Pharmacodynamics and pharmacokinetics
The drug has antiarrhythmic, antianginal, and hypotensive effects. It has negative dromotropic, chronotropic, inotropic and bathmotropic effects.
The hypotensive effect is achieved by influencing the nervous system, reducing the sensitivity of baroreceptors on the aortic arch, reducing the activity of the renin-angiotensin system, and reducing the IOC.
The drug reduces systolic and diastolic blood pressure, reduces IOC, SV.
The medication does not affect the tone of peripheral arteries in therapeutic doses.
The antianginal effect is ensured by a decrease in the oxygen demand of myocardial cardiomyocytes, which leads to a decrease in heart rate. The drug reduces heart rate at rest and during physical activity.
The antiarrhythmic effect is ensured by the elimination of arrhythmogenic factors (arterial hypertension, increased cAMP content, increased activity of the sympathetic nervous system, tachycardia), slowing down atrioventricular conduction, and reducing the rate of spontaneous excitation of the ectopic and sinus pacemaker.
When taking Atenolol, the survival rate of patients who have suffered a myocardial infarction increases significantly.
The drug does not weaken the bronchodilatory effect of isoproterenol.
Indications for use of Atenolol
What are the pills for?
The medicine is prescribed for hypertensive crisis , arterial hypertension , angina pectoris , , neurocirculatory dystonia , hyperkinetic cardiac syndrome of functional origin, withdrawal syndrome , tremor , essential tremor , agitation .
The drug is recommended for use for the prevention of cardiac arrhythmias, myocardial infarction , ventricular extrasystole , sinus tachycardia , atrial flutter, atrial fibrillation , and ventricular tachycardia .
The medication is prescribed for migraine , thyrotoxicosis , pheochromocytoma .
Concor and alcohol
Drinking alcohol with Concor
It is known that when drinking alcohol, blood vessels dilate for a short time, that is, the heartbeat accelerates. True, after a short amount of time the opposite happens - vasospasm. And a sharp rise in blood pressure is not the most pleasant, but also not the most dangerous, thing that can await a patient taking Concor. The instructions directly state that Concor and alcohol are incompatible. The central nervous system is depressed, and the patient’s psychomotor abilities deteriorate. Also, do not forget that the medicine and alcohol will be excreted through one excretory system - the kidneys. This can lead to organ damage, and in some cases functional impairment may develop. Internal bleeding may begin, a hypertensive crisis, pulmonary edema, and vascular collapse may begin. But the worst result of taking Concor and alcohol together is death.
Therefore, doctors strongly recommend that you stop drinking alcohol while taking Concor.
Contraindications
The medicine is not used for severe bradycardia , 2-3 degree atrioventricular block cardiogenic shock , decompensated form of CHF, acute heart failure , SA blockade, Prinzmetal angina , intolerance to the active component, cardiomegaly , breastfeeding, taking MAO inhibitors.
For emphysema , allergies, metabolic acidosis , diabetes mellitus , hypoglycemia , pheochromocytoma , bronchial asthma , thyrotoxicosis , myasthenia gravis , liver failure , pregnancy, psoriasis , depression , children and the elderly, and for Raynaud's syndrome the drug is used with caution.
Side effects
Sense organs: conjunctivitis , visual disturbances, dry eyes, decreased tear production, sore eyes.
Nervous system: depression, insomnia, headaches, dizziness, weakness, asthenia, drowsiness, depression, paresthesia in the extremities, impaired concentration, short-term memory loss, convulsions, myasthenia gravis.
Cardiovascular system: chest pain, vasculitis, coldness of the lower extremities, vasospasm, orthostatic hypotension, CHF, weakened myocardial contractility, arrhythmia, atrioventricular block , palpitations, bradycardia, myocardial conduction disturbances.
Digestive system: changes in taste perception, epigastric pain, nausea, vomiting, dry mouth, stool disorders: constipation , diarrhea.
Respiratory system: bronchospasm , laryngospasm , difficulty breathing, nasal congestion.
Endocrine system: hypothyroid state, hyperglycemia , hypoglycemia .
