Genale
Pharmacological action Synthetic steroid antiprogestagenic drug. It blocks the action of progesterone at the receptor level and does not have gestagenic activity. Antagonism with GCS due to competition at the level of communication with receptors was noted.
Depending on the phase of the menstrual cycle, it causes an increase in the contractility of the myometrium, stimulating the release of interleukin-8 in choriodecidual cells, increasing the sensitivity of the myometrium to prostaglandins. As a result of the action of the drug, desquamation of the decidua occurs and the fertilized egg is expelled. Causes inhibition of ovulation, changes in the endometrium and prevents the implantation of a fertilized egg.
Pharmacokinetics
Suction and distribution
After a single oral dose, Cmax is reached after 1.3 hours. Absolute bioavailability is 69%. In blood plasma, mifepristone is 98% bound to proteins: albumin and acidic α1-glycoprotein.
Removal
After the distribution phase, excretion occurs slowly at first, the concentration decreases by half between 12-72 hours, then more quickly. T1/2 is 18 hours.
Indications for use of the drug ZHENALE®
- emergency (postcoital) contraception within 72 hours after sexual intercourse without previous use of contraceptives or methods, as well as in case of unsuccessful use (including an error when using the calendar method, unsuccessful interruption of sexual intercourse, rupture or slipping of the condom).
Dosage regimen
You should take 1 tablet orally 2 hours before or 2 hours after a meal (in the next 72 hours after unprotected sexual intercourse), regardless of the phase of the menstrual cycle.
Side effect
From the reproductive system: bloody discharge from the genital tract, discomfort and pain in the lower abdomen, exacerbation of inflammatory diseases of the uterus and appendages.
From the digestive system: nausea, vomiting, diarrhea.
From the side of the central nervous system: headache, dizziness.
Other: weakness, hyperthermia, urticaria.
Contraindications to the use of the drug ZHENALE®
- acute or chronic renal and/or liver failure,
- long-term therapy with glucocorticosteroids,
- porphyria,
- anemia,
- hemostasis disorders (including previous treatment with anticoagulants),
- presence of severe extragenital pathology,
- adrenal insufficiency,
- pregnancy,
- lactation period,
- a history of hypersensitivity to mifepristone and/or auxiliary components.
Use of the drug ZHENALE® during pregnancy and breastfeeding
The drug should not be used during pregnancy. Breastfeeding should be stopped for 14 days after taking the drug.
special instructions
The drug does not protect against sexually transmitted diseases and AIDS.
It is not recommended to use the drug as a planned, permanent contraception after each sexual intercourse, or monthly.
After use as postcoital contraception and until the end of the current menstrual cycle, subsequent sexual intercourse without the use of contraceptives is not recommended. For further sexual intercourse, a barrier method of contraception should be used.
A 10 mg dose of the drug is not sufficient to cause abortion, so before further use, a highly sensitive pregnancy test should be performed to ensure that this drug is used only in the absence of pregnancy. If pregnancy occurs despite the use of the drug, it is recommended to terminate it with medication or surgery. If the patient decides to continue the pregnancy, it is impossible to completely eliminate the risk to the health of the unborn child.
Impact on the ability to drive vehicles and operate machinery
The effect of the drug on the ability to drive a car and operate machinery has not been noted.
Overdose
In cases of drug overdose, adrenal insufficiency may occur.
Drug interactions
The use of NSAIDs should be avoided for 8-12 days after taking the drug.
Conditions for dispensing from pharmacies
The drug is available with a prescription.
Storage conditions and periods
The drug should be stored in a dry place, protected from light, out of reach of children, at a temperature not exceeding 25°C. Shelf life: 3 years.
Zhenale tablet 10 mg x1
Pharmacological action Synthetic steroid antiprogestagenic drug. It blocks the action of progesterone at the receptor level and does not have gestagenic activity. Antagonism with GCS due to competition at the level of communication with receptors was noted.
Depending on the phase of the menstrual cycle, it causes an increase in the contractility of the myometrium, stimulating the release of interleukin-8 in choriodecidual cells, increasing the sensitivity of the myometrium to prostaglandins. As a result of the action of the drug, desquamation of the decidua occurs and the fertilized egg is expelled. Causes inhibition of ovulation, changes in the endometrium and prevents the implantation of a fertilized egg.
Pharmacokinetics
Suction and distribution
After a single oral dose, Cmax is reached after 1.3 hours. Absolute bioavailability is 69%. In blood plasma, mifepristone is 98% bound to proteins: albumin and acidic α1-glycoprotein.
Removal
After the distribution phase, excretion occurs slowly at first, the concentration decreases by half between 12-72 hours, then more quickly. T1/2 is 18 hours.
Indications for use of the drug ZHENALE®
- emergency (postcoital) contraception within 72 hours after sexual intercourse without previous use of contraceptives or methods, as well as in case of unsuccessful use (including an error when using the calendar method, unsuccessful interruption of sexual intercourse, rupture or slipping of the condom).
Dosage regimen
You should take 1 tablet orally 2 hours before or 2 hours after a meal (in the next 72 hours after unprotected sexual intercourse), regardless of the phase of the menstrual cycle.
Side effect
From the reproductive system: bloody discharge from the genital tract, discomfort and pain in the lower abdomen, exacerbation of inflammatory diseases of the uterus and appendages.
From the digestive system: nausea, vomiting, diarrhea.
From the side of the central nervous system: headache, dizziness.
Other: weakness, hyperthermia, urticaria.
Contraindications to the use of the drug ZHENALE®
- acute or chronic renal and/or liver failure,
- long-term therapy with glucocorticosteroids,
- porphyria,
- anemia,
- hemostasis disorders (including previous treatment with anticoagulants),
- presence of severe extragenital pathology,
- adrenal insufficiency,
- pregnancy,
- lactation period,
- a history of hypersensitivity to mifepristone and/or auxiliary components.
