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Manufacturers: Ranbaxy Laboratories Ltd
Active ingredients
- Terfenadine
Disease class
- Acute upper respiratory tract infection of multiple and unspecified localization
- Vasomotor and allergic rhinitis
- Asthma with a predominance of an allergic component
- Allergic and nutritional gastroenteritis and colitis
- Atopic dermatitis
- Itching
- Dermatitis, unspecified
- Hives
- Other erythematous conditions
- Allergy unspecified
Clinical and pharmacological group
- Not indicated. See instructions
Pharmacological action
- Antiallergic
- Antihistamine
Pharmacological group
- H1-antihistamines
Pharmacological properties
Desloratadine is a long-acting, non-sedating histamine antagonist with selective peripheral H1 receptor antagonist activity.
after oral administration, desloratadine selectively blocks peripheral histamine H1 receptors so that this substance does not enter the central nervous system. Desloratadine exhibits antiallergic properties. inhibits the release of proinflammatory cytokines such as IL-4, IL-6, IL-8 and IL-13 from human mast cells/basophils, and also inhibits the expression of the adhesion molecule p-selectin on endothelial cells. Desloratadine does not penetrate the central nervous system.
Desloratadine is determined in blood plasma 30 minutes after administration. Cmax of desloratadine in blood plasma is achieved after 3 hours, T½ is on average 27 hours. The degree of accumulation of desloratadine corresponds to its T½ (≈27 hours) and the number of applications (1 time per day). The bioavailability of desloratadine is proportional to the dose in the range of 5–20 mg. Desloratadine is moderately (83–87%) bound to plasma proteins. When using desloratadine at a dose of 5–20 mg once a day for 14 days, no signs of clinically significant accumulation of the drug were detected. The enzyme responsible for the metabolism of desloratadine has not yet been identified, so some interactions with other drugs cannot be excluded. Desloratadine does not inhibit CYP3A4 in vivo, and in vitro studies have shown that this drug does not inhibit CYP2D6 and is neither a substrate nor an inhibitor of P-gp. Food does not affect the distribution of desloratadine.
Trexil Neo tablet. p/captivity coated 5 mg blister No. 10
Name
TREXIL NEO
Basic properties, release form
10 tablets per blister; 1 blister per cardboard package.
Destination category
Over the counter.
Compound
Desloratadine 5 mg
Pharmacological properties
Desloratadine is a long-acting, non-sedating histamine antagonist with selective peripheral H1 receptor antagonist activity. After oral administration, desloratadine selectively blocks peripheral histamine H1 receptors to prevent this substance from entering the central nervous system. Desloratadine exhibits antiallergic properties. Suppresses the release of pro-inflammatory cytokines such as IL-4, IL-6, IL-8 and IL-13 from human mast cells/basophils, and also inhibits the expression of the adhesion molecule P-selectin on endothelial cells. Desloratadine does not penetrate the central nervous system. Desloratadine is determined in blood plasma 30 minutes after administration. Cmax of desloratadine in blood plasma is achieved after 3 hours, T½ is on average 27 hours. The degree of accumulation of desloratadine corresponds to its T½ (≈27 hours) and the number of applications (1 time per day). The bioavailability of desloratadine is proportional to the dose in the range of 5–20 mg. Desloratadine is moderately (83–87%) bound to plasma proteins. When using desloratadine at a dose of 5–20 mg once a day for 14 days, no signs of clinically significant accumulation of the drug were detected. The enzyme responsible for the metabolism of desloratadine has not yet been identified, so some interactions with other drugs cannot be excluded. Desloratadine does not inhibit CYP3A4 in vivo, and in vitro studies have shown that this drug does not inhibit CYP2D6 and is neither a substrate nor an inhibitor of P-gp. Food does not affect the distribution of desloratadine.
Indications
for quick relief of symptoms of allergic rhinitis, such as sneezing, nasal discharge, itching, swelling and nasal congestion, as well as itching and redness of the eyes, watery eyes, itching of the palate and cough. To relieve symptoms associated with hives, such as itching and rashes.
Contraindications
hypersensitivity to the components of the drug, as well as to loratadine.
Application
The drug is intended for oral administration. To relieve symptoms associated with allergic rhinitis (including intermittent and persistent) and cough, Trexil Neo should be taken internally, regardless of the intake. Adults and children over 12 years of age take 1 tablet (5 mg) 1 time per day. Therapy of intermittent allergic rhinitis (presence of symptoms less than 4 days per day or less than 4 days) must be carried out in accordance with the history: take note after symptoms disappear and renew the diagnosis For repeated їх guilt. In case of persistent allergic rhinitis (presence of symptoms for more than 4 days per week or more than 4 days), it is necessary to continue to wash throughout the entire period of contact with the allergen.