Skin: reversible alopecia , psoriasis-like skin rashes, increased sweating, exacerbation of psoriasis , hyperemia of the skin.
Also noted are back pain, bradycardia , decreased potency, decreased libido, arthralgia , and intrauterine growth retardation.
The severity of side effects directly depends on the dose of the drug.
Side effects of the drug Atenolol
Most side effects are mild and temporary. Most likely are bradycardia, a feeling of coldness in the extremities, paresthesia, pain in the lower extremities, nausea, increased concentrations of liver enzymes and/or bilirubin in the blood serum, dizziness, headache, orthostatic hypotension, collapse, fatigue, weakness, drowsiness, general malaise, depression, hallucinations, psychosis, diarrhea, nausea, dyspnea, psoriasiform rash or exacerbation of psoriasis, purpura, reversible alopecia, thrombocytopenia and visual disturbances. Atenolol, like other β-adrenergic receptor blockers, can promote the formation of antinuclear antibodies and the development of lupus syndrome.
Instructions for use of Atenolol (Method and dosage)
The tablets are taken orally, washed down with liquid, and do not chew.
The initial dosage is 25-50 mg per day, after a week, if necessary, the amount of the drug is increased by 50 mg, the average daily dosage is 100 mg.
For tachysystolic disorders and for ischemic heart disease Atenolol is prescribed once a day, 50 mg.
Acute myocardial infarction with stable hemodynamic parameters: intravenous infusions, then take a 50 mg tablet after 10 minutes, repeat after 12 hours.
For cardiac hyperkinetic syndrome, 25 mg per day is indicated.
The drug is effective for 24 hours; the drug is not used more than once a day. It is not recommended to prescribe more than 200 mg per day. The medication is withdrawn gradually, every 3 days - ¼ dose.
Overdose
Manifested by bronchospasm , cyanosis of the nail plates , convulsions , difficulty breathing, arrhythmia , fainting, drop in blood pressure, dizziness , severe bradycardia .
Emergency gastric lavage is required.
In case of atrioventricular conduction disturbance or bradycardia, Atropine , epinephrine , or a temporary pacemaker is installed.
If there is a sharp drop in blood pressure, the patient is placed in the Trendelenburg position .
In the absence of signs of pulmonary edema, plasma-substituting solutions are administered intravenously; in case of ineffectiveness, Dobutamine , epinephrine , and Dopamine .
For convulsive syndrome, intravenous infusion of Diazepam . Dialysis is effective.
Overdose of the drug Atenolol, symptoms and treatment
An overdose of atenolol has been described in patients who took a single dose of about 5 g. Early manifestations of an overdose are drowsiness, respiratory failure, wheezing, and bradycardia. Congestive heart failure, arterial hypotension, bronchospasm and hypoglycemia may develop. Gastric lavage is performed, activated charcoal is prescribed orally, and glucagon is administered. Atenolol can be removed from the systemic circulation by hemodialysis. For bradycardia or AV block, atropine or isoproterenol is administered; if drug treatment is ineffective, transesophageal pacing is performed. For congestive heart failure, digitalization is performed and diuretics are prescribed.
List of pharmacies where you can buy Atenolol:
- Moscow
- Saint Petersburg
Interaction
In patients taking Atenolol, allergen extracts for skin testing, as well as allergens for immunotherapy, significantly increase the risk of developing severe systemic allergic reactions, anaphylaxis. The risk of anaphylactic reactions increases with intravenous administration of radiocontrast agents.
A fall in blood pressure and cardiodepressive effects have been observed with intravenous infusion of phenytoin, as well as with the use of drugs for inhaled general anesthesia. The drug can mask the signs of developing hypoglycemia with the simultaneous use of oral hypoglycemic agents and insulin.
Atenolol reduces the clearance of xanthines and lidocaine . Estrogens, glucocorticosteroids, NSAIDs, BMCC, guanfacine , Reserpine , methyldopa , cardiac glycosides, Amiodarone , Diltiazem , Verapamil and many antiarrhythmic medications increase the likelihood of developing atrioventricular block , bradycardia , cardiac arrest, and worsening heart failure.
