Diazepex - description of the drug, instructions for use, reviews

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Active ingredients

• Diazepam

Disease class

• Mental and behavioral disorders caused by alcohol consumption - dependence syndrome
• Depressive episode
• Panic disorder [episodic paroxysmal anxiety]
• Dystonia
• Essential [primary] hypertension
• Secondary hypertension
• Stomach ulcer
• Duodenal ulcer
• Seropositive rheumatoid arthritis
• Sciatica
• Lumbago with sciatica
• Cramp and spasm
• Anxiety and agitation
• Irritability and anger
• State of emotional shock and stress, unspecified
• Consequences of head injuries
• Premenstrual tension syndrome
• Menopause and menopause in women

Clinical and pharmacological group

• Not indicated. See instructions

Pharmacological action

• Anxiolytic
• Muscle relaxant
• Sedative
• Hypnotic
• Anticonvulsant

Pharmacological group

• Anxiolytics

Release form and composition

Dosage forms of Diazepex:

• tablets (10 pieces in blisters, 2 blisters in a cardboard box);
• injection solution 5 mg/ml: transparent, colorless or slightly yellowish with a green tint (in colorless glass ampoules of 2 ml, in blister packs of 5 ampoules, in a cardboard box of 2 packs).

Active ingredient in 1 tablet: diazepam – 2 or 5 mg.

Composition of 1 ml injection solution:

• active ingredient: diazepam – 10 mg;
• auxiliary components: propylene glycol-1,2, benzoic acid (E 210), sodium benzoate (E 211), 96% ethyl alcohol, benzyl alcohol, water for injection.

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** The Drug Directory is intended for informational purposes only. For more complete information, please refer to the manufacturer's instructions. Do not self-medicate; Before starting to use Diazepex, you should consult a doctor. EUROLAB is not responsible for the consequences caused by the use of information posted on the portal. Any information on the site does not replace medical advice and cannot serve as a guarantee of the positive effect of the drug.

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** Attention! The information presented in this medication guide is intended for medical professionals and should not be used as a basis for self-medication. The description of the drug Diazepex is provided for informational purposes and is not intended for prescribing treatment without the participation of a doctor. Patients need to consult a specialist!

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Indications for use

Pills

Monotherapy:

• anxiety;
• voltage;
• anxiety;
• depression;
• depression.

As an auxiliary component in complex therapy:

• dysalgomenorrhea;
• premenstrual syndrome;
• spasticity of skeletal muscles;
• peptic ulcer of the stomach and duodenum;
• post-traumatic conditions;
• alcoholism;
• arterial hypertension;
• convulsive syndrome;
• lumbago;
• rheumatoid arthritis;
• menopause;
• malignant tumors.

Injection solution

• status epilepticus;
• epileptic seizures (for the purpose of stopping);
• tetanus;
• spasm of skeletal muscles, spastic conditions that are associated with lesions of the spinal cord/brain (cerebral athetosis, paralysis);
• alcohol withdrawal syndrome, including delirium delirium;
• motor excitation of various etiologies in psychiatry/neurology;
• premedication (as a component of combined anesthesia).

Contraindications

Absolute

Pills:

• myasthenia gravis;
• glaucoma;
• I trimester of pregnancy and breastfeeding period;
• individual intolerance to the components of the drug.

Injection solution:

• alcohol addiction (complicated medical history, except acute withdrawal), drug addiction;
• hypercapnia;
• suicidal tendencies;
• a history of epilepsy or epileptic seizures (starting the use of Diazepex or its abrupt withdrawal can lead to the development of status epilepticus or seizures);
• hepatitis;
• cerebral or spinal ataxia;
• glaucoma, angle-closure glaucoma (acute attacks);
• sleep apnea, severe respiratory/heart failure;
• myasthenia gravis;
• porphyria;
• I and III trimesters of pregnancy and breastfeeding;
• age up to 3 years (Diazepex contains benzyl alcohol);
• individual intolerance to the components of the drug, including hypersensitivity to other benzodiazepines.

Relative

Diseases/conditions for which Diazepex should be prescribed with caution:

• functional disorders of breathing, heart, kidneys and liver;
• organic brain damage;
• children and old age.

Directions for use and dosage

Pills

Diazepex is taken orally.

Recommended dosage regimen:

• states of restlessness/anxiety: 2–4 times a day, 2–5 mg;
• spastic conditions: 3–4 times a day, 2–10 mg.

