoagulants);

the presence of severe extragenital pathology;

pregnancy;

lactation period.

Side effects and overdose of Zhenale

Side effects after using Zhenale can affect many vital systems. Thus, in the reproductive system, blood discharge from the vagina, discomfort and pain in the lower abdomen, as well as exacerbation of pathological processes in the appendages and uterus are possible. Digestive upset is accompanied by nausea, vomiting and diarrhea, and central nervous system disorders are represented by dizziness and migraine attacks. In addition, in some clinical pictures there are allergic reactions on the skin, in particular, urticaria, itching and swelling.

In cases of Zhenale overdose, adrenal insufficiency may predominate.

Precautionary measures

The drug does not protect against sexually transmitted diseases and AIDS; It is not recommended to use the drug as a planned, permanent contraception after each sexual intercourse, or monthly.

After use as postcoital contraception and until the end of the current menstrual cycle, subsequent sexual intercourse without the use of contraceptives is not recommended. For further sexual intercourse, a barrier method of contraception should be used.

A 10 mg dose of the drug is not sufficient to cause abortion, so before further use, a highly sensitive pregnancy test should be performed to ensure that this drug is used only in the absence of pregnancy. If pregnancy occurs despite the use of the drug, it is recommended to terminate it with medication or surgery. If the patient decides to continue the pregnancy, it is impossible to completely eliminate the risk to the health of the unborn child.

Impact on the ability to drive a car or perform work that requires increased speed of physical and mental reactions. The effect of the drug on the ability to drive a car and operate machinery has not been noted.

Conclusion

Emergency contraception is a necessary procedure. The drug "Zhenale" is a modern medicinal method of emergency post-coital contraception for women, which can with a high probability prevent the attachment of the egg and prevent pregnancy with minimal risk to the patient's body.

MAKE AN APPOINTMENT

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Abortion and contraception clinic in St. Petersburg - department of the medical gynecological association "Diana"

Make an appointment, tests or ultrasound via the contact form or by calling +8 (812) 62-962-77. We work seven days a week from 09:00 to 21:00.

We are located in the Krasnogvardeisky district, next to the Novocherkasskaya, Ploshchad Alexander Nevsky and Ladozhskaya metro stations.

The cost of a medical abortion in our clinic is 3,300 rubles. The price includes all pills, an examination by a gynecologist and an ultrasound to determine the timing of pregnancy.

Analogs

Level 4 ATC code matches:
Mifepristone

Mifeprex

Mytholian

Ginestril

Esmiya

Mifegin

Miropriston

Gynepristone

Pencrofton

Common analogues of Zhenale: Ginepristone, Agesta, Mensofta, Mifegin, Mifeprex, Mifolian, Escapel, Postinor, Ginestril, Miropriston, Mifepristone, Pencrofton .

Genale or Escapelle - which is better?

Escapelle refers to drugs containing progestogens (hormones). The product, unlike the original, is effective only for the first 24-48 hours after the NPA . Also, when taking the analogue, the likelihood of ectopic pregnancy . The cost of the drugs is approximately the same.

Postinor or Zhenale - what to choose?

Postinor also contains progestogens . The effectiveness of the product greatly depends on the patient’s body weight (this figure is lower for the original). After taking an analogue, there is a greater likelihood of unwanted side effects such as bleeding, general poor health, and a delay in the next menstruation. Both products are in the same price category.

Reviews about the drug Zhenale, price

Of course, many patients prefer the decades-tested medical drug Postinor as emergency contraception, but the popularity of Zhenale is also growing every day.

The fact that Zhenale contains only one tablet, which protects against pregnancy, is captivating, while taking Postinor includes two pills, which should be taken according to a certain scheme. There is only one conclusion: Zhenale is easy to use.

Reviews about Zhenal are extremely positive, since the drug is a real lifesaver after thoughtless sexual intercourse. It gives a 99% guarantee that pregnancy will not occur in the future.

There are no negative reviews regarding the uselessness of Zhenale. It is extremely rare to find notes about the detection of side effects that are limited exclusively to nausea and dizziness.

The use of Zhenale does not require consultation with a specialist, but it still does not hurt to read the instructions carefully before taking it. The drug is truly highly effective, so many women use it with confidence.

