Propofol Kabi emulsion for intravenous administration 10 mg/ml 50 ml bottle 1 pc. in Moscow

What is the drug Propofol?

Let's figure out what kind of medicine this is - Propofol. This is an ultra-short-acting sleeping pill, i.e. It works practically only while it is administered (or while it is present in the blood in sufficient concentration). Method of administration: intravenous.

The effect of Propofol includes 2 important components - hypnotic and amnesic. This means that under the influence of Propofol a person falls asleep and after waking up does not remember what happened during sleep. Propofol does not provide an analgesic effect, so it must be combined with analgesics.

The main active ingredient of Propofol is 2,6-diisopropylphenol. Its main advantage is that it has the same effectiveness as some other previously used drugs, but is safer, provides an easier recovery from anesthesia and fewer side effects.

The substance is insoluble in water, therefore it is used in the form of an aqueous emulsion of oils in which the active ingredient is dissolved (currently soybean oil). It appears as a white liquid resembling milk.

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What group of drugs does Propofol belong to?

Propofol is a drug whose purpose is to induce and maintain general anesthesia, as well as sedation during mechanical ventilation. Chemically, Propofol (more precisely, its main active ingredient diisopropylphenol) is a phenol molecule with two isopropyl groups attached to it. It is not included in the groups of barbiturates or opioids, it is not a narcotic drug, therefore it is not characterized by the severe side effects of drugs from these groups.

General anesthesia at the Denteya clinic

Anesthesia in dentistry is a very important component of treatment, since many dental procedures are associated with painful effects. For pain relief, terminal anesthesia is used (applying local anesthetic gels and sprays to the oral mucosa) and local infiltration anesthesia (for the treatment of pulpitis, tooth extraction). However, there are a number of cases when it is not possible to do without general anesthesia (anesthesia), and we will try to figure out what these indications are.

How does the drug affect the body?

The mechanism of action of Propofol has not yet been fully studied. Its main effect is associated with the fact that it enhances and prolongs the action of GABA (gamma-aminobutyric acid), an amino acid that plays the role of an inhibitory neurotransmitter in the central nervous system, responsible for calm, relaxation and sleep.

When administered, Propofol begins to act almost immediately - it instantly penetrates the brain and causes rapid onset of sleep. Next, a maintenance dose of the drug is administered through an intravenous catheter. An anesthesiologist, using special equipment, controls the depth of sleep, the dosage of incoming medication, the patient's breathing, blood oxygen saturation, blood pressure and heart rate. After completing the treatment procedures, the supply of Propofol is stopped, and the patient wakes up after 5-10 minutes as if from a normal sleep.

How long does Propofol take to leave the body?

Propofol is eliminated through its breakdown in the liver with the formation of inert metabolites and further removal through the kidneys. Only 1-2% of propofol is excreted unchanged. The time it takes to remove half of the substance contained depends on the duration of its administration.

The fact is that the substance penetrates unevenly into different tissues. At the very beginning of the administration of the drug (so far it has penetrated only into tissues directly supplied with blood through large arteries), it takes from 1 to 8 minutes for its concentration to drop by half after stopping the supply.

If Propofol is administered within 8 hours, then it has time to penetrate all tissues of the body, therefore, when the supply is stopped, it begins to enter the blood from those tissues into which it penetrated slowly over all these hours, and therefore the same half-life is already increasing up to 40 minutes. The drug is completely eliminated from the body after a few hours.

Safe treatment of children's teeth under anesthesia in Moscow: utopia or reality?

Contacting the Denteya dental clinic will allow you to avoid adverse events that inevitably accompany the process of dental treatment in children. All fears, pain, tears and psychological trauma will remain outside the pediatric dentist’s office, who will conduct the treatment. And much of the credit goes to the anesthesiologist, who, thanks to treatment under anesthesia, will relieve the child of all the negativity associated with visiting the dentist.

Treatment of baby teeth can be both safe and painless, and the entire process is controlled from start to finish by specialists, because a whole team is present in the dentist’s office at the time of treatment, the presence of which allows you to avoid all sorts of surprises. The successful outcome of treatment largely depends on the parents themselves, because they are obliged to provide the most complete and reliable information related to the child’s health status.

Consequences and side effects

The drug is safer than many of its previously used analogues. However, it also has accompanying actions. Side effects of Propofol include:

arterial hypotension (low blood pressure),
bradycardia (slow heart rate),
depression of respiratory function (up to short-term apnea).

In rare cases, convulsions, allergic reactions may occur, and after waking up - nausea, vomiting, and headache. The vast majority of patients have a completely normal reaction to Propofol.

To minimize side effects, a doctor should prescribe Propofol based on preliminary tests, which should determine how safe the use of this drug is for a particular patient.

In addition, constant monitoring of the patient’s condition under anesthesia and the availability of resuscitation equipment in the clinic, incl. apparatus for artificial ventilation of the lungs.

Propofol can only cause harm if the permissible dosage is exceeded. But provided that the drug is prescribed correctly and the anesthesiologist is equipped with all the means necessary for control, the occurrence of such a situation is excluded.

