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Venofer®
Application
The drug Venofer® is administered only intravenously: by drip infusion, or slow injection, or directly into the venous section of the dialysis system.
Before use, ampoules/vials should be inspected for sediment or damage. Only use ampoules/vials containing a homogeneous, sediment-free, brown solution.
Each ampoule/vial of Venofer® is intended for single use only. Any remaining unused medicinal product or waste should be disposed of in accordance with local requirements.
The administration of the drug Venofer® should be carried out under the supervision of medical personnel experienced in the diagnosis and treatment of anaphylactic reactions, in a specialized department. It should be possible to carry out anti-shock therapy, including a 0.1% solution of epinephrine (adrenaline), antihistamines and/or corticosteroids.
The test dose is not a reliable predictor of the subsequent development of hypersensitivity reactions, and therefore its preliminary administration is not recommended.
During the administration of the drug and immediately after administration, patients should be under medical supervision. When the first signs of anaphylactic reactions appear, the use of the drug should be stopped immediately.
It is necessary to monitor each patient for at least 30 minutes after each administration of Venofer® at a therapeutic dose to ensure the absence of adverse events.
Intravenous drip infusion
Venofer® is diluted only with sterile 0.9% (w/v) sodium chloride (NaCl) solution. The diluted solution should be transparent and brown in color. Dilution should be made immediately before infusion, and the resulting solution should be administered as follows:
Dose of Venofer® (mg iron) | Dose of the drug Venofer® (ml of the drug Venofer®) | Maximum dilution volume of sterile 0.9% (w/v) NaCl solution | Minimum infusion time |
100 mg | 5 ml | 100 ml | 15 minutes |
200 mg | 10 ml | 200 ml | 30 minutes |
300 mg | 15 ml | 300 ml | 1,5 hour |
400 mg | 20 ml | 400 ml | 2.5 hours |
500 mg | 25 ml | 500 ml | 3.5 hours |
Dilution of the drug to lower concentrations of iron is unacceptable for reasons related to solution stability.
Intravenous injection
Venofer® can be administered by slow intravenous injection at a rate of 1 ml of undiluted solution per minute and its dose should not exceed 10 ml (200 mg of iron) per injection.
Injection into the venous site of the dialysis system
Venofer® can be administered during a hemodialysis session directly into the venous portion of the dialysis system under the same conditions as for intravenous injection.
Doses
For each patient, the cumulative dose of Venofer® should be individually calculated and should not be exceeded.
Dose calculation
The total cumulative dose of Venofer®, equivalent to total iron deficiency (mg), is determined based on hemoglobin (Hb) content and body weight (BW). The dose of Venofer® should be individually calculated for each patient in accordance with the total iron deficiency calculated using the Ganzoni formula below, for example:
Total iron deficiency [mg] = body weight [kg] x (target hemoglobin content - actual hemoglobin content) [g/l] x 0.24* + deposited iron [mg]
With body weight less than 35 kg:
target hemoglobin content = 130 g/l, and amount of deposited iron = 15 mg/kg body weight
With a body weight of 35 kg or more:
target hemoglobin content = 150 g/l, and amount of deposited iron = 500 mg
* Coefficient 0.24 = 0.0034 (iron content in hemoglobin = 0.34%) x 0.07 (blood mass ≈7% of body weight) x 1000 (conversion [g] to [mg])
Total amount of Venofer® to be administered (in ml) = Total iron deficiency [mg]/ 20 mg iron/ml
The total amount of Venofer® (ml) that should be administered, depending on body weight, actual hemoglobin content and target hemoglobin content*:
Body weight [kg] | Total amount of Venofer® (20 mg iron per ml) to be administered | |||||||
hemoglobin 60 g/l | hemoglobin 75 g/l | hemoglobin 90 g/l | hemoglobin 105 g/l | |||||
mg Fe | ml | mg Fe | ml | mg Fe | ml | mg Fe | ml | |
5 | 160 | 8 | 140 | 7 | 120 | 6 | 100 | 5 |
10 | 320 | 16 | 280 | 14 | 240 | 12 | 220 | 11 |
15 | 480 | 24 | 420 | 21 | 380 | 19 | 320 | 16 |
20 | 640 | 32 | 560 | 28 | 500 | 25 | 420 | 21 |
25 | 800 | 40 | 700 | 35 | 620 | 31 | 520 | 26 |
