Neurox solution for intravenous and intramuscular administration 50 mg/ml 2 ml ampoules 10 pcs. in Moscow

Neurox

Antioxidant drug. Ethylmethylhydroxypyridine succinate (EMHPS) is an inhibitor of free radical processes, a membrane protector with antihypoxic, stress-protective, nootropic, anticonvulsant and anxiolytic effects. Belongs to the class of 3-hydroxypyridines. The mechanism of action is due to antioxidant and membrane protective properties. Suppresses lipid peroxidation, increases superoxide oxidase activity, increases the lipid-protein ratio, improves the structure and function of the cell membrane. Modulates the activity of membrane-bound enzymes and receptor complexes, which promotes their binding to ligands, preservation of the structural and functional organization of biomembranes, transport of neurotransmitters and improvement of synaptic transmission. Increases the concentration of dopamine in the brain. It enhances the compensatory activation of aerobic glycolysis and reduces the degree of inhibition of oxidative processes in the Krebs cycle under hypoxic conditions with an increase in adenosine triphosphoric acid and creatine phosphate, and activates the energy-synthesizing function of mitochondria.

Increases the body's resistance to the effects of various damaging factors in pathological conditions (shock, hypoxia and ischemia, cerebrovascular accidents, intoxication with ethanol and antipsychotic drugs). Improves metabolism and blood supply to the brain, microcirculation and rheological properties of blood, reduces platelet aggregation. Stabilizes the membranes of blood cells (erythrocytes and platelets), reducing the likelihood of hemolysis. It has a lipid-lowering effect, reduces the content of total cholesterol and LDL. Normalizes metabolic processes in the ischemic myocardium, reduces the necrosis zone, restores and/or improves the electrical activity and contractility of the myocardium, and also increases coronary blood flow in the ischemic zone, increases the antianginal activity of nitro drugs, reduces the consequences of reperfusion syndrome in acute coronary insufficiency.

The stress-protective effect is manifested in the normalization of post-stress behavior, somatovegetative disorders, restoration of sleep-wake cycles, impaired learning and memory processes, and reduction of dystrophic changes in various brain structures.

EMGPS has a pronounced antitoxic effect during withdrawal syndrome, eliminates neurological and neurotoxic manifestations of acute alcohol intoxication, and corrects behavioral and cognitive disorders. Under the influence of ethylmethylhydroxypyridine succinate, the effect of tranquilizing, neuroleptic, antidepressant, hypnotics and anticonvulsants is enhanced, which makes it possible to reduce their doses and reduce side effects.

Pharmacokinetics

Suction

When administered intramuscularly, the drug is detected in the blood plasma for 4 hours after administration. With intramuscular administration, Tmax in plasma is 0.3-0.58 hours. With intramuscular administration at a dose of 400-500 mg, Cmax in plasma is 2.5-4 mcg/ml.

Distribution

EMHPS quickly passes from the bloodstream into organs and tissues and is quickly eliminated from the body. The average retention time of the drug in the body with intramuscular administration is 0.7-1.3 hours.

Metabolism and excretion

Metabolized in the liver by glucuronidation.

It is rapidly excreted in the urine, mainly in the form of metabolites (50% in 12 hours) and in small quantities unchanged (0.3% in 12 hours). The most intensive elimination occurs during the first 4 hours after taking the drug. Urinary excretion rates of unchanged drug and metabolites have significant individual variability.

Questions, answers, reviews on the drug Neuroxin-12

You can look at questions about the drug, as well as ask your question to a specialist, using a free consultation with a pharmacist or pharmacist.
The information provided is intended for medical and pharmaceutical professionals. The most accurate information about the drug is contained in the instructions supplied with the packaging by the manufacturer. No information posted on this or any other page of our website can serve as a substitute for personal contact with a specialist.

Brief characteristics of the drug

Available in the form of a solution for intravenous and intramuscular administration. The solution is transparent. Has a yellowish tint.

The main active ingredient is ethylmethylhydroxypyridine succinate. Auxiliary components – sodium disulfite, water. Up to five ampoules with the drug are placed in the contour cells. In total, the package can contain up to four such cells. The ampoules themselves are made of dark glass. Their volume is 5 milligrams.

When introduced into the body, it has an antioxidant effect. Normalizes the function of blood supply to the brain. Helps eliminate the consequences of myocardial infarction, coronary heart disease, and eliminates the consequences of alcohol intoxication.

Eliminates the symptoms of pancreatitis (that is, helps reduce inflammatory processes). Used to reduce blood cholesterol levels. The level of the hormone dopamine increases in the brain, which helps improve mental functions.

The drug is quickly absorbed. After the injection, the maximum dosage occurs within 30 minutes. The medicine is distributed throughout the organs and tissues in one and a half to two hours. Elimination begins after four hours if the patient’s liver and kidneys are functioning properly. If functionality is impaired, the elimination rate can last up to 7 hours.

The body absorbs the product through liver enzymes. Excreted by the kidneys through the formation of metabolites. The main elimination time is 12 hours.

The drug is prescribed for the treatment of:

• acute circulatory disorders in the brain;
• with a chronic state of anxiety;
• neuroses;
• disruption of cerebral vascular activity;
• cognitive disorders;
• acute myocardial infarction;
• in the treatment of inflammatory and purulent processes in the abdominal area;
• vegetative-vascular disorders;
• removing dependence on ethanol products;
• atherosclerosis.

The dose and mode of administration of the medicine is determined based on the stage of the disease and general health. The maximum daily dose should not exceed 0.8 grams when used two or three times a day.