Hydralazine , sympatholytics, clonidine , diuretics, antihypertensive drugs, BMCC can significantly reduce blood pressure.
Atenolol prolongs the duration of action of coumarins, non-depolarizing muscle relaxants. Neuroleptics, sedatives, hypnotics, ethanol, tetracyclic and tricyclic antidepressants increase the inhibitory effect on the central nervous system.
The simultaneous administration of MAO inhibitors is unacceptable due to the risk of hypotension . Impaired peripheral circulation is observed when using medications with non-hydrogenated ergot alkaloids.
Interaction with other drugs and alcohol
Combination of Concor with other medications
The instructions for the drug Concor describe in some detail the compatibility with other drugs, because there is a list of drugs with which the Concor tandem is prohibited. Concor can be used in conjunction with analogues and generics, but such a combination must be discussed with your doctor so that an overdose does not occur and the blood pressure does not drop below normal levels.
Concor and Amlodipine
Amplodipine is an antihypertensive drug used for high blood pressure. The attending physician may prescribe a similar tandem if he believes that Concor will be ineffective. It is worth remembering that patients with heart failure cannot take Amplodipine and Concor together.
Concor and Arifon
Arifon - a diuretic indapamide - in combination with the beta blocker Concor is an effective complex in the treatment of hypertension. Concor lowers blood pressure, and Arifon reduces the volume of circulating blood, thus protecting the patient from signs of heart failure.
But Arifon has a side effect - it flushes potassium from the body, which can cause hypokalemia.
Concor and Lozap
The active substance of the drug Lozap, losartan potassium, is intended for the treatment of arterial hypertension. That is, it does not allow peripheral vessels to spasm and thereby does not allow blood pressure to rise. Concor and Lozap enhance each other's effects. Concor works to reduce cardiac output, while Lozap dilates arterioles and reduces peripheral pressure. As a result, blood pressure returns to normal.
The combination of drugs Concor and Lozap is most effective when the degree of arterial hypertension is quite high, and treatment with one drug is not so effective.
Concor and Enap
The simultaneous use of Concor and Enap or Enalapril, which are based on the same active ingredient - enalapril, should be prescribed with caution, since the drugs can enhance the effect of each other. So, the instructions say: with the simultaneous use of beta-blockers, methyldopa, nitrates, calcium channel blockers, hydralazine, prazosin, the antihypertensive effect may be enhanced. That is, blood pressure that was already reduced with the help of the drug Concor can decrease further.
Enap is good for kidney disease, excess weight and a history of diabetes. Concor is indicated for use in patients with heart rhythm disturbances, tachycardia, and frequent attacks of angina. But if the resting heart rate is 50 - 60 beats/min, and there are conduction blockades, then you should take Enap, since Concor will only worsen these conditions.
The combined use of Concor and Enalapril lowers blood pressure and slows the progression of complications from the heart and kidneys. If you experience constant weakness, dizziness and fatigue during use, you should immediately inform your doctor.
Concor and Prestarium
Like all other ACE inhibitors, Prestarium combines well with the β1-blocker Concor. They are prescribed in tandem for high blood pressure, when the use of one drug is ineffective, reducing the risk of fatal complications for people with heart failure, obesity, diabetes, and chronic kidney disease.
But the decision to prescribe the combination Concor + Prestarium is made by the attending physician.
Prestarium itself is not as effective a medicine as Concor. If the pressure is 180/105 mmHg. Art., then it must be taken in combination with other drugs for hypertension.
Concor and Moxonidine
Concomitant use of Moxonidine with β-blockers such as Concor is not recommended. This can lead to a decrease in myocardial contractility and increased bradycardia
Concor and Lorista
Lorista is a generic version of the drug Lozap. That is, it contains the same active ingredient as the original drug, but it has not passed all stages of clinical trials. Generic status makes medicines cheaper without losing their properties. Lorista contains valsartan, a drug belonging to the group of sartans, which are prescribed for the development of a dry cough due to ACE inhibitors. The combination of Concor and Lorista is inferior in strength to the combination of Concor and any ACE inhibitor, since Lorista does not reduce the risk of complications of coronary artery disease.
special instructions
Taking the drug should be accompanied by regular measurement of blood pressure, pulse, and sugar levels in people with diabetes .
