Eslidin caps x30
Trade name: Eslidine International name: Methionine + Phospholipids & Pharmacological group: hepatoprotective agent Pharmacological group according to ATK: A05C. Combination of drugs for the treatment of diseases of the liver and biliary tract Pharmacological action: hepatoprotective, metabolic Description: Hard gelatin capsules, light brown body and brown cap. The contents of the capsules are a yellow-brown or brown homogeneous mass of ointment-like to denser consistency with a characteristic odor. Pharmacodynamics: A combined drug that has a hepatoprotective effect, normalizes all types of metabolism (fat, protein, carbohydrate). Methionine, one of the active components of the drug, is an essential amino acid that is a source of mobile methyl groups. Methionine is necessary for the synthesis of choline. An increase in choline content helps to increase the synthesis of endogenous (internal) phospholipids and reduce the deposition of neutral fat in the liver. Methionine is also necessary for the neutralization of xenobiotics. In atherosclerosis, it reduces the concentration of cholesterol and increases the concentration of blood phospholipids.
Essential phospholipids are essential factors for the development and functioning of liver cells. The main fraction of essential phospholipids in the preparation is represented by phosphatidylcholine (73%), which is the main component of biological membranes. Once in the body, phosphatidylcholine restores the integrity of the membranes of affected liver cells and activates phospholipid-dependent enzymes located in the membrane, thereby normalizing permeability and enhancing the detoxification and excretory potential of liver cells. Methionine and essential phospholipids enhance the effect of each other, being a source of endogenous (internal) and exogenous (entering the body) phospholipids, respectively, improve the functional state of liver cells and have a hepatoprotective (protective) effect.
Methionine also participates in the metabolism of sulfur-containing amino acids, in the synthesis of epinephrine, creatinine and other biologically active compounds, transforms the action of hormones, vitamins (B12, ascorbic, folic acids), enzymes, proteins, and participates in remethylation, deamination, and decarboxylation reactions. Eslidin restores liver function, increases its detoxification ability, and also normalizes fat, carbon and protein metabolism in the body. Indications: The drug is used in gastroenterology, dermatology, neurology, cardiology. Gastroenterology: Fatty liver of various etiologies, acute and chronic hepatitis (except viral), cirrhosis of the liver, toxic liver damage - alcohol, drugs, drugs, dysfunction of hepatocytes (as a complication in other diseases), pre- and postoperative treatment for operations in the area hepatobiliary zone. Dermatology: Psoriasis as part of complex therapy. Neurology: Atherosclerosis of cerebral vessels as part of complex therapy. Endocrinology: Diabetes mellitus as part of complex therapy, exhaustion, dystrophy. Cardiology: Atherosclerosis of the coronary arteries as part of complex therapy. Dosage regimen: The drug is taken orally, during meals, swallowed whole, with a sufficient amount of water. For liver diseases, atherosclerosis of the coronary arteries and cerebral vessels, diabetes mellitus, dystrophy and exhaustion, take 2 capsules 3 times a day. The recommended course of treatment is 3 months, the minimum is 1 month. For psoriasis - 2 capsules 3 times a day. The recommended course of treatment is 2 weeks.
Children over 7 years old with liver diseases, diabetes mellitus, fatty liver - 2 capsules 3 times a day, for 1 - 3 months. For psoriasis, children over 7 years old - 2 capsules 3 times a day for 2 weeks. Use of the drug in children from 3 to 7 years old - 1 capsule 3 times a day, for 1-3 months. Side effects: Allergic reactions.
Overdose. If the daily dose is accidentally exceeded several times, a decrease in blood pressure, an increase in heart rate (pulse), and disorientation are possible. Treatment: symptomatic (under medical supervision). Contraindications: Hypersensitivity (increased sensitivity) to the components of the drug, severe liver failure, hepatic encephalopathy, viral hepatitis, children under 3 years of age. Special instructions: Use during pregnancy and lactation. There have been no studies confirming the safety of Eslidin for the fetus and safety for the child during breastfeeding. The use of the drug during pregnancy and lactation is possible only as prescribed by a doctor in cases where the expected benefit to the mother outweighs the possible risk to the fetus and child.
Use with caution is possible during pregnancy and in children from 3 to 7 years of age, as well as in case of renal failure (due to the risk of increasing hyperazotemia).
Manufacturer: Nizhpharm OJSC, Russia Registration certificate holder: Nizhpharm OJSC, Russia Forms of release: capsules (blister packaging), capsules (dark glass jars), capsules (polymer jars) Ingredients: methionine 100 mg, polyunsaturated phospholipids from soy lecithin [lipoid PPL -400] 300 mg Shelf life: 2 years Registration data: LSR-001048/08 dated 02/26/2008 Status of the registration certificate: valid Pharmaceutical article number: FSP 42-0079-7913-06 HS codes: 3004 90 190 9
Instructions for use ESLIDINE®
The drug should be used with caution in case of renal failure (due to the risk of increased hyperazotemia).
Use in pediatrics
The drug should be used with caution in children aged 3 to 7 years.
Preclinical Safety Data
General toxic effect.