It is prohibited to prescribe the medicine to persons who have been found to be hypersensitive to the components or have severe renal and liver failure. It is also not prescribed to pregnant women, as well as during breastfeeding, since there is no information on the effect on the child.

It is prescribed with caution to persons who have various forms of allergies. When used, it is possible to reduce reaction speed and reduce psychomotor skills. In this regard, it is prohibited to drive vehicles or complex technical mechanisms.

Indications

Anxiety in neurotic and neurosis-like conditions; vegetative-vascular dystonia; encephalopathy; mild cognitive disorders of atherosclerotic origin.

Acute cerebrovascular accidents (as part of combination therapy).

Withdrawal syndrome in alcoholism with a predominance of neurosis-like and vegetative-vascular disorders; acute intoxication with antipsychotic drugs.

Acute purulent-inflammatory processes in the abdominal cavity (including acute necrotizing pancreatitis, peritonitis (as part of complex therapy));

Acute myocardial infarction from the first day (parenteral); IHD; complex therapy of ischemic stroke (orally) - as part of complex therapy.

Side effects

When using the drug in accordance with the instructions, side effects and complications, as a rule, are not observed. In some animals, a local inflammatory reaction in the form of erythema and itching may occur at the site of drug administration, which quickly passes and does not require treatment. In case of increased individual sensitivity of the animal to antibiotics of the tetracycline group and the development of a stable allergic reaction, desensitizing therapy is carried out. In the event of anaphylactic shock, animals are prescribed adrenaline, corticosteroids and antihistamines in accordance with the instructions for their use.

In case of an overdose of the drug, the animal may experience food refusal, an inflammatory reaction at the injection site, symptoms of nephropathy, and gastrointestinal bleeding. In this case, intravenous administration of calcium preparations (calcium chloride, calcium borogluconate) and symptomatic therapy are recommended.

Pros and cons of fungicides

Fungicidal preparations have many advantages:

• high efficiency and wide range of effects;
• the active substance begins to work after a couple of hours;
• Can be used to process a large number of crops at a time.

A significant disadvantage of many fungicides is toxicity.

Among the chemical fungicides that have been tested at the expert level and have shown excellent results are copper sulfate, Bordeaux mixture, BC, Abiga-Pik, Tsineb.

Release form, composition and packaging

The solution for injection is viscous, green-brown to dark brown in color.

Excipients: magnesium oxide (prolongator), rongalit (sodium formaldehyde sulfoxylate), N-methylpyrrolidone.

Packaged in 100 ml glass bottles, sealed with rubber stoppers, reinforced with aluminum caps with tamper evident clips. The bottles are packed in individual cardboard packs. Each packaging unit is supplied with instructions for use of the drug.

Medicines, alcohol and chronic diseases

If a person has chronic diseases, simultaneous use of alcohol and medications is potentially dangerous for the functioning of vital organs. Since patients systematically take prescribed medications, the influence of alcohol can lead to negative consequences.

People with chronic heart disease (angina pectoris, heart defects) develop arrhythmias of varying severity. Heart attacks with severe pain syndrome develop, which is not relieved by Nitroglycerin, and the risk of developing myocardial infarction increases significantly.

In case of chronic liver diseases (viral hepatitis, hepatosis), alcohol during treatment can become a trigger in the development of cirrhosis and hepatocellular carcinoma (cancer).

Drinking alcohol during cirrhosis leads to the following consequences:

• bleeding into the abdominal cavity;
• liver decomposition, infection, peritonitis;
• hepatic coma;
• death.

If a person is on long-term treatment with sedatives, psychotropic drugs, tranquilizers, he is contraindicated in drinking alcohol. This leads to severe depression and the appearance of obsessive states (hallucinations, phobias). Suicidal feelings develop. Such a patient needs constant monitoring and assistance from a psychiatrist.

Sources

• https://medkonsu.ru/dejstvie-preparata-nejroks-5-ml-pri-alk.html
• https://zdravcity.ru/p_nejroks-tab-po-plen-125mg-n30-0098439.html
• https://MyWeak.ru/alkogolizm/lekarstva/nejroks-sovmestimost.html
• https://health.mail.ru/drug/neurox/
• https://NarkoPro.ru/lekarstva/nejroks-i-alkogol-sovmestimost.html

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How to work with contact fungicides?

To protect plants from infection, contact fungicides are used. They act externally, forming a microfilm on stems and leaves. Such drugs are optimal for prevention and at the onset of the disease.

These products are often used for crops that are most susceptible to fungal diseases: potatoes, tomatoes, peppers, cucumbers, eggplants, strawberries, apple trees and many indoor plants.

Before treating any crops, prepare a fungicide solution. The dosage and method of preparation are always indicated on the packaging.

You can treat the plant early in the morning or after sunset if there is a stable lack of precipitation.

Treatment of tomatoes, peppers and cucumbers with fungicide against various rots is carried out in several stages:

• soaking before sowing;
• disinfection of seedling roots before picking by immersion in a solution;
• spraying before flowering.

Spraying garden trees, shrubs, roses and other perennial flowers with a protective fungicide is carried out several times:

• in spring before buds open;
• during the growing season before the formation of buds;
• along a bare trunk in autumn.

The roots of the seedlings are dipped in the solution for 1-2 hours before planting in the ground.

It is best to disinfect greenhouse soil after harvesting vegetables or in early spring.

Indoor flowers are treated when transplanted and symptoms of the disease appear. To do this, you should choose safe fungicides from the group of biological products.

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