Compound
Cromohexal nasal spray contains the active ingredient - cromoglicic acid , as well as additional components: disodium salt EDTA, sodium dihydrogen phosphate, sorbitol , benzalkonium chloride , sodium monohydrogen phosphate, sodium chloride, water.
Cromohexal eye drops contain the active ingredient - cromoglicic acid , as well as additional components: sodium chloride, disodium edetate, benzalkonium chloride, liquid sorbitol, disodium hydrogen phosphate dodecahydrate, sodium dihydrogen phosphate dihydrate, water.
Cromohexal for inhalation in the form of a solution contains the active ingredient sodium cromoglycate and purified water as an additional component.
Composition and rules for dispensing the drug
Cromohexal is available in the form of eye drops in a 10 ml bottle with a dropper dispenser.
The medicine contains 2% cromoglycic acid, which has an antiallergic effect, and auxiliary components: solvents, stabilizers and buffer substances.
- Signicef eye drops - instructions for use. For the treatment of infectious pathologies
The product is an over-the-counter product and is freely sold in pharmacies.
Before use, you should consult a specialist.
Release form
Several forms of this medicine are produced.
- Cromohexal nasal spray 2% dosed is a colorless or yellowish solution that does not contain mechanical inclusions. Packaged in 15 ml or 30 ml polyethylene bottles, equipped with a dosing device.
- Eye drops 2% - a transparent, yellowish solution that does not contain mechanical inclusions. Contained in 15 ml bottles.
- The solution for inhalation is transparent, yellowish, and does not contain mechanical inclusions. Contained in polyethylene ampoules of 2 ml, which are placed in cardboard packs of 10 pieces.
During pregnancy and breastfeeding
The drug Cromohexal is not recommended during pregnancy due to the lack of research on the effect of cromoglycic acid on the fetus.
- Zaditen eye drops - instructions for use. To eliminate allergic irritations
The drug is excreted in breast milk in small quantities and can be used as prescribed by a doctor if the expected benefit to the mother is higher than the risk to the baby.
pharmachologic effect
The medicine has an antiallergic effect.
All forms of Cromohexal include the active component disodium salt of cromoglycic acid. The active substance has a stabilizing effect on the membranes of basophilic granulocytes and also inhibits the entry of calcium ions into the cells. Since under the influence of the drug stabilization of mast cell membranes occurs, there is no degranulation and release of histamine, bradykinin and other mediators of allergy and inflammatory processes into the blood.
This remedy is most effective as a prevention of allergic manifestations. The clinical effect is observed after a few days of using the product.
Description of the drug
For your information! Cromohexal drops are an antihistamine for the treatment of acute allergic and chronic eye pathologies.
The disodium salt of cromoglycic acid, which is part of the product , helps in the fight against dry mucous membranes, eliminates swelling, itching and burning caused by the body's reaction to allergens (dust, wool, pollen, household chemicals, cosmetics).
The affordable price and relative safety of the drug allows the drops to be used in pediatric practice and for the treatment of ophthalmological diseases in adults.
Indications for use
Cromohexal nasal spray is indicated for allergic rhinitis , which occurs seasonally or throughout the year.
Cromohexal eye drops are prescribed for both the prevention and treatment of keratoconjunctivitis , allergic conjunctivitis , allergic keratitis , as well as irritation of the eye mucosa associated with allergic reactions (the effect of environmental factors, cosmetics, household chemicals, pets, plants, etc.).
The inhalation solution is prescribed for the purpose of preventive treatment of manifestations of bronchial asthma of allergic and non-allergic origin, as well as for endogenous forms of asthma that are associated with stress, infection, and high stress.
Reviews
Patients who use the drug to treat ophthalmic diseases respond positively to the drug and note its effectiveness.
A trip to visit the dacha was marred by allergic conjunctivitis . Birch blossoms caused watery eyes and redness of the eyes .
Cromohexal eye drops and did not regret it. I instilled the product into both eyes every 6 hours throughout the day .
The next day, the symptoms decreased , and I used the medicine as needed (2 times).