What team works in sleep therapy?

When treating under anesthesia, we always have a well-coordinated team of MINIMUM 5 people: - doctor anesthesiologist-resuscitator, - assistant anesthesiologist, - attending dentist, - 2 dental assistants. This allows us to do the work efficiently and quickly, without prolonging the patient’s stay in a state of sleep !

Dental treatment during sleep (Propofol): reviews

Ekaterina April 24, 2021

I would like to express my HUGE THANKS to the anesthesiologist Igor Valerievich Godomsky for the excellent anesthesia he performed on me. For the well-chosen drugs for anesthesia (I previously had big problems and complications with certain drugs), the doctor approached my problem very carefully, listened to everything, selected the types analyzes, thought everything through correctly! I'm very happy! And, my family too! Thank you very much Igor Valerievich ️

DariaDecember 12, 2020

For several years I decided to have my lower impacted wisdom teeth removed. I visited several surgeons: someone offered to remove two teeth for me in 4 stages with a difference of six months, others sent me to the jaw, some said “a matter of 5 minutes, now we’ll remove everything.” I probably could have been looking for that ideal doctor for a long time if one day they had not recommended Dr. Volberg Roman to me. I always trust my intuition:) At first glance, the doctor inspires confidence. He suggested I have two teeth removed at a time under sedation. The operation went well, the swelling had already disappeared after a week, there were no complications and no loss of sensitivity in the lower third of the face, which is often warned about. Two weeks later, she visited a dental therapist, she said that the surgeon was a virtuoso, as if there had been no operation, the condition of the mucous membranes was ideal. Roman Vyacheslavovich is also a caring and attentive doctor, despite his busy schedule, he is always in touch, you can write to him and share your experiences about the tooth) Thank him very much! I would especially like to thank the anesthesiologist Natalya Danilova. She is a true professional in her field and a wonderful person. During the sedation, it lasted about three hours, I slept so well, it was even a little disappointing that they woke me up so quickly :) I didn’t feel any side effects and 15 minutes later I was already on my feet in a cheerful state.

Margarita YurinaOctober 02, 2020

My warmest and most sincere gratitude to the hands of Roman Ashurov for 4 complex wisdom teeth removals at a time under propofol in 2 hours! All the fears were only until I fell asleep, and then... no one could believe in my operation! Not a minute of pain, not a single swelling, no sensations, if it weren’t for the result in my mouth, I wouldn’t have believed myself))) A brilliant operation! Thank you so much for your professionalism! A minute after waking up, having four-way anesthesia, I was talking as if nothing had happened)) I sincerely wish you many years of successful practice! Thank you Roman and Belgravia! I love! BELGRAVIA DENTAL STUDIO TEAM:

Thank you very much for entrusting us with a complex treatment! You were in the best hands. Roman Siinovich is a world-class surgeon. We wish you good health!

Anna29 August 2020

I would like to express my gratitude to the creators of Belgravia Dental Studio, and especially highlight the professionals who went through all the treatment with me: these are dentist-therapist Azer Fuadovich Melikov, anesthesiologist Mikhail Vladimirovich Nasekin, dental surgeon Roman Vyacheslavovich Volberg and, of course, medical coordinator Ekaterina Mysina (clinic on Leningradsky Prospekt). Backstory: I have accumulated quite a lot of problems with my teeth, which I have not solved, because I am terrified of even ordinary professional cleaning - I was always scared, painful, sensitive, and even had panic attacks during the simplest procedures. Ekaterina and Azer Fuadovich found an approach to me, and I began to feel completely comfortable with them. And already in a calm atmosphere we discussed and chose a treatment plan. It was decided to do everything under anesthesia, since the amount of work was decent, then I met M.V. Nasekin, who at first was always ready to answer my meticulous questions by phone, and then we met in person. Mikhail is not just a professional in his field, but also a very pleasant person - he was with me the entire time I was “coming off” from anesthesia - he entertained me with conversations and was very caring and attentive. Surgeon R.V. Volberg was so meticulous and careful that, after a rather complicated removal, I was able to chew on the damaged side within a couple of days. Azer Fuadovich also did his job perfectly, and, of course, he is also a very pleasant and personable person. Bottom line: all Belgravia employees who worked with me showed their best qualities as professionals and people, which is especially important these days. They really care about you. I will take my child here and recommend it to all my friends. Even if the services at this clinic are a little more expensive than others, the human attitude outweighs everything. AT BELGRAVIA YOU WILL BE LIKE A FAMILY WHO SINCERELY CARE ABOUT YOU. BELGRAVIA DENTAL STUDIO TEAM:

Anna, we are so pleased to receive your feedback! We are very glad that we helped you in a difficult situation! Working with patients like you is a great joy for our team. We wish you good health!

Ekaterina April 24, 2021

Recommended dose of Propofol

The dosage of Propofol depends on age, body weight, and various individual characteristics. The starting dosage for sleep induction for the average adult is approximately 40 mg every 10 seconds, or 2-2.5 mg/kg body weight. For children over 8 years of age, approximately the same dosages are used; for younger children, higher doses are possible.

