Desrinit nasal spray doses 50mcg/dose 18g (140 doses)

pharmachologic effect

Manufacturer: TEVA CZECH ENTERPRISES S.R.O.
(Czech Republic) Release form: nasal spray

Active ingredient: mometasone

Analogs: Nasonex, Avamis, Mometasone

Desrinit is a synthetic local glucocorticoid drug that has anti-inflammatory and antiallergic effects. The action of the medication leads to inhibition of the development of an immediate allergic reaction and a decrease in stimulation of the formation of inflammatory exudate.

The medication exhibits its effect to a high degree at different stages of the allergic reaction.

Indications for use of Desrinit

The drug is prescribed for the following diseases:

• seasonal or year-round allergic rhinitis in adults and children over 2 years of age;
• sinusitis in adults and children over 12 years of age, as part of complex treatment in the acute or chronic phase of the course;
• nasal polyposis, accompanied by difficulty breathing and decreased sense of smell.

Desrinit is used not only for the treatment of diseases, but also for the prevention of seasonal allergic rhinitis. It must be started 2-3 weeks before the start of pollination of plants.

About the drug

According to its chemical structure, Desrinit is a synthetic glucocorticosteroid. Contains mometasone furoate monohydrate 50 mcg as an active ingredient. Among the auxiliary compounds added to the drug:

• cellulose;
• carmellose sodium;
• glycerol;
• benzalkonium chloride;
• polysorbate;
• lemon acid;
• sodium citrate.

Available in the form of a spray for nasal use. The product blocks the production of prostaglandins, due to which it has an antiallergic and anti-inflammatory effect. Prevents the accumulation of immune cells in tissues, reduces the processes of infiltration and granulation. Bioavailability is low, less than 1%. If used incorrectly and the spray gets into the nasopharynx, the organs of the digestive tract are poorly absorbed and metabolized in the liver.

Used in the following conditions:

• allergic rhinitis (runny nose) of a seasonal or year-round nature;
• inflammation of the sinuses, here combined with antibacterial agents;
• nasal polyposis, combined with respiratory failure in persons over eighteen years of age.

Suitable not only for treatment, but also for the prevention of rhinosinusitis. In any case, the dosage and frequency of use should be determined by a specialist. The price of Dezrinit varies between 350-400 rubles, it all depends on the pharmacy and the region.

Desrinit - instructions for use

According to the instructions for use of Desrinat, the drug is used by introducing the drug into the nasal passages using a dispenser, which is located on the bottle. The dosage of the medication is:

• for adults and adolescents over 12 years of age with allergic rhinitis - 2 injections of the medicine into the nasal passages once;
• adults with polyposis of the nasal area - 2 injections of the medicine into the nasal passages twice a day;
• adults and adolescents over 12 years of age with sinusitis - 2 injections twice a day.

When the severity of clinical manifestations decreases and the expected result is achieved, the dosage can be reduced to a single use of the drug. In some cases, with severe manifestations of the pathological process, the dosage can be increased by 2 times.

Mometasone or desrinitis

It differs from most analogues in its release form - it is sold in the form of an ointment for external use. One gram of the product contains 1 mg of mometasone furoate. The drug is poorly absorbed through the skin; only 0.4% of the total amount of the drug penetrates into the systemic circulation.

The list of indications for use is as follows:

• psoriasis;
• atopic dermatitis;
• neurodermatitis;
• eczema;
• dermatosis accompanied by itching;
• deprive Wilson.

If you ignore the advice of doctors and instructions for use, the formation of chronic drug intoxication and chronic adrenal insufficiency is possible. Its signs:

• muscle weakness;
• dry skin;
• the appearance of non-healing ulcers;
• deposition of fatty tissue;
• decreased blood pressure;
• increased fatigue.

In this case, gradual withdrawal of the Desrinit analogue, correction of the patient’s condition, and selection of appropriate therapy is required. When a secondary infection occurs, antibacterial or antifungal drugs are required.

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Dezrinit's analogs

Domestic and foreign manufacturers produce Dezrinit substitutes in sufficient quantities, which have similar indications and therapeutic effects. The following medications are sold in the form of:

• synonyms;
• generics;
• combined means.