For outpatients, the maximum daily dose is 15 mg.

Daily dose for children (frequency of administration – 1–3 times a day):

• up to 3 years: 1–5 mg;
• 4–12 years: 2–10 mg.

Injection solution

Method of administration of Diazepex: intramuscularly (IM) or slowly intravenously (IV).

The regimen of use is determined by the doctor individually.

Recommended dosage regimen:

• tetanus: intravenous; 0.1–0.3 mg/kg every 1–4 hours (4–10 mg/kg per day);
• delirium: i.v.; 10 mg, then every 5 minutes 5 mg (until the state of excitement is relieved);
• alcohol withdrawal syndrome (tension, anxiety or vegetative equivalents of these disorders): IM or IV; 10 mg each, then after 3–4 hours the drug is administered at a dose of 5–10 mg;
• spastic conditions associated with damage to the spinal cord/brain: i.m.; initial dose – 10–20 mg;
• skeletal muscle spasm associated with local trauma: i.v.; 10 mg once or twice;
• anesthesia (as a component of combined anesthesia at the beginning of anesthesia): IV; 0.2–0.5 mg/kg;
• premedication before anesthesia in case of defibrillation: slow IV; 10–30 mg (in separate doses);
• premedication before anesthesia: intramuscularly; adults 10–20 mg 1 hour before the start of anesthesia;
• motor excitation of various origins in psychiatry and neurology: intramuscular or intravenous; 3 times a day 10–20 mg;
• status epilepticus: i.v.; 10 mg;
• epileptic seizures (for the purpose of stopping): intravenous; 10–20 mg, then the drug can be administered intravenously or intramuscularly at a dose of 20 mg.

The average duration of the interval between single doses is 3–4 hours; in acute cases, repeated use within 1 hour is possible.

Weakened/elderly patients require a dose reduction (usually 2–5 mg); its increase should be carried out gradually. The same regimen of use should be followed in cases of combination therapy with other sedatives.

Oral tablets Diazepeks (Diazepeks)

Instructions for medical use of the drug

Description of pharmacological action

The calming and anti-anxiety effects are due to the effect on benzodiazepine receptors of the limbic system; muscle relaxant and anticonvulsant - inhibition of spinal reflexes.

Indications for use

Anxiety, restlessness, tension, depression, depression; as a component of complex treatment, it is also used for convulsive syndrome, arterial hypertension, rheumatoid arthritis, lumbago, malignant tumors, menopause, premenstrual syndrome, dysalgomenorrhea, gastric and duodenal ulcers, spasticity of skeletal muscles, alcoholism, and consequences of injuries.

Release form

tablets 2 mg; blister 10, cardboard pack 2; tablets 5 mg; blister 10, cardboard pack 2; Composition 1 tablet contains diazepam 2 or 5 mg; 10 pcs in a blister, 2 blisters in a cardboard box.

Pharmacodynamics

The calming and anti-anxiety effects are due to the effect on benzodiazepine receptors of the limbic system; muscle relaxant and anticonvulsant - inhibition of spinal reflexes.

Use during pregnancy

Contraindicated in the first trimester of pregnancy; During treatment it is necessary to stop breastfeeding.

Contraindications for use

Hypersensitivity, glaucoma, myasthenia gravis.

Side effects

Drowsiness, dizziness, weakness, ataxia, headache; rarely - visual disturbances, euphoria, jaundice, dry mouth, nausea, constipation, difficulty breathing, tachycardia, hypotension, leukopenia, granulocytopenia, allergic reactions.

Directions for use and doses

Inside. For states of anxiety and restlessness: 2–5 mg 2–4 times a day. For spastic conditions: 2–10 mg 3–4 times a day. The maximum daily dose for outpatients is 15 mg. Children under 3 years old - 1-5 mg, 4-12 years old - 2-10 mg/day, usually in 1-3 doses.

Overdose

Symptoms: drowsiness, inhibition of reflexes, possible coma. Treatment: symptomatic. The specific antidote is flumazenil.

Interactions with other drugs

The effect is enhanced by phenothiazine derivatives, barbiturates, MAO inhibitors, cimetidine, and alcohol.

Precautions for use

Prescribed with caution for dysfunction of the heart, breathing, liver and kidneys, organic brain damage, elderly patients, and children. During use, it is recommended to avoid work associated with risk and rapid reactions.

Storage conditions

In a dry place, at room temperature.