30 | 960 | 48 | 840 | 42 | 740 | 37 | 640 | 32 |
35 | 1260 | 63 | 1140 | 57 | 1000 | 50 | 880 | 44 |
40 | 1360 | 68 | 1220 | 61 | 1080 | 54 | 940 | 47 |
45 | 1480 | 74 | 1320 | 66 | 1140 | 57 | 980 | 49 |
50 | 1580 | 79 | 1400 | 70 | 1220 | 61 | 1040 | 52 |
55 | 1680 | 84 | 1500 | 75 | 1300 | 65 | 1100 | 55 |
60 | 1800 | 90 | 1580 | 79 | 1360 | 68 | 1140 | 57 |
65 | 1900 | 95 | 1680 | 84 | 1440 | 72 | 1200 | 60 |
70 | 2020 | 101 | 1760 | 88 | 1500 | 75 | 1260 | 63 |
75 | 2120 | 106 | 1860 | 93 | 1580 | 79 | 1320 | 66 |
80 | 2220 | 111 | 1940 | 97 | 1660 | 83 | 1360 | 68 |
85 | 2340 | 117 | 2040 | 102 | 1720 | 86 | 1420 | 71 |
90 | 2440 | 122 | 2120 | 106 | 1800 | 90 | 1480 | 74 |
* With body weight less than 35 kg:
Target hemoglobin = 130 g/l
With a body weight of 35 kg or more:
Target hemoglobin = 150 g/l
To convert hemoglobin (mmol) to hemoglobin (g/l), multiply the first value by 16.
If the total dose required exceeds the maximum permitted single dose, it should be divided into several administrations.
If there is no response in hematological parameters after 1-2 weeks, the initial diagnosis should be reconsidered.
Calculation of the dose to replenish iron stores after blood loss or when donating autologous blood
The dose of Venofer® required to compensate for iron deficiency can be calculated using the following formulas:
If the amount of blood lost is known: the administration of 200 mg of iron (10 ml of Venofer®) should lead to approximately the same increase in hemoglobin concentration as a transfusion of 1 unit of blood (400 ml with a hemoglobin concentration = 150 g/l).
Amount of iron that needs to be replaced [mg] = number of units of lost blood x 200 mg
or
Required volume of Venofer® [ml] = number of units of lost blood x 10 ml
If the hemoglobin content is lower than desired: the formula assumes that the iron depot does not need to be replenished.
Amount of iron that needs to be replenished [mg] = body weight [kg] * 0.24 x (target hemoglobin content - actual hemoglobin content) [g/l]
Example:
With body weight = 60 kg and decreased hemoglobin content = 10 g/l
=> = 150 mg of iron must be replenished
=> 7.5 ml of Venofer® is required
The maximum tolerated single and weekly doses are listed below in the sections “Standard Doses” and “Maximum Tolerated Single and Weekly Doses.”
Standard doses
Adult and elderly patients
5-10 ml of Venofer® (100-200 mg iron) 1-3 times a week.
The time of administration of the drug and the method of dilution are indicated in the “Application” section.
Children
There is only a moderate amount of research data on the use of the drug in children. In case of clinical need for use, it is not recommended to exceed a dose of 0.15 ml of Venofer® (3 mg of iron) per kg of body weight no more than 3 times a week.
The time of administration of the drug and the method of dilution are indicated in the “Application” section.
Maximum tolerated single and weekly dose
Adult and elderly patients
The maximum tolerated dose per day, administered by injection no more than 3 times a week:
- 10 ml of Venofer® (200 mg iron), administered over at least 10 minutes.
The maximum tolerated dose per day, administered as an infusion no more than once a week:
- Patients weighing more than 70 kg: 500 mg of iron (25 ml of Venofer®), administered over a minimum of 3.5 hours.
- Patients weighing 70 kg or less: 7 mg iron/kg body weight administered over a minimum of 3.5 hours.
The infusion times specified in the Administration section should be strictly adhered to, even if the patient has not received the maximum tolerated single dose.
Venofer, 5 pcs., 5 ml, 20 mg/ml, solution for intravenous administration
IV
.
Venofer® is administered only intravenously - slowly in a stream or drip, as well as into the venous section of the dialysis system - and is not intended for intramuscular administration. Simultaneous administration of the full therapeutic dose of the drug is unacceptable.
Before administering the first therapeutic dose, a test dose must be prescribed. If during the observation period phenomena of intolerance occur, administration of the drug should be stopped immediately. Before opening the ampoule, you need to inspect it for possible sediment and damage. Only brown solution without sediment can be used.