A wide range of Dezrinit analogues allows the doctor to select the most effective medications for each individual case and obtain the expected treatment result.

List of Dezrinit analogues with price and country of origin

From the presented list of Dezrinit analogues with prices, the patient can choose, on the recommendation of a doctor, medications at a budget cost, but with an effective therapeutic result.

List of desrinite analogues

• Nasonex – from 800 rubles;
• Elokom - from 80 rubles;
• Momat – from 195 rubles;
• Asmanex Twistheiler – from 900 rubles;
• Nasobek - from 182 rubles;
• Nazarel – from 342 rubles;
• Sinoflurin – from 150 rubles;
• Avamis - from 740 rubles;
• Mometasone – from 160 rubles.

To compare the price of desrinite:

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Desrinit or Nasonex - which is better for adenoids and allergies

Manufacturer: SHERING-PLOW LABO N.V.
(Belgium) Release form: nasal spray

Active ingredient: mometasone

Both medications have the same active ingredient and belong to glucocorticosteroid drugs and are a synthetic analogue of adrenal hormones. Desrinit and its analogue have anti-inflammatory and antiallergic effects.

Nasonex is a more modern and safer medication that is used in practical pediatrics from 2 years of age. It will be better for children with adenoids and allergies. Desrinit is more suitable for an adult for allergies, since a bottle of spray contains 140 doses of the drug versus 120 doses of Nasonex and it is almost 2 times cheaper. Patient reviews of the use of both products are mostly positive.

Momat or desrinitis

Release form: ointment or cream for external use. The composition and pharmacological characteristics are no different from Elokom. It is prescribed if the patient has a non-infectious inflammation of the skin area that reacts to the application of glucocorticosteroid ointment. Prescribed to patients over two years of age.

The product is applied to a clean affected area in a thin layer once a day. The duration of therapy depends on the type and severity of the pathology and the characteristics of the patient’s body. It costs almost twice as much as Dezrinit - 180-220 rubles.

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Dezrinit or Avamis - which is better for a child?

Manufacturer: TLAKSO OPERATIONS LTD (Great Britain)
Release form: nasal spray, nasal drops

Active ingredient: fluticasone furoate

Desrinit and its analog Avamis belong to the group of glucocorticosteroids, but have different active substances and mechanisms of action. Avamis has fewer side effects and is used for children from 2 years of age. It will be the best for the child, since the action of the medication is aimed only at eliminating allergies and it will quickly stop its unwanted manifestations.

For adults, Dezrinit would be the best, since, in addition to allergies, it is used for nasal polyposis, contains more doses in the bottle and is 2 times cheaper than its analogue. According to doctors, Avamis is well tolerated by children, allergy symptoms are quickly relieved and the child’s condition improves.

