Pharmacodynamics and pharmacokinetics
Pharmacodynamics
Evkazolin Aqua is a local vasoconstrictor used for rhinitis.
Xylometazoline has an α2-adrenomimetic effect - it quickly and for a long time constricts the vessels of the nasal mucosa, eliminates swelling and inflammation. This makes nasal breathing easier.
The eucalyptus oil included in the composition additionally has anti-inflammatory, antimicrobial, mild antispasmodic and moisturizing effects. The effect appears 5 minutes after application and lasts up to 10 hours.
Pharmacokinetics
Xylometazoline is almost not absorbed when applied topically, therefore its concentrations in the blood are low and cannot be determined by analytical methods.
Evkazolin Aqua nasal spray 1mg/g 10g No.1
Name
Evkazolin Aqua spray name 1 mg/g in bottle with dosage 10 g in pack No. 1
Description
When the drug leaves the bottle through a dispenser pump with a nasal spray, it is sprayed in the form of an aerosol stream that has a specific odor and consists of liquid particles dispersed in the air.
Main active ingredient
1 g of spray contains xylometazoline hydrochloride in terms of 100% substance 1 mg
Release form
Spray
Dosage
10g
Pharmacological properties
Pharmacodynamics
Xylometazoline is a sympathomimetic agent acting on α-adrenergic receptors. Xylometazoline, when administered nasally, causes a constriction of the blood vessels of the nasal mucosa and adjacent areas of the nasopharynx, thus eliminating swelling and hyperemia of the nasal mucosa and nasopharynx, and also reduces the associated increased secretion of mucus and facilitates the removal of blocked nasal secretions, which leads to clearing of nasal passages passages and easier nasal breathing. The effect of the drug begins within 2 minutes after use and lasts up to 10 hours (for example, throughout the night). The drug is well tolerated by patients with sensitive mucous membranes and does not reduce mucociliary function. Research results have shown that xylometazoline reduces the infectivity of human rhinovirus, which is associated with the common cold.
Pharmacokinetics
When applied topically, xylometazoline is practically not absorbed; the concentration of xylometazoline in the blood plasma is so low that it is practically undetectable (the concentration in the blood plasma is close to the detection limit). Xylometazoline does not have mutagenic properties. Also, animal studies did not reveal the teratogenic effect of xylometazoline.
Indications for use
For symptomatic relief of nasal congestion, perennial and allergic rhinitis (including hay fever), sinusitis.
Directions for use and doses
Evkazolin Aqua, nasal spray, for use in adults and children over 12 years of age. Adults and children over 12 years of age: 1 spray into each nasal passage up to 3 times a day as needed. Use no more than 3 times in each nasal passage per day. The duration of treatment depends on the course of the disease and should not exceed 7 days in a row. The metered spray ensures accurate dosing and proper distribution of the solution over the surface of the nasal mucosa. Before use, it is necessary to prepare the dispensing device by making several injection movements until the spray begins to be released into the air. With further use, the dosing device will be ready for immediate use. The spray must be used as follows: - thoroughly clean the nose before using the drug; - hold the bottle vertically, supporting the bottom with your thumb and placing the tip between two fingers; - tilt the bottle slightly and insert the tip into the nostril; - inject and at the same time take a light breath through the nose; — after use, before closing the tip with a cap, you should clean and dry the tip; — in order to prevent infection, each bottle of the drug can only be used by one person. The last use is recommended immediately before bedtime.