The product did not cause burning or itching and helped to cope with tearfulness in a short time.
Arina K.
Cromohexal eye drops were prescribed to the child by an ophthalmologist . In the spring, the baby constantly scratched his eyes and cried.
At the initial visit, the doctor diagnosed atopic conjunctivitis and recommended medications with cromoglycic acid.
They instilled 1 drop 4 times a day , then switched to dosing 3 times a day. A week later, the symptoms disappeared , the child became calm and cheerful, and stopped touching his eyes.
We always use it when the child’s disease is exacerbating and use it ourselves if we feel dryness and burning of the mucous membrane.
Mikhail S.
Side effects
Cromohexal nasal drops can cause the following negative effects:
- respiratory system: burning or symptoms of irritation of the nasal mucosa, cough, sneezing, rhinorrhea , in rare cases - nosebleeds;
- allergic manifestations: itching and rash, urticaria , swelling of the lips, face or eyelids, difficulty swallowing or breathing;
- other manifestations: headaches, bad taste in the mouth.
The inhalation solution can cause the following unpleasant effects:
- irritation of the trachea and pharynx;
- a slight cough, in very rare cases - a reflex spasm of the bronchi;
- skin rash;
- inflammation of the gastrointestinal tract.
All phenomena are short-lived and disappear after discontinuation of the medication.
Eye drops can cause the following effects:
- deterioration in vision clarity;
- burning sensation in the eyes;
- manifestation of lacrimation;
- foreign body sensation;
- swelling of the conjunctiva;
- dry eyes;
- meibomite (barley);
- The lesion of the corneal epithelium is superficial.
Instructions for use of Cromohexal (Method and dosage)
Instructions for nasal spray
It is recommended to administer one dose of the drug into each nasal passage, that is, make one press, 4 times a day.
The maximum permissible dosage is 6 times a day, 1 dose. After the effect has been achieved, you can reduce the number of uses of the product per day. In this case, it is advisable to use a spray when in contact with allergens .
Treatment lasts for 4 weeks, drug withdrawal is carried out gradually over 1 week.
Before using the product, you need to remove the protective cap from the bottle and press the sprayer several times to achieve the optimal dosage. Before using the spray, be sure to thoroughly clean the nasal passages.
Instructions for Cromohexal for inhalation
It is recommended to carry out inhalations 4 times a day, for one inhalation use one bottle of 2 ml. If possible, equal time intervals should pass between inhalations. If necessary, you can increase the frequency of use of the product up to 6 times a day. After the therapeutic effect has been achieved, inhalations can be performed as needed.
When used regularly, Cromohexal solution prevents the manifestation of asthma symptoms, but it does not relieve acute asthma attacks. The course of treatment should be at least 4 weeks, the dose should be reduced gradually over one week. Special inhalers are used for inhalation.
Cromohexal eye drops, instructions for use
It is necessary to instill 1-2 drops of the product into each eye, this must be done 4 times a day. You can increase the number of procedures up to 6-8 times a day. After the therapeutic effect has been achieved, the product can only be used during contact with allergens. For chronic allergies, the duration of treatment is determined by the doctor individually.
Cromohexal eye drops 2% 10ml
Compound
eye drops
Pharmacokinetics
An antiallergic agent, has a membrane-stabilizing effect, blocks the entry of calcium ions into the mast cell, preventing its degranulation and release of histamine, bradykinin, prostaglandins, leukotrienes (including slow-reacting substances) and other biologically active substances. The drug is most effective as a means of prevention. A noticeable clinical effect occurs a few days or weeks after administration.
Indications for use
Absorption through the mucous membrane of the eye is negligible. Systemic bioavailability is less than 0.03%. The half-life is 5-10 minutes. Communication with plasma proteins - 65%. Not metabolized, excreted by the kidneys and through the intestines unchanged (in approximately equal quantities within 24 hours after use).
Contraindications
Prevention and treatment:
- allergic conjunctivitis,
- allergic keratitis, keratoconjunctivitis,
- irritation of the mucous membrane of the eyes caused by allergic reactions (environmental factors, occupational hazards, household chemicals, cosmetics, ophthalmic dosage forms, plants and pets).
