Pharmacological properties of the drug Oxibral
Pharmacodynamics . Vincamine has a selective vasoregulatory effect on cerebral vessels, promoting the adaptation of cerebral blood flow to the metabolic needs of the brain. The drug improves brain metabolism by enhancing the oxidation of glucose, thereby increasing energy production and helping to increase the overall activity of the body. Vincamine increases the oxygen supply to neurons in a state of hypoxia. The drug reduces and stabilizes cerebral vascular resistance. Vincamine has the unique ability to normalize cerebral circulation and improve oxygen supply to neurons. It has been proven that the drug is well tolerated by patients, has no biological, hematological toxicity and no side effects on the kidneys and liver. Vincamine, having a diverse effect that increases the functional activity of the brain, is a promising drug for use as a stimulant of intellectual abilities. Pharmacokinetics . Rapidly absorbed from the gastrointestinal tract after oral administration, the half-life is 60–90 minutes, binding to plasma proteins is 64%. Vincamine is completely metabolized in the liver, only 4–6% is excreted unchanged in the urine.
pharmachologic effect
The active ingredient of Oxybral is vincamine, one of the alkaloids of the Vinca minor plant. Vincamine improves metabolism in brain tissue by activating the process of glucose uptake by brain cells. Tissue trophism is also normalized due to stimulation of cerebral circulation - under the influence of Oxibral, blood flow in the vessels of the brain is normalized, since it has a selective moderately dilating (expanding) effect on the vessels of the cerebral basin. Numerous reviews of Oxybral by experts indicate that the drug eliminates oxygen deficiency in brain tissue by increasing the supply of oxygen to neurons.
Thus, Oksibral has a complex effect on brain tissue, stimulating its functions, improving energy supply and eliminating hypoxia of brain tissue.
Does not have a toxic effect on the blood, liver and kidneys.
Indications for use of the drug Oxibral
To normalize and adapt cerebral circulation to the metabolic needs of the brain, to regulate, improve and maintain its functions. It is used for the following conditions: memory loss, impaired concentration, diabetic angiopathy, atherosclerotic lesions of cerebral vessels, conditions after traumatic brain injury and acute cerebrovascular accident, cerebral disorders after cerebral ischemia, hypertensive encephalopathy, hearing and vision impairment of vascular origin, disorders orientation in space and time, emotional disturbances resulting from various mental disorders.
Analogues of Oksibral
An analogue of Oksibral is the drug Vinoxin, which contains the same active ingredient, vincamine. Aminalon, Cavinton and other neurometabolic stimulants have a similar effect. Based on the nature of the effect, analogues of Oxibral can also include Nootropil and other drugs whose active substance is piracetam. However, unlike Oxybral, piracetam-containing drugs do not have a vasodilating effect on cerebral vessels.
Special instructions for the use of the drug Oxibral
Do not exceed the recommended dose. Use with caution in patients with hypertension (arterial hypertension) and cardiac dysfunction. Do not use if the QT and there is hypokalemia. The drug contains lactose, which should be taken into account in case of hereditary lactose intolerance. during pregnancy and breastfeeding . Children . Oxibral capsules are not recommended for use in children. Does not affect the ability to drive vehicles and operate other mechanisms , but the state of the central nervous system should be taken into account.
Release form
Oxibral is available in the form of capsules and as a solution for injection.
Long-acting capsules, each containing microgranules of two colors - blue and white.
One capsule contains: vincamine (30g) and excipients: sucrose, lactose, povidone, methacrylic acid copolymer, shellac, gelatin, talc, erythrosine, blue sepsis, indigo carmine. The blister contains 20 capsules.
The solution for injection is available in ampoules of 2 ml, transparent, colorless or slightly yellowish. Each ampoule contains 15 mg of vincamine and excipients: propylene glycol, tartaric acid, sodium metabisulfite, sodium bicarbonate, tartaric acid, purified water for injection. The package contains 5 ampoules.
Instructions for use of Oxybral
Following the instructions, Oxibral is prescribed 1 capsule (30 mg) 2 times a day. The drug can also be prescribed in the form of intramuscular or intravenous injections, in this case the dosage for adults: 2 ampoules intramuscularly or intravenously in combination with an isotonic solution for infusion, twice a day.
It is recommended to use Oxibral in pediatric practice exclusively in the form of intramuscular injections or intravenous infusions, a single dose is 15 mg of the active substance (1 ampoule), 1 or 2 times a day as prescribed by a doctor.
The duration of therapy with this drug is determined in each case individually. Due to its good tolerability and lack of pronounced toxic effects, if indicated, long-term use is possible - up to a year.
Oxybral should not be used without a doctor's prescription.