Overdose
In case of overdose, the standard approach is indicated, directly on the amount of unabsorbed active speech. Symptomatic treatment is recommended. In cases of epilepsy, high doses of up to 45 mg were used (which in 9 cases exceeded the recommendations), no serious adverse reactions were observed. Trexil Neo is not available during hemodialysis; The feasibility of this treatment with peritoneal dialysis has not been established.
Interaction
Desloratadine, taken simultaneously with alcohol, does not potentiate the effects of alcohol, which may reduce productivity. With one-hour administration of erythromycin or ketoconazole, no clinically significant interactions were observed. Due to this, the enzyme responsible for the metabolism of desloratadine did not interact with others It is impossible to turn it off completely using medicinal means.
Side effects
The most common unpleasant symptoms were fatigue, dry mouth and headache. Other unforeseen effects that were reported only rarely during the post-marketing period were overestimated. Body: hypersensitivity reactions (anaphylaxis, angioneurotic swelling, backbone, itching, sagging skin, urticaria). On the side of the herbal tract: abdominal pain, nausea, vomiting, dyspepsia, diarrhea, elevated liver enzymes, elevated bilirubin, hepatitis. On the side of the nervous system: confusion, drowsiness, insomnia, psychomotor hyperactivity, seizures, hallucinations. On the side of the cardiovascular system: tachycardia, heart failure. On the side of the bone-muscle system: myalgia.
Special instructions
Desloratadine does not enhance the effects of alcohol such as impaired psychomotor function and drowsiness. Patients should be advised to use Trexil Neo tablets as prescribed. Since food does not affect the bioavailability of the drug, desloratadine tablets can be taken without regard to meals. Patients should be advised not to increase the dose or frequency of the drug as studies have not demonstrated an increase in effectiveness with increasing dose. And increasing the dose may cause drowsiness. The ability to influence reaction speed when driving a vehicle or operating machinery. The effect of desloratadine on driving a car or working with complex technical devices has not been noted. However, patients should be informed that, on rare occasions, some patients experience drowsiness, which may affect their ability to drive and operate machinery. Use during pregnancy and lactation. The safety of the drug during pregnancy has not been established. Therefore, the use of Trexil Neo tablets during pregnancy is not recommended. Desloratadine passes into breast milk; therefore, it is not recommended to use the drug during breastfeeding. Children. The effectiveness and safety of desloratadine tablets in children under 12 years of age have not been established. Experience with the use of desloratadine tablets in adolescents aged 12–17 years is limited, so the drug should be used as prescribed by a doctor.
Storage conditions
Term of attribution. 2 rocks. Save your mind. Store in a dry place, out of reach of children, at a temperature not exceeding 25 °C.
Application
The drug is intended for oral administration.
To eliminate symptoms associated with allergic rhinitis (including intermittent and persistent) and urticaria, Trexil Neo is taken orally, regardless of meals.
Adults and children over 12 years of age take 1 tablet (5 mg) 1 time per day.
Therapy for intermittent allergic rhinitis (the presence of symptoms less than 4 days a week or less than 4 weeks) must be carried out taking into account the history: stop after the symptoms disappear and resume after their reoccurrence. For persistent allergic rhinitis (symptoms present more than 4 days a week or more than 4 weeks), treatment must be continued throughout the entire period of contact with the allergen.
Trexyl oral tablets
Instructions for medical use of the drug
Description of pharmacological action
Blocks histamine H1 receptors.
Indications for use
Seasonal allergic rhinitis, allergic skin lesions with itching and erythema (urticaria, dermographism, atopic eczema, contact dermatitis), atopic asthma and exercise-induced asthma, acute allergic reactions to medications, food, insect bites, etc.; colds.
Release form
tablets 60 mg; blister 10, box (box) 10; tablets 60 mg; blister 10, box (box) 1; Warehouse 1 tablet mist terfenadine 60 mg; 10 pcs in a blister, 1 or 10 blisters in a box.
Pharmacodynamics
The frequency of sedative effects (drowsiness, weakness, confusion, loss of concentration) is similar to that when taking placebo and 2 times lower than when taking traditional antihistamines.