Precautionary measures
The drug should not be used for more than 7 days in a row. If symptoms persist, consult your doctor. Excessive or prolonged use may result in renewed nasal congestion and/or atrophy of the nasal mucosa. The drug, like other sympathomimetics, should be prescribed with caution to patients who have severe reactions to adrenergic drugs, which manifest themselves as insomnia, dizziness, tremors, cardiac arrhythmias, or increased blood pressure. The recommended dose of the drug should not be exceeded, especially when treating children and the elderly. The drug should be prescribed with caution to patients with cardiovascular diseases, arterial hypertension, patients with diabetes mellitus, pheochromocytoma, prostatic hypertrophy, and should not be used in patients receiving treatment with MAO inhibitors and within 2 weeks after stopping their use. The drug contains benzalkonium chloride, which may cause irritation of the nasal mucosa. Use during pregnancy or breastfeeding. The drug should not be used during pregnancy due to potential vasoconstrictive effects. There is no evidence of any adverse effects on the infant. It is not known whether xylometazoline is excreted into breast milk, so caution is necessary and the drug should only be used during breastfeeding as directed by a doctor. Fertility. There are no adequate data on the effect of the drug on fertility. Since systemic exposure to xylometazoline hydrochloride is very low, the likelihood of affecting fertility is extremely low. Children. The drug should not be used in children under 12 years of age. The ability to influence reaction speed when driving a vehicle or operating other mechanisms. Usually the drug has no or negligible effect on the ability to drive vehicles or operate other machines.
Interaction with other drugs
Monoamine oxidase inhibitors (MAO inhibitors): xylometazoline can potentiate the effect of monoamine oxidase inhibitors and induce a hypertensive crisis. Do not use xylometazoline in patients who are taking or have taken MAO inhibitors in the past two weeks. Tri- and tetracyclic antidepressants: with the simultaneous use of tri- or tetracyclic antidepressants and sympathomimetic drugs, the sympathomimetic effect of xylometazoline may be enhanced, so the simultaneous use of such drugs is not recommended. When used together with beta-blockers, it may cause bronchial spasm or a decrease in blood pressure.
Contraindications
Hypersensitivity to xylometazoline or to any other component of the drug, hyperthyroidism, angle-closure glaucoma, transsphenoidal hypophysectomy and previous surgery with exposure of the meninges, dry rhinitis (rhinitis sicca) or atrophic rhinitis.
Compound
active ingredient: xylometazoline; 1 g of spray contains xylometazoline hydrochloride in terms of 100% substance 1 mg; excipients: benzalkonium chloride; eucalyptus oil; disodium edetate; propylene glycol; polyethylene glycol 1500; povidone K-15; hypromellose (substitution type 2910); polysorbate 20; sodium hydrogen phosphate, dodecahydrate; potassium dihydrogen phosphate; purified water.
Overdose
Excessive topical use of xylometazoline hydrochloride or its accidental ingestion can lead to severe dizziness, sweating, a significant decrease in body temperature, headache, bradycardia, hypertension, respiratory depression, coma and convulsions. High blood pressure may change to low. Young children are more sensitive to toxicity than adults. All patients with suspected overdose should be given appropriate supportive measures and, if necessary, immediate symptomatic treatment under medical supervision. Medical care should include monitoring the patient for several hours. In case of severe overdose, which is accompanied by cardiac arrest, resuscitation measures should continue for at least 1 hour.
Side effect
When Evkazolin Aqua was prescribed to people with cardiovascular diseases, systemic cardiovascular disorders were observed. From the immune system: rare (
Storage conditions
Store in a place protected from light at a temperature not exceeding 25 °C. Keep out of the reach of children. Best before date. 2 years. Do not use the drug after the expiration date indicated on the package.
Buy Evkazolin Aqua nasal spray 1mg/g 10g No. 1 in the pharmacy
Price for Evkazolin Aqua nasal spray 1mg/g 10g No. 1
Instructions for use for Evkazolin Aqua nasal spray 1mg/g 10g No. 1
Contraindications
Spray Evkazolin is not used for:
- arterial hypertension;
- tachycardia;
- severe atherosclerosis ;
- thyrotoxicosis;
- glaucoma;
- atrophic rhinitis;
- pregnancy;
- under 12 years of age;
- hypersensitivity to the drug.
It is prescribed with caution for diabetes mellitus , insomnia , dizziness, cardiac arrhythmia , prostatic hyperplasia , and breastfeeding.
Special instructions for the use of the drug Evkazolin
With prolonged use of the drug, tolerance to it develops (decreased effectiveness or complete absence of effect). Use during pregnancy and lactation: in therapeutic doses the drug acts locally and does not have a systemic effect, therefore the use of the drug in therapeutic doses in this population is not contraindicated. In patients with hypertension (arterial hypertension), hyperthyroidism, pathology of the cardiovascular system, diabetes mellitus, the drug should be used carefully, taking into account the possibility of developing hypertension (arterial hypertension), tachycardia and arrhythmia.