Drip administration:
It is preferable to administer Venofer® by drip infusion in order to reduce the risk of a pronounced decrease in blood pressure and the risk of the solution entering the perivenous space. Immediately before infusion, Venofer® should be diluted with 0.9% sodium chloride solution in a ratio of 1:20, for example, 1 ml (20 mg of iron) in 20 ml of 0.9% sodium chloride solution. The resulting solution is administered at the following speed: 100 mg of iron - no less than 15 minutes; 200 mg of iron - within 30 minutes; 300 mg of iron - within 1.5 hours; 400 mg of iron - within 2.5 hours; 500 mg of iron - over 3.5 hours. The maximum tolerated single dose of 7 mg iron/kg should be administered over a minimum of 3.5 hours, regardless of the total dose of the drug.
Before the first drip administration of a therapeutic dose of Venofer®, it is necessary to administer a test dose: 20 mg of iron for adults and children weighing more than 14 kg and half the daily dose (1.5 mg iron/kg) for children weighing less than 14 kg , for 15 minutes. If there are no adverse events, the remainder of the solution should be administered at the recommended rate.
Jet introduction:
Venofer® can also be administered as an undiluted IV solution slowly, at a rate (norm) of 1 ml of Venofer® (20 mg iron) per minute, i.e. 5 ml of Venofer® (100 mg iron) is administered over at least 5 minutes. The maximum volume should not exceed 10 ml of Venofer® (200 mg iron) per injection.
Before the first jet injection of a therapeutic dose of Venofer®, a test dose should be prescribed: 1 ml of Venofer® (20 mg iron) for adults and children weighing more than 14 kg and half the daily dose (1.5 mg iron/kg) for children weighing body less than 14 kg for 1–2 minutes. If there are no adverse events during the next 15 minutes of observation, the remaining part of the solution should be administered at the recommended rate. After the injection, the patient is recommended to fix his arm in an extended position for a while.
Introduction to Dialysis System:
Venofer® can be administered directly into the venous section of the dialysis system, strictly following the rules described for intravenous injection.
Dose calculation:
the dose is calculated individually, in accordance with the general iron deficiency in the body using the formula:
General iron deficiency, mg = body weight, kg × (normal Hb level − patient’s Hb level), g/l × 0.24* + deposited iron, mg.
For patients weighing less than 35 kg: normal Hb level = 130 g/l, amount of deposited iron = 15 mg/kg.
For patients weighing more than 35 kg: normal Hb level = 150 g/l, amount of deposited iron = 500 mg.
*Coefficient 0.24 = 0.0034×0.07×1000 (iron content in Hb = 0.34%; blood volume = 7% of body weight; coefficient 1000 = conversion from “g” to “mg”).
The total volume of Venofer® that must be administered (in ml) = total iron deficiency (mg)/20 mg/ml (see table).
Table
The total volume of Venofer® for treatment
Body weight, kg | Cumulative therapeutic dose of Venofer® for administration | |||||||
Hb 60 g/l | Hb 75 g/l | Hb 90 g/l | Hb 105 g/l | |||||
mg Fe | ml | mg Fe | ml | mg Fe | ml | mg Fe | ml | |
5 | 160 | 8 | 140 | 7 | 120 | 6 | 100 | 5 |
10 | 320 | 16 | 280 | 14 | 240 | 12 | 220 | 11 |
15 | 480 | 24 | 420 | 21 | 380 | 19 | 320 | 16 |
20 | 640 | 32 | 560 | 28 | 500 | 25 | 420 | 21 |
25 | 800 | 40 | 700 | 35 | 620 | 31 | 520 | 26 |
30 | 960 | 48 | 840 | 42 | 740 | 37 | 640 | 32 |
35 | 1260 | 63 | 1140 | 57 | 1000 | 50 | 880 | 44 |
40 | 1360 | 68 | 1220 | 61 | 1080 | 54 | 940 | 47 |
45 | 1480 | 74 | 1320 | 66 | 1140 | 57 | 980 | 49 |
50 | 1580 | 79 | 1400 | 70 | 1220 | 61 | 1040 | 52 |
55 | 1680 | 84 | 1500 | 75 | 1300 | 65 | 1100 | 55 |
60 | 1800 | 90 | 1580 | 79 | 1360 | 68 | 1140 | 57 |
65 | 1900 | 95 | 1680 | 84 | 1440 | 72 | 1200 | 60 |
70 | 2020 | 101 | 1760 | 88 | 1500 | 75 | 1260 | 63 |
75 | 2120 | 106 | 1860 | 93 | 1580 | 79 | 1320 | 66 |
80 | 2220 | 111 | 1940 | 97 | 1660 | 83 | 1360 | 68 |
85 | 2340 | 117 | 2040 | 102 | 1720 | 86 | 1420 | 71 |
90 | 2440 | 122 | 2120 | 106 | 1800 | 90 | 1480 | 74 |
In cases where the total therapeutic dose exceeds the maximum permissible single dose, split administration of the drug is recommended.