Price for Zhenale 10 mg tablet x1 - 305 rubles

01:31 Zhenale: instructions, application, reviews -

Unprotected sexual intercourse often leads to an extremely unwanted pregnancy, which is not included in the plans of many women. That is why many ladies know firsthand about Zhenale tablets, which provide emergency contraception. General description of Zhenale tablets Zhenale is an antigestagenic drug for internal use. Its chemical formula is dominated by the steroidal antiprogestagen drug of synthetic origin mifepristone, which blocks the action of [[...]p>

Currently, contraceptives are widely used to prevent unwanted pregnancies. Among them there are tablets for regular use and means for emergency prevention. Today we will look at the drug of the second group, get acquainted with its action, indications and side effects and find out whether a delay in menstruation occurs after Zhenale and how this phenomenon is explained.

Reviews about Zhenale

In most cases, reviews about Zhenal are related to questions from women who need clarification, advice, or simply moral support. Many people try to find out, for example, what is the likelihood that pregnancy will occur:

• I took Zhenale a day after intercourse. But I'm just ovulating. What if fertilization has already occurred within these 24 hours?!

Consultants who answer such questions about the drug claim that during the first two days its effectiveness is as much as 99%, and on the third day – 98%. But there are reports from women who, after using Zhenale, found themselves pregnant:

• I drank Zhenale two hours after the act. But still, my period didn’t come and it turned out that I was pregnant. I had to have a real abortion.

However, in such cases the personal factor cannot be discounted. We cannot know how and when this conception occurred. For example, it is possible that a woman took the drug while she was pregnant. Or she conceived after taking Zhenale.

Many people report side effects of the drug:

• On the second day I started feeling nauseous and had brown discharge.

• My stomach began to hurt very badly. I went to the doctor and she scolded me very much for not taking care of my health.

Often, in contrast to Genale, the drug Escapelle is cited as easier and more effective. But these comparisons are not supported by any arguments other than personal impressions. It is best to discuss such issues with your gynecologist. It is the specialist who will advise the safest method of birth control for you, including emergency contraception.

INSTRUCTIONS

on the use of the contraceptive drug for emergency use Zhenale®

Compound:

The active substance is mifepristone, dose 10.0 mg. Excipients: lactose monohydrate 123.4 mg, potato starch 22.0 mg, povidone K25 6.0 mg, sodium carboxymethyl starch 5.0 mg, magnesium stearate 1.6 mg.

Description

The tablets are round, biconvex, light yellow with a greenish tint. Pharmacotherapeutic group - antigestagen. Efficiency - up to 95% (subject to conditions and instructions). The trade name is “Zhenale”, analogues are “Ginepriston”.

Manufacturer: Izvarino Pharma LLC, 142750, Moscow, Izvarino village, territory of VNTsMDL, building 1.

Action Genale

Zhenale tablet contains mifepristone, a drug that blocks the action of progesterone at the level of receptors in the uterus. Depending on the phase of the menstrual cycle, it causes an increase in the contractility of the myometrium, stimulating and increasing the sensitivity of the myometrium to prostaglandins. As a result of the action of the drug Zhenal, desquamation of the decidua and the removal of the fertilized egg occurs when this substance is used during the procedure of medical abortion. In the dosage prescribed for emergency contraception purposes for Zhenale tablets, it causes inhibition of ovulation, changes in the endometrium and prevents the implantation of a fertilized egg.

How to drink Genale

Indications for the use of this drug in gynecology are as follows:

1. Postcoital contraception in emergency cases within 72 hours after sexual intercourse without prior use of contraceptives or methods, as well as in case of unsuccessful use (including an error when using the calendar method, unsuccessful interruption of sexual intercourse, rupture or slippage of the condom).

The use of Zhenale according to the instructions is a single dose in cases and according to indications provided for emergency contraception. Barrier contraception (eg, a condom) should be considered until the next menstrual period begins. Repeated unprotected sexual intercourse will require emergency measures to be applied again, because The Genale effect is one-time and the risk does not apply to subsequent episodes!

How often can you drink Zhenale? Since this is an “ambulance” remedy, it should not be used very often, in extreme cases - no more than once a month. The absence of pronounced side effects and influence on the menstrual cycle, like Postinor and its analogs, makes Zhenale relatively “safe” in this regard. However, you should consult with your gynecologist and choose the appropriate contraceptive method for yourself if you need to take Zhenale birth control pills quite regularly, more than 8-10 times a year.

Drinking alcohol after Genale for 3-6 hours is not recommended - alcohol-containing drinks can reduce the effectiveness of this remedy. The drug itself is drunk during the first 3 days after the act, the sooner the better, preferably 2 hours before or 2 hours after eating, regardless of the phase of the cycle.