Pharmacokinetics
It’s good to get wet with the SHKT; binding to plasma proteins - 97%; Most of it is converted into active metabolites in the liver. After taking the drug (60 mg), the maximum plasma concentration of terfenadine is achieved after 1 year, active metabolites - after 2-3 years. The gestation period is 3-4 years, the transitional period is 16-23 years (on average 17 years). The action begins after 1-2 years, reaches a maximum after 3-4 years and lasts for more than 12 years. Distributed throughout all fabrics, accumulates in the liver and skin. It is excreted by the intestines (60% of the administered dose) and by drugs (40%), mainly in the form of metabolites.
Use during pregnancy
Do not take during lactation; in case of gestation, it is recommended only in these cases, if the results of the therapeutic action really pose a risk for the fetus.
Contraindications for use
Hypersensitivity.
Side effects
Dyspeptic disorders, dryness of the mucous membranes of the mouth, nose, pharynx, cough, sore throat, epistaxis, elevated transaminases, skin reactions (alopecia, angioedema, photosensitivity Iya, vysipannya), extrasystoles (in patients with impaired liver function).
Directions for use and doses
For adults and children over 12 years of age: 60 mg 2 times/day. Children under 12 years of age: 1/2 tablet. 2 times/dobu.
Overdose
It is recommended to use the drug without getting wet, cardiac monitoring for at least 24 years (extrasystole may occur), symptomatic and supportive therapy.
Interactions with other drugs
Does not affect the depressive effects of alcohol and benzodiazepines, enhances the effect of corticosteroids and sodium cromoglycate, in combination with bronchodilators and H2 receptor antagonists.
Storage conditions
In a dry, cool, light-protected place.
Best before date
36 months
ATX classification:
R Respiratory system
R06 Antihistamines for systemic use
R06AX Other antihistamines for systemic use
R06AX12 Terfenadine
Side effects
The most common adverse events were fatigue, dry mouth and headache. other side effects that have been reported very rarely during post-marketing experience are listed below.
General disorders: hypersensitivity reactions (anaphylaxis, angioedema, shortness of breath, itching, rash, urticaria).
From the gastrointestinal tract: abdominal pain, nausea, vomiting, dyspepsia, diarrhea, increased levels of liver enzymes, bilirubin, hepatitis.
From the nervous system: dizziness, drowsiness, insomnia, psychomotor hyperactivity, convulsions, hallucinations.
From the cardiovascular system: tachycardia, palpitations.
From the musculoskeletal system: myalgia.
special instructions
Desloratadine does not enhance the effects of alcohol such as impaired psychomotor function and drowsiness.
Patients should be advised to use Trexil Neo tablets as prescribed. Since food does not affect the bioavailability of the drug, desloratadine tablets can be taken without regard to meals. Patients should be advised not to increase the dose or frequency of the drug as studies have not demonstrated an increase in effectiveness with increasing dose. And increasing the dose may cause drowsiness.
The ability to influence reaction speed when driving a vehicle or operating machinery. The effect of desloratadine on driving a car or working with complex technical devices has not been noted. However, patients should be informed that, on rare occasions, some patients experience drowsiness, which may affect their ability to drive and operate machinery.
Use during pregnancy and lactation. The safety of the drug during pregnancy has not been established. Therefore, the use of Trexil Neo tablets during pregnancy is not recommended.
Desloratadine passes into breast milk; therefore, it is not recommended to use the drug during breastfeeding.
Children. The effectiveness and safety of desloratadine tablets in children under 12 years of age have not been established.
Experience with the use of desloratadine tablets in adolescents aged 12–17 years is limited, so the drug should be used as prescribed by a doctor.
Note!
Description of the drug Trexil Neo tablet. p/o 5 mg No. 10 on this page is a simplified author’s version of the apteka911 website, created on the basis of the instructions for use.
Before purchasing or using the drug, you should consult your doctor and read the manufacturer's original instructions (attached to each package of the drug). Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.
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** The Drug Directory is intended for informational purposes only. For more complete information, please refer to the manufacturer's instructions. Do not self-medicate; Before you start using Trexil, you should consult your doctor. EUROLAB is not responsible for the consequences caused by the use of information posted on the portal. Any information on the site does not replace medical advice and cannot serve as a guarantee of the positive effect of the drug.
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** Attention! The information presented in this medication guide is intended for medical professionals and should not be used as a basis for self-medication. The description of the drug Trexil is provided for informational purposes only and is not intended for prescribing treatment without the participation of a doctor. Patients need to consult a specialist!
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