Indications for use of Oxibral
The use of Oxybral is indicated for all types of disorders or decreases in brain activity. According to the instructions, Oksibral is prescribed for the following indications:
- Drug rehabilitation after an ischemic stroke and as a preventive measure in the event of a threat of its development;
- Cerebrovascular insufficiency;
- Increased intracranial pressure;
- Hypertension, especially with a pronounced cerebral component;
- Migraine and migraine-like attacks;
- Attacks of dizziness of unknown origin;
- Deterioration in concentration and memory due to various pathologies (atherosclerosis of cerebral vessels, consequences of traumatic brain injury, consequences of brain surgery, diabetic angiopathy, etc.);
- As part of complex therapy for menopausal changes in women;
- Deterioration of speech, vision and hearing of vascular and neurological origin;
- As part of complex therapy in the treatment of mental illness;
- Decrease in intellectual abilities in older people;
- Underdevelopment of intellectual abilities in childhood and adolescence, including severe mental retardation.
There are reviews about Oksibral, confirming the advisability of its use in cerebral palsy, as well as for stimulating mental abilities when intense mental activity is necessary.
Contraindications
The use of Oxibral is contraindicated in the presence of increased individual sensitivity to any of the components of the drug, heart rhythm disturbances, brain tumors, hypokalemia, hypocalcemia, convulsive syndrome of unknown origin. The drug is not recommended for use during pregnancy and breastfeeding, since studies confirming its safety during these periods have not been conducted.
In the case of treatment of concomitant diseases with other drugs while using Oxibral, it is necessary to notify the attending physician, as undesirable interactions are possible.
Pharmacological action Oxibral is a drug for improving cerebral circulation. The active ingredient is vincamine. Vinacmin is of plant origin (Vinca minor L. alkaloid). Oksibral acts through a regulatory effect on the blood vessels of the brain. Causes adaptation of the metabolic needs of brain tissue to the parameters of cerebral blood flow. Improves metabolic processes in the brain by increasing the oxidative reactions of glucose, which helps to increase energy production in cells and enhance their overall activity. The drug also increases the supply of oxygen to neurons under hypoxic conditions. Normalizes blood circulation in the vessels of the brain. Oxibral is well tolerated by patients. Has no hematological and biological toxicity. Does not have a negative effect on the liver and kidneys. It is considered a promising means for correcting mental abilities. Oxybral is quickly absorbed from the digestive system after internal administration. The half-life is 60-90 minutes. 64% bound by blood proteins. The drug is metabolized in the liver almost completely (only 4-6% is eliminated unchanged in the urine).
Indications for use
• Adaptation and normalization of blood circulation in the vessels of the brain to changed needs (to improve, regulate and maintain brain functions); • decreased concentration, deterioration of cognitive functions, • condition after head injury, acute cerebrovascular accidents, • diabetic angiopathy, • hypertension, hypertensive encephalopathy, • disturbances in orientation in time and space in mental illness, • visual and hearing impairment due to cerebrovascular disorders , • improvement of intellectual abilities.
Mode of application
For adults, use a dose of 1 capsule 2 times a day.
The duration of therapy is determined by the doctor individually. Side effects There have been isolated cases of individual intolerance (skin rash).
Contraindications
• Children's age, • brain tumors, • hypersensitivity to the active substance and components of Oxibral.
Pregnancy
Oxibral is contraindicated during pregnancy and breastfeeding.
Drug interactions
An increase in the effects of antihypertensive drugs and antiplatelet agents was noted.
Overdose
The specific antidote is unknown. Overdose symptoms are currently unknown.
Release form
The capsules are two-color (one half is transparent, the other is blue with the inscription “Oxybral” in pharmaceutical ink). The capsule contains a mixture of white and blue microgranules. Capsules have a prolonged action. The blister contains 20 capsules of 30 mg of vincamine.
Storage conditions
Temperature no more than 30°C. Shelf life – 3 years
Compound
Active substance: vincamine. Inactive substances: lactose, sugar, methacrylic acid copolymer, povidone, shellac, blue sepsis, gelatin, talc, erythrosine, indigo carmine. Attention! The description of the drug on this page is simplified. Before purchasing and using the drug, consult your doctor or pharmacist, and also read the instructions approved by the manufacturer. Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. ATTENTION! This section is provided for informational purposes only and is not a catalog or price list of our company. To obtain information about the availability of drugs, call + 99871 202 0999 Pharmacy Network Helpline 999.
Side effects
When used in accordance with the instructions, Oxibral is well tolerated by patients. Side effects occur extremely rarely and are usually caused by individual hypersensitivity to Vincamine or by exceeding the recommended dosage of Oxybral. However, in medical practice the following side effects have been reported as a result of taking the drug:
- Psychomotor agitation;
- Heart rhythm disturbances;
- Headache;
- Dizziness;
- Symptoms of dyspepsia: heartburn, nausea, dry mouth, stool disorders;
- Allergic reactions: skin itching, urticaria, erythema, angioedema.
To eliminate side effects, reduce the dosage of the drug or interrupt treatment for 1-2 days. In case of allergic reactions, replace Oxibral with another drug of similar effect.