Desrinit nasal spray 50 mcg/dose 140 doses 18 g

The drug is used intranasally. Inhalation of the suspension contained in the bottle is carried out using a special dispensing nozzle on the bottle. Before using Dezrinit nasal spray for the first time, it is necessary to “calibrate” it. Do not pierce the nasal applicator. To carry out “calibration”, you need to press the dosing nozzle 10 times until splashes appear, which indicates that the drug is ready for use. Tilt your head and inject the medication into each nostril according to the recommended dosage regimen. If the drug has not been used for 14 days or more, press the dispensing nozzle 2 times until splashes appear. Tilt your head and inject the medication into each nostril according to the recommended dosage regimen. Cleaning the dispensing nozzle. It is important to clean the dispensing nozzle regularly to prevent it from malfunctioning. Remove the cap that protects the nozzle from dust, then carefully remove the spray tip. Rinse the spray tip and dust cap thoroughly in warm water and rinse under the tap. Do not try to open the nasal applicator with a needle or other sharp object, as this will damage the applicator, which may result in the patient taking the wrong dose of the drug. Dry the cap and tip in a warm place. After this, attach the spray tip to the bottle and screw the dust cap back onto the bottle. When using the nasal spray for the first time after cleaning, it is necessary to recalibrate by pressing the dispensing nozzle 2 times. Before each use, shake the bottle vigorously. Seasonal and year-round allergic rhinitis. Adults (including older people) and adolescents aged 12 years and older. The recommended preventive and therapeutic dose of the drug is 2 inhalations (50 mcg each) into each nostril 1 time / day (total daily dose - 200 mcg). Upon achieving a therapeutic effect for maintenance therapy, it is possible to reduce the dose by 1 inhalation in each nostril 1 time / day (total daily dose - 100 mcg). If a reduction in the symptoms of the disease cannot be achieved by using the drug at the recommended therapeutic dose, the daily dose can be increased to 4 inhalations into each nostril 1 time per day (total daily dose - 400 mcg). After the symptoms of the disease decrease, a dose reduction is recommended. The onset of action of the drug is usually observed clinically within 12 hours after the first use of the drug. Children aged 2-11 years. The recommended therapeutic dose is 1 inhalation (50 mcg) into each nostril 1 time / day (total daily dose - 100 mcg). To use the drug in young children, adult assistance is required. Adjuvant treatment of acute sinusitis or exacerbation of chronic sinusitis. Adults (including the elderly) and teenagers from 12 years of age. The recommended therapeutic dose is 2 inhalations (50 mcg each) into each nostril 2 times a day (total daily dose - 400 mcg). If a reduction in the symptoms of the disease cannot be achieved by using the drug at the recommended therapeutic dose, the daily dose of the drug can be increased to 4 inhalations into each nostril 2 times a day; total daily dose - 800 mcg. After the symptoms of the disease decrease, a dose reduction is recommended. Treatment of acute rhinosinusitis without signs of severe bacterial infection. The recommended dose for adults and adolescents is 2 inhalations of 50 mcg in each nasal passage 2 times a day (total daily dose 400 mcg). If symptoms worsen during treatment, consultation with a specialist is necessary. Treatment of nasal polyposis. Adults (including older people) over 18 years old. The recommended therapeutic dose is 2 injections (50 mcg each) into each nostril 2 times a day; total daily dose - 400 mcg. After the symptoms of the disease have reduced, it is recommended to reduce the dose to 2 inhalations (50 mcg each) into each nostril 1 time / day (total daily dose - 200 mcg).

Desrinit or Mometasone - which is better?

Manufacturer: JSC VERTEKS (Russia)
Release form: cream, ointment for external use

Active ingredient: mometasone

Both drugs belong to the same pharmacological group and are synthetic glucocorticosteroids with the same mechanism of action. The difference between medications is their dosage form. Mometasone in the form of an ointment will be best for dermatitis, accompanied by inflammation of the skin, itching and swelling.

Mometasone Sandoz in the form of a nasal spray has equivalent indications and therapeutic effect. This analogue of Dezrinit spray is cheaper, but has the same anti-inflammatory and antiallergic effect. It will be the best, since you can buy it almost 2 times cheaper, and the effectiveness of the analogue is equivalent to Dezrinit.

Elokom or dezrinit – what to choose

The product also belongs to glucocorticosteroids, like Desrinit, but is sold in the form of an ointment for external use. Includes 1 mg mometasone furoate. The product eliminates signs of inflammation: redness, itching, tissue swelling. After application to the skin, it is poorly absorbed into the systemic bloodstream and acts mainly locally in the affected area.

During treatment, side effects may occur, the list of which is as follows:

• dry skin;
• burning sensation, irritation of the mucous membrane;
• rash;
• dermatitis;
• allergy;
• development of secondary infectious inflammation;
• papulogenesis.

Not everyone is prescribed the medicine. The following are absolute contraindications:

• rosacea;
• fungus on the skin;
• tuberculosis;
• syphilis;
• local reaction to vaccination;
• period of pregnancy and breastfeeding;
• individual intolerance to components.

Apply the Dezrinit analogue to large areas for a long period of time with extreme caution and apply bandages.

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Desrinit or Momat Rino - which is better?

