Piracetam is an effective nootropic


Indications for piracetam

Piracetam, the instructions for use indicate this, is in demand to combat many neurological, psychiatric and drug addiction problems. The wide scope of use is associated with the following properties:

  • Positive effect on metabolic processes.
  • The ability to improve blood circulation in the brain.

Indications for use are:

  • Headaches and dizziness of various etiologies.
  • The need to protect the brain from the effects of various damaging factors: intoxication, trauma, etc.
  • The occurrence of cognitive impairment against the background of various diseases, which is manifested by memory deterioration.

The drug is used in the complex treatment of various mental illnesses and depressive conditions. It is also used in the treatment of chronic alcoholism, when persistent disorders of brain activity occur. When using the drug, it is possible to recover faster from brain injuries. This remedy improves the condition of patients with the development of dementia resulting from cerebral circulatory disorders. It is recommended for the prevention of Alzheimer's disease.

The drug is approved for the treatment of children in cases of confirmed dyslexia and other painful conditions, the symptoms of which are learning difficulties. The drug is indicated for perinatal brain damage. It is used for oligophrenia, cerebral palsy, and mental retardation.

Piracetam

Inside. During meals or on an empty stomach, with liquid.

If oral administration is not possible, the drug is administered intravenously in the same dose.

For intellectual and mental disorders: 2.4-4.8 g/day in 2-3 doses.

Treatment of cortical myoclonus: treatment begins with a dose of 7.2 g/day, every 3-4 days the dose is increased by 4.8 g/day to a maximum dose of 24 g/day in 2-3 doses.

The use of other drugs for the treatment of myoclonus should be continued at the same dosage. Depending on the effect obtained, the dose of these drugs should be reduced if possible.

Treatment with piracetam should be continued as long as symptoms of the disease persist.

In patients with acute episodes of myoclonus, spontaneous improvement may occur, so attempts should be made to reduce the dose or discontinue the drug every 6 months. To do this, gradually reduce the dose by 1.2 g/day every two days (in the case of Lance-Adams syndrome, every 3-4 days to prevent a possible sudden relapse or withdrawal syndrome).

Dosing in patients with impaired renal function: Piracetam is eliminated almost exclusively by the kidneys; caution should be used when treating patients with renal insufficiency or requiring monitoring of renal function. The half-life increases in direct proportion to the deterioration of renal function and creatinine clearance; this is also true in the elderly, in whom creatinine excretion varies with age.

The dose should be adjusted depending on the creatinine clearance.

Creatinine clearance for men can be calculated from the serum creatinine concentration (CSC) using the following formula:

Creatinine clearance for women can be calculated by multiplying the resulting value by a factor of 0.85.

Kidney failure CC ml/min Dosage regimen
Norm > 80 usual dose in 2-4 doses
Lightweight 50-79 2/3 of the usual dose in 2-3 doses
Average 30-49 1/3 of the usual dose in 2 divided doses
Heavy <� 30 1/6 of the usual dose once
Terminal stage contraindicated

In elderly patients, the dose is adjusted in the presence of renal failure; with long-term therapy, monitoring of the functional state of the kidneys is necessary.

Dosing in patients with impaired liver function: patients with impaired liver function do not require dose adjustment. For patients with impaired renal and liver function, dosing is carried out according to the dosing schedule (see subsection “Dosing for patients with impaired renal function”).

Contraindications and side effects

Since piracetam is used in the treatment of various pathologies, the instructions focus on this, only a doctor should prescribe its use, based on the patient’s condition and the presence of contraindications. Do not use the drug if you are hypersensitive to the active substance or other components included in its composition. The medicine is not used to treat children under one year of age, as well as during pregnancy and lactation.

Piracetam tablets, the instructions indicate this, are not used in the presence of the following pathologies:

  • Huntington's chorea, which is a genetic disease and is characterized at the initial stage of development by impaired coordination of movements.
  • Chronic renal failure in severe form.
  • Hemorrhagic stroke.
  • Psychomotor agitation.

The decision to take piracetam should be made with extreme caution in case of hemostasis disorders, severe bleeding, or after major surgical operations.

Various side effects were observed when taking the drug. Patients most often experienced the following body reactions:

  • Nausea and vomiting.
  • Headache.
  • Hives.
  • Diarrhea.

As a rule, such side effects disappear on their own during therapy. More dangerous symptoms while taking the drug are decreased blood pressure, abdominal pain, depression, hallucinations, dermatitis, and confusion. Sometimes during treatment with the drug, motor disinhibition, increased libido, drowsiness or insomnia, and a constant feeling of internal anxiety occur. Overdose may increase side effects.

Piracetam 1200 mg

Inside. During meals or on an empty stomach, with liquid.

If oral administration is not possible, the drug is administered intravenously in the same dose.

For intellectual and mental disorders: 2.4-4.8 g/day in 2-3 doses.

Treatment of cortical myoclonus: treatment begins with a dose of 7.2 g/day, every 3-4 days the dose is increased by 4.8 g/day to a maximum dose of 24 g/day in 2-3 doses.

The use of other drugs for the treatment of myoclonus should be continued at the same dosage. Depending on the effect obtained, the dose of these drugs should be reduced if possible.

