Pharmacodynamics and pharmacokinetics
Baneocin is an antimicrobial combination remedy used exclusively for topical (local) use and includes two antibacterial drugs, characterized by their pronounced bactericidal effect .
Neomycin is an aminoglycoside antibiotic bacterial protein synthesis . The activity of this antibacterial agent is manifested against many gram-positive and gram-negative bacterial microorganisms .
Bacitracin belongs to the group of polypeptide antibiotics that inhibit the replication processes of the bacterial cell membrane . The main antibacterial effect of this drug is observed against gram-positive microorganisms representing the genus Staphylococcus and Streptococcus , as well as against some gram-negative bacteria (resistance to bacitracin is very rarely formed).
The synergism (combined action) of these two antibacterial drugs leads to a significant increase in the therapeutic spectrum of action of bacitracin and an increase in its effectiveness against a number of microorganisms , in particular staphylococci .
When using the drug locally, absorption of its active ingredients, as a rule, is not observed (even when applied to damaged skin). However, at the time of therapy, their high concentration is detected in the skin.
This drug is characterized by good tissue tolerance , and therefore its use on large skin areas may cause systemic absorption.
Baneocin®
Baneocin® is a combined antibacterial drug intended for external use.
Baneocin® contains two bactericidal antibiotics: neomycin and bacitracin, the combination of which achieves synergistic action. Bacitracin primarily inhibits the synthesis of murein in the cell wall of gram-positive bacteria (and some gram-negative bacteria).
Bacitracin is active primarily against gram-positive microorganisms: Streptococcus hemolyticus, Staphylococcus spp., Clostridium spp., Corynebacterium
diphtheriae ,
and some gram-negative microorganisms:
Neisseria spp.
and
Haemophilus influenzae.
Bacitracin is also active against
Treponema pallidum, Actinomyces spp.
and
Fusobacteria spp.
Resistance to bacitracin is extremely rare.
The effectiveness of neomycin is due in part to an increase in cell membrane permeability due to inhibition of protein synthesis. Neomycin is active against both gram-positive and gram-negative pathogens, such as Staphylococcus spp., Proteus spp., Enterobacter aerogenes, Klebsiella pneumoniae, Salmonella spp., Shigella spp., Haemophilus influenzae, Pasteurella, Neisseria meningitidis, Vibrio cholerae, Bordetella pertussis, Bacillus anthracis, Corynebacterium diphtheriae, Streptococcus faecalis, Listeria monocytogenes, Escherichia coli
and
Mycobacterium tuberculosis.
Also active against
Borrelia
and
Leptospira interrogans (L. icterohaemorrhagiae).
Some strains of staphylococci are resistant to neomycin.
Thanks to the use of a combination of these two substances, a wide spectrum of action of the drug is achieved, with the exception of action against pseudomonas, nocardia, fungi and viruses. Tissue tolerance of the drug Baneocin® is assessed as good; inactivation by biological products, blood and tissue components is not observed.
If the drug is applied to large areas of skin lesions (in violation of the recommended dosage regimen), the possibility of absorption of the drug and its consequences should be taken into account (see sections “Contraindications”, Interaction with other drugs”, “Special instructions” and “Side effects”) .
Baneocin® powder also has a drying, soothing and cooling effect.
Indications for use
The use of Baneocin ointment and Baneocin powder is indicated for the purpose of local therapy of infectious and inflammatory skin diseases that were caused by microorganisms sensitive to the active ingredients of the drug, including:
- of umbilical infection in newborns ;
- prevention of possible infectious complications after surgical ( dermatological ) manipulations, as additional therapy in the postoperative period after episiotomy , cauterization , tissue excision, treatment of weeping wounds , cracks and sutures ;
- treatment of local bacterial skin infections trophic ulcerative lesions of the lower extremities, contagious weeping impetigo , infected eczema , bacterial diaper dermatitis , including bacterial complications caused by Varicella zoster and Herpes simplex .
Indications and method of use
Baneocin is very widely used for infectious and inflammatory skin diseases. It has an antibacterial effect and wound healing. Has a detrimental effect on bacteria and microorganisms. Where exactly is Baneocin ointment used, and where is Baneocin powder?
- Baneocin ointment is a fatty substance that has a wide range of uses: for dry wounds, skin inflammation, cracks and postoperative sutures. Baneocin ointment in gynecology for perineal rupture. The effectiveness of Baneocin ointment doubles under a bandage.
- Baneocin powder is a dry substance that is indicated for weeping wounds and bedsores. Baneocin is also used for the navel in infants with an umbilical infection. Baneocin powder has a cooling effect.
Let's look at how to use Baneocin correctly using the example of burns.
