Desrinit, 1 piece, 18 g, 50 mcg/dose, metered nasal spray


Nosological classification (ICD-10)

  • E14.5 Diabetic ulcer
  • H10.9 Conjunctivitis, unspecified
  • H57.9 Disorder of the eye and adnexa, unspecified
  • I73.9 Peripheral vascular disease, unspecified
  • I84 Hemorrhoids
  • I87.2 Venous insufficiency (chronic) (peripheral)
  • J00 Acute nasopharyngitis [runny nose]
  • J01 Acute sinusitis
  • J01.0 Acute maxillary sinusitis
  • J01.1 Acute frontal sinusitis
  • J01.9 Acute sinusitis, unspecified
  • J06 Acute upper respiratory tract infections of multiple and unspecified localization
  • J31.0 Chronic rhinitis
  • J32 Chronic sinusitis
  • J32.0 Chronic maxillary sinusitis
  • J32.1 Chronic frontal sinusitis
  • J32.9 Chronic sinusitis, unspecified
  • K12 Stomatitis and related lesions
  • K13.7 Other and unspecified lesions of the oral mucosa
  • L58 Radiation radiation dermatitis
  • L98.4.2* Trophic skin ulcer
  • N76 Other inflammatory diseases of the vagina and vulva
  • R02 Gangrene, not elsewhere classified
  • T14.1 Open wound of unspecified body area
  • T30 Thermal and chemical burns of unspecified location
  • T35 Frostbite involving multiple areas of the body and unspecified frostbite

Desrinit, 1 piece, 18 g, 50 mcg/dose, metered nasal spray

When using mometasone for 12 months, there were no signs of atrophy of the nasal mucosa.

A study of biopsy samples of the nasal mucosa revealed that mometasone tended to normalize the histological picture.

When using the drug for a long time (as with any long-term treatment), periodic examination of the nasal mucosa by an otolaryngologist is necessary.

If a local fungal infection of the nose or pharynx develops, it is recommended to stop treatment with the drug and begin specific therapy.

Irritation of the mucous membrane of the nasal cavity and pharynx that persists for a long time is an indication for discontinuation of the drug. With long-term use of the drug, no signs of suppression of the function of the hypothalamic-pituitary-adrenal system were observed. Patients who switch to mometasone therapy after long-term treatment with systemic GCS require special attention. Withdrawal of systemic corticosteroids in such patients may lead to adrenal insufficiency, which may require appropriate measures. During the transition from treatment with systemic corticosteroids to mometasone therapy, some patients may experience withdrawal symptoms of systemic corticosteroids (for example, joint and/or muscle pain, fatigue, depression), despite a decrease in the severity of symptoms associated with damage to the nasal mucosa , such patients must be specifically convinced of the advisability of continuing treatment with Desrinit.

The transition from systemic corticosteroids to local corticosteroids may also reveal pre-existing allergic diseases, such as allergic conjunctivitis and eczema, that were masked by systemic corticosteroid therapy.

The effectiveness and safety of mometasone have not been studied in the treatment of unilateral polyps, polyps associated with cystic fibrosis, and polyps that completely occlude the nasal cavity. Unilateral polyps that are irregular in shape or bleeding should be further examined. Patients undergoing GCS therapy have a reduced immune reactivity and should be warned about the increased risk of infection when contacting patients with certain infectious diseases (for example, chicken pox, measles), as well as the need for medical consultation if such contact occurs.

With long-term use of nasal corticosteroids in high doses, systemic side effects may develop. The likelihood of developing these effects is much less than with the use of systemic corticosteroids and may vary in individual patients, as well as between different corticosteroids. Potential systemic effects include Cushing's syndrome, Cushingoid features, adrenal suppression, growth retardation in children and adolescents, cataracts, glaucoma, and less commonly, a number of psychological or behavioral effects including psychomotor hyperactivity, sleep disturbance, anxiety, depression, or aggression (especially in children). It is recommended to regularly monitor the growth of children receiving long-term therapy with mometasone. If growth slows, therapy should be reconsidered in order to reduce the dose of mometasone to the minimum effective dose to control the symptoms of the disease. In addition, the patient should be referred to a pediatrician for consultation. Treatment of GCS with higher doses than recommended may lead to clinically significant suppression of adrenal function. If high doses of corticosteroids are known to be used, the possibility of additional use of systemic corticosteroids should be considered during periods of stress or planned surgery.