Manufacturer: GLENMARK PHARMACEUTICALS LTD (India)
Release form: nasal spray

Active ingredient: mometasone

Desrinit and its analogue have the same active substances, mechanism of action and are synthetic analogues of adrenal hormones. Both drugs provide an equivalent therapeutic effect. Momat Rino will be the best, as it has wider indications. It can be used not only for intranasal administration of medication to treat allergies.

The analogue is also prescribed for inhalation in the treatment of bronchial asthma of any severity and chronic obstructive pulmonary disease. According to patient reviews, the medication is well tolerated and quickly relieves the negative manifestations of allergies.

Asmanex Twisthaler

It is a powder for inhalation to eliminate the clinical picture of allergies or other types of inflammation. Includes mometasone furoate (200 mcg), anhydrous lactose.

Replacing Desrinit spray reduces the release of arachidonic acid, a substrate for the synthesis of prostaglandins. The latter are biologically active substances that lead to the development of the inflammatory process. In addition, the medication blocks the release of tumor necrosis factor, interleukins, and leukotrienes into the systemic circulation. The analogue is suitable for the treatment of chronic obstructive pulmonary disease and bronchial asthma.

During therapy, the development of undesirable effects cannot be ruled out; the details are listed below in the table.

Table - Side effects of Asmanex Twistheiler

The systemic reaction of the body to the use of the Desrinit analogue is described separately. In this case, the clinical picture will include delayed growth and development in childhood, fragility of bone tissue due to a decrease in the functional activity of the adrenal glands.

It is undesirable to use the spray if the patient has tuberculosis or fungal flora. With long-term use of the drug, regular blood tests and examination by an otolaryngologist are required. Not suitable for immediate relief of bronchospasm; used in combination with other drugs.

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Dezrinit or Nasobek - which is better?

Manufacturer: TEVA CZECH ENTERPRISES SRO (Czech Republic)
Release form: nasal spray

Active ingredient: beclomethasone

Both drugs are synthetic hormonal agents with anti-inflammatory, anti-edematous and anti-allergic effects, but with different mechanisms of action.

For vasomotor rhinitis and hay fever, Nasobek will be the best, as it copes well with pathological symptoms, reducing the production of mucous secretions, swelling of the mucous membrane and nasal congestion. The advantage of Nasobek is noted in the reviews of patients who took allergy treatment with this medication. The analogue of Desrinit nasal spray costs 2 times less.

Nasobek or desrinitis

Sold in pharmacies as a nasal spray containing 50 mcg of beclomethasone dipropionate. It is also a synthetic glucocorticosteroid. The mechanism of action is no different from the other Dezrinit analogues described above.

The medicine is well tolerated, acts predominantly locally, and rarely causes complications. When released into the systemic circulation, it binds to plasma proteins by 87%. It undergoes enzymatic processing in the liver. The half-life is fifteen hours. After four days, it is completely excreted in feces and 15% in urine.

Like any other medicine, Nasobek has a number of contraindications for which the use of the spray is strictly prohibited. The list includes:

• regular nosebleeds;
• tuberculosis;
• fungal and viral tissue damage;
• age less than six years;
• first three months of pregnancy;
• risk of developing an allergic reaction.

It is not recommended to prescribe if the patient develops glaucoma, severe liver dysfunction, in late pregnancy, or during breastfeeding.

Unlike drugs that have a local vasoconstrictor effect, the effect of a nasal glucocorticoid is not immediately visible. Improvement in well-being is noted after five days or a week. In the postoperative period, in case of ulceration of the tissues of the nasal cavity, the Desrinit analogue is not prescribed, since the drug slows down the healing of wounds.

Drug intoxication can occur if the patient takes very high doses of the drug for a long period of time. Treatment consists of gradually reducing the dosage until the drug is completely discontinued.

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Desrinit or Tafen Nasal - which is better?

Manufacturer: LEK D.D.
(Slovenia) Release form: nasal spray

Active ingredient: budesonide

Desrinit and its analogue are local hormonal agents that belong to the same pharmacological group. Medicines differ in their mechanism of action, as they have different active substances. Tafen Nasal reduces the manifestations of allergic rhinitis (rhinorrhea, sneezing, itching) and reduces the inflammatory process in the upper respiratory tract.