Toxicity of the drug Eslidin® in acute and subchronic experiments. A study of the acute toxicity of the drug Eslidin® was carried out on random-bred white male mice with intraperitoneal administration at doses of 3000, 5000 and 6000 mg/kg. Intoxication (a slight change in behavioral reactions, manifested in the form of increased breathing, grouping of animals, decreased motor activity) in experimental mice developed during the first 30-40 minutes, after which behavioral reactions gradually normalized. No animal deaths were observed. Based on the results of determining acute toxicity when administered into the abdominal cavity of an animal, Eslidin® is classified as toxicity class VI (according to K. K. Sidorov’s classification, it is a relatively harmless substance).
The subchronic toxicity of the drug Eslidin® was studied on 33 random-bred white male rats with an average weight of 206 ± 4 g. The contents of the capsules were administered as an aqueous solution intragastrically once daily, for 1 month at a dose of 70 mg/kg (therapeutic) and 700 mg/kg kg, ten times the therapeutic dose for rats and 70 times the therapeutic dose for humans.
According to the results of the experiment, Eslidin® in the studied doses did not cause significant changes in integral indicators in experimental animals (body weight gain, behavioral reactions, food and water consumption), cellular composition and coagulation parameters of peripheral blood, excretory, absorption, protein-synthesizing, carbohydrate functions of the liver , cholesterol content in blood serum, functional state of the excretory, cardiovascular and nervous systems. Eslidin® had no local irritant effect.
The drug in the studied doses did not cause structural disorders in organs and tissues. Under the influence of the drug at a dose of 700 mg/kg, follicles with wide reactive centers and a significant macrophage reaction were found in the lymph nodes; proliferation of Hassall's bodies was observed in the medulla of the thymus; venous congestion, lymphoid-histiocytic infiltration and mild degeneration of hepatocytes were noted in the liver.
Mutagenicity, carcinogenicity.
In vitro studies with Salmonella and yeast strains, with human cell lines, as well as in vivo studies have not revealed the mutagenic potential of essential phospholipids. According to the FDA (USA), as well as the German Cancer Center, essential phospholipids do not belong to the class of substances with suspected carcinogenicity. No data have been obtained on the carcinogenicity of methionine.
Reproductive toxicity, embryotoxicity, teratogenicity.
No toxic effects were observed in pregnant females and their fetuses when essential phospholipids were administered at doses up to 1000 mg/kg (rats) and 500 mg/kg (rabbits). The administration of essential phospholipids in doses up to 3750 mg/kg orally did not affect perinatal and postnatal development in rats. When essential phospholipids were administered orally at doses of 150, 750 and 3750 mg/kg/day to male (for 10 weeks) and female (2 weeks) rats, no effect on fertility and reproductive ability was detected.
ESLIDIN (capsules)
Damn my liver, I was prescribed a course of these pills.
Then I took them, I will say that I did not feel any side effects from either this medicine or the antibiotic, so I can say for sure that it helps. Although the liver is a difficult question, since I can only share with you my feelings, and how true they are can be confirmed by tests that I did not do.
But then I had no negative reaction from the drug. Today, my husband and I were prescribed strong antibiotics due to some infection that we had. I just had to drink them, but at the pharmacy my husband was offered to take any drug to support the liver and mentioned this as one of the possible ones. Since I was already familiar with it, I bought it. Moreover, it had a more or less adequate price. And I just thought that liver prevention would never hurt. This way, the husband won’t take the pills, and you can slip it to him on the sly, saying that this is a mandatory course of treatment.
I couldn’t take the drug, as it is prohibited for pregnant and lactating women. Which is quite strange, since this drug is still originally of plant origin, which is always good. The less chemicals we use, the better our body is. Well, how else to treat a living organ like the liver, if not with vegetation, which was also once alive.
For example, here is another herbal preparation to restore the liver. But at the time of purchase this drug was not available in the pharmacy. Europa-Biopharm capsules “Tykveol” This is what the packaging of the drug Eslidin Nizhpharm looks like for restoring liver function. There are 30 capsules in a package. As I already said, the legal entity is Nizhpharm, and it is sold under the brand of the makizpharma group of companies.
The shelf life of the drug is only 2 years.
The drug is available without a prescription. Therefore, anyone can buy it.
There are three such packs of 10 tablets in total in boxes. The tablets themselves are in capsules, brown in color. It has no taste due to the shell. Easy to drink. The packaging contains very detailed instructions for use. The drug Eslidin is a hepatoprotective drug.
Indications for use of Eslidin.
Contraindications for Eslidin include children under 3 years of age, pregnancy and lactation, as well as allergies to the components of the drug. It should also not be taken in advanced stages of liver failure.
The dosage method depends on why you are taking this drug. Since any hepatoprotector should be taken for at least two weeks, as it has a long cumulative effect. I can say that at one time these medications helped me restore my liver after a course of antibiotics. I can also say that after taking this drug, my husband said that he began to feel much better, despite taking antibiotics.
Therefore, I certainly recommend this drug. Just of course you need to consult your doctor before using it.
I don’t know why, but this medicine is not very promoted, it has no advertising and I haven’t heard much about it before. But I'm sure it helps.
For such a package I paid 340 rubles at the pharmacy "Farmokopeika"