Best before date

60 months

ATX classification:

N Nervous system

N05 Psycholeptics

N05B Anxiolytics

N05BA Benzodiazepine derivatives

N05BA01 Diazepam

Side effects

Pills

Possible adverse reactions: dizziness, ataxia, weakness, drowsiness, headache.

In rare cases, the development of disorders such as euphoria, visual disturbances, jaundice, nausea, constipation, xerostomia, tachycardia, hypotension, granulocytopenia, leukopenia, difficulty breathing, allergic reactions is observed.

Injection solution

Possible adverse reactions: bradycardia, arterial hypotension, cardiac arrest, fatigue, drowsiness, muscle weakness, impaired coordination of movement, apnea, respiratory depression, thrombophlebitis/thrombosis at the site of intravenous administration of the solution.

In rare cases, the development of such disorders as:

• depression, anterograde amnesia, confusion, behavioral/thinking disorders, paradoxical reactions (manifest as insomnia, nervousness, outbursts of anger, agitation, aggression, hostility, hallucinations, unusual agitation; requires discontinuation of Diazepex);
• dizziness, headache, hiccups;
• tremor, dysarthria;
• jaundice, liver dysfunction;
• anemia, leukopenia, agranulocytosis, neutropenia, thrombocytopenia;
• allergic reactions (in the form of skin rash, itching);
• inactivity;
• tachycardia, fainting, cardiovascular collapse;
• urinary retention/urinary incontinence, decreased libido;
• diplopia, decreased vision clarity, nystagmus;
• functional changes in the salivary glands (in the form of xerostomia or increased salivation), constipation, nausea;
• local reactions with intramuscular injection (in the form of pain, redness at the injection site).

How to take Diazepam

Always take this medication exactly as directed by your doctor. You should not take Diazepam for more than 4 weeks. If you have any doubts about taking the drug, you should consult your doctor or pharmacist.

The tablets are swallowed whole with a glass of water.

Dosage

Adults

• For anxiety or mental disorders: 5mg-30mg every day in divided doses
• For insomnia: 5 mg-15 mg at night.
• For cerebral palsy or other spastic conditions: 5mg-60mg every day in divided doses
• For muscle spasms: 5mg-15mg every day in divided doses
• For epilepsy: 2 mg – 60 mg every day in divided doses.
• To relieve alcohol withdrawal symptoms: 5mg-20mg should be repeated after 2 - 4 hours if necessary.
• Before dental surgery: 5 mg the night before the procedure, 5 mg in the morning and 5 mg 2 hours before the procedure
• For premedication: 5 mg – 20 mg

Children

For cerebral spasticity to eliminate tension and irritability:

5 mg – 40 mg every day in divided doses.

If the doctor prescribed Diazepam to your child before surgery, then the usual dose is 2 mg-10 mg.

Elderly or sick patients

If you are an elderly or sick patient, you are more sensitive to the effects of Diazepam, such as confusion, and your doctor should reduce your dose. The dose should not be more than half the adult dose.

If you have liver or kidney problems, you should also reduce your dose.

If you take more Diazepam than recommended

If you (or someone else) took many tablets at once, or you suspect that a child may have swallowed tablets, go to the nearest emergency room or tell your doctor immediately.

If you overdose, you may feel uneasy and uncoordinated, feeling drowsy or in deep sleep, trouble speaking, irregular or slow heartbeat, uncontrolled eye movements, muscle weakness or agitation.

Severe overdose can lead to coma (lack of consciousness), impaired reflexes and difficulty breathing.

If you forget to take Diazepam

Do not take a double dose to make up for a missed dose.

If you forget to take the next dose of the drug, take it as soon as you remember and continue taking the next dose as usual.

If you stop taking Diazepam

You should not stop taking the drug without consulting your doctor, since before stopping the drug, the dose should be gradually reduced until the drug is completely discontinued.

If you suddenly stop taking Diazepam, you may experience unpleasant side effects, including depression, nervousness, irritability, sweating or diarrhea. If you took a large dose, you may sometimes experience confusion, seizures, or unusual behavior.

• Treatment should be discontinued gradually, otherwise the symptoms for which you were treated may recur more intensely than before (recurrent insomnia and anxiety). The risk of all this increases if the drug is suddenly stopped. You may also experience mood changes, anxiety, restlessness, or changes in your sleep patterns.

If you have any additional questions about the use of the drug, please contact your doctor or pharmacist.