Desrinit in its action and indications will be the best, since it has wider application and its high effectiveness is noted in preventive treatment to prevent seasonal allergic reactions.

Nosephrine or Dezrinit - which is better?

Manufacturer: JSC VERTEKS (Russia)
Release form: nasal spray

Active ingredient: mometasone

Nosephrine and Dezrinit are drugs from the same pharmacological group that have the same active substance, indications and treatment results. The difference in medications lies in the composition of their additional ingredients.

Desrinitis has more side effects and can be used in the form of inhalations for bronchial asthma, so Nosephrine will be the best. The analogue has a drug release form of 60 doses, which will be practical for patients who do not suffer from chronic respiratory diseases.

Flixonase

Manufacturer: GLAXO WELLCOM S.A.
(Spain) Release form: nasal spray

Active ingredient: fluticasone

An analogue of Desrinat nasal spray is included in the group of glucocorticosteroid drugs with anti-inflammatory, anti-edematous and anti-allergic effects. The medication is effective at any phase of the allergic reaction. Flixonase has a rapid anti-inflammatory effect on the mucous membrane of the nasal area, reducing itching, congestion, sneezing, and runny nose.

Sinoflurin or desrinitis

Similar in composition and pharmacological effects to the previous medication. Suitable for the treatment and prevention of allergic rhinitis. It is prohibited to prescribe the spray to persons under four years of age, patients at risk of developing hypersensitivity, or individual intolerance to the components of the Desrinit substitute.

During the treatment process, the formation of undesirable effects is not excluded. The list includes:

• bronchospasm;
• anaphylaxis;
• headache;
• increased pressure inside the eyes;
• cataract;
• nosebleeds;
• discomfort, burning of the mucous membrane;
• the addition of a secondary infection against the background of a decrease in the body’s immune forces.

Regular use of the drug, taking into account medical recommendations, allows you to completely get rid of the symptoms of the pathology within 2-4 days. During therapy, it is necessary to regularly monitor the functional activity of the adrenal glands, since in rare cases Itsenko-Cushing syndrome develops with the subsequent clinical picture.

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Polydexa

Manufacturer: SOFARTEX (France)
Release form: nasal spray

Active ingredients: dexamethasone, neomycin, polymyxin B, phenylephrine

Polydexa is a combination medication that combines glucocorticoid, anti-inflammatory and broad-spectrum antibacterial action, intended for topical use. Due to the antibiotics contained in the drug, the growth and development of pathogenic bacterial flora that provoke infection in the nasal cavity and paranasal sinuses is suppressed.

Rinofluimucil

Manufacturer: ZAMBON S.P.A.
(Italy) Release form: nasal spray

Active ingredient: acetylcysteine, tuaminoheptane

The combined analogue of Dizrinit has mucolytic, anti-inflammatory and vasoconstrictor effects. Rinofluimucil intensively thins the mucous and mucopurulent secretions released from the nasal cavity, eliminates swelling and hyperemia of the mucous membrane. Under the influence of the drug, manifestations of inflammation, discharge and nasal congestion are stopped, the mucous membrane of the nasal passages is actively restored.

Vibrocil

Manufacturer: GSK CONSUMER HEALTHCARE S.A.
(Switzerland) Release form: nasal drops

Active ingredient: dimethindene, phenylephrine

Vibrocil is a combined antiallergic drug with a vasoconstrictor effect. An analogue of drops for allergic rhinitis quickly eliminates swelling of the mucous membrane of the nasal passages and paranasal sinuses, without reducing the activity of the ciliated epithelium of the mucous membrane.

What else can replace Dezrinit, what effective analogs that relieve the manifestations of allergic rhinitis?

You can supplement the presented list of medications with the following medications:

• Nazarel;
• Derinat;
• Isofra;
• Momenza;
• Flix;
• Forinex;
• Glenspray.

These medications are sold in pharmacies both without a prescription and with a doctor’s prescription, depending on the composition of the medication and the presence of potent ingredients in them.

A properly selected analogue of Dezrinit by a doctor will help the patient in a short time to significantly reduce the manifestations of allergic rhinitis, prevent further progression of the disease and its complications.