Use of the drug ZHENALE® during pregnancy and breastfeeding
The drug should not be used during pregnancy. Breastfeeding should be stopped for 14 days after taking the drug.
special instructions
The drug does not protect against sexually transmitted diseases and AIDS.
It is not recommended to use the drug as a planned, permanent contraception after each sexual intercourse, or monthly.
After use as postcoital contraception and until the end of the current menstrual cycle, subsequent sexual intercourse without the use of contraceptives is not recommended. For further sexual intercourse, a barrier method of contraception should be used.
A 10 mg dose of the drug is not sufficient to cause abortion, so before further use, a highly sensitive pregnancy test should be performed to ensure that this drug is used only in the absence of pregnancy. If pregnancy occurs despite the use of the drug, it is recommended to terminate it with medication or surgery. If the patient decides to continue the pregnancy, it is impossible to completely eliminate the risk to the health of the unborn child.
Impact on the ability to drive vehicles and operate machinery
The effect of the drug on the ability to drive a car and operate machinery has not been noted.
Overdose
In cases of drug overdose, adrenal insufficiency may occur.
Drug interactions
The use of NSAIDs should be avoided for 8-12 days after taking the drug.
Conditions for dispensing from pharmacies
The drug is available with a prescription.
Storage conditions and periods
The drug should be stored in a dry place, protected from light, out of reach of children, at a temperature not exceeding 25°C. Shelf life: 3 years.
Instructions for Zhenale
How do pills work after intercourse ? "Zhenale" ® is a synthetic steroidal antiprogestogen drug. By blocking the action of progesterone at the level of receptors in peripheral organs (uterus and ovaries), its contraceptive effect is achieved. Depending on the phase of the menstrual cycle, it causes an increase in the contractility of the myometrium, stimulating and increasing the sensitivity of the uterine muscle to prostaglandins. As a result of the action of the drug after sexual intercourse, desquamation of the decidua occurs within 72 hours and the fertilized egg is expelled.
Used for emergency post-coital contraception, Zhenale inhibits ovulation, changes the endometrium and prevents the implantation of a fertilized egg into the uterus.
Application of zhenale
The main indication for taking the Zhenale tablet is emergency (postcoital) contraception within 72 hours after sexual intercourse without the use of contraceptives or methods.
Also recommended in case of unsuccessful use or absence of main contraceptives, including in situations:
• error in calculating the calendar method, • unsuccessful interruption of sexual intercourse, • rupture or slipping of the condom, • forced intercourse, • anal intercourse with a high probability of sperm entering the external genital area, • intimate intimacy in a virgin without penetration, but with ejaculation in the vaginal area, • other situations that are potentially unsafe with regard to the occurrence of unwanted conception.
Zhenale is not used to terminate a pregnancy that has taken place and is clinically confirmed! The composition and dosage of the product do not serve the purpose of stopping the development of the fertilized egg and cannot cause a miscarriage!
POSSIBLE SIDE EFFECTS
- Bloody discharge from the genital tract, discomfort and pain in the lower abdomen, exacerbation of inflammatory diseases of the uterus and appendages.
- From the digestive system: nausea, vomiting, diarrhea.
- From the side of the central nervous system: headache, dizziness.
- Other: weakness, hyperthermia, urticaria.
CONTRAINDICATIONS
- acute or chronic renal and/or liver failure;
- long-term therapy with glucocorticosteroids;
- porphyria and anemia;
- hemostasis disorders (including previous treatment with anticoagulants);
- the presence of severe extragenital pathology;
- adrenal insufficiency;
- pregnancy and lactation;
- a history of hypersensitivity to mifepristone.
Breastfeeding should be stopped for 14 days after taking the drug. Contraindicated in acute or chronic liver and liver failure. You can buy Zhenale in a pharmacy with a doctor's prescription.
Which is better: Genale or Postinor / Escapelle
Below is a table that shows a comparison of Postinor or Escapel, which are similar in their indications for taking drugs, and Zhenale tablets - which is better, more effective and, most importantly, has fewer side effects on the reproductive organs and the female body as a whole?
| Features of tablets | Genale | Escapelle Postinor |
| For how long is it used? | up to 72 hours | 24-48 hours |
| Efficiency, up to | 99% | 80% |
| Number of receptions | 1 | 2 |
| Blood discharge after | + | +++ |
| Nausea, vomiting | + | +++ |
| Lower abdominal pain | — | + |
| Exacerbation of gynecological diseases | + — | + |
| Skin rashes, itching, swelling | + — | ++ |
| Delayed menstruation (up to 7 days) | — | + |
| Acyclic bleeding | — | + |
| Teratogenic effect on the fetus | + | + — |
| The need to have an abortion if it doesn’t help | + | + — |
| Reduced effectiveness with excess body weight, up to | 50% | 30-50% |
| Limiting breastfeeding to | 14 days | 1-3 days |
| Effect on reaction speed and attention | — | — |
| Protection from STDs | — | — |
| Recommendations from WHO | + | — |
Reviews from specialists. Doctors believe that Zhenale is better, as evidenced by positive reviews from women, greater effectiveness, reasonable price, and much less frequently reported side effects. Postinor and ago analog Escapelle, in comparison with Zhenale, are less preferable tablets to take and have a number of negative qualities. If a woman is undergoing treatment, you should know that the list of drugs not recommended for simultaneous use with Postinor is quite wide (antibiotics, antiviral drugs, tetracycline, sleeping pills). It would be wiser to generally avoid situations that require the use of this method of contraception and select contraceptives in advance.