Possible side effects

Like all medicines, Diazepam can cause side effects, although not everyone gets them.

You should call your doctor immediately if you notice any of these side effects or if you experience side effects not listed in this leaflet:

Some side effects may be serious and require immediate medical attention:

Uncommon: may affect 1 to 10 in 1,000 people

• Respiratory depression (very slow and/or shallow breathing)

Rare: may affect 1 to 10 in 10,000 people

• Stopping breathing
• Loss of consciousness
• Jaundice (yellowing of the skin or whites of the eyes)

Very rare: may affect 1 in 10,000 people

• anaphylactic reaction (severe allergic reaction) with symptoms such as sudden shortness of breath, swelling of the lips, tongue, throat or body, rash, fainting, or difficulty swallowing.

Other side effects:

Very common: may affect 1 in 10 people

• Drowsiness

Common: May affect 1 to 10 out of 100 people

• Fatigue
• Withdrawal syndrome (for possible symptoms, see “If you stop taking Diazepam”)
• Confusion
• Lack of coordination of muscle movements (ataxia) and other movement disorders, tremors

Uncommon: may affect 1 to 10 in 1,000 people

• Muscle weakness
• Memory loss
• Impaired concentration
• Vestibular disorders
• Dizziness
• Headache
• Slurred speech
• Gastrointestinal disorders such as nausea, vomiting, constipation, diarrhea
• Increased salivation
• Allergic skin reactions in the form of itching, redness of the skin and swelling and skin rash.

Rare: may affect 1 to 10 in 10,000 people

Psychiatric side effects such as restlessness, agitation, restlessness, irritation, aggressiveness, memory loss, confusion, rage, psychosis, nightmares or hallucinations. They can also become severe. These side effects are most likely to occur in children or older adults.

You should inform your doctor about this.

• Decreased vigilance
• Depression
• Emotional withdrawal
• Insomnia
• Heart problems such as a slower heartbeat (bradycardia), heart failure, and stopping of the heart rhythm (cardiac arrest).
• Decreased blood pressure, fainting
• Increased mucus secretion in the lungs
• Dry mouth
• Increased appetite
• Changes in the levels of certain liver enzymes, as detected by liver tests
• Lack of urination, loss of control of the bladder sphincter (urinary incontinence)
• Breast enlargement in men
• Impotence, changes in sexual desire (libido)
• Problems with the hematopoietic system (may cause sore throat, nosebleeds, or infections)

Very rare: may affect 1 in 10,000 people

• Decreased white blood cell count (leukopenia)
• Increased levels of certain enzymes in the blood (transaminase)

Unknown: incidence cannot be estimated from available data

• Blurred vision, double vision, and involuntary eye movements (these side effects disappear when you stop taking diazepam).

Withdrawal: See “If you stop taking Diazepam.”

Side Effect Reporting:

If you notice any side effects, tell your doctor, pharmacist or pharmacist, including any side effects not listed in this leaflet. You can also report side effects by going to the website www.arpimed.com and filling out the appropriate form “Report a side effect or ineffectiveness of a drug” and to the Scientific Center for Expertise of Medicines and Medical Technologies named after. Academician E. Gabrielyan by going to the website www.pharm.am to the “Report a side effect of a drug” section and fill out the form “Card of reporting a side effect of a drug.” Scientific center hotline phone number: +37410237665; +37498773368.

How to store Diazepam

• The drug should be stored out of the reach of children, protected from moisture and light at a temperature of 15-25ºC.
• Shelf life – 3 years. Do not use after the expiration date indicated on the product packaging. When indicating the expiration date, we mean the last day of the specified month.

The medicine should not be disposed of in wastewater or sewer systems. Ask your pharmacist how to dispose of any medicine you no longer need. These measures are aimed at protecting the environment.

Package contents and additional information

One tablet of Diazepam 5 mg contains: Active substance: diazepam 5 mg

Other components: microcrystalline cellulose, lactose monohydrate, ethylcellulose, sodium starch glycolate, magnesium stearate What Diazepam looks like and contents of the package:

Round, flat, white tablets with a score on one side and a bevel on both sides.

Description of packaging

Cardboard packaging containing 24 tablets (1 blister of 24 tablets) along with an insert.

Vacation conditions

Dispensed by prescription.

special instructions

With intravenous administration of Diazepex, an inflammatory process may occur at the injection site (manifested as swelling, phlebitis, burning sensation, thrombophlebitis). In this regard, administration should be carried out slowly, using a catheter, no more than 5 mg (1 ml) per minute. The solution should not be injected into veins of small diameter (for example, veins of the hand). It is necessary to avoid getting the drug into the perivascular space or arteries.