Elderly patients are advised to periodically monitor the condition of the renal system. The doctor needs to instruct the patient and teach him how to measure heart rate correctly. In 20% of patients with angina pectoris , adrenergic blockers do not provide the desired effect due to severe coronary atherosclerosis with a low ischemic threshold and impaired subendocardial blood flow.
In patients with nicotine addiction, the effectiveness of Atenolol is significantly lower than in patients who do not smoke. During therapy, there may be a decrease in the production of tear fluid, which should be warned about in patients who wear contact lenses.
The drug may mask the clinical picture of thyrotoxicosis ( tachycardia ). Abrupt withdrawal of the drug in patients with thyrotoxicosis is unacceptable due to the risk of increasing the severity of the symptoms of the disease. Atenolol is able to mask tachycardia during hypoglycemia .
The medication is discontinued several days before the planned general anesthesia with ether or chloroform . Otherwise, the patient is selected a drug for general anesthesia, which has minimal inotropic effects.
Intravenous administration of Atropine eliminates reciprocal activation of the vagus nerve. The drug can be prescribed to patients with bronchospastic pathology if other antihypertensive drugs are ineffective or intolerant, subject to strict adherence to the dosage regimen.
If elderly people develop arterial hypotension , increasing bradycardia , ventricular arrhythmia , bronchospasm , severe disorders of the liver and kidneys, the dosage of the drug is reduced or therapy is stopped completely. If depression develops, the drug is replaced. Abrupt withdrawal can cause myocardial infarction , a severe form of arrhythmia . The drug is discontinued by gradually reducing the dosage over 2 weeks.
Atenolol is discontinued before determining the level of normetanephrine, catecholamines, titers of antinuclear bodies, and vanillylmandelic acid.
The medication affects driving.
Analogs
When choosing analogues, it is important to understand that each of them has its own indications for use, side effects, contraindications, active substances, etc. It is important to consult a doctor and not change the drug yourself.
Which is better: Concor, Bisoprolol, Coronal?
All of these drugs contain the same active substance - bisoprolol. They have similar contraindications and indications for use.
Bisoprolol is used to treat arterial hypertension, tachycardic heart rhythm disorders, ischemia, heart failure and various forms of arrhythmia. It is considered antihypertensive and lowers blood pressure. Patients whose blood pressure is 90 mm or lower (hypotension) are prohibited from taking Bisoprolol. It is easier to tolerate by patients and there is less risk of complications when taking it. This applies to diabetes mellitus, respiratory tract diseases, and hypotension.
Coronal is a generic drug Concor, that is, it has the same spectrum of pharmacological action as the original drug, but differs in strength. Coronal also reduces pain and blood pressure, improves blood supply to the heart muscle, and normalizes heart rhythm. But Coronal does not have such a noticeable effect on the patient’s heart rate.
Which is better: Concor, Betalok Zok, Betalok or Egilok?
The active ingredient in the drugs Betalok ZOK, Betalok and Egilok is the same - metoprolol.
The effectiveness of Concor and Betaloc ZOK in reducing blood pressure and stopping attacks of tachycardia is the same. The duration of the therapeutic effect lasts more than a day. But only a cardiologist has the right to prescribe Concor or Betaloc ZOK, having studied the risk factors, medical history and individual sensitivity of the patient to the components of the drug.
Betaloc is a medicine for hypertension, angina and heart failure. Today it is considered obsolete. He was replaced by Betalok ZOK.
Egilok, like Concor, is effective for high blood pressure, but since the active components are different, there are differences. Compared to Concor, Egilok acts very quickly (15-20 minutes after taking the tablet), but this means that the duration of the therapeutic effect is not so long. The drug should be taken two to three times a day during or after meals.
Which is better: Concor, Nebivolol or Nebilet?