Directions for use and doses
Reduces the need to use ophthalmic drugs containing glucocorticosteroids.
Storage conditions
On prescription
Best before date
At a temperature not exceeding 25C in a place protected from light. Keep out of the reach of children.
special instructions
During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.
Description
1 ml of eye drops contains:
Active substance: sodium cromoglycate (20.0 mg).
Excipients: benzalkonium chloride, sodium chloride, disodium edetate, non-crystallized liquid sorbitol, sodium dihydrogen phosphate dihydrate, disodium hydrogen phosphate decahydrate, sodium hydroxide, water for injection.
Dosage form
Cromoglicic acid
Pharmacodynamics
A transparent, colorless to slightly yellowish solution without mechanical inclusions.
Side effects
carefully.
Use during pregnancy and breastfeeding
- hypersensitivity to sodium cromoglycate or to any other component of the drug
- children up to 2 years old
Interaction
Impaired clarity of visual perception, burning in the eye, swelling of the conjunctiva, foreign body sensation, dry eyes, lacrimation, meibomitis (styre), superficial damage to the corneal epithelium.
Overdose
Prevention and treatment:
- allergic conjunctivitis,
- allergic keratitis, keratoconjunctivitis,
- irritation of the mucous membrane of the eyes caused by allergic reactions (environmental factors, occupational hazards, household chemicals, cosmetics, ophthalmic dosage forms, plants and pets).
Impact on the ability to drive vehicles and operate machinery
For adults and children over 2 years of age, instill 1-2 drops into each conjunctival sac 4 times a day with an interval of 4-6 hours. If necessary, the dose can be increased to 6-8 instillations.
After achieving a therapeutic effect, the frequency of use of the drug can be reduced and CromoHEXAL can be used only when in contact with allergens (house dust, fungal spores, pollen).
special instructions
The product should not be used after the expiration date indicated on the drug packaging has expired.
If irritation or burning of the mucous membrane occurs, which does not disappear or intensifies, treatment should be stopped.
The inhalation solution should not be used to relieve acute asthma .
When using any form of the drug for a long time, it is necessary to monitor the condition of the patient’s liver and kidneys.
When using Cromohexal eye drops, the need to take ophthalmic agents that contain glucocorticoids is reduced.
Due to the content of Cromohexal benzalkonium chloride drops, you should not wear contact lenses - remove them 15 minutes before instillation of the product and put them on no earlier than the same amount of time after.
The tip of the pipette must not touch the eye; the bottle must be closed after each use.
During treatment, you should be careful when performing activities that require concentration.
Contraindications
Need to know! Cromohexal in the form of eye drops is not approved for use:
- in children under 2 years of age and in the 1st trimester of pregnancy (due to the lack of data on studies on this population group);
- in patients with erosive lesions of the cornea ;
- in case of intolerance to the components of the composition.
The drug is prescribed with caution pregnant women in the 2nd and 3rd trimester and lactating women .
The reason for refusing to use the medicine is renal and liver failure: cromoglycic acid is excreted through the liver and kidneys and puts a strain on them.
Analogs
Level 4 ATC code matches:
Polynadim
Vizin Alergy
Zaditen
Lecrolin
Opatanol
Ketotifen
Analogues of the drug Cromohexal containing the same active component are the following products: Vividrin , Intal , Cromoglin , Ifiral , Cromolyn , Lecrolin , Taleum , Kuzikrom , Cromogen , etc.
The drug can be replaced only after prior approval by the attending physician.
Reviews of Cromohexal
Many reviews of the nasal spray, as well as reviews of eye drops, indicate that the drug provides effective prevention of allergy symptoms. A particularly pronounced effect from the use of Cromohexal is observed during seasonal exacerbations of allergies in people prone to such symptoms.
Many parents use the inhalation solution for children who suffer from bronchial asthma to prevent attacks. However, there are also reviews that after using Cromohexal, coughing attacks occurred more often in children. Therefore, it is important that only a specialist prescribes the medicine.