The maintenance dosage to maintain anesthesia is 4-12 mg/kg/h for adults and 9-15 mg/kg/h for children.

Use of propofol

Medication-induced sleep during dental treatment is used in several cases. First of all, this is dental phobia - a pathological fear of dental treatment. This is not just a fear that a strong-willed adult can cope with. As a rule, this is a series of involuntary nervous and physiological reactions that a person cannot control. In addition, a long complex operation, even in the absence of pain, often causes stress and deterioration of physical condition - increased stress on the heart and vascular system, exacerbation of chronic diseases, etc. Therefore, indications for the use of Propofol include:

dental phobia,
long operations with a high level of injury,
increased sensitivity to pain,
inability to establish contact with a doctor in some patients.

The drug is used to induce medicinal sleep in both adults and children, and even children under 1 year of age are not an obstacle.

Where in Moscow can you have your teeth treated under anesthesia?

Muscovites and guests of the capital, when contacting Denteya dentistry, are guaranteed to receive professional and high-quality dental treatment under anesthesia. There are many medical institutions in Moscow that provide this type of service, but the abundance of positive reviews, the presence of high-tech equipment, highly qualified staff and the use of the most modern drugs for anesthesia give the Dentey clinic undeniable advantages. All this together allows you to treat teeth without complications or side effects, which is a considerable merit of an attentive and responsible anesthesiologist.

The medical staff of the Denteya clinic is distinguished by their professionalism and knowledge of innovative techniques, which is very important when providing dental treatment for children, because young patients require a special approach. Before starting treatment, the anesthesiologist will certainly issue a referral for examination, and after the patient has completed all the examinations, he will evaluate their results. This is necessary in order to reduce the risk of side effects to a minimum. It remains to add that the clinic uses innovative drugs that have passed certification.

During anesthesia, the anesthesiologist doses the anesthetic drug and monitors vital parameters of the body. Full compliance with all safety measures, attentive attitude towards each patient and professionalism of specialists are the main reasons why the Dentya clinic in Moscow enjoys well-deserved popularity among all segments of the population. After all, dental treatment under anesthesia is the best way to solve dental problems.

Contraindications to the use of Propofol

The drug cannot be used by everyone. Absolute contraindications for the use of Propofol are:

presence of allergies to the components of the drug,
children's age up to 1 month.

It is also not recommended to use Propofol during pregnancy, because it penetrates the placental barrier. During the feeding period, the use of the medicine is allowed, provided that the woman does not feed for several hours after using the drug.

Relative contraindications for Propofol:

serious diseases of the cardiovascular system,
respiratory diseases,
pathologies of the liver and kidneys,
anemia,
epilepsy,
lipid metabolism disorders.

In all these cases, consultation with a specialized doctor is necessary. In case of stable remission of the disease, in the absence of a conflict between Propofol and the medications taken by the patient and some other circumstances, the doctor may authorize the use of Propofol.

How much does dental treatment under anesthesia cost?

This question arises for every person who wants to tidy up their oral cavity using anesthesia, but does not know exactly where in Moscow to find a suitable clinic and how much the services of its specialists will cost. The Denteya Clinic offers high-quality painless treatment, which involves the use of the most advanced techniques and the use of innovative drugs for general anesthesia. Even the most complex clinical case will not cause severe pain if specialists use sevorane inhalation anesthesia.

Professionals working at the Denteya clinic constantly improve their qualifications, gain valuable experience, and use the best drugs that allow them to treat patients of different age categories under anesthesia.

It is noteworthy that in special cases treatment cannot be carried out without an accurate diagnosis. This problem can be solved very simply, because the Denteya clinic has the necessary x-ray equipment, therefore, the patient will not have to resort to the services of third-party clinics. As for the cost of treatment, it can only be determined after diagnostic measures and personal examination.

Analogs

Propofol can, if necessary, be replaced with other drugs of similar action. Propofol analogues from the group of non-inhalational anesthetics:

brietal,
hexenal,
ketamine,
hypnomidate.

These drugs have a comparable effect in terms of mechanism and results (stimulation of GABA and suppression of excitatory neurotransmitters), but it must be borne in mind that almost all of them have more severe side effects and provide a more difficult recovery from anesthesia (drowsiness, headache, confusion, hallucinations etc.) compared to Propofol. In addition, not all of them can be used in childhood.

Of the inhaled analogues of Propofol, Sevoran has proven itself well. This drug has the same effect, is slightly more effective and safe, but it is a gas and the method of administration is less convenient - inhalation.

Propofol is currently the most successful drug for anti-stress treatment in dentistry, widely used for both adults and children of all age groups.

Types of anesthesia used in dentistry

If the patient has no contraindications, then anesthesia is completely safe for him, and it can be used to both treat and remove teeth. Treatment, depending on the condition of the oral cavity, may take different times, but on average, within two hours. . With a competent approach, supervision by a qualified anesthesiologist and a correctly calculated dose, dentistry under anesthesia is as safe and highly effective as possible, allowing the specialist to calmly and focusedly perform complex manipulations.