Impact on the ability to drive vehicles and machinery.

No studies have been conducted to study the effect on the ability to drive vehicles and machinery.

Pharmacodynamics

The drug activates cellular and humoral immunity. Optimizes specific responses against fungal, viral and bacterial infections. The drug stimulates reparative and regenerative processes, normalizes the condition of tissues and organs in dystrophies of vascular origin. Derinat® promotes the healing of trophic ulcers of various etiologies, as well as the rapid healing of deep burns, significantly accelerating the dynamics of epithelization. When ulcerative formations on the mucous membrane are restored under the influence of the drug, scarless restoration occurs. Derinat® does not have teratogenic or carcinogenic effects.

Derinat

Derinat is a domestic immunomodulatory agent that affects cellular and humoral defense factors. The name "derinat" is derived from the active substance of the drug - sodium deoxyribonucleate (DNA-Na). At the end of the 60s of the last century, scientists from the Institute of Biophysics of the USSR Ministry of Health began a large-scale study of the radioprotective properties of DNA-Na. The milt of salmon fish was used as a raw material for the production of this substance. Over several decades, a solid evidence base was accumulated and in 1996 Derinat was officially registered as a medicine. Clinical studies of the drug were conducted in a variety of directions. A large number of works have been devoted to the use of derinat in pediatrics, in particular for the treatment of frequent acute respiratory infections against the background of suppressed immunity. To date, solid experience has been accumulated in using the drug in otorhinolaryngological, gynecological, urological, ophthalmological, dermatological, surgical, cardiological, gastroenterological and oncological practice. Special attention should be paid to the use of derinat for the treatment and prevention of influenza and ARVI in frequently ill children. One of the most important tasks in the treatment of such patients is to increase the general nonspecific reactivity of the body, which is successfully accomplished with immunomodulator drugs and, in particular, Derinat, the effectiveness of which is based on a combination of immunomodulatory, antihypoxic, regenerative and antioxidant properties. The drug has a beneficial effect on general and local immunity and helps remove the infectious agent at the initial stage of its entry into the body. Derinat reduces the risk of acute respiratory viral infection during periods of epidemic trouble, which is due to the normalization of immune parameters responsible for antiviral protection.

The drug has a positive effect on the immune defense factors of the mucous membranes of the upper respiratory tract, regulates the secretion of lysozyme and immunoglobulin, protects epithelial cells and improves the barrier protective functions of the mucous membrane of the oral cavity and pharynx, and also normalizes the content of immunoglobulins in the blood, which promotes recovery and helps not to get sick in further. Derinat can be combined with most drugs, which is even welcome, because allows you to more effectively prevent the chronicization of the pathological process. Thus, the drug potentiates the therapeutic effect of antibacterial drugs, while simultaneously neutralizing their side effects by reducing the dose and eliminating the possibility of unjustified prescription of “extra” drugs. The immunomodulatory effect of derinat is associated with its ability to stimulate B lymphocytes and T helper cells, optimizing the immune response to viral, bacterial and fungal antigens. In addition, the drug activates the course of reparative and regenerative processes, regulates hematopoiesis, promotes the implementation of its drainage and detoxification function by the lymphatic system, and desensitizes cells to the damaging effects of radio and chemotherapy.

Derinat is quickly absorbed from the injection site when administered intramuscularly and is distributed through the lymph flow into organs and tissues. DNA-Na has a high affinity for hematopoietic organs and actively participates in metabolic processes inside cells. The highest concentration of the active substance of the drug is observed in the bone marrow, thymus gland, lymph nodes and spleen. After intramuscular administration, the peak concentration of derinat is reached after 5 hours. The drug is excreted mainly in urine and to a lesser extent in feces.

Indications for the drug Derinat®

Monotherapy:

acute respiratory infections;

prevention and treatment of ARVI;

ophthalmology - inflammatory and dystrophic processes;

inflammatory diseases of the mucous membranes of the oral cavity.

