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Otrivin Menthol nasal spray dosed 0.1% 10ml

A country

Switzerland
The country of production may vary depending on the batch of goods. Please check with the operator for detailed information when confirming your order.

Active substance

Xylometazoline

Description

You feel Otrivin Menthol immediately!
* Otrivin Menthol with menthol and eucalyptus is used for respiratory diseases with symptoms of rhinitis (runny nose)*: • Helps fight nasal congestion thanks to the active substance - xylometazoline. • Due to the presence of menthol and eucalyptus in the composition, it has a cooling effect on the mucous membrane and gives a feeling of freshness. • Relieves congestion in 2 minutes, maintaining the effect for up to 12 hours**. * This refers to the effect of menthol. ** Instructions for medical use, RU No. P N011649/05 dated 09.11.2008

Compound

1 ml of the drug contains active ingredient: xylometazoline hydrochloride 1 mg. Excipients: sodium dihydrogen phosphate dihydrate 2 mg, sodium hydrogen phosphate dodecahydrate 2.8 mg, sodium chloride 5 mg, benzalkonium chloride, 50% solution 0.1 mg (in terms of benzalkonium chloride 0.05 mg), sorbitol 70% 14 mg, disodium edetate 0.5 mg, levomenthol (menthol) 0.3 mg, cineole (eucalyptol) 0.2 mg, macrogol glyceryl hydroxystearate 2.5 mg, purified water to 1 ml.

Product description

Colorless opalescent solution with a characteristic odor of menthol and eucalyptus.

pharmachologic effect

Xylometazoline belongs to the group of local vasoconstrictors (decongestants) with an α-adrenomimetic effect; it causes constriction of the blood vessels of the nasal mucosa, eliminating swelling and hyperemia of the nasopharyngeal mucosa. Xylometazoline also reduces the accompanying hypersecretion of mucus and facilitates the drainage of nasal passages blocked by secretions, and thus improves nasal breathing during nasal congestion. Otrivin is well tolerated by patients with sensitive mucous membranes; its effect does not interfere with mucus secretion. Otrivin has a balanced pH value characteristic of the nasal cavity. The menthol and eucalyptol contained in the preparation have a cooling effect on the nasal mucosa, giving a feeling of freshness. In therapeutic concentrations, the drug does not irritate the mucous membrane and does not cause hyperemia. The effect occurs 2 minutes after application and lasts for 12 hours (for example, throughout the night). In vitro studies have shown that xylometazoline inhibits the infectivity of human rhinovirus, which causes the common cold. When applied topically in recommended dosages, it is practically not absorbed, plasma concentrations are below the detection limit.

Indications for use

Acute respiratory diseases with symptoms of rhinitis (runny nose), acute allergic rhinitis, hay fever, sinusitis, eustachitis, otitis media (to reduce swelling of the nasopharyngeal mucosa). Preparing the patient for diagnostic manipulations in the nasal passages.

Contraindications

Hypersensitivity to xylometazoline and other components of the drug, arterial hypertension, tachycardia, severe atherosclerosis, glaucoma, dry rhinitis or atrophic rhinitis, hyperthyroidism, condition after transsphenoidal hypophysectomy, surgical interventions on the meninges (history), children under 12 years of age.

Carefully

With caution: diabetes mellitus; pheochromocytoma; diseases of the cardiovascular system; prostatic hyperplasia; with increased sensitivity to adrenergic drugs, accompanied by insomnia, dizziness, arrhythmia, tremor, increased blood pressure.

Use during pregnancy and lactation

The drug should not be used during pregnancy. During lactation, the drug should be used only after a thorough assessment of the risk-benefit ratio for the mother and baby, under the supervision of a physician. Do not exceed the recommended dosage

Directions for use and doses

Intranasally. Adults and children over 12 years of age: 1 spray into each nasal passage 3 times a day. Should not be used more than 3 times a day. It is recommended to carry out the last application immediately before bedtime.

Side effect

Classification of the frequency of occurrence of adverse reactions: very often (≥ 10); often (≥1/100, from the immune system: very rarely: hypersensitivity reactions, angioedema, rash, itching). From the nervous system: often: headache. Rarely: insomnia, depression (with long-term use in high doses). From the senses: Very rarely: impaired clarity of visual perception. From the cardiovascular system: Rarely: palpitations, increased blood pressure. Very rare: tachycardia, arrhythmia. From the respiratory system: Often: irritation and/or dryness of the nasal mucosa, burning, tingling, sneezing, hypersecretion of the nasopharyngeal mucosa. From the digestive system: Often: nausea. Rarely: vomiting. Local reactions: Often: burning at the site of application. If any of the side effects indicated in the instructions get worse, or you notice any other side effects not listed in the instructions, tell your doctor.