Contraindications

• The presence of hypersensitivity to mifepristone and/or any other of the excipients,
• Adrenal insufficiency,
• Acute or chronic renal and/or liver failure,
• long-term therapy with glucocorticoid drugs,
• The presence of severe extragenital pathology,
• Established pregnancy, breastfeeding period,
• Children and teenagers up to 16 years of age.

The use of this medication in adolescents under 16 years of age is possible in exceptional cases (including rape) and only after consultation with a gynecologist (with repeated monitoring after the procedure).

Restrictions

With caution, gynecologists use Zhenal tablets in women with chronic obstructive pulmonary diseases, including severe bronchial asthma; severe arterial hypertension, cardiac arrhythmias, chronic heart failure, hemostasis disorders and during treatment with anticoagulants. Use during pregnancy and breastfeeding is not permitted. In case of emergency use, breastfeeding should be stopped for 12-15 days.

Side effects

• Acyclic spotting/bleeding from the genital tract,
• Discomfort and pain in the lower abdomen,
• Menstrual irregularities (delayed menstruation),
• Weakness, headache, nausea, vomiting, diarrhea,
• Dizziness and hives.

“Zhenale” or “Postinor” / “Escapelle” - which is better

WHO experts and modern gynecologists argue that emergency contraception drugs can be used as often as necessary. In this case, a reasonable requirement is made - for example, 2-3 times a year is reasonable, but the same 2-4 times a month is extremely undesirable and even dangerous. Of course, any contraception is still a better choice than abortion, and here proven means will come to the rescue. Among them is “Postinor”, ​​“favorite” by all girls, “Escapelle”, known to many, and the least harmful option with minimal side effects - “Zhenale” or its analogue.

The urgency of the problem of unprotected, spontaneous sex and the desire to avoid its unplanned consequences dictates the need to use appropriate medications. Further in the table we will try to conduct a comparative analysis of the three main tablets, these are Escapelle, Postinor and Zhenale - which are the best in terms of effectiveness and the number of consequences for women's health. The basis is taken from reviews of women and doctors about Zhenal, opinions about the tolerability and undesirable effects of Postinor, etc. and the experience of specialists from our Moscow clinic.

Legend: ★ - minimum, ★★★★★ - maximum

Recommendations

Zhenale does not protect against sexually transmitted diseases and sexually transmitted infections, including AIDS. It is not recommended to use Zhenal tablets as planned, permanent contraception after each sexual intercourse, or monthly.

Zhenale is not used to terminate pregnancy! The dose of the drug in a 10 mg package is not sufficient to cause an abortion, so in the future you should take a hCG blood test for pregnancy, which ensures that this pharmaceutical drug was used only in the absence of a fertilized egg.

If conception occurs despite the use of the drug, interruption by medication or surgery is recommended. If the patient decides to continue the pregnancy, it is impossible to completely eliminate the risk to the health of the unborn child. Further on the link you can find out what methods of abortion in the early stages and where, according to reviews, it is better to do this in Moscow.

Delay after Genale in 80-90% of cases is associated with pregnancy. Therefore, if you took the pills according to the instructions and within the recommended time frame, but your period did not come, visit a gynecologist to clarify the reasons for the menstrual cycle failure (sign up via the link at the bottom of the page)!

If you consider it necessary to play it safe and take advantage of emergency protection against possible conception, then taking Zhenale is the best and effective way to get out of a difficult situation. Well, a preliminary consultation with a specialist from our clinic will minimize the consequences associated with contraindications and possible side effects! Only certified medicines from the official supplier in the Russian Federation!

Certificate of conformity

Features of Genale

Emergency medications are divided into 2 large groups:

• Hormonal medications containing progesterone. These are Postinor, Escapelle and others.
• Antigestagens, which include Zhenale.

Zhenale is used as a means of emergency contraception in the first 72 hours after unprotected sexual intercourse, once per monthly cycle. It is not recommended to take it often, much less regularly.

Advantages of Genale

The active ingredient of the drug Mifepristone. It is not a hormone, and the principle of action is based on blocking the work of progesterone, which is why the ovulation process is inhibited. Fertilization and implantation of the embryo becomes impossible, but given its influence, a delay in menstruation after Genale occurs quite often.

Delayed menstruation after Genale

Regardless of whether there is a delay after taking Zhenale or not, in comparison with other drugs with similar effects, it has some advantages. For example, when using Postinor you need to take two tablets, one after sexual intercourse, and the second after 12 hours, but here there is only one. The contraceptive effect of Zhenale is carried out within three days, while Postinora takes a day. According to reviews, adverse reactions when using this drug rarely occur, if you do not take into account the delay after Genale, but all other means of emergency contraception cause exactly the same reaction of the genital organs to their action.