Complex therapy:

chronic inflammatory diseases, fungal, bacterial and other infections of the mucous membranes in gynecology;

acute and chronic diseases of the upper respiratory tract (rhinitis, sinusitis, sinusitis, sinusitis);

obliterating diseases of the lower extremities;

trophic ulcers, long-term non-healing and infected wounds (including diabetes mellitus);

gangrene;

burns, frostbite;

haemorrhoids;

post-radiation necrosis of the skin and mucous membranes.

Indications for use

The drug is used as a primary and additional medicine. In the first case, Derinat is used to treat infectious diseases (external use):

  • ARVI (including for prevention purposes);
  • inflammatory ophthalmological pathologies, including those with purulent discharge;
  • inflammation of the oral mucosa.

The drug is also used as an additional remedy as part of the complex treatment of such pathologies (external use):

  • inflammatory processes (chronic);
  • gynecological infections of a bacterial or fungal nature;
  • acute and chronic pathologies of the nasal sinuses, including sinusitis, rhinitis;
  • wounds and ulcers that do not go away for a long time, including due to the development of diabetes mellitus;
  • gangrene;
  • burns of varying degrees;
  • haemorrhoids;
  • partial death of the skin or mucous membrane;
  • frostbite.

Injections are given for the treatment of a number of diseases of the cardiovascular, digestive and other organ systems:

  • ulcers in the gastrointestinal tract;
  • IHD;
  • OSC (stages of development: I, II);
  • long-lasting wounds, burns and other skin damage;
  • dysfunction of hematopoiesis;
  • radiation injuries;
  • myelodepression;
  • stomatitis of various nature;
  • rheumatoid type arthritis;
  • endometritis;
  • COPD;
  • prostatitis;
  • bacterial infections of the genitourinary system, including chlamydia, ureaplasmosis.

Directions for use and doses

Externally, locally.

The drug is prescribed to children from the first day of life and to adults.

To prevent ARVI, instill 2 drops into each nasal passage 2–4 times a day for 1–2 weeks.

For acute respiratory infections, acute respiratory viral infections, the drug is instilled into the nose, 2-3 drops into each nasal passage every 1-1.5 hours, during the first day; further - 2-3 drops in each nasal passage 3-4 times a day, course duration - 1 month.

For inflammatory diseases of the nasal cavity and paranasal sinuses, the drug is instilled 3-5 drops into each nasal passage 4-6 times a day. Course duration is 7–15 days.

For diseases of the oral mucosa, rinse with the drug 4-6 times a day (1 vial - 1-2 rinses). The duration of treatment is 5–10 days.

For chronic inflammatory diseases, fungal, bacterial and other infections in gynecology - intravaginal administration with irrigation of the cervix or intravaginal administration of tampons with the drug, 5 ml per procedure, 1-2 times a day for 10-14 days.

For hemorrhoids, the drug is prescribed as microenemas of 15–40 ml into the rectum. The duration of treatment is 4–10 days.

For severe inflammatory and dystrophic processes in ophthalmology, Derinat® is instilled into the eyes 2-3 times a day, 1-2 drops, for 14-45 days.

For obliterating diseases of the lower extremities, the drug is instilled 1-2 drops into each nasal passage 6 times a day, the course duration is up to 6 months.

For post-radiation necrosis of the skin and mucous membranes, long-term non-healing wounds, burns, frostbite, trophic ulcers of various etiologies, gangrene, application bandages (gauze in two layers) are applied to the affected areas with the drug applied to it 3-4 times during the day (course of treatment - 1–3 months).

Derinat, spray 0.25% 10 ml

Manufacturer

FZ Immunnolex, Russia

Compound

1 ml of solution contains sodium deoxyribonucleate – 2.5 mg,
sodium chloride – 1.0 mg

pharmachologic effect

The drug activates cellular and humoral immunity. Optimizes specific responses against fungal, viral and bacterial infections. The drug stimulates reparative and regenerative processes, normalizes the condition of tissues and organs in dystrophies of vascular origin.

Derinat promotes the healing of trophic ulcers of various etiologies. Derinat promotes rapid healing of deep burns, significantly accelerating the dynamics of epithelization. When ulcerative formations on the mucous membrane are restored under the influence of Derinat, scarless restoration occurs. The drug does not have teratogenic or carcinogenic effects.