Overdose

Xylometazoline, when administered topically in an excessive dose or accidentally ingested, can cause severe dizziness, increased sweating, a sharp decrease in body temperature, headache, bradycardia, increased blood pressure, respiratory depression, coma and convulsions. Following an increase in blood pressure, a sharp decrease may be observed. Appropriate supportive measures should be taken if overdose is suspected, and in some cases immediate symptomatic treatment under medical supervision is indicated. These measures should include monitoring the patient for several hours. In case of severe poisoning with cardiac arrest, resuscitation efforts should last at least 1 hour.

Interaction with other drugs

Xylometazoline is contraindicated in patients currently receiving MAO inhibitors or who have received them within the previous 2 weeks. The simultaneous use of tri- or tetracyclic antidepressants and sympathomimetic drugs can lead to an increase in the sympathomimetic effect of xylometazoline, so this combination is recommended to be avoided.

special instructions

It is not recommended to use continuously for more than 10 days. Do not exceed recommended doses, especially in children and the elderly. Long-term (more than 10 days) or excessive use of the drug may cause a rebound effect (rhinitis medicamentosa) and/or atrophy of the nasal mucosa. Benzalkonium chloride, which is part of the drug, can cause irritation of the nasal mucosa.

Release form

Dosed nasal spray [with menthol and eucalyptus] 0.1%. 10 ml of the drug in a white or transparent bottle made of high-density polyethylene, equipped with a pump dispenser with a tip and a protective cap made of polyethylene. The bottle along with instructions for use is placed in a cardboard pack. Secondary packaging is allowed to have a first-opening control.

Storage conditions

At a temperature not exceeding 25 C, out of the reach of children.

Best before date

2.5 years. Do not use after expiration date.

Otrivin spray naz with menthol and eucalyptus 0.1% cor 10 ml x1

Trade name: Otrivin International name: Xylometazoline

Release form: dosed nasal spray with menthol and eucalyptus 0.1% (plastic bottles with a dosing device) 10 ml

Composition: xylometazoline hydrochloride 100 mg - 100 ml

Pharmacological group: anticongestive agent - alpha-adrenergic agonist

Pharmacological group according to ATK: R01AA07 (Xylometazoline)

Pharmacological action: alpha-adrenomimetic, vasoconstrictive, anticongestive,

Indications: Acute allergic rhinitis, acute respiratory infections with symptoms of rhinitis, sinusitis, hay fever, otitis media (to reduce swelling of the nasopharyngeal mucosa). Preparing the patient for diagnostic manipulations in the nasal passages.

Dosage regimen: Intranasal. Nasal drops for adults and children over 6 years old - 2-3 drops of 0.1% solution or one spray from a sprayer into each nasal passage, usually 4 times a day is enough, for infants and children under 6 years old - 1-1 2 drops of 0.05% solution in each nasal passage 1 or 2 times a day, should not be used more than 3 times a day. Nasal gel (only for adults and children over 7 years old) - place a small amount of gel as deep as possible into each nasal passage 3-4 times a day. The last time the gel is applied is usually shortly before bedtime.

Contraindications: Hypersensitivity, arterial hypertension, tachycardia, severe atherosclerosis, glaucoma, atrophic rhinitis, thyrotoxicosis, surgical interventions on the meninges (history), pregnancy, children (up to 12 years - for 0.1% solution).

Side effects: With frequent and/or prolonged use - irritation and/or dryness of the nasopharyngeal mucosa, burning, paresthesia, sneezing, hypersecretion. Rarely - swelling of the nasal mucosa, palpitations, tachycardia, arrhythmias, increased blood pressure, headache, vomiting, insomnia, blurred vision, depression (with long-term use in high doses). Overdose. Symptoms: increased side effects.

Pharmacodynamics: Alpha adrenergic stimulant, constricts the blood vessels of the nasal mucosa, eliminating swelling and hyperemia of the mucous membrane. Facilitates nasal breathing during rhinitis. The action begins within a few minutes and lasts for several hours.

Pharmacokinetics: When applied topically, it is practically not absorbed; plasma concentrations are so small that they cannot be determined by modern analytical methods.

Special instructions: Before use, it is necessary to clean the nasal passages. For children under 2 years of age, generally accepted clinical doses have not been developed (use only 0.5% solution). Should not be used for a long time, for example for chronic rhinitis. For “cold” diseases in cases where crusts form in the nose, it is preferable to administer it in the form of a gel. Missed dose: use immediately within 1 hour, do not use after 1 hour, do not double the dose. Carefully. Lactation period, ischemic heart disease (angina pectoris), prostatic hyperplasia, thyrotoxicosis, diabetes mellitus, childhood (for 0.05% solution - up to 2 years, for gel - up to 7 years).

Interaction: Incompatible with MAO inhibitors and tricyclic antidepressants.

Dispensed from pharmacies: Dispensed without a prescription

Drug registration number: P No. 011649/05

Date of registration (re-registration) of the drug: December 22, 2004