Baneocin for burns. If the burn is fresh or if it is a weeping wound, then it is rational to treat it with Baneocin powder. Apply a thin layer to damaged tissue without touching the surface with your hands. The area of application of the drug should not cover more than 1% of the patient’s body area. Use within 7 days.
Contraindications
It is prohibited to use any of the dosage forms of the drug when:
- extensive skin lesions (due to the risk of an ototoxic effect manifested by hearing loss );
- personal hypersensitivity to neomycin , bacitracin or other aminoglycosides ;
- severe disorders of renal excretory function (due to renal or heart failure );
- diagnosed pathologies of the cochleo-vestibular system (if systemic absorption of the active ingredients of the drug is possible);
- diseases of the visual organs.
Side effects
Baneocin ointment and Baneocin powder, as a rule, do not lead to any negative effects when used topically on small problem areas of the skin and mucous membranes, which is why the ointment and powder of this drug are recommended for use specifically for the treatment of local infectious diseases .
With prolonged use, allergic manifestations , including dry skin , redness , skin rash / itching . Mostly these phenomena occur similar to contact eczema , in half of the cases they are provoked by cross- allergy to other aminoglycosides and are observed quite rarely.
of systemic negative effects is allowed , in most cases noted in the treatment of extensive skin lesions, when there is a high possibility of absorption of the active ingredients of the drug and the occurrence of its nephrotoxic and ototoxic neuromuscular conduction disorders .
Contraindications and adverse reactions
You should avoid taking Baneocin in the following cases:
- increased susceptibility to constituent components;
- in case of serious skin damage, do not take the drug in the form of an ointment;
- when infected with an infection of the ear canal in the presence of perforating damage to the eardrum;
- for problems with the excretory system;
- for problems with the muscular-nervous system;
- diseases of the visual organs.
You should strictly adhere to the instructions for use and not exceed the permissible dose.
With prolonged use of the product, allergic processes may begin, accompanied by redness, itching and rashes. When treating large skin lesions, systemic negative reactions may occur.
To date, no cases of overdose with Baneocin have been recorded.
Instructions for use of Baneocin (Method and dosage)
Baneocin powder, instructions for use
The drug in powder form is indicated for use 2-4 times a day with a thin layer of it on the affected skin areas.
In the case of treating burns that occupy more than 20% of the patient’s body surface, the powder can be used only once every 24 hours, especially if the patient has reduced renal function (due to the possible absorption of active ingredients into the systemic circulation).
When used topically, the maximum daily dosage of neomycin can be 1 gram, which corresponds to the use of 200 grams of powder per week. A repeated therapeutic course requires reducing the weekly maximum dosage by half (up to 100 grams).
Baneocin ointment, instructions for use
The drug in the form of an ointment is allowed for use 2-3 times a day, for which Baneocin ointment is applied in a thin layer to the affected areas of the skin. You can practice applying ointment under the bandage .
It is possible to use the ointment in the postoperative period as an additional therapeutic agent. Application of the drug directly to bandages is preferable in the case of local treatment of infected wounds and cavities (including surgical scars healed by secondary intention and bacterial infections of the external auditory canal without damage to the eardrum ).
How to use
Before using this or that form of the drug, you should definitely consult a specialist. You also need to do a test for the sensitivity of the skin to the constituent components in order to prevent the occurrence of allergic processes.
Ointment
The ointment is applied exclusively to damaged areas of the skin. For maximum results, apply a gauze bandage over the area. You can apply the ointment no more than 3 times a day. You can use up to 1 g of neomycin per day. The dosage for a child does not require adjustment. The duration of the therapeutic course is a week. In certain cases, the specialist may extend the treatment. When prolonging treatment, the dose used should be reduced by 2 times.
Powder
The medicine in this form is convenient to use as a powder on the umbilical wound, as well as for healing scratches. Used to treat injured skin areas. The powder can be used no more than 4 times a day. It must be applied in a thin layer. Up to 200 g of powder can be used per day. For long-term treatment, the dosage should be reduced to 100 g per day.
Interaction
If systemic absorption of the active ingredients of the drug is possible, parallel use of aminoglycosides or cephalosporins increases the risk of nephrotoxic phenomena .
The combined administration of Baneocin with Furosemide or Ethacrynic acid increases the possibility of nephrotoxic and ototoxic reactions.
With observed systemic absorption, the combined use of Baneocin with muscle relaxants , anesthetics and opioid analgesics can lead to the development of neuromuscular blockade .
cases of incompatibility of neomycin and bacitracin with other medications.
special instructions
In the case of using dosages of Baneocin that significantly exceed the recommended ones, due to the possible absorption of its active ingredients, it is necessary to pay attention to negative symptoms that may indicate ototoxic or nephrotoxic reactions.