Spray Evkazolin Aqua, instructions for use (Method and dosage)
The aerosol form of the drug is prescribed to children over 12 years of age and adults. Before administration, the nasal passages should be cleaned. The bottle sprayer with the nozzle is held vertically upward and inserted into the nasal passage. Keep your head straight, you should not tilt it back. While inhaling, inject the drug once. The injection interval is 8-12 hours.
The instructions for Evkazolin Aqua contain warnings: do not exceed the dose of the drug, and should not be used for more than 7 days in a row. Evkazoline can affect the speed of psychomotor reactions.
Analogs
Level 4 ATX code matches:
Xymelin Eco
Xymelin
Nazivin
Galazolin
Lazorin
Nazivin Sensitive for children
Otrivin
Naphthyzin
Sanorin
Knoxprey
For the nose
Lazolvan Rino
Afrin
Rhinorus
Rinazolin
Grippostad Reno
Farmazolin
Xylometazoline
Nazol Advance
Nazol Baby
In the form of sprays with the active ingredient xylometazoline, are available: Rinonorm , Rinorus , Rinostop , Otrivin , Ximelin , Snoop , Tizin Xylo .
Reviews
Many users note the advantages of using a spray compared to similar drops: the spray is more economical, the medicinal substance is evenly distributed over the surface of the mucous membrane, it is convenient to use in any conditions - at work and in public places. The drug acts quickly and effectively.
Xylometazoline is a decongestant with an average duration of action, which allows you to reduce the frequency of use and reduce it to 1-2 times a day. This is also noted as a positive quality of the drug. It is important that everyone who took it noted that after using the spray the mucous membrane does not dry out (due to the presence of eucalyptus oil and water).
With prolonged use, any decongestants can worsen a runny nose , cause a persistent deterioration in the blood supply to the mucous membrane and cause its atrophy. Addiction to them quickly develops, which is expressed in a decrease or complete cessation of the effect. In this regard, many drugs are used for 3–5 days. Preparations containing essential oils, which include Evkazolin Aqua , Pinosol , Kameton , can be used for a longer period - up to 7 days.
It must be remembered that all vasoconstrictors for topical use can cause increased blood pressure and tachycardia . This is mentioned in reviews of Eucazoline Aqua. This fact limits its use in the elderly, patients suffering from arterial hypertension and thyrotoxicosis . For some users, the spray caused irritation of the nasal mucosa, a burning sensation in the nose and throat.
Overdose of the drug Evkazolin, symptoms and treatment
With frequent use of the drug, symptoms of overdose may appear in the form of headache, dry nose, nausea, depression, increased blood pressure, short-term visual impairment, and possibly increased intraocular pressure. It is necessary to stop using the drug and prescribe antagonist drugs: sympatholytics and α-adrenergic receptor blockers (phentolamine, tropafen), symptomatic therapy. If the drug is accidentally taken orally, it is necessary to lavage the stomach, prescribe enterosorbents and laxatives, α-adrenergic receptor blockers and symptomatic therapy. Frequent overdose can lead to the development of atrophy of the nasal mucosa.
Price of Evkazolina Aqua, where to buy
You can buy it in many pharmacies in Moscow without a doctor's prescription. Approximate price of Evkazoline 0.1% spray in 10 ml bottles is 109-115 rubles.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Evkazolin Aqua nasal spray.
1 mg/g 10g PJSC "Farmak" 114 rub. order
Pharmacy Dialogue
- Evkazoline aqua nasal spray 1mg/g bottle 10gFarmak
104 rub. order
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Pharmacy24
- Evkazolin Aqua 1 mg/g 10 ml spray PAT "Farmak", Ukraine
47 UAH. order
PaniPharmacy
- Evkazolin aqua liquid Evkazolin Aqua nasal spray 1 mg/g vial. 10g Ukraine, Farmak OJSC
49 UAH order
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