Desrinit nasal spray. dosage 50mcg/dose 140doses

As with any treatment, patients using mometasone nasal spray dosage form for several months or longer should be periodically examined by a doctor for possible changes in the nasal mucosa. It is necessary to monitor patients receiving intranasal corticosteroids for a long time. Possible development of growth retardation in children. If growth retardation is detected in children, it is necessary to reduce the dose of intranasal corticosteroids to the lowest that allows for effective control of symptoms. In addition, the patient should be referred to a pediatrician for consultation.

If a local fungal infection of the nose or pharynx develops, it may be necessary to discontinue therapy with mometasone in dosage form - dosed nasal spray and carry out special treatment. Irritation of the mucous membrane of the nose and pharynx that persists for a long time can also serve as a basis for discontinuing treatment with mometasone in dosage form - dosed nasal spray.

In placebo-controlled clinical studies in children, when mometasone in dosage form - nasal spray was used in a daily dose of 100 mcg for a year, no growth retardation was observed in children.

With long-term treatment with mometasone in the dosage form - nasal spray, no signs of suppression of the function of the hypothalamic-pituitary-adrenal system were observed.

Patients who switch to treatment with mometasone in dosage form - a dosage nasal spray after long-term therapy with systemic glucocorticosteroids require special attention. Withdrawal of systemic corticosteroids in such patients can lead to adrenal insufficiency, the subsequent recovery of which may take up to several months. If signs of adrenal insufficiency appear, systemic corticosteroids should be resumed and other necessary measures taken.

When using intranasal corticosteroids, systemic side effects may develop, especially with long-term use in high doses. The likelihood of developing these effects is much less than with the use of oral corticosteroids.

Systemic side effects may vary in individual patients and depending on the glucocorticosteroid drug used.

Potential systemic effects include Cushing's syndrome, characteristic Cushingoid signs, adrenal suppression, growth retardation in children and adolescents, cataracts, glaucoma, and less commonly a number of psychological or behavioral effects including psychomotor hyperactivity, sleep disturbance, anxiety, depression, or aggression (especially in children).

During the transition from treatment with systemic glucocorticosteroids to treatment with mometasone nasal spray, some patients may experience initial symptoms of systemic glucocorticosteroid withdrawal (for example, joint and/or muscle pain, fatigue and depression), despite a decrease in the severity of symptoms. associated with damage to the nasal mucosa. If these signs appear, you should resume taking systemic glucocorticosteroids and take other necessary measures. Switching from systemic to topical glucocorticosteroids may also reveal pre-existing allergic diseases such as allergic conjunctivitis and eczema that were masked by systemic glucocorticosteroid therapy.

Patients treated with glucocorticosteroids have a potentially reduced immune responsiveness and should be warned of their increased risk of infection if exposed to patients with certain infectious diseases (eg, chickenpox, measles), as well as the need for medical advice if such exposure occurs .

If signs of a severe bacterial infection appear (for example, fever, persistent and sharp pain on one side of the face or toothache, swelling in the orbital or periorbital area), immediate medical consultation is required.

When using mometasone in dosage form - dosed nasal spray for 12 months, there were no signs of atrophy of the nasal mucosa. In addition, mometasone furoate tended to promote normalization of the histological picture when examining biopsy specimens of the nasal mucosa.

The effectiveness and safety of mometasone have not been studied in the treatment of unilateral polyps, polyps associated with cystic fibrosis, and polyps that completely occlude the nasal cavity.

If unilateral polyps of an unusual or irregular shape are detected, especially those that are ulcerated or bleeding, additional medical examination is necessary.

Visual disturbances have been reported with systemic and topical corticosteroid use. If a patient develops symptoms such as blurred vision or other visual disturbances, consider referring the patient to an ophthalmologist to evaluate possible causes, which may include cataracts, glaucoma, or rare diseases such as central serous chorioretinopathy (CSCR).

Effect on the ability to drive vehicles and machinery There is no data on the effect of the drug Desrinit on the ability to drive vehicles or moving machinery.