When administered intramuscularly, Diazepex should be injected deep into the muscle.

The solution in the infusion system/syringe must not be mixed with other medications.

When administered intravenously, special attention is needed in elderly patients, patients in particularly severe conditions, as well as patients with cardiorespiratory failure, which is associated with the likelihood of developing cardiac arrest and/or apnea.

When combined with narcotic analgesics, their dose should be significantly reduced (at least by 1/3).

The administration of Diazepex in patients with shock, coma or acute alcohol intoxication with signs of depression is not recommended.

The drug acts quickly after intravenous administration, but does not last long, so it is not recommended for maintenance therapy.

In case of impaired renal/hepatic function in cases of prolonged use of the drug, it is advisable to conduct a blood test and assess the functional state of the liver.

In case of strong feelings of fear and depression, Diazepex should not be used as monotherapy (associated with the likelihood of developing suicidal tendencies).

When using the drug, there is a potential risk of physical/mental dependence, especially with a long course using high doses. There is also a high risk of this disorder in patients with a tendency to abuse alcohol or a history of drug addiction.

If therapy is suddenly stopped after the development of physical dependence, withdrawal syndrome may develop (manifested in the form of convulsions, tremors, colic, muscle cramps, vomiting, increased sweating). Severe symptoms may occur in patients who use high doses of Diazepex for longer than necessary. Disturbances in milder forms (in the form of dysphoria, insomnia) may occur in patients who follow the course for several months using therapeutic doses. After completing the treatment course, the drug should be discontinued gradually.

It is recommended that you refrain from driving while using Diazepex.

Diazepam (injection solution)

Name: Diazepam (injection solution) (Diazepam) Pharmacological action: Diazepam is a drug with anxiolytic, hypnotic, anticonvulsant, sedative and central muscle relaxant effects. Diazepam reduces the severity of emotional stress, reduces anxiety, and also reduces increased muscle tone. The effect of the drug is based on its ability to enhance the central effect of gamma-aminobutyric acid (one of the inhibitory mediators of the central nervous system) on the receptors of the reticular formation of the brain column. Diazepam leads to a decrease in excitation of the cerebral cortex, hypothalamus, thalamus and limbic system. Diazepam has a muscle relaxant effect due to the slowing of postsynaptic spinal reflexes. During alcohol withdrawal, diazepam helps reduce the severity of the acute state of agitation, tremor, acute alcoholic delirium, hallucinations and negativism.

With continuous administration, the effect of the drug is enhanced due to chalk excretion and, as a consequence, the accumulation of diazepam in tissues. Initial diazepam levels decline fairly quickly over 6 hours, after which the decline in plasma concentrations slows. The half-life of diazepam ranges from 20 to 70 hours, depending on the individual characteristics of the patients. Diazepam is metabolized in the liver with the formation of active substances (the main metabolite N-desmethyldiazepam is determined in plasma 24-36 hours after administration of the drug). Diazepam and its metabolites are excreted primarily by the kidneys.

Indications for use: Diazepam in the form of a parenteral solution is used to treat patients with acute neuropsychic stress, which is accompanied by insomnia, tension, anxiety and fear. Diazepam is used to treat patients with epilepsy, severe emotional symptoms and spastic paralysis. Diazepam can also be prescribed for alcohol withdrawal and delirium tremens.

Directions for use: Diazepam solution is intended for parenteral use. The drug is administered intravenously or intramuscularly. Intravenous Diazepam can be administered by drip or stream. It is recommended to administer intramuscularly only into large muscles (for example, the gluteal muscle), following the rules for intramuscular administration of solutions. The duration of therapy and dose of Diazepam is determined by the doctor individually. Adults with diseases that are accompanied by severe psychomotor agitation and convulsions, as well as for the relief of epileptic seizures, are usually prescribed 10 mg of diazepam (2 ml of Diazepam 0.5% solution) up to 3 times a day. The maximum recommended single dose of diazepam is 30 mg, the highest daily dose is 70 mg. For status epilepticus, a single dose of diazepam can be increased to 40 mg. If necessary, for patients with status epilepticus, injections are repeated every 3-4 hours, but not more than 4 times a day.