The drugs have a positive effect on the heart with high blood pressure, chronic heart failure, ischemia, tachycardia, but Nebilet and its almost complete analogue Nebivolol are based on the active component - nebivolol, which is capable of dilating peripheral vessels and reducing cardiac output. This adds to its effectiveness as an antihypertensive agent.
The active substance nebivolol promotes the production of nitric oxide, which relaxes blood vessels for a longer period. Unlike Concor, it does not contribute to the patient’s weight gain. Since nebivolol dilates blood vessels, it acts faster, but the effect does not last long.
Nebilet and differing from it solely in the degree of purification and, accordingly, in price, Nebivolol is also used for hypertension and coronary heart disease. But it is contraindicated in patients with low blood pressure, cardiogenic shock, severe heart failure, diseases of the respiratory system and liver. Not for use by children, pregnant and lactating women. Treatment should not be started if you have diabetes, thyroid dysfunction, psoriasis or in old age. Concor is safer for the elderly, children and patients with breathing problems.
Concor or Sotahexal
The active ingredient in Sotahexal, sotalol hydrochloride, copes well with arrhythmia and lowers blood pressure. Contraindicated for use in patients with hypotension.
Sotahexal can cause side effects in the form of bronchospasms, disorders of carbohydrate and lipid metabolism.
Concor, compared to Sotahexal, is easier to tolerate and more effective for patients suffering from chronic heart failure. Also, Concor has a lower risk of complications. This applies to diabetes mellitus (Sotahexal increases hypoglycemia), respiratory diseases, and hypotension. But Sotahexal is more often prescribed for arrhythmic disorders.
Concor or Anaprilin
Anaprilin is a “veteran” of beta-blockers. Time-tested drug. However, since it affects not only the adrenergic receptors of the heart muscle, side effects and dangerous complications develop much more often when taking anaprilin. Therefore, cardiologists advise using new generation beta-blockers, for example, Concor.
Take care of your heart and blood vessels.
Be healthy!
Atenolol's analogs
Level 4 ATC code matches:
Biol
Metocard
Metozok
Nebilet
Nebilong
Betaxolol
Bisogamma
Aritel
Cordinorm
Vasocardin
Corvitol
Bidop
Bisoprolol
Nebivolol
Biprol
Bisoprol
Concor Cor
Lokren
Concor
Niperten
Analogs of Atenolol are:
- Betacard
- Atenobene
- Atenova
- Atenol
- Tenolol
Reviews of Atenolol
The drug is effective for hypertension and arrhythmia , and is quite inexpensive. However, side effects are common, such as hallucinations and a decrease in blood sugar. Reviews of Atenolol Nycomed are generally better than those of drugs produced by other manufacturers.
Reviews during pregnancy are generally positive; those who used the medication mostly did not notice any side effects. However, it should be remembered that according to the results of clinical studies, such side effects on the fetus are very possible.
Concor during pregnancy
Reception during pregnancy is limited
Expectant mothers should be extremely careful when choosing certain medications. In the case of Concor, you can take it only if the benefit to the mother’s body is greater than the damage. Concor should not be taken during lactation, since the baby receives bisoprolol and auxiliary components through breast milk. If discontinuation of the drug is not possible, then breastfeeding should be discontinued.
Atenolol price, where to buy
Packaging price of Atenolol 50 mg 30 pcs. in Russia - about 50 rubles.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Atenolol tab.
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- Atenolol tablets 100 mg No. 30Update PFK ZAO
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Pharmacy24
- Atenolol-Zdorovye 0.05 g No. 20 tablets TOV" Pharmaceutical company "Zdorovya", Kharkiv, Ukraine
9 UAH. order - Atenolol-Astrapharm 50 mg No. 20 tablets TOV Astrapharm, Ukraine
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- Atenolol-Astrapharm 100 mg No. 20 tablets TOV Astrapharm, Ukraine
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- Atenolol 50 mg No. 20 tablets PAT Monpharm, Ukraine
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PaniPharmacy
- ATENOLOL tablets Atenolol tablets 50 mg No. 20 Ukraine, Astrapharm LLC
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- ATENOLOL tablets Atenolol tablets 50 mg No. 20 Ukraine, Monfarm JSC
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