Pharmacokinetics:

Derinat, when applied topically, is quickly absorbed and distributed in organs and tissues via the endolymphatic transport route. During the phase of intensive entry of the drug into the blood, redistribution occurs between plasma and blood cells, in parallel with metabolism and excretion. Derinat is metabolized in the body.

It is excreted from the body (in the form of metabolites) partially with feces, and, to a greater extent, with urine according to a biexponential dependence.

Indications

Monotherapy:

  • acute respiratory diseases (ARI);
  • prevention and treatment of acute respiratory viral infections (ARVI);
  • ophthalmology: inflammatory and dystrophic processes;
  • inflammatory diseases of the mucous membranes of the oral cavity;

Complex therapy:

  • chronic inflammatory diseases, fungal, bacterial and other infections of the mucous membranes in gynecology;
  • acute and chronic diseases of the upper respiratory tract (rhinitis, sinusitis, sinusitis, sinusitis);
  • obliterating diseases of the lower extremities;
  • trophic ulcers, long-term non-healing and infected wounds (including diabetes mellitus);
  • gangrene;
  • burns, frostbite;
  • haemorrhoids;
  • post-radiation necrosis of the skin and mucous membranes.

Contraindications

  • hypersensitivity to the components of the drug.

Side effects

No side effects were identified with external or local use of the drug.

How to take, course of administration and dosage

Derinat in the form of a solution for external and local use is prescribed depending on the location of the pathological process. The drug is prescribed to children from the first day of life and to adults. To prevent ARVI, instill 2 drops into each nasal passage 2-4 times a day for 1-2 weeks.

When symptoms of a respiratory disease appear, the drug is instilled 2-3 drops into each nasal passage every 1-1.5 hours during the first day, then 2-3 drops into each nasal passage 3-4 Duration of therapy - from 5 days to 1 month . For inflammatory diseases of the nasal cavity and paranasal sinuses, the drug is instilled 3-5 drops into each nasal passage 4-6 times a day; Course duration is 7-15 days. For inflammatory diseases of the oral cavity, rinse the mouth with a solution of the drug 4-6 times a day (1 bottle for 2-3 rinses). The duration of the course of therapy is 5-10 days.

For chronic inflammatory diseases, fungal, bacterial and other infections in gynecological practice - intravaginal administration of tampons with the drug or irrigation of the vagina and cervix, 5 ml per procedure 1-2 times a day for 10-14 days. For hemorrhoids, the drug is administered rectally using microenemas of 15-40 ml.

The duration of treatment is 4-10 days. In ophthalmological practice, for severe inflammatory and dystrophic processes, Derinat is instilled into the eyes, 1-2 drops 2-3 times a day for 14-45 days. For obliterating diseases of the lower extremities, in order to achieve a systemic effect, the drug is instilled 1-2 drops into each nasal passage 6 times a day, the course duration is up to 6 months.

In case of post-radiation necrosis of the skin and mucous membranes, with long-term non-healing wounds, burns, frostbite, trophic ulcers of various etiologies, gangrene, it is recommended to apply application bandages (gauze in 2 layers) to the affected areas with the application of the drug 3-4 times a day or treat the affected area surfaces with the drug from a spray bottle 10-40 ml 4-5 times a day. The course of treatment is 1-3 months.

Release form

Spray.

Storage conditions

It is recommended to store the drug in a dry place, protected from light, at a temperature of 4° to 18°C.

Active substance

Sodium deoxyribonucleate

Dosage form

nasal spray

Purpose

For children, For pregnant women, Nursing mothers, For adults

Indications

Hemorrhoids, Burns, Sinusitis, Runny nose, Trophic ulcers, Prevention of influenza and colds, Bedsores, Influenza, Frostbite, Colds, Inflammation of the female genital organs, Sinusitis

Barcode and weight

Barcode: 4605962000349, 4607173030108 Weight: 0.040 kg

Rating
( 1 rating, average 5 out of 5 )
Did you like the article? Share with friends:
For any suggestions regarding the site: [email protected]
Для любых предложений по сайту: [email protected]