The sedative effect develops within a few minutes after intravenous administration of diazepam and within 30-40 minutes after intramuscular administration. The recommended duration of therapy is from 3 to 10 days. After relief of acute symptoms of the disease, continued therapy with oral diazepam is recommended. Recommended doses for children: For febrile convulsions, children 1-6 years old are usually prescribed 2-5 mg of diazepam per day. For febrile seizures, children aged 6-14 years are usually prescribed 5-10 mg of diazepam per day. For children, it is recommended to administer Diazepam solution intravenously slowly. After prolonged therapy, withdrawal of Diazepam should be carried out gradually.

Side effects: Diazepam is usually well tolerated by patients. In some cases, when using the drug Diazepam, patients may develop drowsiness, dizziness, lethargy, myasthenia gravis, as well as allergic skin reactions. With prolonged use of the drug Diazepam, drug dependence may develop. When administering Diazepam intravenously, local inflammatory reactions may develop; to prevent this undesirable effect, it is recommended to change the injection site with each injection.

Contraindications: Diazepam is not prescribed to patients with a history of intolerance reactions to the components of the solution, as well as to drugs of the benzodiazepine group. Diazepam is not used in the treatment of patients with myasthenia gravis and glaucoma. Diazepam should not be used in patients with occupational restrictions. Diazepam is not prescribed to patients with alcoholism (except in cases of alcohol withdrawal and alcoholic delirium). Diazepam solution in pediatric practice is used only for the treatment of children over 1 year of age. Caution must be exercised when prescribing Diazepam to patients at increased risk of developing drug dependence. Potentially unsafe activities should be avoided during therapy with Diazepam.

Pregnancy: Diazepam is not used during pregnancy. For health reasons, Diazepam can be used during pregnancy under the supervision of a physician for a minimum period of time and in the minimum effective doses. If it is necessary to regularly use the drug Diazepam during lactation, the issue of stopping breastfeeding should be decided.

Interaction with other drugs: It is prohibited to mix Diazepam solution in the same syringe with other drugs. Diazepam potentiates the effect of barbiturates, phenothiazines, monoamine oxidase inhibitors, as well as other psychotropic drugs. Medicines that depress the central nervous system, including hypnotics, sedatives, analgesics, antipsychotics and anesthetics, as well as antidepressants, potentiate the inhibitory effect of diazepam on the central nervous system.

Overdose: When using excessive doses of Diazepam, patients may develop drowsiness, dysarthria, myasthenia gravis and paradoxical agitation. With further increases in the dose, patients experienced the development of decreased reflexes, loss of consciousness and coma. A fatal outcome from an overdose of diazepam is unlikely, but the risk increases significantly when using excessive doses of diazepam in combination with ethyl alcohol and other substances that potentiate the effect of benzodiazepines.

With an overdose of Diazepam, it is also possible to develop arterial hypotension, respiratory depression and paradoxical reactions, including sleep disturbances, hallucinations and agitation. In case of an overdose of Diazepam, maintenance therapy and constant monitoring of the patient's condition are prescribed. If necessary, central nervous system stimulants and cardiovascular drugs are used.

Release form: Solution for parenteral use Diazepam 2 ml in ampoules, 10 ampoules placed in blister packs are placed in a cardboard box.

Storage conditions: Diazepam in the form of a solution for parenteral use should be stored in rooms where the temperature is maintained from 8 to 25 degrees Celsius. The shelf life of Diazepam is 2 years.

Synonyms: Sibazon solution for injection 0.5%.

Composition: 2 ml of Diazepam (1 ampoule) contain: Diazepam – 10 mg; Additional substances.

Attention! The description of the drug “ Diazepam (solution for injection) ” on this page is a simplified and expanded version of the official instructions for use. Before purchasing or using the drug, you should consult your doctor and read the instructions approved by the manufacturer. Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.

Drug interactions

When using Diazepex in combination with certain drugs/substances, the following effects may develop:

• estrogen-containing contraceptives, diltiazem, verapamil, ketoconazole, cimetidine, erythromycin, nefazodone, itraconazole, ranitidine: increased concentration and, as a consequence, toxicity of Diazepex (associated with inhibition of liver enzymes);
• alcohol, drugs that can cause depression of the central nervous system (including antipsychotics, anesthetics, drugs with sedative and hypnotic effects, opioid analgesics): increased inhibitory effect of diazepam;
• rifampicin, carbamazepine: decrease in concentration and, therefore, effectiveness of Diazepex.