Treatment with piracetam should be continued as long as symptoms of the disease persist.

In patients with acute episodes of myoclonus, spontaneous improvement may occur, so attempts should be made to reduce the dose or discontinue the drug every 6 months. To do this, gradually reduce the dose by 1.2 g/day every two days (in the case of Lance-Adams syndrome, every 3-4 days to prevent a possible sudden relapse or withdrawal syndrome).

Dosing in patients with impaired renal function: Piracetam is eliminated almost exclusively by the kidneys; caution should be used when treating patients with renal insufficiency or requiring monitoring of renal function. The half-life increases in direct proportion to the deterioration of renal function and creatinine clearance; this is also true in the elderly, in whom creatinine excretion varies with age.

The dose should be adjusted depending on the creatinine clearance.

Creatinine clearance for men can be calculated from the serum creatinine concentration (CSC) using the following formula:

Creatinine clearance for women can be calculated by multiplying the resulting value by a factor of 0.85.

Kidney failure CC ml/min Dosage regimen
Norm > 80 usual dose in 2-4 doses
Lightweight 50-79 2/3 of the usual dose in 2-3 doses
Average 30-49 1/3 of the usual dose in 2 divided doses
Heavy <� 30 1/6 of the usual dose once
Terminal stage contraindicated

In elderly patients, the dose is adjusted in the presence of renal failure; with long-term therapy, monitoring of the functional state of the kidneys is necessary.

Dosing in patients with impaired liver function: patients with impaired liver function do not require dose adjustment. For patients with impaired renal and liver function, dosing is carried out according to the dosing schedule (see subsection “Dosing for patients with impaired renal function”).

Instructions for use, price, reviews analogues

Piracetam must be taken in accordance with the instructions for use, as tablets and capsules are intended for internal use. The daily dosage is calculated depending on the patient’s weight and is 30-160 mg per kilogram of weight. The drug is taken 2-4 times a day, but to prevent the occurrence of insomnia, the last dose should be no later than 17 hours before bedtime.

The dosage regimen is developed by the doctor. It may vary depending on the pathology. Thus, the drug is used in complex methods of rehabilitation therapy in the treatment of serious brain damage. For recovery from complex psychotic disorders, it is used in combination with psychotropic drugs.

The price of pirocetam may vary depending on the manufacturer. But in any case, it is accessible. Today you can buy analogues of the drug in pharmacies. They are presented as single drugs and complex drugs. When prescribing such drugs, the doctor must take into account their interaction with other medications.

All nootropic drugs are highly effective, as evidenced by numerous patient reviews. First of all, they note the cumulative effect of the drug. Many note the ability to withstand heavy loads without losing concentration. You can also often find positive reviews about the treatment of children.

Piracetam

Inside.

During meals or on an empty stomach, with liquid.

If oral administration is not possible, piracetam is administered intravenously at the same dose in the appropriate dosage form.

For intellectual-mnestic disorders:

2.4-4.8 g per day in 2-3 divided doses

Treatment of cortical myoclonus

Treatment begins with 7.2 g per day, every 3-4 days the dose is increased by 4.8 g per day to a maximum dose of 24 g per day in 2-3 doses.

The use of other drugs for the treatment of myoclonus should be continued at the same dosage. Depending on the effect obtained, the dose of these drugs should be reduced if possible.

After starting treatment with piracetam, treatment is continued as long as symptoms of the disease persist.

Patients with acute episodes of myoclonus may experience spontaneous improvement, so dose reduction should be attempted every 6 months or

drug withdrawal. To do this, gradually reduce the dose by 1.2 g per day every 2 days (in the case of Lance-Adams syndrome, every 3-4 days to prevent a possible sudden relapse or withdrawal syndrome).

Dosing in patients with renal impairment

Piracetam is excreted almost exclusively by the kidneys; caution should be used when treating patients with renal failure or requiring monitoring of renal function. The half-life increases in direct proportion to the deterioration of renal function and creatinine clearance; this is also true in the elderly, in whom creatinine excretion varies with age.

The dose should be adjusted depending on the creatinine clearance (CC): Creatinine clearance for men can be calculated based on the serum creatinine concentration (CCR), using the following formula:

CC (ml/min)=([ 140-age (years)xbody weight (kg))/(72xKKServorota (mg/dl))

Creatinine clearance for women can be calculated by multiplying the resulting value by a coefficient of 0.85.

Kidney failure Creatinine clearance (ml/min) Dosing regimen
Norm >80 Usual dose in 2-4 divided doses
Lightweight 50-79 2/3 of the usual dose in 2-3 doses
Average 30-49 1/3 of the usual dose in 2 divided doses
Heavy <30 1/6 of the usual dose, once
Terminal stage contraindicated

In elderly patients, the dose is adjusted in the presence of renal failure; with long-term therapy, monitoring of the functional state of the kidneys is necessary.

Dosing in patients with impaired liver function

Patients with impaired liver function do not need dose adjustment. For patients with impaired renal and liver function, dosing is carried out according to the dosing schedule (see section “Dosing for patients with impaired renal function”).

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