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Manufacturers: Minskintercaps
Active ingredients
- Ascorbic acid
- Calcium carbonate
- Loratadine
- Paracetamol
- Rimantadine
- Rutoside
Disease class
- Influenza caused by an identified influenza virus
Clinical and pharmacological group
- Not indicated. See instructions
Pharmacological action
- Antipyretic
- Antiviral
- Angioprotective
- Antihistamine
- Painkiller
Pharmacological group
- Antiviral (except HIV) agents in combinations
- Anilides in combinations
Contraindications
Absolute:
- lactase deficiency, lactose intolerance, glucose-galactose malabsorption;
- period of pregnancy and lactation (breastfeeding);
- children and adolescents up to 14 years of age;
- increased individual sensitivity to one or more substances included in the drug.
Relative (the drug is taken with caution):
- renal and/or liver failure;
- nephrolithiasis;
- functional hyperbilirubinemia (including Gilbert's syndrome);
- viral hepatitis;
- alcoholic liver disease;
- epilepsy (including history);
- sideroblastic anemia;
- elderly age.
Side effects
- central nervous system: rarely - increased fatigue, headache, hyperexcitability, tremor, dizziness, hyperkinesia;
- gastrointestinal tract (if use lasts more than 1 week): possible - dry mouth, dyspepsia, nausea, damage to the gastric and duodenal mucosa, flatulence, diarrhea, anorexia;
- blood system (if use lasts more than 1 week): possible – leukopenia, agranulocytosis, thrombocytopenia, anemia, neutropenia;
- hypersensitivity reactions: rarely - skin rash, urticaria, itching.
Symptoms of overdose on the first day may be: nausea, epigastric pain, vomiting, pallor, drowsiness, tremor, increased bilirubin in the blood, tachycardia, exacerbation of concomitant chronic diseases. Signs of liver dysfunction may appear 1/2-2 days after an overdose of paracetamol included in the drug. As a result of a severe overdose, the following are possible: pancreatitis, arrhythmia, acute renal failure as a result of tubular necrosis (including without severe liver damage), liver failure with progressive encephalopathy, coma, death.
To treat the condition, you should induce a gag reflex, perform gastric lavage, take adsorbents and carry out symptomatic treatment, after which you must consult a doctor.
special instructions
The maximum duration of therapy with AnGriCaps Maxima should not exceed 5 days. Long-term (more than 7 days) use of capsules can cause exacerbation of concomitant chronic pathologies. In elderly patients with arterial hypertension, the risk of developing hemorrhagic stroke increases due to rimantadine, which is part of the drug.
During treatment, you must avoid drinks containing alcohol to reduce the risk of gastrointestinal bleeding. In patients with alcoholic hepatosis, the likelihood of developing liver damage increases.
Paracetamol distorts laboratory data for the quantitative determination of uric acid and glucose in plasma.
Since ascorbic acid has a stimulating effect on the synthesis of glucocorticosteroids, it is important to control blood pressure and adrenal function. Vitamin C, as a reducing agent, can change the data of the following laboratory tests: the quantitative content of bilirubin and glucose in the blood, indicators of the activity of lactate dehydrogenase and liver transaminases.
AnGriCaps Maxim capsules are prohibited from being taken by patients with metastatic tumors.
When engaging in potentially hazardous activities (including driving vehicles) that require rapid psychomotor reactions and increased concentration, caution should be exercised due to the rimantadine contained in the drug.
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** The Drug Directory is intended for informational purposes only. For more complete information, please refer to the manufacturer's instructions. Do not self-medicate; Before starting to use the drug AnGriCaps Maxima, you should consult a doctor. EUROLAB is not responsible for the consequences caused by the use of information posted on the portal. Any information on the site does not replace medical advice and cannot serve as a guarantee of the positive effect of the drug.