If 1–2 weeks after the start of treatment with Venofer® there is no improvement in hematological parameters, it is necessary to reconsider the initial diagnosis.
Dose calculation for replenishing iron levels after blood loss or autologous blood donation
The dose of Venofer® is calculated using the following formula:
- if the amount of blood lost is known:
IV administration of 200 mg of iron (10 ml of Venofer®) leads to the same increase in Hb concentration as the transfusion of 1 unit of blood (400 ml with Hb concentration = 150 g/l).
Amount of iron to be replaced (mg) = number of units of blood lost × 200
or
Required volume of Venofer® (ml) = number of units of blood lost × 10.
- when Hb level decreases:
use the previous formula provided that iron depots do not need to be replenished.
The amount of iron that needs to be replenished (mg) = body weight, kg × 0.24 × (normal Hb level - patient’s Hb level), g/l.
For example: body weight 60 kg, Hb deficiency = 10 g/l » required amount of iron » 150 mg » required volume of Venofer® = 7.5 ml.
Standard dosage
Adults and elderly patients:
5–10 ml Venofer® (100–200 mg iron) 1–3 times a week, depending on the hemoglobin level.
Children:
There is only limited data on the use of the drug in children under 3 years of age. The recommended dose for children of other age groups is no more than 0.15 ml (3 mg of iron) per kg of body weight 1-3 times a week, depending on the hemoglobin level.
Maximum tolerated single dose
Adults and elderly patients:
— for jet injection:
10 ml of Venofer® (200 mg iron), duration of administration of at least 10 minutes.
- for drip administration:
depending on the indications, a single dose can reach 500 mg of iron. The maximum permissible single dose is 7 mg/kg and is administered once a week, but it should not exceed 500 mg of iron. For the time of drug administration and method of dilution, see above.
Venofer
Venofer is a drug for the treatment of iron deficiency anemia and preanemic conditions. Intended for intravenous administration. Used:
• if it is necessary to quickly compensate for iron deficiency;
• in patients who poorly tolerate tablet forms of iron, as well as with poor adherence to treatment;
• in cases where the patient has an acute inflammatory process in the gastrointestinal tract, when tablet forms of iron are ineffective.
The production process of Venofer (the drug is produced in Switzerland by Vifor International Inc.) is so complex that reproducing its pharmacotherapeutic characteristics and safety profile is currently not possible. In other words, there are no generics (pharmaceutical copies) of Venofer - this is the only drug of its kind. On the outside, the polynuclear centers of ferric hydroxide are surrounded by molecules of the disaccharide sucrose. The molecular weight of this complex is so large that in this form its elimination by the kidneys is impossible. The complex is characterized by high stability and does not release iron ions under physiological (as opposed to artificial, laboratory) conditions. The retention of iron in this complex is ensured by structures similar to ferritin, a complex protein complex that functions as the main intracellular iron depot in the human body. The peak concentration of iron in the blood is reached 10 minutes after intravenous injection.
The half-life of the drug is 6 hours. Venofer is contraindicated in cases of non-iron deficiency anemia, excessive iron deposits in organs and tissues of various etiologies, individual intolerance to the drug, and in the first trimester of pregnancy. Intramuscular administration of Venofer is unacceptable. Before using the drug for the first time, it is necessary to check its tolerance to the body, for which the so-called drug is administered. test dose. If there are no reactions of individual intolerance during the monitoring period, the drug can be prescribed for further use. Before administration, it is necessary to ensure that there are no mechanical damage or sediment at the bottom of the ampoule. The presence of sediment is unacceptable; such a solution cannot be used. If there is no clinical improvement after 7-14 days of using the drug, it is necessary to re-diagnose the possible causes of iron deficiency. The prescription of Venofer is justified only when the diagnosis of iron deficiency anemia is based on appropriate laboratory parameters. The drug is administered slowly, because otherwise, you can provoke a sharp increase in blood pressure. Too high a dose of the drug, on the contrary, can cause a decrease in blood pressure. The drug should be injected directly into a vein, because its entry into the perivenous space can cause tissue necrosis.