Due to the increased risk of toxic effects in patients with observed / kidney pathologies, urine and blood together with audiometric studies , both before the start of therapy and during treatment .
If during therapy the possibility of absorption of the active ingredients of the drug is allowed (in case of extensive skin damage), then there is a need to control the possible formation of symptoms of neuromuscular blockade , especially in patients with myasthenia , other neuromuscular pathologies , as well as acidosis . If neuromuscular blockade it is recommended to prescribe neostigmine calcium supplements .
Long-term use of Baneocin requires monitoring for a possible excessive increase in the number of resistant microorganisms , sometimes with the need to prescribe appropriate therapy.
Long-term use of Baneocin for the treatment of children with liver / kidney , as well as the use of the drug to treat large areas of skin, must be previously agreed with a doctor.
If superinfection or allergic manifestations , Baneocin therapy should be discontinued.
Analogs
Level 4 ATC code matches:
Bacitracin
Fucidin
Bactroban
Fusiderm
Sintomycin
Analogues of Baneocin ointment and powder are represented by medicinal products used for topical use (ointments, aerosols, creams, solutions):
- Bactroban;
- Altargo;
- Gentamicin;
- Chitosan-Ghent;
- Levomycetin;
- Tyrosur;
- Sintomycin;
- Fusiderm;
- Neomycin;
- Supirocin;
- Fusicutane.
Baneocin for children
The use of the drug Baneocin is allowed for the treatment of children only after prior consultation with a pediatrician. Most often, I prescribe this powder and ointment for children for acne ( boils , carbuncles ), paronychia , hidradenitis , burns , and even for the treatment of chickenpox (chickenpox).
Note!
The description of the drug Baneocin on this page is a simplified author’s version of the apteka911 website, created on the basis of the instructions for use.
Before purchasing or using the drug, you should consult your doctor and read the manufacturer's original instructions (attached to each package of the drug). Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.
Reviews about Baneocin
Reviews of Baneocin ointment, as well as reviews of the powder of this remedy, are overwhelmingly positive. The use of this drug, both for the treatment of adult patients and for the treatment of children, really leads to rapid and high-quality healing of infected wound skin surfaces and almost never causes the development of any side effects.
Also, favorable reviews of Baneocin are left by young mothers who use the powder of this remedy to prevent possible umbilical infection in their newborn babies.
Baneocin receives a somewhat less positive assessment when used for acne and in the case of treating large affected skin areas, but in any case, the effectiveness of the drug remains high.
Popular questions about Baneocin
How to use Baneocin for the treatment of diaper rash?
When treating diaper rash, Baneocin is used both in ointment and in the form of powder. It should be applied to the baby's well-washed and dried skin. If skin redness does not go away after one use, repeat the procedure after each diaper change.
Baneocin ointment or powder - which is better?
Baneocin is a remedy that is prescribed for the treatment of infected wounds. It comes in two forms - ointment and powder. Both forms do their job well, but there are some differences. Baneocin ointment is a fatty substance that has a wide range of uses: in surgery, dermatology, gynecology, for dry wounds or skin inflammation. Baneocin powder is a dry substance that is indicated for weeping wounds (bedsores, umbilical infections in newborns).
How quickly does Baneocin work?
Baneocin has 2 effects. In the first case, the action occurs immediately after application. This is a bactericidal effect. The second effect - healing - occurs depending on various factors: the depth of the injury, the age of the patient, the degree of tissue damage. In any case, Baneocin accelerates the natural process of skin regeneration at the wound site.
How often can Baneocin be used?
The medicine must be applied to the site of injury; to enhance the effect, it can be applied under a bandage. Both adults and children should apply the medication 2-3 times a day. The treatment period is 7 days.
Baneocin price, where to buy
The ointment and powder of the drug are approximately in the same price category. The price of Baneocin ointment is about 350-400 rubles, the price of Baneocin powder ranges from 360-420 rubles.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Baneocin powder for external use.
approx. 10g Pharmazoitische Fabrik Montavit GmbH RUB 445 order
Pharmacy Dialogue
- Baneocin (por. 10g) Montavit Fabrik
RUB 423 order
- Baneocin ointment (tube 5g)Merck KgaA
200 rub. order
show more
Pharmacy24
- Baneocin 10 g powder Pharmaceuticals Factory Montavit GesmbH/Sandoz GmbH, Austria/Austria
103 UAH.order - Baneocin 20 g ointment Merck KgaA & Co. Werk Spittal/Sandoz GmbH-TechOps, Austria/Austria
104 UAH order
PaniPharmacy
- Baneocin ointment Baneocin ointment 20g tube Austria, Sandoz
109 UAH order
- Baneocin Baneocin powder for external use 10g No. 1 Austria, Sandoz
119 UAH order
show more