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Drug interactions
- glucocorticoid drugs, hepatotoxic and anticonvulsants, barbiturates, anticoagulants, rifampicin, alcohol - their combination with AnGriCaps Maxima should be avoided if possible;
- diflunisal - increases the concentration of paracetamol in plasma by 50%, increasing the risk of developing hepatotoxicity of the drug;
- myelotoxicants – enhance the manifestation of paracetamol hematotoxicity;
- metoclopramide – increases the absorption of paracetamol;
- benzylpenicillin and tetracyclines - ascorbic acid increases their concentration in the blood;
- iron preparations - vitamin C improves their absorption in the intestines, promoting the transformation of ferric iron into ferrous iron;
- short-acting salicylates and sulfonamides - ascorbic acid increases the risk of developing crystalluria;
- acids - ascorbic acid slows down their excretion by the kidneys;
- drugs with an alkaline reaction, including alkaloids - ascorbic acid increases the rate of their elimination;
- oral contraceptives - their concentration in the blood decreases;
- antipsychotic drugs (neuroleptics), phenothiazine derivatives - their therapeutic effect decreases;
- amphetamine and tricyclic antidepressants - their tubular reabsorption decreases;
- CYP3A4 inhibitors (including erythromycin and ketoconazole), CYP3A4 and CYP2D6 inhibitors (cimetidine, etc.) - increase the blood concentration of loratadine;
- rutoside - ascorbic acid enhances its effect;
- tetracyclines, digoxin, oral iron preparations - calcium carbonate slows down their absorption (it is necessary to maintain an interval between doses of at least 2 hours);
- thiazide diuretics - can increase hypercalcemia, reduce the effect of calcitonin due to hypercalcemia, and reduce the bioavailability of phenytoin.
If you need to take AnGriCaps Maxim together with other medications, you must consult your doctor in advance.
Capsule AngriCaps maxima (Angricaps maxima)
Instructions for medical use of the drug
Indications for use
Symptomatic treatment of influenza A.
Release form
capsules; contour packaging 10, cardboard pack 2.
Pharmacodynamics
The pharmacological activity of the drug AnGricaps maxima is due to the complex action of its components - paracetamol, rimantadine, ascorbic acid, loratadine, rutoside and calcium. The drug has antiviral, antipyretic, analgesic, antihistamine, angioprotective effects. Paracetamol has analgesic and aromatogenic effects. Rimantadine is an antiviral agent derived from adamantane. Active against various strains of influenza A virus. Suppresses the early stage of specific reproduction (after the virus enters the cell and before the start of RNA transcription). Rimantadine inhibits the release of viral particles from the cell, i.e. interrupts transcription of the viral genome. Ascorbic acid is involved in many redox reactions and increases the body's resistance to infections. Loratadine is a long-acting H1-histamine receptor blocker. Prevents the development of tissue edema associated with the release of histamine. It has antiallergic, antipruritic, antiexudative effects. Calcium prevents the development of increased permeability and fragility of blood vessels and has a membrane-stabilizing effect. Rutoside is an angioprotector. Prevents the development of increased permeability and fragility of blood vessels, causing hemorrhagic processes in influenza. Rutoside, together with ascorbic acid, participates in redox processes, has antioxidant properties, prevents oxidation and promotes the deposition of ascorbic acid in tissues.
Contraindications for use
Hypersensitivity to one or more components included in the drug; pregnancy and lactation; age under 18 years; lactose intolerance, lactase deficiency, glucose-galactose malabsorption. With caution: renal and liver failure, kidney stones, benign hyperbilirubinemia (including Gilbert's syndrome), viral hepatitis, alcoholic liver damage, old age, epilepsy (including a history), sideroblastic anemia.
Side effects
From the side of the central nervous system: rarely - headache, increased fatigue, increased excitability, dizziness, tremor, hyperkinesia. From the gastrointestinal tract: if taken for more than 7 days, damage to the mucous membrane of the stomach and duodenum, dyspepsia, dry mouth, nausea, anorexia, flatulence, diarrhea is possible. From the blood system: when taken for more than 7 days - agranulocytosis, leukopenia, thrombocytopenia, neutropenia, anemia. Allergic reactions: rarely - possible skin rash, itching, urticaria.
Directions for use and doses
Inside, after meals, with water. Adults - 2 caps. 2-3 times a day for 3-5 days, until the symptoms of the disease disappear. If you do not feel better, you should stop taking the drug and consult a doctor!
Overdose
Symptoms: in the first 24 hours, pallor, nausea, vomiting and pain in the epigastric region, tremor, drowsiness, tachycardia, increased bilirubin in the blood, exacerbation of concomitant chronic diseases are possible. Symptoms of liver dysfunction may appear 12–48 hours after an overdose (paracetamol). In case of severe overdose - liver failure with progressive encephalopathy, coma, death; acute renal failure with tubular necrosis (including in the absence of severe liver damage); arrhythmia, pancreatitis. Treatment: induction of the gag reflex, gastric lavage, taking adsorbents, symptomatic therapy. You need to see a doctor.
Interactions with other drugs
If you need to take it together with other drugs, consult your doctor first. It is recommended to avoid simultaneous use with glucocorticoid drugs, hepatotoxic and anticonvulsants, barbiturates, anticoagulants, rifampin, and alcohol. Diflunisal increases the plasma concentration of paracetamol by 50% - the risk of developing hepatotoxicity. Myelotoxic drugs enhance the manifestations of hematotoxicity of the paracetamol included in the drug. Metoclopramide increases the absorption of paracetamol when used together. Ascorbic acid increases the concentration of benzylpenicillin and tetracyclines in the blood; improves the absorption of iron preparations in the intestines (converts ferric iron to divalent iron). Increases the risk of developing crystalluria during treatment with salicylates and short-acting sulfonamides, slows down the excretion of acids by the kidneys, increases the excretion of drugs that have an alkaline reaction (including alkaloids), and reduces the concentration of oral contraceptives in the blood. Reduces the therapeutic effect of antipsychotic drugs (neuroleptics) - phenothiazine derivatives, tubular reabsorption of amphetamine and tricyclic antidepressants. CYP3A4 inhibitors (including ketoconazole, erythromycin), CYP3A4 and CYP2D6 inhibitors (cimetidine, etc.) increase the concentration of loratadine in the blood. The effect of rutoside is enhanced by ascorbic acid. Calcium carbonate slows down the absorption of tetracyclines, digoxin, and oral iron supplements (the interval between doses should be at least 2 hours). When combined with thiazide diuretics, it can increase hypercalcemia, reduce the effect of calcitonin in hypercalcemia, and reduce the bioavailability of phenytoin.
Special instructions for use
Duration of use - no more than 5 days. During treatment, you should avoid drinking alcoholic beverages (increased risk of gastrointestinal bleeding). With long-term use (more than 7 days), exacerbation of chronic concomitant diseases is possible; in elderly patients with arterial hypertension, the risk of developing hemorrhagic stroke increases (due to the rimantadine included in the drug). When taken, the risk of developing liver damage increases in patients with alcoholic hepatosis. Distorts laboratory test results in the quantitative determination of glucose and uric acid in plasma (paracetamol). Due to the stimulating effect of ascorbic acid on the synthesis of glucocorticosteroid hormones, it is necessary to monitor adrenal function and blood pressure. Ascorbic acid as a reducing agent can distort the results of various laboratory tests (blood glucose, bilirubin, liver transaminase and lactate dehydrogenase activity). Do not use in the presence of metastatic tumors. Care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions (contains rimantadine).
Storage conditions
In a place protected from light and moisture, at a temperature of 15–25 °C.
Best before date
24 months
ATX classification:
R Respiratory system
R05 Medicines used for coughs and colds
R05X Other combination drugs used for colds
